Chemical and traditional mutagenesis of vaccinia DNA topoisomerase provides insights to cleavage site recognition and transesterification chemistry

Journal of Biological Chemistry

Volumn 283, Issue 23, 2008, Pages 16093-16103

  Yakovleva, Lyudmila ^a   Chen, Shengxi ^b   Hecht, Sidney M ^b   Shuman, Stewart ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b UNIVERSITY OF VIRGINIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; GENES; HYDROGEN; HYDROGEN BONDS; MUTAGENESIS; ORGANIC ACIDS; OXYGEN; PLANTS (BOTANY); VAN DER WAALS FORCES;

ACTIVE SITES; CATALYTIC RESIDUES; CHEMICAL MUTAGENESISES; CLEAVAGE RATES; CLEAVAGE SITES; DINUCLEOTIDE; DNA CLEAVAGES; DNA TOPOISOMERASE; DOUBLE MUTATIONS; FUNCTIONAL REDUNDANCIES; IN VITRO TRANSLATIONS; MAJOR GROOVES; MISSENSE MUTATIONS; NUCLEOBASES; PHOSPHODIESTER; POX VIRUSES; SIDE CHAINS; TARGET SITES;

NUCLEIC ACIDS;

ARGININE; ASPARAGINE; DEOXYRIBONUCLEIC ACID TOPOISOMERASE IB; DNA TOPOISOMERASE; LYSINE; PHOSPHATE; THREONINE; TRANSFER RNA; TYROSINE; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ARTICLE; CATALYSIS; CHEMICAL MUTAGENESIS; CONTROLLED STUDY; CRYSTAL STRUCTURE; DNA CLEAVAGE; DNA HELIX; DNA SEQUENCE; ESCHERICHIA COLI; HYDROGEN BOND; IN VITRO STUDY; MISSENSE MUTATION; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL; TRANSESTERIFICATION; AMINO ACID SUBSTITUTION; BINDING SITE; CHEMISTRY; ENZYMOLOGY; GENETICS; METABOLISM; MUTAGENESIS; PHYSIOLOGY; PROTEIN SECONDARY STRUCTURE; VACCINIA VIRUS;

POXVIRIDAE;

AMINO ACID SUBSTITUTION; BINDING SITES; DNA TOPOISOMERASES, TYPE I; MUTAGENESIS; PROTEIN STRUCTURE, SECONDARY; VACCINIA VIRUS; VIRAL PROTEINS;

EID: 47049085300     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M801595200     Document Type: Article

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