Leptospiral Nephropathy

Seminars in Nephrology

Volumn 28, Issue 4, 2008, Pages 383-394

  Andrade, Lúcia ^a,b   de Francesco Daher, Elizabeth ^c   Seguro, Antonio Carlos ^a,b  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b INSTITUTO DE INFECTOLOGIA EMÍLIO RIBAS   (Brazil)

^c Federal University   (Brazil)

Author keywords

kidney failure; Leptospirosis; mortality; respiratory distress syndrome; therapy

Indexed keywords

AMPICILLIN; AQUAPORIN 2; AZITHROMYCIN; BACTERIAL VACCINE; CEFOTAXIME; CEFTRIAXONE; DOXYCYCLINE; IMMUNOGLOBULIN M; METHYLPREDNISOLONE; PENICILLIN G; POTASSIUM; SODIUM POTASSIUM CHLORIDE COTRANSPORTER; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA;

ADULT RESPIRATORY DISTRESS SYNDROME; AGGLUTINATION TEST; ANOREXIA; ANTIBIOTIC THERAPY; ANTIBODY TITER; ARTICLE; ARTIFICIAL VENTILATION; BACTERIAL GENOME; BACTERIAL TRANSMISSION; CELL INFILTRATION; CHILL; CLINICAL FEATURE; CONVALESCENCE; DIAGNOSTIC ACCURACY; DIARRHEA; DISEASE COURSE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEVER; FLUID INTAKE; GENE SEQUENCE; GLOMERULUS FILTRATION RATE; HEADACHE; HEART ARRHYTHMIA; HEMODIALYSIS; HUMAN; HYPOKALEMIA; IMMUNOHISTOCHEMISTRY; IMMUNOPATHOGENESIS; INCIDENCE; INNATE IMMUNITY; INTERSTITIAL NEPHRITIS; KIDNEY DISEASE; KIDNEY FUNCTION; KIDNEY TUBULE FUNCTION; LABORATORY TEST; LEPTOSPIRA; LEPTOSPIRA BIFLEXA; LEPTOSPIRA INTERROGANS; LEPTOSPIROSIS; LEUKOCYTE COUNT; LUNG EDEMA; LUNG HEMORRHAGE; MALAISE; MENINGITIS; MICROSCOPY; MONONUCLEAR CELL; MORBIDITY; MORTALITY; MYALGIA; NAUSEA AND VOMITING; NONHUMAN; POLYMERASE CHAIN REACTION; POSITIVE END EXPIRATORY PRESSURE; POTASSIUM BLOOD LEVEL; PRIORITY JOURNAL; PROTECTIVE CLOTHING; PROTEIN EXPRESSION; PROTEIN URINE LEVEL; SODIUM ABSORPTION; TIDAL VOLUME; TREATMENT DURATION; UNSPECIFIED SIDE EFFECT; URINARY EXCRETION; WESTERN BLOTTING;

ADOLESCENT; ADULT; CHILD; HUMANS; KIDNEY FAILURE, ACUTE; MIDDLE AGED; RESPIRATORY DISTRESS SYNDROME, ADULT; WEIL DISEASE;

EID: 46749116796     PISSN: 02709295     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.semnephrol.2008.04.008     Document Type: Article

References (54)

