The Immune System and Atopic Dermatitis

Seminars in Cutaneous Medicine and Surgery

Volumn 27, Issue 2, 2008, Pages 138-143

  Dokmeci, Elif ^a   Herrick, Christina A ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN E;

ARTICLE; ATOPIC DERMATITIS; CELL HOMING; DENDRITIC CELL; EOSINOPHIL; HISTOPATHOLOGY; HUMAN; IMMUNE SYSTEM; INNATE IMMUNITY; NATURAL KILLER T CELL; PATHOGENESIS; SKIN DEFECT; STAPHYLOCOCCUS AUREUS; T LYMPHOCYTE;

DERMATITIS, ATOPIC; HUMANS; IMMUNE SYSTEM; IMMUNITY, INNATE; T-LYMPHOCYTES;

EID: 46649083824     PISSN: 10855629     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.sder.2008.04.006     Document Type: Article

References (72)

1. Maintz L., and Novak N. Getting more and more complex: The pathophysiology of atopic eczema. Eur J Dermatol 17 (2007) 267-283
2. Boguniewicz M., and Leung D.Y. Atopic dermatitis. J Allergy Clin Immunol 117 (2006) S475-S480
3. Kuster W., Petersen M., Christophers E., et al. A family study of atopic dermatitis; Clinical and genetic characteristics of 188 patients and 2,151 family members. Arch Dermatol Res 282 (1990) 98-102
4. Rudikoff D., and Lebwohl M. Atopic dermatitis. Lancet 351 (1998) 1715-1721
5. Wollenberg A., and Bieber T. Atopic dermatitis: From the genes to skin lesions. Allergy 55 (2000) 205-213
6. Leung D.Y., and Bieber T. Atopic dermatitis. Lancet 361 (2003) 151-160
7. Cork M.J., Robinson D.A., Vasilopoulos Y., et al. New perspectives on epidermal barrier dysfunction in atopic dermatitis: Gene-environment interactions. J Allergy Clin Immunol 118 (2006) 3-21
8. Proksch E., Folster-Holst R., and Jensen J.M. Skin barrier function, epidermal proliferation and differentiation in eczema. J Dermatol Sci 43 (2006) 159-169
9. Leung D. Pathogenesis of atopic dermatitis. J Allergy Clin Immunol 104 (1999) S99-S108
10. Leung D.Y.M., Bhan A.K., Schneeberger E.E., et al. Characterization of the mononuclear cell infiltrate in atopic dermatitis using monoclonal antibodies. J Allergy Clin Immunol 71 (1983) 47-56
11. Bos J.D., Hagenara C., Das P.K., et al. Predominance of "memory". T cells (CD4+, CDw29+) over "naive" T cells (CD4+, CD45R+) in both normal and diseased human skin. Arch Dermatol Res 81 (1989) 24-30
12. Kagi M.K., Joller-Jemelka H., and Wuthrich B. Correlation of eosinophils, eosinophil cationic protein, soluble interleukin-2 receptor with the clinical activity of atopic dermatitis. Dermatology 185 (1992) 88-92
13. Wollenberg A., Wetzel S., Burgdorf W.H.C., et al. Viral infections in atopic dermatitis: Pathogenic aspects and clinical management. J Allergy Clin Immunol 112 (2003) 667-674
14. Hamid Q.A., Boguneiwicz M., and Leung D.Y.M. Differential in situ cytokine gene expression in acute versus chronic atopic dermatitis. J Clin Invest 94 (1994) 870-876
15. Hamid Q.A., Naseer T., Minshall E.M., et al. In vivo expression of IL-12 and IL-13 in atopic dermatitis. J Allergy Clin Immunol 98 (1996) 225-231
16. Grewe M., Bruijnzeel-Koomen C., Schopf E., et al. A role for Th1 and Th2 cells in the immunopathogenesis of atopic dermatitis. Immunol Today 19 (1998) 359-361
17. Teunissen M.B.M., Koomen C.W., Malefyt R.D., et al. Interleukin-17 and interferon-gamma synergize in the enhancement of proinflammatory cytokine production by human keratinocytes. J Invest Dermatol 111 (1998) 645-649
18. Albanesi C., Cavani A., and Girolomoni G. IL-17 is produced by nickel-specific T lymphocytes and regulates ICAM-1 expression and chemokine production in human keratinocytes: Synergistic or antagonist effects with IFN-gamma and TNF-alpha. J Immunol 162 (1999) 494-502
19. Kolls J.K., and Linden A. Interleukin-17 family members and inflammation. Immunity 21 (2004) 467-476
20. Toda M., Leung D.Y.M., Molet S., et al. Polarized in vivo expression of IL-11 and IL-17 between acute and chronic skin lesions. J Allergy Clin Immunol 111 (2003) 875-881
21. Joseph A., Bellanti M.D., Russell A., et al. Atopic dermatitis, genetics, immunology, and t regulatory cells. Allergy Asthma Proc 28 (2007) 507-509
22. Ou L.S., Goleva E., Hall M.S., et al. T regulatory cells in atopic dermatitis and subversion of their activity by superantigens. J Allergy Clin Immunol 113 (2004) 756-763
23. Caproni M., Antiga E., Torchia D., et al. FoxP3-expressing T regulatory cells in atopic dermatitis lesions. Allergy Asthma Proc 28 (2007) 525-528
