Mutational analysis of 39 residues of vaccinia DNA topoisomerase identifies Lys-220, Arg-223, and Asn-228 as important for covalent catalysis

Journal of Biological Chemistry

Volumn 272, Issue 13, 1997, Pages 8263-8269

  Cheng, Chonghui ^a   Wang, Li Kai ^a   Sekiguchi, JoAnn ^a   Shuman, Stewart ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA TOPOISOMERASE; VIRUS DNA;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; CONFORMATIONAL TRANSITION; DNA CLEAVAGE; DNA CONFORMATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME CONFORMATION; NONHUMAN; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; STRUCTURE ACTIVITY RELATION; VACCINIA VIRUS;

AMINO ACID SEQUENCE; AMINO ACIDS; ARGININE; ASPARTIC ACID; BASE SEQUENCE; DNA MUTATIONAL ANALYSIS; DNA TOPOISOMERASES, TYPE I; DNA, SUPERHELICAL; KINETICS; LYSINE; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; POLYMERASE CHAIN REACTION; VACCINIA VIRUS;

EID: 1842333250     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.272.13.8263     Document Type: Article

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