Evidence for a role of Langerhans cell-derived IL-16 in atopic dermatitis

Journal of Allergy and Clinical Immunology

Volumn 109, Issue 4, 2002, Pages 681-687

  Reich, Kristian ^a   Hugo, Sabine ^a   Middel, Peter ^a   Blaschke, Volker ^a   Heine, Andrea ^a   Gutgesell, Carsten ^a   Williams, Ruth ^b   Neumann, Christine ^a  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

^b UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

Atopic dermatitis; Chemotaxis; IL 16; Keratinocytes; Langerhans cells; Real time RT PCR; Tacrolimus

Indexed keywords

CD1 ANTIGEN; INTERLEUKIN 16; IONOMYCIN; MESSENGER RNA; PHORBOL ESTER; TACROLIMUS;

ARTICLE; ATOPIC DERMATITIS; CELL ACTIVATION; CELL INFILTRATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DOWN REGULATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN SITU HYBRIDIZATION; INFLAMMATORY CELL; KERATINOCYTE; LANGERHANS CELL; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

EID: 0036226279     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1067/mai.2002.122234     Document Type: Article

References (26)

1. Atopic dermatitis: New insights and opportunities for therapeutic intervention
2. Chemokines and atopic dermatitis
3. Enhanced expression of eotaxin and CCR3 in atopic dermatitis
4. Evidence for increased expression of eotaxin and monocyte chemotactic protein-4 in atopic dermatitis
5. Interleukin 16 and its function as a CD4 ligand
6. Synergistic activation of CD4+ T cells by IL-16 and IL-2
7. Molecular cloning, sequence, expression, and processing of the interleukin 16 precursor
8. Processing and activation of pro-interleukin-16 by caspase-3
9. Early identification of interleukin-16 (lymphocyte chemoattractant factor) and macrophage inflammatory protein 1 alpha (MIP1 alpha) in bronchoalveolar lavage fluid of antigen-challenged asthmatics
10. Involvement of IL-16 in the induction of airway hyper-responsiveness and up-regulation of IgE in a murine model of allergic asthma
11. Increased expression of IL-16 immunoreactivity in bronchial mucosa after segmental allergen challenge in patients with asthma
12. Association of increased CD4+ T-cell infiltration with increased IL-16 gene expression in atopic dermatitis
13. IgE-mediated allergen presentation via Fc epsilon RI on antigen-presenting cells
14. A role for IL-16 in the cross-talk between dendritic cells and T cells
15. Successful treatment of resistant facial lesions of atopic dermatitis with 0.1% FK506 ointment
16. Rapid purification of human Langerhans cells using paramagnetic microbeads
17. Human keratinocytes constitutively express IL-4 receptor molecules and respond to IL-4 with an increase in B7/BB1 expression
18. Rapid quantitation of proinflammatory and chemoattractant cytokine expression in small tissue samples and monocyte-derived dendritic cells: Validation of a new real-time RT-PCR technology
19. Leukocyte chemotactic factor, a natural ligand to CD4, is expressed by lymphocytes and microglial cells of the MS plaque
20. Engagement of the FcεRI stimulates the production of IL-16 in Langerhans cell-like dendritic cells
21. Expression of the CD4+ cell-specific chemoattractant interleukin-16 in mycosis fungoides
22. Tissue and T cell distribution of precursor and mature IL-16
23. The cytokine profile expressed by human dendritic cells is dependent on cell subtype and mode of activation
24. Immunomorphological and ultrastructural characterization of Langerhans cells and a novel, inflammatory dendritic epidermal cell (IDEC) population in lesional skin of atopic eczema
25. Role of IL-16 in delayed-type hypersensitivity reaction
26. Topical FK506 suppresses cytokine and costimulatory molecule expression in epidermal and local draining lymph node cells during primary skin immune responses