24. Leung D.Y.M. Atopic dermatitis: New insights and opportunities for therapeutic intervention. J Allergy Clin Immunol 105 (2000) 860-876
25. Trautmann A., Akdis M., Brocker E.B., et al. New insights into the role of T cells in atopic dermatitis and allergic contact dermatitis. Trends Immunol 22 (2001) 530-532
26. Akdis M., Trautmann A., Klunker S., et al. Cytokine network and dysregulated apoptosis in atopic dermatitis. Acta Odontol Scand 59 (2001) 178-182
27. Homey B., Alenius H., Muller A., et al. CCL27-CCR10 interactions regulate T cell-mediated skin inflammation. Nat Med 8 (2002) 157-165
28. Cantani A. Pathogenesis of atopic dermatitis (AD) and the role of allergic factors. Eur Rev Med Pharmacol Sci 5 (2001) 95-117
29. Hwang S.T. Mechanisms of T-cell homing to skin. Adv Dermatol 17 (2001) 211-241
30. Jung K., Imhof B.A., Linse R., et al. Adhesion molecules in atopic dermatitis: Upregulation of alpha6 integrin expression in spontaneous lesional skin as well as in atopen, antigen and irritative induced patch test reactions. Int Arch Allergy Immunol 113 (1997) 495-504
31. Wollenberg A., Wen S., and Bieber T. Langerhans cell phenotyping: A new tool for differential diagnosis of inflammatory skin diseases. Lancet 346 (1995) 1626-1627
32. Wollenberg A., Kraft S., Hanau D., et al. Immunomorphological and ultrastructural characterization of langerhans cells and a novel, inflammatory dendritic epidermal cell (IDEC) population in lesional skin of atopic eczema. J Invest Dermatol 106 (1996) 446-453
33. Wollenberg A., Wen S., and Bieber T. Phenotyping of epidermal dendritic cells: Clinical applications of a flow cytometric micromethod. Cytometry 37 (1999) 147-155
34. Wollenberg A., Mommaas M., Oppel T., et al. Expression and function of the mannose receptor CD206 on epidermal dendritic cells in inflammatory skin diseases. J Invest Dermatol 118 (2002) 327-334
35. Maurer D., Ebner C., Reininger B., et al. Mechanisms of Fc epsilon RI-IgE-facilitated allergen presentation by dendritic cells. Adv Exp Med Biol 417 (1997) 175-178
36. Maurer D., Fiebiger E., Reininger B., et al. Fc epsilon receptor I on dendritic cells delivers IgE-bound multivalent antigens into a cathepsin s-dependent pathway of MHC class II presentation. J Immunol 161 (1998) 2731-2739
37. Fesenkova V.I., Kurchenko A.I., Castellani M.L., et al. Expression of co-stimulatory molecules on langerhans cells in lesional epidermis of human atopic dermatitis. Immunopharmacol Immunotoxicol 29 (2007) 487-498
38. Schuller E., Teichmann B., Haberstok J., et al. In situ-expression of the costimulatory molecules CD80 and CD86 on Langerhans cells and inflammatory dendritic epidermal cells (IDEC) in atopic dermatitis. Arch Dermatol Res 293 (2001) 448-454
39. Galli E., Cicconi R., Rossi P., et al. Atopic dermatitis: molecular mechanisms, clinical aspects and new therapeutical approaches. Curr Mol Med 3 (2003) 127-138
40. Reich K., Hugo C., Middel P., et al. Evidence for a role of Langerhans cell-derived IL-16 in atopic dermatitis. Clin Immunol 109 (2002) 681-687
41. Laberge S., Ghaffar O., Boguneiwicz M., et al. Association of increased CD41 T-cell infiltration with increased IL-16 gene expression in atopic dermatitis. J Allergy Clin Immunol 102 (1998) 645-650
42. Wollenberg A., Wagner M., Gunther S., et al. Plasmacytoid dendritic cells: A new cutaneous dendritic cell subset with distinct role in inflammatory skin diseases. J Invest Dermatol 119 (2002) 1096-1102
43. Farag S.S., and Caligiuri M.A. Human natural killer cell development and biology. Blood Rev 20 (2006) 123-137
44. Trinchieri G. Biology of natural killer cells. Adv Immunol 47 (1989) 187-376
45. Peritt D., Robertson S., Gri G., et al. Differentiation of human NK cells into NK1 and NK2 subsets. J Immunol 161 (1998) 5821-5824
46. Aktas E., Akdis M., Bilgic S., et al. Different natural killer (NK) receptor expression and immunoglobulin E (IgE) regulation by NK1 and NK2 cells. Clin Exp Immunol 140 (2005) 301-309
47. Katsuta M., Takigawa Y., Kimishima M., et al. NK cells and gamma delta+ T cells are phenotypically and functionally defective due to preferential apoptosis in patients with atopic dermatitis. J Immunol 176 (2006) 7736-7744
