Renal magnesium wasting and tubular dysfunction in leptospirosis

Nephrology Dialysis Transplantation

Volumn 23, Issue 3, 2008, Pages 952-958

  Khositseth, Sookkasem ^a   Sudjaritjan, Niwatchai ^b   Tananchai, Paiboon ^b   Ong Ajyuth, Sompong ^c   Sitprija, Visith ^d   Thongboonkerd, Visith ^c  

^a THAMMASAT UNIVERSITY   (Thailand)

^b Nan Hospital   (Thailand)

^c MAHIDOL UNIVERSITY   (Thailand)

^d QUEEN SAOVABHA MEMORIAL INSTITUTE   (Thailand)

Author keywords

Leptospirosis; Magnesium; Nephropathy; Renal failure; Tubular dysfunction

Indexed keywords

BETA 2 MICROGLOBULIN; CALCIUM; CREATININE; MAGNESIUM; N ACETYL BETA GLUCOSAMINIDASE; PHOSPHATE; PHOSPHORUS; ACETYLGLUCOSAMINIDASE;

ADOLESCENT; ADULT; AGED; ARTICLE; CALCIUM URINE LEVEL; CLINICAL ARTICLE; CLINICAL FEATURE; CREATININE URINE LEVEL; EVALUATION; FEMALE; HUMAN; HYPOMAGNESEMIA; HYPOPHOSPHATEMIA; INTERSTITIAL NEPHRITIS; KIDNEY INJURY; KIDNEY TUBULE ABSORPTION; LEPTOSPIROSIS; MAGNESIUM BLOOD LEVEL; MAGNESIUM EXCRETION; MALE; PHOSPHATE BLOOD LEVEL; PRIORITY JOURNAL; SYMPTOM; THAILAND; URINARY EXCRETION; KIDNEY TUBULE; LEPTOSPIRA; METABOLISM; MICROBIOLOGY; MIDDLE AGED; PATHOGENICITY; PATHOPHYSIOLOGY; PROSPECTIVE STUDY; URINE;

ACETYLGLUCOSAMINIDASE; ADOLESCENT; ADULT; AGED; BETA 2-MICROGLOBULIN; CALCIUM; CREATININE; FEMALE; HUMANS; KIDNEY TUBULES; LEPTOSPIRA; LEPTOSPIROSIS; MAGNESIUM; MALE; MIDDLE AGED; NEPHRITIS, INTERSTITIAL; PHOSPHATES; PROSPECTIVE STUDIES; THAILAND;

EID: 42449137968     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gfm698     Document Type: Article

References (42)

