Methylation status of cyclin-dependent kinase inhibitor genes within the transforming growth factor beta pathway in human T-cell lymphoblastic lymphoma/leukemia

Leukemia Research

Volumn 28, Issue 12, 2004, Pages 1293-1301

  Scott, Stuart A ^a   Kimura, Tomofumi ^a   Dong, Wei Feng ^a   Ichinohasama, Ryo ^b   Bergen, Susan ^a   Kerviche, Annette ^a   Sheridan, David ^a   Decoteau, John F ^a  

^a ROYAL UNIVERSITY HOSPITAL   (Canada)

^b TOHOKU UNIVERSITY   (Japan)

Author keywords

CDKI; cyclin dependent kinase inhibitor; methylation specific PCR; MSP; RNase Protection Assay; RPA; T ALL; T cell acute lymphoblastic leukemia; T cell lymphoblastic lymphoma; T LBL; TGF ; transforming growth factor beta; TSG; TTGE; tumor suppressor gene

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR; MESSENGER RNA; RIBONUCLEASE; TRANSFORMING GROWTH FACTOR BETA;

ACUTE LYMPHOBLASTIC LEUKEMIA; ADULT; ARTICLE; BIOPSY; CANCER CELL CULTURE; CONTROLLED STUDY; CPG ISLAND; DENSITY; ENZYME ASSAY; GEL ELECTROPHORESIS; GENE; GENE EXPRESSION; HEMATOLOGIC MALIGNANCY; HUMAN; HUMAN CELL; HUMAN TISSUE; LYMPHATIC LEUKEMIA; LYMPHOBLASTOMA; METHYLATION; PATHOGENESIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; PROTECTION; SAMPLE; T CELL LEUKEMIA; T CELL LYMPHOBLASTIC LYMPHOMA;

CARRIER PROTEINS; CELL CYCLE PROTEINS; CYCLIN-DEPENDENT KINASE INHIBITOR P15; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLIN-DEPENDENT KINASE INHIBITOR P27; CYCLIN-DEPENDENT KINASES; CYCLINS; DNA METHYLATION; DNA PRIMERS; EPIGENESIS, GENETIC; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LEUKEMIA, T-CELL, ACUTE; POLYMERASE CHAIN REACTION; PROMOTER REGIONS (GENETICS); TRANSFORMING GROWTH FACTOR BETA; TUMOR SUPPRESSOR PROTEINS;

EID: 4744357204     PISSN: 01452126     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.leukres.2004.03.019     Document Type: Article

References (52)

