Randomized controlled trial of doxycycline prophylaxis against leptospirosis in an endemic area

International Journal of Antimicrobial Agents

Volumn 13, Issue 4, 2000, Pages 249-255

  Sehgal, S C ^a   Sugunan, A P ^a   Murhekar, M V ^a   Sharma, S ^a   Vijayachari, P ^a  

^a INDIAN COUNCIL OF MEDICAL RESEARCH   (India)

Author keywords

Andaman; Doxycycline prophylaxis; Leptospirosis

Indexed keywords

DOXYCYCLINE; PLACEBO;

ADOLESCENT; ADULT; ARTICLE; CHEMOPROPHYLAXIS; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; ENVIRONMENTAL EXPOSURE; FEMALE; HUMAN; INCIDENCE; INDIA; INFECTION RATE; LEPTOSPIRA; LEPTOSPIROSIS; MAJOR CLINICAL STUDY; MALE; MORBIDITY; MORTALITY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SCHOOL CHILD;

ADOLESCENT; ADULT; ANTI-BACTERIAL AGENTS; CHILD; DOXYCYCLINE; ENDEMIC DISEASES; FEMALE; HEMAGGLUTINATION TESTS; HUMANS; LEPTOSPIROSIS; MALE; SEROLOGIC TESTS; VITAMIN B COMPLEX;

EID: 0033969524     PISSN: 09248579     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0924-8579(99)00134-X     Document Type: Article

References (15)

1. Sehgal S.C., Murhekar M.V., Sugunan A.P. Outbreak of leptospirosis with pulmonary involvement in North Andaman. Indian J. Med. Res. 102:1995;9-12.
2. Trevejo R.T., Rigau-Perez J.G., Ashford D.A. et al. Epidemic leptospirosis associated with pulmonary hemorrhage - Nicaragua, 1995. J. Infect. Dis. 178(5):1998;1457-1463.
3. Sehgal S.C. Human Leptospirosis - an emerging public health problem in India. Trans. R. Soc. Trop. Med. Hyg. 90:1996;5.
4. John T.J. Emerging and re-emerging bacterial pathogens in India. Indian J. Med. Res. 103:1996;92-97.
5. Katz A.R., Sasaki D.M., Mumm A.H., Escamilla J., Middleton C.R., Romero S.E. Leptospirosis on Oahu: an outbreak among military personnel associated with recreational exposure. Mil. Med. 162(2):1997;101-104.
6. Jackson L.A., Kaufmann A.F., Adams W.G. et al. Outbreak of leptospirosis associated with swimming. Pediatr. Infect. Dis. J. 12(1):1993;48-54.
7. Faine S. Leptospira and Leptospirosis. 1994;253-259 CRC Press, Boca Raton, FL.
8. Faine S. Guidelines for the Control of Leptospirosis. 1982;World Health Organization, Geneva.
9. Takafuji E.T., Kirkpatrick J.W., Miller R.N. et al. An efficacy trial of doxycycline chemoprophylaxis against leptospirosis. N. Engl. J. Med. 310(8):1984;497-500.
10. Singh S.S., Vijayachari P., Sinha A., Sugunan A.P., Rasheed M.A., Sehgal S.C. Clinico-epidemiological study of hospitalized cases of severe leptospirosis. Indian J. Med. Res. 109:1999;94-99.
11. Sehgal S.C., Murhekar M.V., Sugunan A.P. A serosurvey for leptospirosis in North Andaman. Indian J. Med. Microbiol. 12:1994;289-291.
12. Wolff J.W. The Laboratory Diagnosis of Leptospirosis. 1954;Charles C. Thomas, Illinois.
13. Gonsalez C.R., Casseb J., Monteiro F.G. et al. Use of doxycycline after high risk exposure in Aso Paulo, Brazil. Rev. Inst. Med. Trop. Sao. Paulo. 40(1):1998;59-61.
14. Kapusnik-Uner J.E., Sande M.A., Chambers H.F. Tetracyclines, chloramphenicol, erythromycin and miscellaneous antibacterial agents. Hardman J.G., Limbird L.E., Molinoff P.B., Ruddon R.W., Gilman A.G. Goodman & Gilman's: The Pharmacological Basics of Therapeutics. 1996;McGraw-Hill Health Profession Division, New York.
15. Murhekar M.V., Sugunan A.P., Vijayachari P., Sharma S., Sehgal S.C. Risk factors in the transmission of leptospiral infection. Indian J. Med. Res. 107:1998;218-223.