A novel spray-drying technique to produce low density particles for pulmonary delivery

International Journal of Pharmaceutics

Volumn 278, Issue 1, 2004, Pages 187-195

  Steckel, Hartwig ^a   Brandes, Heike G ^a  

^a UNIVERSITY OF KIEL   (Germany)

Author keywords

Dipalmitoylphosphatidylcholine; Dry powder inhaler; Efficiency; Emulsion spray technique; Fine particle fraction; Phosphatidylcholine; Spray drying

Indexed keywords

BULKING AGENT; CYCLODEXTRIN DERIVATIVE; LACTOSE; LUTROL; PHOSPHATIDYLCHOLINE; POLOXAMER; PROPELLANT; SALBUTAMOL SULFATE; SURFACTANT;

AQUEOUS SOLUTION; ARTICLE; DRUG DELIVERY SYSTEM; DRUG MIXTURE; DRUG SOLUBILITY; DRUG STRUCTURE; EMULSION; LIQUEFACTION; PARTICLE SIZE; POWDER INHALER; PRIORITY JOURNAL; SPRAY DRYING;

ADMINISTRATION, INHALATION; DRUG DELIVERY SYSTEMS; LUNG; PARTICLE SIZE; POWDERS;

EID: 2442666256     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2004.03.010     Document Type: Article

References (21)

1. Anderson P.J. Delivery options and devices for aerosolized therapeutics. Chest. 120:2001;89-93
2. Brocklebank D., Ram F., Wright J., Barry P., Cates C., Davies L., Douglas G., Muers M., Smith D., White J. Comparison of the effectiveness of inhaler devices in asthma and chronic obstructive airways disease: a systematic review of the literature. Health Technol. Assess. 5:2001;1-149
3. Borgstrom L., Derom E., Stahl E., Wahlin-Boll E., Pauwels R. The inhalation device influences lung deposition and bronchodilating effect of terbutaline. Am. J. Respir. Crit. Care Med. 153:1996;1636-1640
4. Bronsky E., Bucholtz G.A., Busse W.W., Chervinsky P., Condemi J., Ghafouri M.A., Hudson L., Lakshminarayan S., Lockey R., Reese M.E. Comparison of inhaled albuterol powder and aerosol in asthma. J. Allergy Clin. Immunol. 79:1987;741-747
5. Buckton G. Characterization of small changes in the physical properties of powders of significance for dry powder inhaler formulations. Adv. Drug Del. Rev. 26:1997;17-27
6. Chawla A., Taylor K.M.G., Newton J.M., Johnson M.C.R. Production of spray-dried salbutamol sulphate for use in dry powder aerosol formulations. Int. J. Pharm. 108:1994;233-240
7. Crompton G.K. Problems patients have using pressurized aerosol inhalers. Eur. Respir. Dis. 119:1982;101-410
8. Dellamary L.A., Tarara T.E., Smith D.J., Woelk C.H., Adractas A., Costello M.L., Gill H., Weers J.G. Hollow porous particles in metered dose inhalers. Pharm. Res. 17:2000;168-174
9. Edwards D.A., Ben-Jebria A., Langer R. Recent advances in pulmonary drug delivery using large, porous inhaled particles. J. Appl. Physiol. 85:1998;379-385
10. Edwards, D.A., Caponetti, G., Hrkach, J.S., Lotan, N., Hanes, J., Ben-Jebria, A., Langer, R., 1999. Aerodynamically light particles for pulmonary drug delivery. USA patent #5,874,064 (1999).
11. Edwards D.A., Hanes J., Caponetti G., Hrkach J.S., Ben-Jebria A., Eskew M.L., Mintzes J., Deaver D., Lotan N. Large porous particles for pulmonary drug delivery. Science. 276:1997;1868-1871
12. Elamin A.A., Sebhatu T., Ahlneck C. The use of amorphous model substances to study mechanically activated materials in the solid state. Int. J. Pharm. 119:1995;25-36
13. Feeley J.C., York P., Sumby B.S., Dicks H. Determination of surface properties and flow characteristics of salbutamol sulphate, before and after micronisation. Int. J. Pharm. 172:1998;89-96
14. French D.L., Edwards D.A., Niven R.W. The influence of formulation of emission, deaggregation and deposition of dry powders for inhalation. J. Aerosol Sci. 27:1996;769-783
15. Hickey A.J., Martonen T.B., Yang Y. Theoretical relationship of lung deposition to the fine particle fraction of inhalation aerosols. Pharm. Acta Helv. 71:1996;185-190
16. Parrott, E.L., 1990. Comminution. In: Swarbrick, J., Boylan, J.C. (Eds.), Encyclopedia of Pharmaceutical Technology, vol. 3, 1990, pp. 101-121.
17. Shekunov, B.Y., Chow, A.H.L., Walker, S.E., York, P., 2001. Physical properties and aerosol behaviour of salmeterol xinafoate. British Pharmaceutical Conference Abstract Book, 2001, p. 141.
18. Ticehurst M.D., Basford P.A., Dallman C.I., Lukas T.M., Marshall P.V., Nichols G., Smith D. Characterisation of the influence of micronisation on the crystallinity and physical stability of revatrope hydrobromide. Int. J. Pharm. 193:2000;247-259
19. Vidgrén M.T., Vidgrén P.A., Paronen T.P. Comparison of physical and inhalation properties of spray-dried and mechanically micronized disodium cromoglycate. Int. J. Pharm. 35:1987;139-144
20. Ward G.H., Schultz R.K. Process-induced crystallinity changes in albuterol sulfate and its effect on powder physical stability. Pharm. Res. 12:1995;773-779
21. Weers J.G. Dispersible powders for inhalation applications. Innovations Pharm. Technol. 1:2000;111-116