Synthesis and structure-activity correlations of the cytotoxic bifunctional 1,4-diamidoanthraquinone derivatives

Bioorganic and Medicinal Chemistry

Volumn 12, Issue 23, 2004, Pages 6163-6170

  Huang, Hsu Shan ^a   Chiu, Hui Fen ^b   Lee, An Long ^a   Guo, Ching Long ^a   Yuan, Chun Lung ^a  

^a NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

^b KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Amidoanthraquinone; Anthraquinone; Cytotoxic; Mitoxantrone; Regioisomeric

Indexed keywords

1,4 BIS(2 CHLOROBENZAMIDO)ANTHRAQUINONE; 1,4 BIS(2 CHLOROPROPIONAMIDO)ANTHRAQUINONE; 1,4 BIS(2 FLUOROBENZAMIDO)ANTHRAQUINONE; 1,4 BIS(2 FURYLAMIDO)ANTHRAQUINONE; 1,4 BIS(2 NITROBENZAMIDO)ANTHRAQUINONE; 1,4 BIS(2 THIOPHENEACETAMIDO)ANTHRAQUINONE; 1,4 BIS(2 THIOPHENYLAMIDO)ANTHRAQUINONE; 1,4 BIS(3 CHLOROBENZAMIDO)ANTHRAQUINONE; 1,4 BIS(3 CHLOROPROPIONAMIDO)ANTHRAQUINONE; 1,4 BIS(3 CYCLOPENTANEPROPYLAMIDO)ANTHRAQUINONE; 1,4 BIS(3 FLUOROBENZAMIDO)ANTHRAQUINONE; 1,4 BIS(3 METHYLBENZAMIDO)ANTHRAQUINONE; 1,4 BIS(4 CHLOROBENZAMIDO)ANTHRAQUINONE; 1,4 BIS(4 FLUOROBENZAMIDO)ANTHRAQUINONE; 1,4 BIS(ACETAMIDO)ANTHRAQUINONE; 1,4 BIS(BENZAMIDO)ANTHRAQUINONE; 1,4 BIS(CHLOROACETAMIDO)ANTHRAQUINONE; 1,4 BIS(CYCLOHEXYLAMIDO)ANTHRAQUINONE; 1,4 BIS(CYCLOPENTYLAMIDO)ANTHRAQUINONE; 1,4 BIS(CYCLOPROPYLAMIDO)ANTHRAQUINONE; 1,4 BIS[2 (CYCLOPROPYLMETHYLAMINO)PROPIONAMIDO]ANTHRAQUINONE; 1,4 BIS[2 (DIETHYLAMINO)ACETAMIDO]ANTHRAQUINONE; 1,4 BIS[2 (DIETHYLAMINO)PROPIONAMIDO]ANTHRAQUINONE; 1,4 BIS[3 (CYCLOPROPYLMETHYLAMINO)PROPIONAMIDO]ANTHRAQUINONE; 1,4 BIS[3 (DIETHYLAMINO)PROPIONAMIDO]ANTHRAQUINONE; ANTHRAQUINONE DERIVATIVE; ANTINEOPLASTIC AGENT; DOXORUBICIN; MITOXANTRONE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG MECHANISM; DRUG SYNTHESIS; HUMAN; HUMAN CELL; NONHUMAN; STRUCTURE ACTIVITY RELATION;

AMIDES; ANIMALS; ANTHRAQUINONES; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL SURVIVAL; HUMANS; INTERCALATING AGENTS; MICE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 7444230327     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2004.09.001     Document Type: Article

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