Adhesion molecules in atopic dermatitis: Upregulation of α6 integrin expression in spontaneous lesional skin as well as in atopen, antigen and irritative induced patch test reactions

International Archives of Allergy and Immunology

Volumn 113, Issue 4, 1997, Pages 495-504

  Jung, Kirsten ^a   Imhof, B A ^b   Linse, R ^a   Wollina, U ^c   Neumann, C ^d  

^a Clinic of Dermatology Erfurt   (Germany)

^b BASEL INSTITUTE FOR IMMUNOLOGY   (Switzerland)

^c FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^d UNIVERSITY OF GÖTTINGEN   (Germany)

Author keywords

Adhesion molecules; Atopic dermatitis; Endothelial cells; Integrins; Keratinocyte

Indexed keywords

ANTIGEN; CELL ADHESION MOLECULE; DITHRANOL; GAMMA INTERFERON; INTEGRIN; INTERLEUKIN 1; INTERLEUKIN 4; IRRITANT AGENT; MITOGENIC AGENT; NICKEL SULFATE; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; ATOPIC DERMATITIS; BASAL CELL; BLOOD VESSEL; CLINICAL ARTICLE; CONTROLLED STUDY; DERMATOPHAGOIDES PTERONYSSINUS; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INFLAMMATION; KERATINOCYTE; PATCH TEST; PRIORITY JOURNAL; SKIN DEFECT; SKIN EPITHELIUM; T LYMPHOCYTE;

ANTHRALIN; ANTIGENS, CD; ANTIGENS, CD3; ANTIGENS, DERMATOPHAGOIDES; BLOOD VESSELS; CELL MOVEMENT; CELLS, CULTURED; CYTOKINES; DERMATITIS, ATOPIC; ENDOTHELIUM; EPIDERMIS; EPITHELIUM; GLYCOPROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; INTEGRIN ALPHA6; INTERLEUKIN-6; KERATINOCYTES; NICKEL; ORGAN CULTURE TECHNIQUES; PATCH TESTS; SKIN; T-LYMPHOCYTES; TETRADECANOYLPHORBOL ACETATE; TRANSFORMING GROWTH FACTOR BETA; UP-REGULATION;

EID: 0030850852     PISSN: 10182438     EISSN: 14230097     Source Type: Journal    
DOI: 10.1159/000237628     Document Type: Article

References (56)

