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Volumn 63, Issue 6, 2008, Pages 464-469

Development of an automated 7-day 96-well Caco-2 cell culture model

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; CARBON 14; DRUG; GLYCOPROTEIN P; HYDROCHLOROTHIAZIDE; KETOPROFEN; LUCIFER YELLOW; MANNITOL; METOPROLOL; NAPROXEN; RHODAMINE 123; VERAPAMIL;

EID: 46849095431     PISSN: 00317144     EISSN: None     Source Type: Journal    
DOI: 10.1691/ph.2008.7855     Document Type: Article
Times cited : (16)

References (52)
  • 1
    • 0031896882 scopus 로고    scopus 로고
    • Active apical secretory efflux of the HTV protease inhibitors saquinavir and ritonavir in Caco-2 cell mono-layers
    • Alsenz J, Steffen H, Alex R (1998) Active apical secretory efflux of the HTV protease inhibitors saquinavir and ritonavir in Caco-2 cell mono-layers. Pharm Res 15: 423-428.
    • (1998) Pharm Res , vol.15 , pp. 423-428
    • Alsenz, J.1    Steffen, H.2    Alex, R.3
  • 2
    • 0346216088 scopus 로고    scopus 로고
    • Development of a 7-day, 96-well Caco-2 permeability assay with high-throughput direct UV compound analysis
    • Alsenz J, Haenel E (2003) Development of a 7-day, 96-well Caco-2 permeability assay with high-throughput direct UV compound analysis. Pharm Res 20: 1961-1969.
    • (2003) Pharm Res , vol.20 , pp. 1961-1969
    • Alsenz, J.1    Haenel, E.2
  • 5
    • 0035286778 scopus 로고    scopus 로고
    • Caco-2 monolayers in experimental and theoretical predictions of drug transport
    • Artursson P, Palm K, Luthman K (2001) Caco-2 monolayers in experimental and theoretical predictions of drug transport. Adv Drug Deliv Rev 46: 27-43.
    • (2001) Adv Drug Deliv Rev , vol.46 , pp. 27-43
    • Artursson, P.1    Palm, K.2    Luthman, K.3
  • 7
    • 0030588644 scopus 로고    scopus 로고
    • The use of the intestinal epithelial cell culture model, Caco-2, in pharmaceutical development
    • Bailey CA, Bryla P, Malick AW (1996) The use of the intestinal epithelial cell culture model, Caco-2, in pharmaceutical development. Adv Drug Deliv Rev 22: 85-103.
    • (1996) Adv Drug Deliv Rev , vol.22 , pp. 85-103
    • Bailey, C.A.1    Bryla, P.2    Malick, A.W.3
  • 8
    • 33646640645 scopus 로고    scopus 로고
    • Balimane PV, Han YH, Chong S (2006) Current industrial practices of assessing permeability and P-glycoprotein interaction. AAPS J. 8: El-13.
    • Balimane PV, Han YH, Chong S (2006) Current industrial practices of assessing permeability and P-glycoprotein interaction. AAPS J. 8: El-13.
  • 9
    • 2942682950 scopus 로고    scopus 로고
    • Utility of 96 well Caco-2 cell system for increased throughput of P-gp screening in drug discovery
    • Balimane PV, Patel K, Marino A, Chong S (2004) Utility of 96 well Caco-2 cell system for increased throughput of P-gp screening in drug discovery. Eur J Pharm Biopharm 58: 99-105.
    • (2004) Eur J Pharm Biopharm , vol.58 , pp. 99-105
    • Balimane, P.V.1    Patel, K.2    Marino, A.3    Chong, S.4
  • 10
    • 0030909506 scopus 로고    scopus 로고
    • The influence of culture time and passage number on the morphological and physiological development of Caco-2 cells
    • Briske-Anderson MJ, Finley JW, Newman SM (1997) The influence of culture time and passage number on the morphological and physiological development of Caco-2 cells. Proc Soc Exp Biol Med 214: 248-257.
    • (1997) Proc Soc Exp Biol Med , vol.214 , pp. 248-257
    • Briske-Anderson, M.J.1    Finley, J.W.2    Newman, S.M.3
  • 11
    • 25844530789 scopus 로고    scopus 로고
    • Role of monocarboxylic acid transporters in the cellular uptake of NSAIDs
    • Choi JS, Jin MJ, Han, HK (2005) Role of monocarboxylic acid transporters in the cellular uptake of NSAIDs. J Pharm Pharmacol 57: 1185-1189.