1. Thomas D.A., Kantarjian H.M. Lymphoblastic lymphoma. Hematol Oncol Clin North Am. 15:2001;51
2. Ono Y., Fukuhara N., Yoshie O. Transcriptional activity of TAL1 in T cell acute lymphoblastic leukemia (T-ALL) requires RBTN1 or -2 and induces TALLA1, a highly specific tumor marker of T-ALL. J Biol Chem. 272:1997;4576
3. Bash R.O., Hall S., Timmons C.F., Crist W.M., Amylon M., Smith R.G., et al. Does activation of the TAL1 gene occur in a majority of patients with T-cell acute lymphoblastic leukemia? A childhood oncology group study. Blood. 86:1995;666
4. Fisch P., Boehm T., Lavenir I., Larson T., Arno J., Forster A., et al. T-cell acute lymphoblastic lymphoma induced in transgenic mice by the RBTN1 and RBTN2 LIM-domain genes. Oncogene. 7:1992;2389
5. Lichty B.D., Ackland-Snow J., Noble L., Kamel-Reid S., Dube I.D. Dysregulation of HOX11 by chromosome translocations in T-cell acute lymphoblastic leukemia: a paradigm for homeobox gene involvement in human cancer. Leuk Lymphoma. 16:1995;209
6. Massague J. How cells read TGF-beta signals. Nat Rev Mol Cell Biol. 1:2000;169
7. Blobe G.C., Schiemann W.P., Lodish H.F. Role of transforming growth factor beta in human disease. N Engl J Med. 342:2000;1350
8. Markowitz S., Wang J., Myeroff L., Parsons R., Sun L., Lutterbaugh J., et al. Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability. Science. 268:1995;1336
9. Grady W.M., Myeroff L.L., Swinler S.E., Rajput A., Thiagalingam S., Lutterbaugh J.D., et al. Mutational inactivation of transforming growth factor beta receptor type II in microsatellite stable colon cancers. Cancer Res. 59:1999;320
10. Yamamoto H., Sawai H., Perucho M. Frameshift somatic mutations in gastrointestinal cancer of the microsatellite mutator phenotype. Cancer Res. 57:1997;4420
11. Schwartz S. Jr., Yamamoto H., Navarro M., Maestro M., Reventos J., Perucho M. Frameshift mutations at mononucleotide repeats in caspase-5 and other target genes in endometrial and gastrointestinal cancer of the microsatellite mutator phenotype. Cancer Res. 59:1999;2995
12. Inoue K., Kohno T., Takakura S., Hayashi Y., Mizoguchi H., Yokota J. Corrigendum to: Frequent microsatellite instability and BAX mutations in T cell acute lymphoblastic leukemia cell lines. Leuk Res. 25:2001;275
13. Scott S., Kimura T., Ichinohasama R., Bergen S., Magliocco A., Reimer C., et al. Microsatellite mutations of transforming growth factor-β receptor type II and caspase-5 occur in human precursor T-cell lymphoblastic lymphomas/leukemias in vivo but are not associated with hMSH2 or hMLH1 promoter methylation. Leuk Res. 27:2003;23
14. Lowsky R., Magliocco A., Ichinohasama R., Reitmair A., Scott S., Henry M., et al. MSH2-deficient murine lymphomas harbor insertion/deletion mutations in the transforming growth factor beta receptor type 2 gene and display low not high frequency microsatellite instability. Blood. 95:2000;1767
15. Osada H., Tatematsu Y., Masuda A., Saito T., Sugiyama M., Yanagisawa K., et al. Heterogeneous transforming growth factor (TGF)-beta unresponsiveness and loss of TGF-beta receptor type II expression caused by histone deacetylation in lung cancer cell lines. Cancer Res. 61:2001;8331
16. Rich J.N., Zhang M., Datto M.B., Bigneri D.D., Wang X.F. Transforming growth factor-beta-mediated p15INK4B induction and growth inhibition in astrocytes is SMAD3-dependent and a pathway prominently altered in human glioma cell lines. J Biol Chem. 274:1999;35053
17. Hannon G.J., Beach D. p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest. Nature. 371:1994;257
18. Pardali K., Kurisaki A., Moren A., ten Dijke P., Kardassis D., Moustakas A. Role of Smad proteins and transcription factor Sp1 in p21(waf1/Cip1) regulation by transforming growth factor-beta. J Biol Chem. 275:2000;29244
19. Liu X., Sun Y., Ehrlich M., Lu T., Kloog Y., Weinberg R.A., et al. Disruption of TGF-beta growth inhibition by oncogenic ras is linked to p27Kip1 mislocalization. Oncogene. 19:2000;5926
20. Tsihlias J., Kapusta L., Slingerland J. The prognostic significance of altered cyclin-dependent kinase inhibitors in human cancer. Annu Rev Med. 50:1999;401
21. Drexler H.G. Review of alterations of the cyclin-dependent kinase inhibitor INK4 family genes p15, p16, p18 and p19 in human leukemia-lymphoma cells. Leukemia. 12:1998;845
22. Batova A., Diccianni M.B., Yu J.C., Nobori T., Link M.P., Pullen J., et al. Frequent and selective methylation of p15 and deletion of both p15 and p16 in T-cell acute lymphoblastic leukemia. Cancer Res. 57:1997;832
23. Omura-Minamisawa M., Diccianni M.B., Batova A., Chang R.C., Bridgeman L.J., Yu J., et al. Universal inactivation of both p16 and p15 but not downstream components is an essential event in the pathogenesis of T-cell acute lymphoblastic leukemia. Clin Cancer Res. 6:2000;1219
24. Herman J.G., Civin C.I., Issa J.P., Collector M.I., Sharkis S.J., Baylin S.B. Distinct patterns of inactivation of p15INK4B and p16INK4A characterize the major types of hematological malignancies. Cancer Res. 57:1997;837
25. Nakatsuka S., Liu A., Yao M., Takakuwa T., Tomita Y., Hoshida Y., et al. Methylation of promoter region in p27 gene plays a role in the development of lymphoid malignancies. Int J Oncol. 22:2003;561
