Analogues of vaccinia virus DNA topoisomerase I modified at the active site tyrosine

Journal of the American Chemical Society

Volumn 127, Issue 10, 2005, Pages 3321-3331

  Gao, Rong ^a   Zhang, Yi ^a   Choudhury, Ambar K ^a   Dedkova, Larisa M ^a   Hecht, Sidney M ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICAL MODIFICATION; DNA; HYDROGEN BONDS; PH EFFECTS; STEREOCHEMISTRY; STRUCTURE (COMPOSITION);

ELECTRONIC EFFECTS; TOPOISOMERASE FUNCTIONS; TYROSINE ANALOGUES;

ENZYMES;

DNA TOPOISOMERASE; HYDROCARBON SUBSTITUENT; HYDROGEN; PHENOL DERIVATIVE; TYROSINE;

ARTICLE; CHEMICAL MODIFICATION; CHEMICAL STRUCTURE; DNA VIRUS; ENZYME ACTIVITY; HYDROGEN BOND; PROTEIN STRUCTURE; STEREOCHEMISTRY; STEREOSPECIFICITY; VACCINIA VIRUS;

AMINO ACID SEQUENCE; BINDING SITES; DNA TOPOISOMERASES, TYPE I; HYDROGEN-ION CONCENTRATION; KINETICS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PLASMIDS; RNA, TRANSFER, AMINO ACYL; RNA, TRANSFER, PHE; STRUCTURE-ACTIVITY RELATIONSHIP; TYROSINE; VACCINIA VIRUS;

EID: 14944354815     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja044182z     Document Type: Article

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