BRCA1 modulates sensitivity to 5F-203 by regulating xenobiotic stress-inducible protein levels and EROD activity

Cancer Chemotherapy and Pharmacology

Volumn 62, Issue 4, 2008, Pages 689-697

  Kang, Hyo Jin ^a   Kim, Hee Jeong ^a   Kwon, Sang Hoon ^a,b   Kang, Brian DongHoon ^c   Eling, Thomas E ^d   Lee, Sang Han ^a,e   Bae, Insoo ^a  

^a GEORGETOWN UNIVERSITY   (United States)

^b Keimyung University   (South Korea)

^c UNIVERSITY OF MICHIGAN   (United States)

^d NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^e Soonchunhyang University   (South Korea)

Author keywords

5F 203; AhR; BRCA1; CYP1A1; EROD activity; P53

Indexed keywords

2 (4 AMINO 3 METHYLPHENYL) 5 FLUOROBENZOTHIAZOLE; 2 (4 AMINO 3 METHYLPHENYL) BENZOTHIAZOLE; 2 (4 AMINO 3 METHYLPHENYL)BENZOTHIAZOLE; AROMATIC HYDROCARBON RECEPTOR; BENZOTHIAZOLE DERIVATIVE; BRCA1 PROTEIN; CYTOCHROME P450 1A1; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MESSENGER RNA; NSC 703786; PRODRUG; PROTEIN P21; PROTEIN P53;

ARTICLE; BREAST CANCER; CANCER RESISTANCE; CELL SURVIVAL; CONTROLLED STUDY; CYTOTOXICITY; DRUG PROTEIN BINDING; DRUG SENSITIVITY; ENZYME ACTIVITY; HUMAN; HUMAN CELL; ONCOGENE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING; XENOBIOTIC STRESS;

ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL SURVIVAL; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYTOCHROME P-450 CYP1A1; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME INDUCTION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE SILENCING; HUMANS; PRODRUGS; RNA, SMALL INTERFERING; THIAZOLES; TUMOR SUPPRESSOR PROTEIN P53; UBIQUITIN-PROTEIN LIGASES;

EID: 47549096228     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00280-007-0657-7     Document Type: Article

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