Lung lesions in human leptospirosis: Microscopic, immunohistochemical, and ultrastructural features related to thrombocytopenia

American Journal of Tropical Medicine and Hygiene

Volumn 56, Issue 2, 1997, Pages 181-187

  Nicodemo, Antonio C ^a   Duarte, Maria Irma S ^b   Alves, Venancio A F ^b   Takakura, Cleusa F H ^b   Santos, Raimunda T M ^b   Nicodemo, Elisabeth L ^a  

^a Universidad de Sao Paulo ^*  (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL ANTIGEN; FIBRIN; THROMBOCYTE ANTIGEN;

ADULT; ADULT RESPIRATORY DISTRESS SYNDROME; ARTICLE; BRAZIL; CELL ULTRASTRUCTURE; CLINICAL ARTICLE; CONTROLLED STUDY; DISSEMINATED INTRAVASCULAR CLOTTING; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LEPTOSPIRA; LEPTOSPIROSIS; LUNG CAPILLARY; LUNG HEMORRHAGE; MALE; PINOCYTOSIS; THROMBOCYTE AGGREGATION; THROMBOCYTOPENIA; VASCULAR ENDOTHELIUM;

BACTERIA (MICROORGANISMS); LEPTOSPIRA;

EID: 0030899881     PISSN: 00029637     EISSN: None     Source Type: Journal    
DOI: 10.4269/ajtmh.1997.56.181     Document Type: Article

References (40)