    • (2005) J Pharm Pharmacol , vol.57 , pp. 1185-1189
    • Choi, J.S.1    Jin, M.J.2    Han, H.K.3
  • 12
    • 3242686014 scopus 로고    scopus 로고
    • Rapid induction of P-glyco-protein expression by high permeability compounds in colonic cells in vitro: A possible source of transporter mediated drug interactions?
    • Collett A, Tanianis-Hughes J, Warhurst G (2004) Rapid induction of P-glyco-protein expression by high permeability compounds in colonic cells in vitro: a possible source of transporter mediated drug interactions? Biochem Pharmacol 68: 783-790.
    • (2004) Biochem Pharmacol , vol.68 , pp. 783-790
    • Collett, A.1    Tanianis-Hughes, J.2    Warhurst, G.3
  • 14
    • 0032885452 scopus 로고    scopus 로고
    • Role of P-glycoprotein-mediated secretion in absorptive drug permeability: An approach using passive membrane permeability and affinity to P-glycoprotein
    • Doppenschmitt S, Spahn-Langguth H, Regardh CG, Langguth P (1999) Role of P-glycoprotein-mediated secretion in absorptive drug permeability: An approach using passive membrane permeability and affinity to P-glycoprotein. J Pharm Sci 88: 1067-1072.
    • (1999) J Pharm Sci , vol.88 , pp. 1067-1072
    • Doppenschmitt, S.1    Spahn-Langguth, H.2    Regardh, C.G.3    Langguth, P.4
  • 16
    • 0034960419 scopus 로고    scopus 로고
    • A functional assay for quantitation of the apparent affinities of ligands of P-glycoprotein in Caco-2 cells
    • Gao J, Murase O, Schowen RL, Aube J, Borchardt RT (2001) A functional assay for quantitation of the apparent affinities of ligands of P-glycoprotein in Caco-2 cells. Pharm Res 18: 171-176.
    • (2001) Pharm Res , vol.18 , pp. 171-176
    • Gao, J.1    Murase, O.2    Schowen, R.L.3    Aube, J.4    Borchardt, R.T.5
  • 17
    • 0027484689 scopus 로고
    • Absence of cooperativity for MgATP and verapamil effects on the ATPase activity of P-glycoprotein containing membrane vesicles
    • Garrigos M, Belehradek J Jr, Mir LM, Orlowski S (1993) Absence of cooperativity for MgATP and verapamil effects on the ATPase activity of P-glycoprotein containing membrane vesicles. Biochem Biophys Res Commun 196: 1034-1041.
    • (1993) Biochem Biophys Res Commun , vol.196 , pp. 1034-1041
    • Garrigos, M.1    Belehradek Jr, J.2    Mir, L.M.3    Orlowski, S.4
  • 18
    • 0041386827 scopus 로고    scopus 로고
    • Role of ADME characteristics in drug discovery and their in silico evaluation: In silico screening of chemicals for their metabolic stability
    • Gombar VK, Silver IS, Zhao Z (2003) Role of ADME characteristics in drug discovery and their in silico evaluation: in silico screening of chemicals for their metabolic stability. Curr Top Med Chem 3: 1205-1225.
    • (2003) Curr Top Med Chem , vol.3 , pp. 1205-1225
    • Gombar, V.K.1    Silver, I.S.2    Zhao, Z.3
  • 19
    • 0033957756 scopus 로고    scopus 로고
    • Influence of P-glycoprotein on the transport and metabolism of indinavir in Caco-2 cells expressing cytochrome P-450 3A4
    • Hochman JH, Chiba M, Nishime J, Yamazaki M, Lin JH (2000) Influence of P-glycoprotein on the transport and metabolism of indinavir in Caco-2 cells expressing cytochrome P-450 3A4. J Pharmacol Exp Ther 292: 310-318.
    • (2000) J Pharmacol Exp Ther , vol.292 , pp. 310-318
    • Hochman, J.H.1    Chiba, M.2    Nishime, J.3    Yamazaki, M.4    Lin, J.H.5
  • 20
    • 0029896241 scopus 로고    scopus 로고
    • Age-dependent expression of P-glycoprotein gp170 in Caco-2 cell monolayers
    • Hosoya KI, Kim KJ, Lee VH (1996) Age-dependent expression of P-glycoprotein gp170 in Caco-2 cell monolayers. Pharm Res 13: 885-890.
    • (1996) Pharm Res , vol.13 , pp. 885-890
    • Hosoya, K.I.1    Kim, K.J.2    Lee, V.H.3
  • 21
    • 0025668535 scopus 로고
    • Mechanism of L-alpha-methyldopa transport through a monolayer of polarized human intestinal epithelial cells (Caco-2)
    • Hu M, Borchardt RT (1990) Mechanism of L-alpha-methyldopa transport through a monolayer of polarized human intestinal epithelial cells (Caco-2). Pharm Res 7: 1313-1319.