26. Nakamura M., Sakaki T., Hashimoto H., Nakase H., Ishida E., Shimada K., et al. Frequent alterations of the p14(ARF) and p16(INK4a) genes in primary central nervous system lymphomas. Cancer Res. 61:2001;6335
27. Kibel A.S., Christopher M., Faith D.A., Bova G.S., Goodfellow P.J., Isaacs W.B. Methylation and mutational analysis of p27(kip1) genes in prostate carcinoma. Prostate. 48:2001;248
28. Go J.H. Methylation analysis of cyclin-dependent kinase inhibitor genes in primary gastrointestinal lymphomas. Mod Pathol. 16:2003;752
29. Roman-Gomez J., Castillejo J.A., Jimenez A., Gonzalez M.G., Moreno F., Rodriguez Mdel C., et al. 5′ CpG island hypermethylation is associated with transcriptional silencing of the p21(CIP1/WAF1/SDI1) gene and confers poor prognosis in acute lymphoblastic leukemia. Blood. 99:2002;2291
30. Shen L., Kondo Y., Issa J.P., Garcia-Manero G. Lack of p21(CIP1) DNA methylation in acute lymphocytic leukemia. Blood. 100:2002;3432
31. Herman J.G., Graff J.R., Myohanen S., Nelkin B.D., Baylin S.B. Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands. Proc Natl Acad Sci USA. 93:1996;9821
32. Warnecke P.M., Stirzaker C., Melki J.R., Millar D.S., Paul C.L., Clark S.J. Detection and measurement of PCR bias in quantitative methylation analysis of bisulphite-treated DNA. Nucleic Acids Res. 25:1997;4422
33. Ying J., Srivastava G., Gao Z., Zhang X., Murray P., Ambinder R., et al. Promoter hypermethylation of the cyclin-dependent kinase inhibitor (CDKI) gene p21WAF1/CIP1/SDI1 is rare in various lymphomas and carcinomas. Blood. 103:2004;743
34. Kretzschmar M. Transforming growth factor-beta and breast cancer: Transforming growth factor-beta/SMAD signaling defects and cancer. Breast Cancer Res. 2:2000;107
35. Markowitz S.D., Roberts A.B. Tumor suppressor activity of the TGF-beta pathway in human cancers. Cytokine Growth Factor Rev. 7:1996;93
36. Verma M., Srivastava S. Epigenetics in cancer: implications for early detection and prevention. Lancet Oncol. 3:2002;755
37. Kantarjian H.M. Adult Acute Lymphocytic Leukemia. Hematol Oncol Clin North Am. 14:2000;1205
38. Kawamura M., Ohnishi H., Guo S.X., Sheng X.M., Minegishi M., Hanada R., et al. Alterations of the p53, p21, p16, p15 and RAS genes in childhood T-cell acute lymphoblastic leukemia. Leuk Res. 23:1999;115
39. Morosetti R., Kawamata N., Gombart A.F., Miller C.W., Hatta Y., Hirama T., et al. Alterations of the p27KIP1 gene in non-Hodgkin's lymphomas and adult T-cell leukemia/lymphoma. Blood. 86:1995;1924
40. Ponce-Castaneda M.V., Lee M.H., Latres E., Polyak K., Lacombe L., Montgomery K., et al. p27Kip1: chromosomal mapping to 12p12-12p13.1 and absence of mutations in human tumors. Cancer Res. 55:1995;1211
41. Worm J., Bartkova J., Kirkin A.F., Straten P., Zeuthen J., Bartek J., et al. Aberrant p27Kip1 promoter methylation in malignant melanoma. Oncogene. 19:2000;5111
42. Loda M., Cukor B., Tam S.W., Lavin P., Fiorentino M., Draetta G.F., et al. Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas. Nat Med. 3:1997;231
43. Chen B., He L., Savell V.H., Jenkins J.J., Parham D.M. Inhibition of the interferon-gamma/signal transducers and activators of transcription (STAT) pathway by hypermethylation at a STAT-binding site in the p21WAF1 promoter region. Cancer Res. 60:2000;3290
44. Cameron E.E., Baylin S.B., Herman J.G. p15(INK4B) CpG island methylation in primary acute leukemia is heterogeneous and suggests density as a critical factor for transcriptional silencing. Blood. 94:1999;2445
45. Leroy K., Haioun C., Lepage E., Le Metayer N., Berger F., Labouyrie E., et al. p53 gene mutations are associated with poor survival in low and low-intermediate risk diffuse large B-cell lymphomas. Ann Oncol. 13:2002;1108
46. Yang H, Hoshino K, Canalli A, Sanchez-Gonzalez B, Kantarjian H, Issa JP, Garcia-Manero G, Preclinical Studies of the Combination of the Hypomethylating Agent 5-aza-2-Deoxycytidine (Decitabine) and the Histone Deacetylase Inhibitor (HDI) Valproic Acid (VPA) in Leukemic Cell Systems, Blood 2003;102:Abstract 2295.
47. Nakano K., Mizuno T., Sowa Y., Orita T., Yoshino T., Okuyama Y., et al. Butyrate activates the WAF1/Cip1 gene promoter through Sp1 sites in a p53-negative human colon cancer cell line. J Biol Chem. 272:1997;22199
48. Kostyniuk C.L., Dehm S.M., Batten D., Bonham K. The ubiquitous and tissue specific promoters of the human SRC gene are repressed by inhibitors of histone deacetylases. Oncogene. 21:2002;6340
49. Richon V.M., Sandhoff T.W., Rifkind R.A., Marks P.A. Histone deacetylase inhibitor selectively induces p21WAF1 expression and gene-associated histone acetylation. Proc Natl Acad Sci USA. 97:2000;10014
50. el-Deiry W.S., Tokino T., Velculescu V.E., Levy D.B., Parsons R., Trent J.M., et al. WAF1, a potential mediator of p53 tumor suppression. Cell. 75:1993;817
51. Westendorf J.J., Zaidi S.K., Cascino J.E., Kahler R., van Wijnen A.J., Lian J.B., et al. Runx2 (Cbfa1, AML-3) interacts with histone deacetylase 6 and represses the p21(CIP1/WAF1) promoter. Mol Cell Biol. 22:2002;7982
52. Wu S., Cetinkaya C., Munoz-Alonso M.J., von der Lehr N., Bahram F., Beuger V., et al. Myc represses differentiation-induced p21CIP1 expression via Miz-1-dependent interaction with the p21 core promoter. Oncogene. 22:2003;351