Ku70, an essential gene, modulates the frequency of rAAV-mediated gene targeting in human somatic cells

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 25, 2008, Pages 8703-8708

  Fattah, Farjana J ^a   Lichter, Natalie F ^a   Fattah, Kazi R ^a   Oh, Sehyun ^a   Hendrickson, Eric A ^a  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

Author keywords

DNA protein kinase; Gene therapy; Ku; Nonhomologous end joining (NHEJ); Recombinant adeno associated virus (rAAV)

Indexed keywords

HETERODIMER; KU ANTIGEN; SHORT HAIRPIN RNA;

ADENO ASSOCIATED VIRUS; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DNA REPAIR; DOUBLE STRANDED DNA BREAK; ESSENTIAL GENE; GENE; GENE DELETION; GENE TARGETING; GENE THERAPY; HUMAN; HUMAN CELL; KNOCKOUT GENE; KU70 GENE; KU86 GENE; PRIORITY JOURNAL; PROTEIN DEPLETION; RNA INTERFERENCE; SOMATIC CELL; STATISTICAL SIGNIFICANCE; WILD TYPE;

ANTIGENS, NUCLEAR; CELL LINE, TUMOR; DEPENDOVIRUS; DNA-BINDING PROTEINS; GENE TARGETING; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; HCT116 CELLS; HUMANS; RECOMBINATION, GENETIC; TRANSFECTION;

ADENO-ASSOCIATED VIRUS;

EID: 47249150446     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0712060105     Document Type: Article

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