    • (1990) Pharm Res , vol.7 , pp. 1313-1319
    • Hu, M.1    Borchardt, R.T.2
  • 22
    • 0343488673 scopus 로고    scopus 로고
    • Intestinal secretion of drugs. The role of P-glycoprotein and related drug efflux systems in limiting oral drug absorption
    • Hunter J, Hirst BH (1997) Intestinal secretion of drugs. The role of P-glycoprotein and related drug efflux systems in limiting oral drug absorption. Adv Drug Deliv Rev 25: 129-157.
    • (1997) Adv Drug Deliv Rev , vol.25 , pp. 129-157
    • Hunter, J.1    Hirst, B.H.2
  • 24
    • 0034194476 scopus 로고    scopus 로고
    • Regulation of volume-activated chloride channels by P-glycoprotein: Phosphorylau'on has the final say!
    • Idriss HT, Hannun YA, Boulpaep E, Basavappa S (2000) Regulation of volume-activated chloride channels by P-glycoprotein: phosphorylau'on has the final say! J Physiol 524: 629-636.
    • (2000) J Physiol , vol.524 , pp. 629-636
    • Idriss, H.T.1    Hannun, Y.A.2    Boulpaep, E.3    Basavappa, S.4
  • 25
    • 33751221603 scopus 로고    scopus 로고
    • In-vitro mutagenic potential and effect on permeability of co-administered drugs across Caco-2 cell monolayers of Rubus idaeus and its fortified fractions
    • Kreander K, Galkin A, Vuorela S, Tammela P, Laitinen L, Heinonen M, Vuorela P (2006) In-vitro mutagenic potential and effect on permeability of co-administered drugs across Caco-2 cell monolayers of Rubus idaeus and its fortified fractions. J Pharm Pharmacol 58: 1545-1552.
    • (2006) J Pharm Pharmacol , vol.58 , pp. 1545-1552
    • Kreander, K.1    Galkin, A.2    Vuorela, S.3    Tammela, P.4    Laitinen, L.5    Heinonen, M.6    Vuorela, P.7
  • 26
    • 6344230038 scopus 로고    scopus 로고
    • Effects of extracts of commonly consumed food supplements and food fractions on the permeability of drugs across Caco-2 cell monolayers
    • Laitinen LA, Tammela PS, Galkin A, Vuorela HJ, Marvola ML, Vuorela PM (2004) Effects of extracts of commonly consumed food supplements and food fractions on the permeability of drugs across Caco-2 cell monolayers. Pharm Res 21: 1904-1916.
    • (2004) Pharm Res , vol.21 , pp. 1904-1916
    • Laitinen, L.A.1    Tammela, P.S.2    Galkin, A.3    Vuorela, H.J.4    Marvola, M.L.5    Vuorela, P.M.6
  • 27
    • 0030023536 scopus 로고    scopus 로고
    • Comparison between active and passive drug transport in human intestinal epithelial (Caco-2) cells in vitro and human jejunum in vivo
    • Lennernäs H, Palm K, Fagerholm U, Artursson P (1996) Comparison between active and passive drug transport in human intestinal epithelial (Caco-2) cells in vitro and human jejunum in vivo. Int J Pharm 127: 103-107.
    • (1996) Int J Pharm , vol.127 , pp. 103-107
    • Lennernäs, H.1    Palm, K.2    Fagerholm, U.3    Artursson, P.4
  • 28
    • 23844440624 scopus 로고    scopus 로고
    • Strategies for targeting the multidrug resistance-1 (MDRl)/P-gp transporter in human malignancies
    • Mahadevan D, Shirahatti N (2005) Strategies for targeting the multidrug resistance-1 (MDRl)/P-gp transporter in human malignancies. Curr Cancer Drug Targets 5: 445-455.
    • (2005) Curr Cancer Drug Targets , vol.5 , pp. 445-455
    • Mahadevan, D.1    Shirahatti, N.2
  • 29
    • 0027328896 scopus 로고
    • Interaction of the 43 kd postsynaptic protein with all subunits of the muscle nicotinic acetylcholine receptor
    • Maimone MM, Merlie JP (1993) Interaction of the 43 kd postsynaptic protein with all subunits of the muscle nicotinic acetylcholine receptor. Neuron 11:53-66.
