Nonpolar nucleobase analogs illuminate requirements for site-specific DNA cleavage by vaccinia topoisomerase

Journal of Biological Chemistry

Volumn 281, Issue 47, 2006, Pages 35914-35921

  Yakovleva, Lyudmila ^a   Lai, Jacob ^b   Kool, Eric T ^b   Shuman, Stewart ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b STANFORD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA CLEAVAGE; NUCLEOBASE ANALOGS; TRANSESTERIFICATION; VACCINIA TOPOISOMERASE;

BINDING ENERGY; ENZYMES; ESTERIFICATION; MOLECULAR BIOLOGY; REACTION KINETICS; SUBSTITUTION REACTIONS;

DNA;

2 AMINOPURINE; DNA TOPOISOMERASE; GUANINE; INDOLE; INOSINE; MONOFLUOROTOLUENE; NUCLEIC ACID BASE; PYRIMIDINE ISOSTERES DIFLUOROTOLUENE; TOLUENE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; DNA CLEAVAGE; DNA FLANKING REGION; DNA SEQUENCE; DNA STRAND; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DETERMINATION; PROTEIN FUNCTION; PROTEIN METABOLISM; SUBSTITUTION REACTION; TRANSESTERIFICATION; VACCINIUM;

2-AMINOPURINE; BASE SEQUENCE; DNA; DNA TOPOISOMERASES, TYPE I; GUANINE; INDOLES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; OLIGONUCLEOTIDES; PROTEIN BINDING; RECOMBINANT PROTEINS; TOLUENE; TYROSINE; VACCINIA VIRUS;

EID: 33846027123     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M608349200     Document Type: Article

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