1. McBride A.J., Athanazio D.A., Reis M.G., and Ko A.I. Leptospirosis. Curr Opin Infect Dis 18 (2005) 376-386
2. Bharti A.R., Nally J.E., Ricaldi J.N., Matthias M.A., Diaz M.M., Lovett M.A., et al. Leptospirosis: a zoonotic disease of global importance. Lancet Infect Dis 3 (2003) 757-771
3. Vinetz J.M. Leptospirosis. Curr Opin Infect Dis 14 (2001) 527-538
4. Sambasiva R.R., Naveen G., Bhalla P., and Agarwal S.K. Leptospirosis in India and the rest of the world. Braz J Infect Dis 7 (2003) 178-193
5. Levett P.N. Leptospirosis. Clin Microbiol Rev 14 (2001) 296-326
6. Ko A.I., Reis M.G., Dourado C.M., Johnson Jr. W.D., and Riley L.W. Urban epidemic of severe leptospirosis in Brazil. Lancet 354 (1999) 820-825
7. Plank R., and Dean D. Overview of the epidemiology, microbiology, and pathogenesis of Leptospira spp. in humans. Microb Infect 2 (2000) 1265-1276
8. Edwards C.N., Nicholson G.D., Hassel T.A., Everard C.O.R., and Callender J. Leptospirosis in Barbados. A clinical study. West Indian Med J 39 (1990) 27-34
9. Costa E., Costa Y.A., Lopes A.A., Sacramento E., and Bina J.C. Severe forms of leptospirosis: clinical, demographic and environmental aspects. Rev Soc Bras Med Trop 34 (2001) 261-267
10. Ko A.I. Leptospirosis. In: Goldman L., and Ausiello D. (Eds). Cecil medicine (2008), Elsevier Saunders, Philadelphia 2296-2298
11. De Brito T., Morais C.F., Yasuda P.H., Lancellotti C.P., Hoshino-Shimizu S., Yamashiro E., et al. Cardiovascular involvement in human and experimental leptospirosis: pathologic finding and immunohistochemical detection for leptospiral antigen. Ann Trop Med Parasitol 81 (1987) 207-214
12. Nicodemo A.C., Duarte M.I., Alves V.A., Takakura C.H., Santos R.T., and Nicodemo E.L. Lung lesions in human leptospirosis. Microscopic, immunohistochemical and ultrastructural features related to thrombocytopenia. Am J Trop Med Hyg 56 (1997) 181-187
13. Wagenar J.F., Goris M.G., Sakundarno M.S., Gasem M.H., Mairuhu A.T., and Kruif M.D. What role do coagulation disorders play in the pathogenesis of leptospirosis?. Trop Med Int Health 12 (2007) 111-122
14. Daher E.F., Zanetta D.M., Cavalcante M., and Abdulkader R.C. Risk factors for death and changing patterns in acute renal failure of leptospirosis. Am J Trop Med Hyg 61 (1999) 630-634
15. Sitprija V., Losuwanrak K., and Kanjanabuch T. Leptospiral nephropathy. Semin Nephrol 23 (2003) 42-48
16. Penna D., DeBrito T., Pupo A.A., Machado M.M., Galvão P.A.A., and Soares S.S. Kidney biopsy in human Leptospirosis. Am J Trop Med Hyg 12 (1963) 896-901
17. Sitprija V., and Evans H. The kidney in human Leptospirosis. Am J Med 49 (1970) 780-788
18. Seguro A.C., Lomar A.V., and Rocha A.S. Acute renal failure of leptospirosis: non-oliguric and hypokalemic forms. Nephron 55 (1990) 146-151
19. Magaldi A.J., Yasuda P.N., Kudo L.H., Seguro A.C., and Rocha A.S. Renal involvement in Leptospirosis: a pathophysiology study. Nephron 62 (1992) 332-339
20. Marotto P.C., Nascimento C.M., Eluf-Neto J., Marotto M.S., Andrade L., Sztajnbok J., et al. Acute lung injury in Leptospirosis: clinical and laboratory features, outcome, and factors associated with mortality. Clin Infect Dis 29 (1999) 1561-1563
21. Andrade L., Rodrigues Jr. A.C., Sanches T.R., Souza R.B., and Seguro A.C. Leptospirosis leads to dysregulation of sodium transporters in the kidney and lung. Am J Physiol Renal Physiol 292 (2007) 586-592