48. Buentke E., Heffler L.C., Wilson J.L., et al. Natural killer and dendritic cell contact in lesional atopic dermatitis skin-Malassezia-influenced cell interaction. J Invest Dermatol 119 (2002) 850-857
49. Leiferman K.M. A role for eosinophils in atopic dermatitis. J Am Acad Dermatol 45 suppl 1 (2001) S21-S24
50. Karawajczyk M., Sevéus L., Garcia R., et al. Piecemeal degranulation of peripheral blood eosinophils: A study of allergic subjects during and out of the pollen season. Am J Respir Cell Mol Biol 23 (2000) 521-529
51. Breuer K., Kapp A., and Werfel T. Urine eosinophil protein X (EPX) is an in vitro parameter of inflammation in atopic dermatitis of the adult age. Allergy 56 (2001) 780-784
52. Wedi B., Raap U., Lewrick H., et al. Delayed eosinophil programmed cell death in vitro: a common feature of inhalant allergy and extrinsic and intrinsic atopic dermatitis. J Allergy Clin Immunol 100 (1997) 536-543
53. Hossny E., Aboul-Magd M., and Bakr S. Increased plasma eotaxin in atopic dermatitis and acute urticaria in infants and children. Allergy 56 (2001) 996-1002
54. Satoh T., Kaneko M., Wu M.H., et al. Contribution of selectin ligands to eosinophil recruitment into the skin of patients with atopic dermatitis. Eur J Immunol 32 (2002) 1274-1281
55. Kay A.B., Barata L., Meng Q., et al. Eosinophils and eosinophil-associated cytokines in allergic inflammation. Int Arch Allergy Immunol 113 (1997) 196-199
56. Baker B.S. The role of microorganisms in atopic dermatitis. Clin Exp Immunol 144 (2006) 1-9
57. Leung D. Superantigens, steroid insensitivity and innate immunity in atopic eczema. Acta Derm Venereol Suppl 215 (2005) 11-15
58. Zdolsek H.A., and Jenmalm M.C. Reduced levels of soluble CD14 in atopic children. Clin Exp Allergy 34 (2004) 532-539
59. Terui T., Hirao T., and Sato Y. An increased ratio of interleukin-1 receptor antagonist to interleukin-1alpha in inflammatory skin diseases. Exp Dermatol 7 (1998) 327-334
60. Miller L.S., O'Connell R.M., and Gutierrez M.A. MyD88 mediates neutrophil recruitment initiated by IL-1R but not TLR2 activation in immunity against Staphylococcus aureus. Immunity 24 (2006) 79-91
61. Rieg S., Steffen H., Seeber S., et al. Deficiency of dermcidin-derived antimicrobial peptides in sweat of patients with atopic dermatitis correlates with an impaired innate defense of human skin in vivo. J Immunol 174 (2005) 8003-8010
62. Stone S.P., Muller S.A., and Gleich G.J. IgE levels in atopic dermatitis. Arch Dermatol 108 (1973) 806-811
63. Sampson H.A., and McCaskill C.C. Food hypersensitivity and atopic dermatitis: Evaluation of 113 patients. J Pediatr 107 (1985) 669-675
64. Burks A.W., James J.M., and Hiegel A. Atopic dermatitis and food hypersensitivity reactions. J Pediatr 132 (1998) 132-136
65. Gutgesell C., Heise S., Seubert S., et al. Double-blind placebo-controlled house dust mite control measures in adult patients with atopic dermatitis. Br J Dermatol 145 (2001) 70-74
66. Oosting A.J., de Bruin-Weller M.S., Terreehorst I., et al. Effect of mattress encasings on atopic dermatitis outcome measures in a double-blind, placebo-controlled study: The Dutch mite avoidance study. J Allergy Clin Immunol 110 (2002) 500-506
67. Koopman L.P., van Strien R.T., Kerkhof M., et al. Placebo-controlled trial of house dust mite-impermeable mattress covers: effect on symptoms in early childhood. Am J Respir Crit Care Med 166 (2002) 307-313
68. Bergmann R.L., Edenharter G., Bergmann K.E., et al. Atopic dermatitis in early infancy predicts allergic airway disease at 5 years. Clin Exp Allergy 28 (1998) 965-970
69. Wang L.F., Lin J.Y., Hsieh K.H., et al. Epicutaneous exposure of protein antigen induces a predominant Th2-like response with high IgE production in mice. J Immunol 156 (1996) 4077-4082
70. Spergel J.M., Mizoguchi E., Brewer J.P., et al. Epicutaneous sensitization with protein antigen induces localized allergic dermatitis and hyperresponsiveness to methacholine after single exposure to aerosolized antigen in mice. J Clin Invest 101 (1998) 1614-1622
71. Herrick C.A., MacLeod H., Glusac E., et al. Th2 responses induced by epicutaneous or inhalational protein exposure are differentially dependent on IL-4. J Clin Invest 105 (2000) 765-775
72. Lack G., Fox D., Northstone K., et al. Factors associated with the development of peanut allergy in childhood. N Engl J Med 348 (2003) 977-985