1. Jung K, Linse F, Heller R, Goebel R, Neumann Ch: Adhesion molecules in alopic dermatitis: VCAM-I and ICAM-I expression is increased in healthy appearing skin. Allergy 1996:51: 452-460.
2. Hynes RO: Intcgrins: Versatility, modulation, and signaling in cell adhesion. Cell 1992:69: 11-25
3. Springer TA, Thompson WS, Miller LJ, Schmalsteig FC, Anderson C: Inherited deficiency of the Mac-1. LFA-i, p 150.95 glycoprotein family and its molecular basis. J F.xp Med 1984:160:1901.
4. Vennegoor CJGM, van de Wiel-van Kemenade F, Huijbcn RJF, Sanchcz-Madrid F, Melief CJM, Figdor CG: Role of LFA-I and VLA-4in the adhesion of cloned nonnal and LFA-1 (CD 1 l/CDI8)-dcficient T cells to cultured endothelial cells. J Immunol 1992:148:1093-1101.
5. Konter U, Kellner I, Klein E, Kaufmann R, Mielkc V, Sterry W: Adhesion molecule mapping in normal human skin. Arch Dermatol Res 1989:281:454-462.
6. Kennel SJ, Godfrey V, Chang LY, Lankford TK, Foote LJ, Makkinje A: The beta 4 subunit of the intcgrin family is displayed on a restricted subset of endothelium in mice. J Cell Sei 1992:101: 145.
7. Conforti G, Dominguez C, Zanctti A, Gim-bronc MJ, Cremona O, Marchisio PC, Dejana F: Human endothelial cells express integrin receptors on the luminal aspect of their membrane. Blood 1992:80:437.
8. Ruiz P, Dunon D, Sonnenberg A, Imhof BA: Suppression of mouse melanoma metastasis by EA-I. a monoclonal antibody specific for α6 in-tegrins. Cell Adhcs Commun 1993; 1:67.
9. Yancey KB: Adhesion molecules. II. Interactions of kcratinocytes with epidermal basement membrane. J Invest Dermatol 1995:104:1008-1014.
10. Carter WG, Wayner EA, Bouchard TS, Kaur P: The role of α2β1 and α3βl in cell-cell and cell-substrate adhesion of human epidermal cells. J Cc.l Biol 1990:110:1387-1404.
11. Hcrtle MD, Adams JC, Watt FM: Integrin expression during human epidermal development in vivo and in vitro. Development 1991:112: 193-206.
12. Hertlc MD, Kubler MD, Leigh IM, Watt FM: Abenant integrin expression during epidermal wound healing and in psoriatic epidermis. J Clin Invest 1992;89:1892-1901.
13. Ralfsiacr F, Thomsen K, Vejlsgaard GL: Expression of a cell adhesion protein (VLA p) in normal and diseased skin. Br J Dermatol 1991; 124:527-532.
14. Kellner I, Konter U, Sterry W: Overexpression of extracellular matrix receptors (VLA-3,5 and 6) on psoriatic kcratinocytes. Br J Dermatol 1991:125:211-216.
15. Bochncke W, Kellner I, Konter U, Sterry W: Differential expression of adhesion molecules on infiltrating cells in inflammatory dermatoses. J Am Acad Dermatol 1992:26:907-913.
16. Cavani A, Zambruno G, Marconi A, Manea V, Marchctti M, Gianetti A: Distinctive integrin expression in the newly forming epidermis during wound healing in humans. J Invest Dermatol 1993:1101:600-604.
17. Driesch P, Fartasch M, Iliiner A, Poncc M: Expression of integrin receptors and ICAM-1 on kcratinocytes in vivo and in an in vitro reconstructed epidermis: Effect of sodium dodccyl sulphate. Arch Dermatol Res 1995:287:249-253.
18. Simon M Jr, von den Driesch P: Expressionsmuster von Adhäsionsmolekülen bei PUVA-be-handelten Lichen-planus-Patientcn. Hautarzt 1994;45:161-165.
19. Imhof BA, Ruiz P, Hesse B, Palacios R, Dunon D: EA-1, a novel adhesion molecule involved in the homing of progenitor T lymphocytes to the thymus. J Cell Biol 1991;114:1069.
20. Ruiz P, Wiles MV, Inthof BA: a6 integrins participate in pro-T cell homing to the thymus. F.ur J Immunol 1995;25:2034-2041.
21. Hanifin JM, Rajka G: Diagnostic features of atopic dermatitis. Acta Derm Venercol Stippl (Stockh) 1980:92:44-47.
22. Sager N, Feldman A, Schilling G, Neumann C: House dust mite-specific T cells in the skin of subjects with atopic dermatitis: Frequency and lymphokine profile in the allergen patch test, J Allergy Clin Immunol 1992;89:801-810.
23. Wollina U, Bonnekoh B, Klinger R, Wetzker R, Mahrle G: Vasoactive intestinal peptide (VIP) acting as a growth factor for human keratino-cytes. Neuroendocrinology Letters 1992:14: 21-31.
24. Quaranta V, Jones JCR: The internal affairs of an integrin. Trends Cell Biol 1991; 1:2-4.
25. Lee EC, Lotz MM, Steele GD Jr, Mercurio AM: The integrin α6β4 is a laminin receptor. J Cell Biol 1992:117:671-678.
26. Lotz MM, Korzelius CA, Mercurio AM: Human colon carcinoma cells use multiple receptors to adhere to laminin: Involvement of α6β4 and α2βl integrins. Cell Regul 1990; 1:249.
27. Sonnenberg A, Linders CJT, Modderman PW, Damsky CH, Aumaillev M, Timpl R: Integrin recognition of different cell-binding fragments of laminin (PI. E3. E8) and evidence that α6βl but not α6β4 functions as a major receptor for fragment E8. J Cell Biol 1990:110:2145-2155.
28. Sonnenberg A, Gehlscn KR, Auntailley M, Timpl R: Isolation of α6βl integrins from platelets and adherent cells by affinity chromatography on mouse laminin fragment E8 and human laminin pepsin fragment. Exp Cell Res 1991:197:234.
29. Almeida EAC, Huovilla APJ, Sutherland AE, Stephens LE, Calarco PG, Shaw LM, Mercirio AM, Sonnenberg A, Primakoff P, Myles DG, White JM: Mouse egg integrin u6ßl functions as a sperm receptor. Cell 1996,81:1095-1104.