22. Khositseth S., Sudjaritjan N., Tananchai P., Ong-ajyuth S., Sitprija V., and Thongboonkerd V. Renal magnesium wasting and tubular dysfunction in leptospirosis. Nephrol Dial Transplant 23 (2008) 952-958
23. Faria M.T., Athanazio D.A., Ramos E.A.G., Silva E.F., Reis M.G., and Ko A.I. Morphological alterations in the kidney of rats with natural and experimental Leptospira infection. J Comp Pathol 137 (2007) 231-238
24. El-Achkar T.M., Huang X., Plotkin Z., Sandoval R.M., Rhodes G.J., and Dagher P.C. Sepsis induces changes in the expression and distribution of Toll-like receptor 4 in the rat kidney. Am J Physiol Renal Physiol 290 (2006) F1034-F43
25. Viriyakosol S., Matthias M.A., Swancutt M.A., Kirkland T.N., and Vinetz J.M. Toll-like receptor 4 protects against lethal Leptospira interrogans serovar icterohaemorrhagiae infection and contributes to in vivo control of leptospiral burden. Infect Immun 74 (2006) 887-895
26. Yang C.W., Wu M.S., Pan M.J., Hsieh W.J., Vandewalle A., and Huang C.C. The Leptospira outer membrane protein LipL32 induces tubulointerstitial nephritis-mediated gene expression in mouse proximal tubule cells. J Am Soc Nephrol 13 (2002) 2037-2045
27. Daher E.F., Zanetta D.M., and Abdulkader R.C. Pattern of renal function recovery after leptospirosis acute renal failure. Nephron Clin Pract 98 (2004) 8-14
28. Marotto P.C., Marotto M.S., Santos D.L., Souza T.N., and Seguro A.C. Outcome of Leptospirosis in children. Am J Trop Med Hyg 56 (1997) 307-310
29. de Souza A.L., Sztajnbok J., Marques S.R., and Seguro A.C. Leptospirosis-induced meningitis and acute renal failure in a 19-month-old male child. J Med Microbiol 55 (2006) 795-797
30. Trevejo R.T., Rigau-Pérez J.G., Ashford D.A., McClure E.M., Jarquín-González C., Amador J.J., et al. Epidemic leptospirosis associated with pulmonary hemorrhage-Nicaragua, 1995. J Infect Dis 178 (1998) 1457-1463
31. Spichler A., Athanazio D., Buzzar M., Castro B., Chapolla E., Seguro A., et al. Using death certificate reports to find severe leptospirosis cases, Brazil. Emerg Infect Dis 13 (2007) 1559-1561
32. Dupont H., Dupont-Perdrizet D., Pierie J.L., Zehner-Hansen S., Jarrige B., and Daijardin J.B. Leptospirosis: prognostic factors associated with mortality. Clin Infect Dis 25 (1997) 720-724
33. Spichler A., Ko A.I., Silva E.F., De Brito T., Silva A.M., Athanazio D., et al. Reversal of renal tubule transporter downregulation during severe leptospirosis with antimicrobial therapy. Am J Trop Med Hyg 77 (2007) 1111-1119
34. Dolhnikoff M., Mauad T., Bethlem E.P., and Carvalho C.R. Leptospiral pneumonias. Curr Opin Pulm Med 13 (2007) 230-235
35. Nally J.E., Chantranuwat C., Wu X.Y., Fishbein M.C., Pereira M.M., Da Silva J.J., et al. Alveolar septal deposition of immunoglobulin and complement parallels pulmonary hemorrhage in a guinea pig model of severe pulmonary leptospirosis. Am J Pathol 164 (2004) 1115-1127
36. Shenoy V.V., Nagar V.S., Chowdhury A.A., Bhalgat P.S., and Juvale N.I. Pulmonary leptospirosis: an excellent response to bolus methylprednisolone. Post Grad Med J 82 (2006) 602-606
37. Matthay M.A., Folkesson H.G., and Verkman A.S. Salt and water transport across alveolar and distal airway epithelia in the adult lung. Am J Physiol 270 (1996) L487-L503