    • (1993) Neuron , vol.11 , pp. 53-66
    • Maimone, M.M.1    Merlie, J.P.2
  • 30
    • 19344367311 scopus 로고    scopus 로고
    • Validation of the 96 well Caco-2 cell culture model for high throughput permeability assessment of discovery compounds
    • Marino AM, Yarde M, Patel H, Chong S, Balimane PV (2005) Validation of the 96 well Caco-2 cell culture model for high throughput permeability assessment of discovery compounds. Int J Pharm 297: 235-241.
    • (2005) Int J Pharm , vol.297 , pp. 235-241
    • Marino, A.M.1    Yarde, M.2    Patel, H.3    Chong, S.4    Balimane, P.V.5
  • 32
    • 46849122439 scopus 로고    scopus 로고
    • Millipore Corporation
    • ™ Caco-2. 2002.
    • (2002) ™ Caco-2
  • 33
    • 0028284288 scopus 로고
    • Characterization of rhodamine 123 binding to P-glycoprotein in human multidrug-resistant cells
    • Nare B, Prichard RK, Georges E (1994) Characterization of rhodamine 123 binding to P-glycoprotein in human multidrug-resistant cells. Mol Pharmacol 45: 1145-1152.
    • (1994) Mol Pharmacol , vol.45 , pp. 1145-1152
    • Nare, B.1    Prichard, R.K.2    Georges, E.3
  • 35
    • 0030035535 scopus 로고    scopus 로고
    • Effects of steroids and verapamil on P-glycoprotein ATPase activity: Progesterone, desoxycorticosterone, corticosterone and verapamil are mutually non-exclusive modulators
    • Orlowski S, Mir LM, Belehradek J Jr, Garrigos M (1996) Effects of steroids and verapamil on P-glycoprotein ATPase activity: progesterone, desoxycorticosterone, corticosterone and verapamil are mutually non-exclusive modulators. Biochem J 317: 515-522.
    • (1996) Biochem J , vol.317 , pp. 515-522
    • Orlowski, S.1    Mir, L.M.2    Belehradek Jr, J.3    Garrigos, M.4
  • 36
    • 33644684597 scopus 로고    scopus 로고
    • Investigation of vesicle electroki-netic chromatography as an in vitro assay for the estimation of intestinal permeability of pharmaceutical drag candidates
    • Pascoe RJ, Masucci JA, Foley JP (2006) Investigation of vesicle electroki-netic chromatography as an in vitro assay for the estimation of intestinal permeability of pharmaceutical drag candidates. Electrophoresis 27: 793-804.
    • (2006) Electrophoresis , vol.27 , pp. 793-804
    • Pascoe, R.J.1    Masucci, J.A.2    Foley, J.P.3
  • 37
    • 0043127390 scopus 로고    scopus 로고
    • Rapid assessment of P-glycoprotein inhibition and induction in vitro
    • Perloff MD, Stormer E, von Moltke LL, Greenblatt DJ (2003) Rapid assessment of P-glycoprotein inhibition and induction in vitro. Pharm Res 20: 1177-1183.
    • (2003) Pharm Res , vol.20 , pp. 1177-1183
    • Perloff, M.D.1    Stormer, E.2    von Moltke, L.L.3    Greenblatt, D.J.4
  • 40
    • 0031158805 scopus 로고    scopus 로고
    • The physiological function of drag-transporting P-gly-coproteins
    • Schinkel AH (1997) The physiological function of drag-transporting P-gly-coproteins. Semin Cancer Biol 8: 161-170.
    • (1997) Semin Cancer Biol , vol.8 , pp. 161-170
    • Schinkel, A.H.1
  • 41
    • 34547663275 scopus 로고    scopus 로고
    • Effect of cell differentiation and passage number on the expression of efflux proteins in wild type and vin-blastine-induced Caco-2 cell lines
    • Siissalo S, Laitinen L, Koljonen M, Vellonen K, Kortejärvi H, Urtti A, Hirvonen J, Kaukonen AM (2007) Effect of cell differentiation and passage number on the expression of efflux proteins in wild type and vin-blastine-induced Caco-2 cell lines. Eur J Pharm Biopharm 67: 548-554.
    • (2007) Eur J Pharm Biopharm , vol.67 , pp. 548-554
    • Siissalo, S.1    Laitinen, L.2    Koljonen, M.3    Vellonen, K.4    Kortejärvi, H.5    Urtti, A.6    Hirvonen, J.7    Kaukonen, A.M.8
  • 42
    • 0028358657 scopus 로고
    • pH-dependent and carrier-mediated transport of salicylic acid across Caco-2 cells
    • Takanaga H, Tamai I, Tsuji A (1994) pH-dependent and carrier-mediated transport of salicylic acid across Caco-2 cells. J Pharm Pharmacol 46: 567-570.