1. Sitprija V, Losuwanrak K, Kanjanabuch T. Leptospiral nephropathy. Semin Nephrol 2003; 23: 42-48
2. Covic A, Goldsmith DJ, Gusbeth-Tatomir P et al. A retrospective 5-year study in Moldova of acute renal failure due to leptospirosis: 58 cases and a review of the literature. Nephrol Dial Transplant 2003; 18: 1128-1134
3. Panaphut T, Domrongkitchaiporn S, Vibhagool A et al. Ceftriaxone compared with sodium penicillin g for treatment of severe leptospirosis. Clin Infect Dis 2003; 36: 1507-1513
4. Cetin BD, Harmankaya O, Hasman H et al. Acute renal failure: a common manifestation of leptospirosis. Ren Fail 2004; 26: 655-661
5. Suputtamongkol Y, Niwattayakul K, Suttinont C et al. An open, randomized, controlled trial of penicillin, doxycycline, and cefotaxime for patients with severe leptospirosis. Clin Infect Dis 2004; 39: 1417-1424
6. Katz AR, Ansdell VE, Effler PV et al. Assessment of the clinical presentation and treatment of 353 cases of laboratory-confirmed leptospirosis in Hawaii, 1974-1998. Clin Infect Dis 2001; 33: 1834-1841
7. Sitprija V, Evans H. The kidney in human leptospirosis. Am J Med 1970; 49: 780-788
8. SeguroAC, LomarAV, Rocha AS. Acute renal failure of leptospirosis: nonoliguric and hypokalemic forms. Nephron 1990; 55: 146-151
9. Abdulkader RC, Seguro AC, Malheiro PS et al. Peculiar electrolytic and hormonal abnormalities in acute renal failure due to leptospirosis. Am J Trop Med Hyg 1996; 54: 1-6
10. Yang CW, Pan MJ, Wu MS et al. Leptospirosis: an ignored cause of acute renal failure in Taiwan. Am J Kidney Dis 1997; 30: 840-845
11. Lin CL, Wu MS, Yang CW et al. Leptospirosis associated with hypokalaemia and thick ascending limb dysfunction. Nephrol Dial Transplant 1999; 14: 193-195
12. Liberopoulos E, Bairaktari E, Elisaf M. Reversible proximal tubular dysfunction in a patient with acute febrile illness, marked hyperbilirubinemia and normal renal function: evidence of leptospirosis. Nephron 2002; 91: 532-533
13. Krishnan A, Karnad DR, Medhekar TP. Paralysis due to renal potassium wasting: an unusual presentation of leptospirosis. Nephrol Dial Transplant 2003; 18: 2454-2455
14. Wu MS, Yang CW, Pan MJ et al. Reduced renal Na+-K+-Cl- cotransporter activity and inhibited NKCC2 mRNA expression by Leptospira shermani: from bed-side to bench. Nephrol Dial Transplant 2004; 19: 2472-2479
15. Liamis G, Rizos E, Elisaf MS. Reversible proximal tubular dysfunction in a patient with acute febrile illness and normal renal function: an evidence towards leptospirosis. Clin Nephrol 2000; 53: 316
16. Andrade L, Rodrigues Jr AC, Sanches TR et al. Leptospirosis leads to dysregulation of sodium transporters in the kidney and lung. Am J Physiol Renal Physiol 2007; 292: F586-F592
17. Magaldi AJ, Yasuda PN, Kudo LH et al. Renal involvement in leptospirosis: a pathophysiologic study. Nephron 1992; 62: 332-339
18. Barnett JK, Barnett D, Bolin CA et al. Expression and distribution of leptospiral outer membrane components during renal infection of hamsters. Infect Immun 1999; 67: 853-861
19. Kuo HL, Lin CL, Huang CC. Reversible thick ascending limb dysfunction and aseptic meningitis syndrome: early manifestation in two leptospirosis patients. Ren Fail 2003; 25: 639-646
20. Appassakij H, Silpapojakul K, Wansit R et al. Evaluation of the immunofluorescent antibody test for the diagnosis of human leptospirosis. Am J Trop Med Hyg 1995; 52: 340-343
21. Pradutkanchana S, Pradutkanchana J, Khuntikij P. Detection of IgM specific antibody using indirect immunofluorescent assay for diagnosis of acute leptospirosis. J Med Assoc Thai 2003; 86: 641-646
22. Gravekamp C, Van de Kemp H, Franzen M et al. Detection of seven species of pathogenic leptospires by PCR using two sets of primers. J Gen Microbiol 1993; 139: 1691-1700
23. Moore JC, Morris JE. A simple automated colorimetric method for determination of N-acetyl- beta-D-glucosaminidase. Ann Clin Biochem 1982; 19: 157-159
24. Hemmingsen L, Skaarup P. Beta 2-microglobulin in urine and serum determined by ELISA technique. Scand J Clin Lab Invest 1985; 45: 367-371
25. Ginsberg JM, Chang BS, Matarese RA et al. Use of single voided urine samples to estimate quantitative proteinuria. N Engl J Med 1983; 309: 1543-1546
26. Futrakul P, Yenrudi S, Futrakul N et al. Tubular function and tubulointerstitial disease. Am J Kidney Dis 1999; 33: 886-891
27. Ong-ajyooth S, Ong-ajyooth L, Nilwarnagkur S. The serum levels and urinary excretion of N-acetyl-β-D-glucosaminidase in normal Thai adults. Intern Med 1986; 2: 5-8
28. Ong-ajyooth S, Ong-ajyooth L, Nilwarnagkur S et al. The serumlevels and urinary excretion of β2-microglobulin in normal Thai subjects. Intern Med 1985; 1: 82-84
29. Gault MH, Longerich LL, Harnett JD et al. Predicting glomerular function from adjusted serum creatinine. Nephron 1992; 62: 249-256
30. Ko AI, Galvao Reis M, Ribeiro Dourado CM et al. Urban epidemic of severe leptospirosis in Brazil. Salvador Leptospirosis Study Group. Lancet 1999; 354: 820-825
31. Sitprija V, Pipatanagul V, Mertowidjojo K et al. Pathogenesis of renal disease in leptospirosis: Clinical and experimental studies. Kidney Int 1980; 17: 827-836
32. Quamme GA. Renal magnesium handling: new insights in understanding old problems. Kidney Int 1997; 52: 1180-1195
33. Thompson JC, Manktelow BW. Pathogenesis of renal lesions in haemoglobinaemic and non-haemoglobinaemic leptospirosis. J Comp Pathol 1989; 101: 201-214
34. Guder WG, Hofmann W. Markers for the diagnosis and monitoring of renal tubular lesions. Clin Nephrol 1992; 38: S3-S7
35. Lopes AA, Costa E, Costa YA et al. The association between serum potassium at hospital admission and the case-fatality rate of leptospirosis in men. Rev Inst Med Trop Sao Paulo 2001; 43: 217-220
36. Yang CW, Wu MS, Pan MJ et al. Leptospira outer membrane protein activates NF-kappaB and downstream genes expressed in medullary thick ascending limb cells. J Am Soc Nephrol 2000; 11: 2017-2026
37. Yang CW, Wu MS, Pan MJ et al. The Leptospira outer membrane protein LipL32 induces tubulointerstitial nephritis-mediated gene expression in mouse proximal tubule cells. J Am Soc Nephrol 2002; 13: 2037-2045
38. Hung CC, Chang CT, Tian YC et al. Leptospiral membrane proteins stimulate pro-inflammatory chemokines secretion by renal tubule epithelial cells through toll-like receptor 2 and p38 mitogen activated protein kinase. Nephrol Dial Transplant 2006; 21: 898-910
39. Younes-Ibrahim M, Burth P, Faria MV et al. Inhibition of Na,K-ATPase by an endotoxin extracted from Leptospira interrogans: a possible mechanism for the physiopathology of leptospirosis. C R Acad Sci III 1995; 318: 619-625
40. Sion ML, Hatzitolios AI, Armenaka MC et al. Acute renal failure caused by leptospirosis and hantavirus infection in an urban hospital. Eur J Intern Med 2002; 13: 264-268
41. Kudesia G, Christie P, Walker E et al. Dual infection with leptospira and hantavirus. Lancet 1988; 1: 1397
42. Suputthamongkol Y, Nitatpattana N, Chayakulkeeree M et al. Hantavirus infection in Thailand: first clinical case report. Southeast Asian J Trop Med Public Health 2005; 36: 217