Transplacental exposure to the vacuolar-ATPase inhibitor bafilomycin disrupts survival signaling in β cells and delays neonatal remodeling of the endocrine pancreas

Experimental and Toxicologic Pathology

Volumn 60, Issue 4-5, 2008, Pages 295-306

  Hettiarachchi, Kalindi D ^a   Zimmet, Paul Z ^a,b   Danial, Nika N ^c   Myers, Mark A ^a  

^a MONASH UNIVERSITY   (Australia)

^b BAKER IDI HEART AND DIABETES INSTITUTE   (Australia)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Apoptosis; Bafilomycin; Islet cell; Type 1 diabetes; Vacuolar proton translocating ATPase

Indexed keywords

BAFILOMYCIN; PROTEIN BAD; PROTEIN BCL 2; SOMATOMEDIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; B LYMPHOCYTE; CELL ACTIVATION; CELL DEATH; CELL STRUCTURE; CELL SURVIVAL; CONTROLLED STUDY; DIABETES MELLITUS; DOWN REGULATION; MOUSE; NONHUMAN; PANCREAS ISLET; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; WEANING;

ANIMALS; ANIMALS, NEWBORN; APOPTOSIS; BCL-ASSOCIATED DEATH PROTEIN; BLOTTING, WESTERN; CELL SURVIVAL; ENZYME INHIBITORS; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; FORKHEAD TRANSCRIPTION FACTORS; IN SITU NICK-END LABELING; INSULIN; INSULIN-SECRETING CELLS; ISLETS OF LANGERHANS; MACROLIDES; MICE; MICE, INBRED C57BL; PHOSPHORYLATION; POLYMERASE CHAIN REACTION; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; SIGNAL TRANSDUCTION;

MUS; RATTUS;

EID: 46649100457     PISSN: 09402993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.etp.2008.02.009     Document Type: Article

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