38. Matthay M.A., Folkesson H.G., and Clereci C. Lung epithelial fluid transport and the resolution of pulmonary edema. Physiol Rev 82 (2002) 569-600
39. Mehta R., Pascual M., Soroko S., Savage B., Himmelfarb J., Ikizler T., et al. Spectrum of acute renal failure in the intensive care unit: the PICARD experience. Kidney Int 66 (2004) 1613-1621
40. Andrade L., Cleto S., and Seguro A.C. Door-to-dialysis time and daily hemodialysis in patients with leptospirosis: impact on mortality. Clin J Am Soc Nephrol 2 (2007) 739-744
41. Ronco C., Bellomo R., Homel P., Brendolam A., Dan M., Piccinni P., et al. Effects of different doses in continuous veno-venous hemofiltration on outcome of acute renal failure: a prospective randomised trial. Lancet 356 (2000) 26-30
42. The National Heart Lung, and Blood Institute. Acute respiratory distress syndrome (ARDS) clinical trials network: comparison of two fluid-management strategies in acute lung injury. N Engl J Med 354 (2006) 2564-2575
43. Carvalho C.R., and Bethlem E.P. Pulmonary complications of Leptospirosis. Clin Chest Med 23 (2002) 469-478
44. Amato M.B., and Carvalho C.R. Severe acute respiratory distress syndrome, Leptospirosis, and lung protective strategies. Crit Care Med 34 (2006) 2703-2704
45. Pappas G., and Cascio A. Optimal treatment of leptospirosis: queries and projections. Int J Antimicrob Agents 28 (2006) 491-496
46. Panaphut T., Domrongkitchaiporn S., Vibhagool A., Thinkamrop B., and Susaengrat W. Ceftriaxone compared with sodium penicillin G for treatment of severe leptospirosis. Clin Infect Dis 36 (2003) 1507-1513
47. Ghouse M., Maulana A.B., Mohamed Ali M.G., and Sarasa V.D. A two year study of the efficacy of azithromycin in the treatment of leptospirosis in human. Indian J Med Microbiol 24 (2006) 345-346
48. Phimda K., Hoontrakul S., Suttinont C., Chareonwat S., Losuwanaluk K., Chueasuwanchai S., et al. Doxycycline versus azithromycin for treatment of leptospirosis and scrub typhus. Antimicrob Agents Chemother 51 (2007) 3259-3263
49. Suputtamongkol Y., Niwattayakul K., Suttinont C., Losuwanaluk K., Limpaiboon R., Chierakul W., et al. An open, randomized, controlled trial of penicillin, doxycycline, and cefotaxime for patients with severe leptospirosis. Clin Infect Dis 39 (2004) 1417-1424
50. Sehgal S.C., Sugunan A.P., Murhekar, Sharma S., and Vijayachari P. Randomized controlled trial of doxycycline prophylaxis against leptospirosis in an endemic area. Int J Antimicrob Agents 13 (2000) 249-255
51. Ren S.X., Fu G., Jiang X.G., Zeng R., Miao Y.G., Xu H., et al. Unique physiological and pathogenic features of Leptospira interrogans revealed by whole-genome sequencing. Nature 422 (2003) 888-893
52. Nascimento A.L., Ko A.I., Martins E.A., Monteiro-Vitorello C.B., Ho P.L., Haake D.A., et al. Comparative genomics of two Leptospira interrogans serovars reveals novel insights into physiology and pathogenesis. J Bacteriol 186 (2004) 2164-2172
53. Fournier P.E., Drancourt M., and Raoult D. Bacterial genome sequencing and its use in infectious disease. Lancet Infect Dis 7 (2007) 711-723
54. Neves F.O., Abreu P.A., Vasconcellos S.A., de Morais Z.M., Romero E.C., and Nascimento A.L. Identification of a novel potential antigen for early diagnosis of leptospirosis. Arch Microbiol 188 (2007) 523-532