1. Arean VM, 1962. The pathologic anatomy and pathogenesis of fatal human leptospirosis (Well's Disease). Am J Pathol 40: 393-423.
2. Arean VM, 1962. Studies of the pathogenesis of leptospirosis. Lab Invest 11: 273-288.
3. Mariscal D, Trilla A, Mensa J, Pumarola T, Moya X, Soriano E, Jimenez De Anta MT, 1990. Svere leptospirosis. Description of a series of 10 cases. Enferm Infect Microbiol Clin 8: 602-605.
4. Park SK, Lee SH, Rhee YK, Kang SK, Kim KJ, Kim MC, Kim KW, Chang WH, 1989. Leptospirosis in Chonbuk Province of Korea in 1987: a study of 93 patients. Am J Trop Med Hyg 41: 345-351.
5. Pertuiset E, Fen Chong M, Duval G, Genin R, 1988. Clinical aspects and prognostic factors of icterohemorrhagic leptospirosis in adults. Apropos of 249 cases in La Reunion. Rev Med Interne 9: 487-493.
6. Nicodemo AC, Del Negro G, Amato Neto V, 1990. Thrombocytopenia and leptospirosis. Rev Inst Med Trop Sa Paulo 32: 252-259.
7. De Brito T, Bohm GM, Yasuda PH, 1979. Vascular damage in acute experimental leptospirosis of the guinea pig. J Pathol 128: 177-182.
8. Miller NG, Allen JE, Wilson RE, 1974. The pathogenesis of hemorrhage in the lung of the hamster during acute leptospirosis. Med Microbiol Immunol 160: 269-278.
9. Zollinger HU, Colombi A, Schiltknecht J, 1971. New clinical and ultrastructural aspects in leptospirosis icterohaemorrhagica (Weil's Disease). Virchows Arch 354: 336-348.
10. Alves VAF, Vianna MR, Yasuda PH, De Brito T, 1987. Detection of leptospiral antigen in the human liver and kidney using an immunoperoxidase staining procedure. J Pathol 151: 125-131.
11. Fernandes M, Irulegui I, Deane MP, Ruiz RC, 1992. Trypanosoma cruzi: course of infection in platelet-depleted mice. Rev Inst Med Trop Sao Paulo 34: 9-13.
12. Reynolds ES, 1963. The use of lead citrate at high pH as an electron-opaque stain in electron microscopy. J Cell Biol 17: 208-213.
13. Alien P, Raftery S, Phelan D, 1989. Massive pulmonary haemorrhage due to leptospirosis. Intensive Care Med 15: 322-324.
14. Burke BJ, Searle JF, Mattingly D, 1976. Leptospirosis presenting with profuse haemoptysis. Br Med J 2: 982.
15. Ragnaud JM, Dupon M, Echinard E, Teboulle D, Wone C, 1987. Manifestations pulmonaires au cours de leptospiroses icterohemorragiques severes. Ann Med Interne (Paris) 138: 282-286.
16. Emmanouilides CE, Kohn OF, Garibaldi R, 1994. Leptospirosis complicated by a Jarisch-Herxheimer reaction and adult respiratory distress syndrome: case report. Clin Infect Dis 18: 1004-1006.
17. Hidou M, 1991. Syndrome de detresse respiratoire aigue de l'adulte au cours d'une leptospirose. Cah Anesthesiol 39: 281-284.
18. O'Neil KM, Rickman LS, Lazarus AA, 1991. Pulmonary manifestation of leptospirosis. Rev Infect Dis 13: 705-709.
19. Ramachandran S, Perera MVF, 1977. Cardiac and pulmonary involvement in leptospirosis. Trans R Soc Trop Med Hyg 71: 56-59.
20. Tulli G, Gabini R, Feri M, Maurizi P, Nannoni S, Vignali G, 1989. MOFS (multiple organs failure syndrome) in corso di infezione da Leptospira ittero-emorragica. Minerva Anestesiol 55: 423-426.
21. Turner JS, Willcox PA, 1989. Respiratory failure in leptospirosis. Q J Med 72: 841-847.
22. Zaltzman M, Kallenbach JM, Goss GD, Lewis M, Zwi S, Gear JHS, 1981. Adult respiratory distress syndrome in Leptospira canicola infection. Br Med J 283: 519-520.
23. Alves VAF, Gayotto LCC, De Brito T, Santos RTM, Wakarnatsu A, Vianna MR, Sakata EE, 1992. Leptospiral antigens in the liver of experimentally infected guinea pig and their relation to the morphogenesis of liver damage. Exp Toxicol Pathol 44: 425-434.
24. Alves VAF, Yasuda PH, Yarnashiro EH, Santos RTM, Yamarnoto LU, De Brito T, 1986. An immunohistochemical assay to localize leptospires in tissue specimens. Rev Inst Med Trop Sao Paulo 28: 170-173.
25. Alves VAF, Gayotto LCC Yasuda PH, Wakamatsu A, Kanamura CT, De Brito T, 1991. Leptospiral antigens (L. interrogans serogroup icterohaemorrhagiae) in the kidney of experimentally infected guinea pigs and their relation to the pathogenesis of the renal injury. Exp Pathol 42: 81-93.
26. Sitprija V, Pipatanagul V, Mertowidjojo K, Boonpucknavig V, Boonpucknavig S, 1980. Pathogenesis of renal disease in leptospirosis: clinical and experimental studies. Kidney Int 17: 827-836.
27. Vinh T, Adler B, Faine S, 1986. Glycolipoprotein cytotoxin from Leptospira interrogans serovar copenhageni. J Gen Microbiol 132: 111-123.
28. DeBrito T, Prado MJBA, Negreiros VAC, Nicastri AL, Sakata EE, Yasuda PH, Santos RT, Alves VAF, 1992. Detection of leptospiral antigen (L. interrogans serovar copenhageni serogroup icterohaemorrhagiae) by immunoelectron microscopy in the liver and kidney of experimentally infected guinea pigs. Int J Exp Pathol 73: 633-642.
29. Edwards CN, Nicholson GD, Hassell TA, Everard COR, Callender J, 1986. Thrombocytopenia in leptospirosis: the absence of evidence for disseminated intravascular coagulation. Am J Trop Med Hyg 35: 352-354.
30. Edwards CN, Nicholson GD, Hassell TA, Everard COR, Callender J, 1990. Leptospirosis in Barbados. A clinical study. West Indian Med J 39: 27-34.
31. Bick RL, Baker WF, 1992. Disseminated intravascular coagulation syndromes. Hematol Pathol 6: 1-24.
32. Zilla P, Groscurth P, Rhyner K, von Felten A, 1984. Surface morphology of human platelets during in vitro aggregation. Scand J Haematol 33: 440-447.
33. Henderson WR Jr, 1992. The role of the platelet in the pathogenesis of infectious disease. Curr Opin Infect Dis 5: 375-380.
34. Heumann D, Glauser MP, 1994. Pathogenesis of sepsis. Sci Am Sci Med 1: 28-37
35. Schorer AE, Moldow CF, Rick ME, 1987. Interleukin 1 or endotoxin increases the release of von Willebrand factor from human endothelial cells. Br J Haematol 67: 193-197.
36. Coller BS, 1990. Platelets and thrombolytic therapy. N Engl J Med 322: 33-42.
37. Ruoslahti E, 1991. Integrins. J Clin Invest 87: 1-5.
38. Sporn LA, Shi R, Lawrence SO, Silverman DJ, Marder VJ, 1991. Ricketisia rickettsii infection of cultured endothelial cells induces release of large von Willebrand factor multimers from Weibel-Palade bodies. Blood 78: 2595-2602.
39. Herrmann KS, Voigt WH, 1984. Ultrastructural observations of an electron dense amorphous layer on selectively damaged endothelial cells, a possible trigger of thrombogenesis in vivo, and its inhibition by nafazatrom. Thromb Res 36: 205-215.
40. Herrmann KS, Voigt WH, Kreuzer H, 1987. Influence of heparin, aspirin, streptokinase, and factor VIII (AHF) on amorphous electron-dense substance, a mediator of platelet and thrombus adhesion in vivo. Haemostasis 7: 59-65.