    • (1994) J Pharm Pharmacol , vol.46 , pp. 567-570
    • Takanaga, H.1    Tamai, I.2    Tsuji, A.3
  • 44
    • 2142714474 scopus 로고    scopus 로고
    • Permeability characteristics and membrane affinity of flavonoids and alkyl gallates in Caco-2 cells and in phospho-lipid vesicles
    • Tammela P, Laitinen L, Galkin A, Wennberg T, Heczko R, Vuorela H, Slotte JP, Vuorela P (2004) Permeability characteristics and membrane affinity of flavonoids and alkyl gallates in Caco-2 cells and in phospho-lipid vesicles. Arch Biochem Biophys 425: 193-199.
    • (2004) Arch Biochem Biophys , vol.425 , pp. 193-199
    • Tammela, P.1    Laitinen, L.2    Galkin, A.3    Wennberg, T.4    Heczko, R.5    Vuorela, H.6    Slotte, J.P.7    Vuorela, P.8
  • 45
    • 0041402720 scopus 로고    scopus 로고
    • Efflux ratio cannot assess P-glycoprotein-mediated attenuation of absorptive transport: Asymmetric effect of P-glycoprotein on absorptive and secretory transport across Caco-2 cell monolayers
    • Troutman MD, Thakker DR (2003) Efflux ratio cannot assess P-glycoprotein-mediated attenuation of absorptive transport: asymmetric effect of P-glycoprotein on absorptive and secretory transport across Caco-2 cell monolayers. Pharm Res 20: 1200-1209.
    • (2003) Pharm Res , vol.20 , pp. 1200-1209
    • Troutman, M.D.1    Thakker, D.R.2
  • 46
    • 0028029150 scopus 로고
    • Transcellular transport of benzoic acid across Caco-2 cells by a pH-dependent and carrier-mediated transport mechanism
    • Tsuji A, Takanaga H, Tamai I, Terasaki T (1994) Transcellular transport of benzoic acid across Caco-2 cells by a pH-dependent and carrier-mediated transport mechanism. Pharm Res 11: 30-37.
    • (1994) Pharm Res , vol.11 , pp. 30-37
    • Tsuji, A.1    Takanaga, H.2    Tamai, I.3    Terasaki, T.4
  • 47
    • 0019430432 scopus 로고
    • Overcoming of vincristine resistance in P388 leukemia in vivo and in vitro through enhanced cytotoxicity of vincristine and vinblastine by verapamil
    • Tsumo T, Iida H, Tsukagoshi S, Sakurai Y (1981) Overcoming of vincristine resistance in P388 leukemia in vivo and in vitro through enhanced cytotoxicity of vincristine and vinblastine by verapamil. Cancer Res 41: 1967-1972.
    • (1981) Cancer Res , vol.41 , pp. 1967-1972
    • Tsumo, T.1    Iida, H.2    Tsukagoshi, S.3    Sakurai, Y.4
  • 48
    • 46849092914 scopus 로고    scopus 로고
    • Center for Drag Evaluation and Research (CDER, ) Guidance for industry, waiver of in vivo bioavailability and bioequiva-lence studies for immediate-release solid dosage forms based on a bio-pharmaceutics classification system
    • U.S. Department of Health and Human Services, Food and Drag Administration, Center for Drag Evaluation and Research (CDER) (2000) Guidance for industry, waiver of in vivo bioavailability and bioequiva-lence studies for immediate-release solid dosage forms based on a bio-pharmaceutics classification system, (http://www.fda.gov/cder/guidance/3618fnl.htm).
    • (2000) Food and Drag Administration
  • 49
    • 0342762062 scopus 로고    scopus 로고
    • The barrier function of CYP3A4 and P-glycoprotein in the small bowel
    • Watkins PB (1997) The barrier function of CYP3A4 and P-glycoprotein in the small bowel. Adv Drag Deliv Rev 27: 161-170.
    • (1997) Adv Drag Deliv Rev , vol.27 , pp. 161-170
    • Watkins, P.B.1
  • 52
    • 0030963896 scopus 로고    scopus 로고
    • Evidence for diminished functional expression of intestinal transporters in Caco-2 cell monolayers at high passages
    • Yu H, Cook TJ, Sinko PJ (1997) Evidence for diminished functional expression of intestinal transporters in Caco-2 cell monolayers at high passages. Pharm Res 14: 757-762.
    • (1997) Pharm Res , vol.14 , pp. 757-762
    • Yu, H.1    Cook, T.J.2    Sinko, P.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.