Mechanisms of FcεRI-IgE-facilitated allergen presentation by dendritic cells

Advances in Experimental Medicine and Biology

Volumn 417, Issue , 1997, Pages 175-178

  Maurer, Dieter ^a   Ebner, Christof ^b   Reininger, Bärbel ^a   Petzelbauer, Peter ^a   Fiebiger, Edda ^a   Stingl, Georg ^a  

^a Universitatsklinik fur Dermatologie   (Austria)

^b MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

ALLERGEN; IMMUNOGLOBULIN E; IMMUNOGLOBULIN E RECEPTOR;

ALLERGY; ANTIGEN ANTIBODY COMPLEX; ANTIGEN PRESENTATION; ANTIGEN RECOGNITION; ATOPY; CELL MIGRATION; CELLULAR IMMUNITY; CONFERENCE PAPER; DENDRITIC CELL; PINOCYTOSIS; PRIORITY JOURNAL; ARTICLE; CLASSIFICATION; HUMAN; IMMEDIATE TYPE HYPERSENSITIVITY; IMMUNOLOGY; IN VITRO STUDY; METABOLISM;

ALLERGENS; ANTIGEN PRESENTATION; DENDRITIC CELLS; HUMANS; HYPERSENSITIVITY, IMMEDIATE; IMMUNOGLOBULIN E; RECEPTORS, IGE;

EID: 0030611793     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4757-9966-8_29     Document Type: Conference Paper

References (18)

1. R.M. Steinman, The dendritic cell system and its role in immunogenicity, Annu. Rev. Immunol. 9:271 (1991).
2. R.M. Steinman and J. Swanson, The endocytotic activity of dendritic cells, J. Exp. Med. 182: 283 (1995).
3. F. Sallusto, M. Cella, C. Danielli, and A. Lanzavecchia, Dendritic cells use macropinocytosis and the mannose receptor to concentrate antigen in the MHC II compartment. Downregulation by cytokines and bacterial products, J. Exp. Med. 182:389 (1995).
4. F. Manca, D. Fenoglio, G.L. Pira, A. Kunkel, and F. Celada, Effect of antigen/antibody ratio on macrophage uptake, processing, and presentation to T cells of antigen complexed with polyclonal antibodies, J. Exp. Med. 173:37 (1991).
5. F. Sallusto and A. Lanzavecchia, Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor α. J. Exp. Med. 179:1109 (1994).
6. P.D. Stahl, The mannose receptor and other macrophage lectins, Curr. Opin. Immunol. 4: 49 (1992).
7. W. Jiang, W.J. Swiggard, C. Heufler, M. Peng, A. Mirza, R.M. Steinman, and M.C. Nussenzweig, DEC-205, a receptor expressed by dendritic cells and thymic epithelial cells, has ten C-type lectin domains and is involved in antigen presentation, Nature 305:151 (1995).
8. D. Maurer, C. Ebner, B. Reininger, E. Fiebiger, D. Kraft, J.-P. Kinet, and G. Stingl, The high affinity immunoglobulin E receptor (FcεRI) mediates IgE-dependent allergen presentation, J. Immunol. 154: 6285 (1995).
9. B. Wang, A. Rieger, O. Kilgus, K. Ochiai, D. Maurer, D. Födinger, J.-P. Kinet, and G. Stingl, Epidermal Langerhans cells from normal human skin bind monomeric IgE via FcεRI, J. Exp. Med. 175:1353 (1992).
10. T. Bieber, H. de la Salle, A. Wollenberg, J. Hakimi, R. Chizzonite, J. Ring, D. Hanau, and C. de la Salle, Human epidermal Langerhans cells express the high affinity receptor for immunoglobulin E (FcεRI), J. Exp. Med. 175:1285 (1992).
11. B. Osterhoff, C. Rappersberger, B. Wang, F. Koszik, K. Ochiai, J.-P. Kinet, and G. Stingl, Immunomorphological characterization of FcεRI-bearing cells within the human dermis, J. Invest. Dermatol. 102:315 (1994).
12. D. Maurer, E. Fiebiger, B. Reininger, B. Wolff-Winiski, M.-H. Jouvin, O. Kilgus, J.-P. Kinet, and G. Stingl, Expression of functional high affinity IgE receptors (FcεRI) on monocytes of atopic individuals, J. Exp. Med. 179:745 (1994).
13. D. Maurer, E. Fiebiger, C. Ebner, B. Reininger, G.F. Fischer, S. Wichlas, M.-H. Jouvin, M. Schmitt-Egenolf, D. Kraft, J.-P. Kinet, and G. Stingl, Peripheral blood dendritic cells express FcεRI as a complex composed of FcεRIα- and FcεRIγ-chains and can use this receptor for IgE-mediated allergen presentation, J. Immunol. 157:607 (1996).
14. I.S. Townbridge and J.F. Collawn, Signal-dependent membrane protein trafficking in the endocytotic pathway, Annu. Rev. Cell Biol. 9: 129 (1993).
15. H. Ohno, J. Stewart, M.-C. Fournier, H. Bosshart, I. Rhee, S. Miyatake, T. Saito, A. Gallusser, T. Kirchhausen, and J.S. Bonifacio, Interaction of tyrosine-based sorting signals with clathrin-associated proteins, Science 269:1872 (1995).
16. M. Sugita, R.M. Jackman, E. van Donselaar, S.M. Behar, R.A. Rogers, P.J. Peters, M.B. Brenner, and S.A. Porcelli, Cytoplasmic tail-dependent localization of CD1b antigen presenting molecules to MIICs, Science 273:349 (1996).
17. R. Lindstedt, M. Liljedahl, A. Péléraux, P.A. Peterson, and L. Karlsson, The MHC class II molecule H2-M is targeted to an endosomal compartment by a tyrosine-based targeting motif, Immunity 3: 561 (1995).
18. C. Watts and A. Lanzavecchia, Suppressive effect of antibody on processing of T cell epitopes, J. Exp. Med. 187:1459 (1993).