30. Zambruno G, Manea V, Santantonio ML, Soli-go D, Ciiannetti A: VLA protein expression on epidermal cells (keratinocytes. Langerhans cells, melanocytes): A light and electron microscopic immunohistochemical study. Br J Dermatol 1991;124:135-145.
31. Sonnenberg A, Calafat J, Janssen H, Daams H, van der Raaij-Helmer LM, Falcioni R, Kennel SJ, Aplin JD, Baker J, Leizidou M, Garod D: Integrin α6β4 complex is located in hemides-mosomes. suggesting a major role in epidermal cell-basement membrane adhesion. J Cell Biol 1991:113:907-917.
32. Klein EC, Steinmayer T, Mattes JM, Kaufmann R, Weber L: Integrins of normal human epidermis: Differential expression, synthesis and molecular structure. BrJ Dermatol 1990:123:171-178.
33. De Luca M, Tamura RN, Kajiji S, Bondanza S, Rossini P, Cancedda R, et al: Polarized integrin mediates human kcratinocyte adhesion to basal lamina. Proc Natl Acad Sei USA 1990:87: 6888-6892.
34. Stepp MA, Spurr-Miehaud S, Tisdale A, Elwell J, Gipson IK: α6β4 integrin is a component of hemidesmosomes. Proc Natl Acad Sei USA 1990:87:8970-8974.
35. Kaufmann R, Hainzl A, Sterry W, Alberti S, Klein CE: In vivo targeting of integrin receptors in human skin xenografts by intravenously applied antibodies. Arch Dermatol Res 1994:286: 6-11.
36. Streilcin J: Skin-associated lymphoid tissue (SALT): Origins and functions. J Invest Dermatol 1983:80 (Suppl): 12.
37. Kupper TS, Coleman DL, McGuire J, Gold-minz D, Horowitz MC: Keratinocyte-derived T-cell growth factor: A T-cell growth factor functionally distinct from interleukin 2. Proc Natl Acad Sei USA 1986:83:4451.
38. Tschachler E, Schuler G, Hutterer J, Leibi H, Wolff K, Stingl G: Expression ofThy-l antigen by murine epidermal cells. J Invest Dermatol 1983:81:282.
39. Bcrgstrcsscr PR, Tigelaar RE, Dees JIL, Strci-lein JW: Thy-1 antigen-bearing dendritic cells in murine epidermis are derived from bone marrow precursors. J Invest Dermatol 1983:81:286.
40. Janeway CA Jr, Jones B, Hayday A: Specificity and functions of T cells bearing yö receptors. Immunol Today 1988;9:73.
41. Shimizu Y, van Seventer GA, Morgan KJ, Shaw S: Roles of adhesion molecules in T cell recognition: Fundamental similarities between four integrins on resting human T cells (LFA-1. VI.A-4. VLA-5, VLA-6) in expression, binding, and costimulation. Immunol Rev 1990: 114:109-143.
42. Friedrichs K, Ruiz P, Franke F, Gille I, Terpe HJ, Imhof BA: High expression level of α6 integrin in human breast carcinoma is correlated with reduced survival. Cancer Res 1995:55:901.
43. Uccini S, Ruco LP, Monardo F, La Parola IL, Cerimcle D, Baroni CD: Molecular mechanisms involved in intraepithelial lymphocyte migration: A comparative study in skin and tonsil. J Pathol 1993;169:413-419
44. Poumay Y, Leclercq-Smckens M, Grailly S, Degen A, Leloup R: Specific internalization of basal membrane domains containing the integrin α6β4 in dispase-dctaehed cultured human keratinocytes. EurJ Cell Biol 1993:60:12-20.
45. Kurpakus MA, Quaranta V, Jones JCR: Surface relocation of u6ß4 integrins and assembly of hemidesmosomes in an in vitro model of wound healing, J Cell Biol 1991:1 15:1737-1750.
46. Fleming TE, Mirando WS, Trcfzcr U, Tubesing KA, Elmets CA: In situ expression of a B7-likc adhesion molecule on keratinocytes from human epidermis. J Invest Dermatol 1993:101: 754-758.
47. Mitra R, Barker J, Stoof T, et al: Comparison of lymphocyte adhesion to kcratinocytes (KC), fibroblast (FB). melanocytes (MC): CD-18 (LFA-I) dependent and independent pathways. Clin Res 1991:39:234A.
48. Nickooff BJ, Mitra RS, Shimizu Y, Barker JNWN, Karabin G, Stoof T, Stoolman LM: HUT 78 T cells bind to noncytokine-stimulated keratinocytes using a non-C'D 18-dependent adhesion pathway. Am J Pathol 1992:140:1365-1374.
49. Sterry W, Mielke V, Konter U, Kellner I, Boehnke WH: Role of ß I -integrins in epider-motropism of malignant T cells. Am J Pathol 1992:141:855-860.
50. Mackay CR, Marston WL, Dudler L, Spertini O, Tedder TF, Hein WR: Tissue-specific migration pathways by phenotypically distinct sub-populations of memory cells. Eur J Immunol 1992:22:887.
51. Altevogt P, Hubbe M, Ruppen M, Lohr J, von Hocgen P, Sammar M, Andrew DP, McEvoy L, Humphries MJ, Butcher EC: The α4 integrin chain:s a ligand for α4β7 and α4β1. J Exp Med 1995:182:345-355.
52. La Reviere G, Gebbinck JW, Schipper CA, Mooi WJ, Roos E: In vitro invasiveness of cytotoxic T lymphocytes clones and in vivo dissemination of CTL hybridomas. J Leukoc Biol 1993: 53:381-389.
53. Ilertle MD, Jones PH, Groves RW, Hudson DL, Watt FM: Integrin expression by human epidermal keratinocytes can be modulated by interfc-ron-y. transforming growth factor-β. tumor necrosis factor-u, and culture on a dermal equivalent. J Invest Dermatol 1995:104:260-265.
54. Rossen K, Dahlstrom KK, Mercurio AM, Wewer UM: Expression of the u6β4 integrin by squamous cell carcinomas and basal cell carcinomas: Possible relation to invasive potential? Acta Derm Venereol (Stockh) 1994:74:101-105.
55. Le TKM, Van der Valk PGM, Schalkwijk J, Van de Kerkhof PCM: Changes in epidermal proliferation and differentiation in allergic and irritant dermatitis reactions. BrJ Dermatol 1995; 133:236-240.
56. Kondo S, Hozumi Y, Macjima H, Aso K: Organ culture of psoriatic skin: Effect of TGF-u and TGF-β on epidermal structure in vitro. Arch Dermatol Res 1992:284:150-153.