Sequential production of IL-2, IFN-γ and IL-10 by individual staphylococcal enterotoxin B-activated T helper lymphocytes

European Journal of Immunology

Volumn 28, Issue 5, 1998, Pages 1534-1543

  Assenmacher, Mario ^a,b   Löhning, Max ^a   Scheffold, Alexander ^a   Manz, Rudolf A ^a   Schmitz, Jürgen ^b   Radbruch, Andreas ^a,c  

^a UNIVERSITY OF COLOGNE   (Germany)

^b MILTENYI BIOTEC GMBH   (Germany)

^c DEUTSCHES RHEUMA FORSCHUNGSZENTRUM   (Germany)

Author keywords

Cell surface affinity matrix; Cytokine; Superantigen; Surface IFN ; T helper cell

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2; LIPOSOME; STAPHYLOCOCCUS ENTEROTOXIN B; SUPERANTIGEN;

ANIMAL CELL; ARTICLE; CYTOKINE PRODUCTION; HELPER CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; CELL SEPARATION; CELLS, CULTURED; ENTEROTOXINS; INTERFERON TYPE II; INTERLEUKIN-10; INTERLEUKIN-2; INTERPHASE; KINETICS; L-SELECTIN; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED BALB C; STAPHYLOCOCCUS AUREUS; T-LYMPHOCYTES, HELPER-INDUCER; TIME FACTORS;

EID: 0031898351     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-4141(199805)28:05<1534::AID-IMMU1534>3.0.CO;2-R     Document Type: Article

References (55)

1. Herrmann, T., Baschieri, S., Lees, R. K. and MacDonald, H. R., In vivo responses of CD4+ and CD8+ cells to bacterial superantigens. Eur. J. Immunol. 1992. 22: 1935-1938.
2. Miethke, T., Wahl, C., Heeg, K., Echtenacher, B., Krammer, P. H. and Wagner, H., T cell-mediated lethal shock triggered in mice by the superantigen staphylococcal enterotoxin B: critical role of tumor necrosis factor. J. Exp. Med. 1992. 175: 91-98.
3. Litton, M. J., Sander, B., Murphy, E., O'Garra, A. and Abrams, J. S., Early expression of cytokines in lymph nodes after treatment in vivo with Staphylococcus enterotoxin B. J. Immunol. Methods 1994. 175: 47-58.
4. Florquin, S., Amraoui, Z., Abramowicz, D. and Goldman, M., Systemic release and protective role of IL-10 in staphylococcal enterotoxin B-induced shock in mice. J. Immunol. 1994. 153: 2618-2623.
5. Cardell, S., Hoiden, I. and Moller, G., Manipulation of the superantigen-induced lymphokine response. Selective induction of interleukin-10 or interferon-gamma synthesis in small resting CD4+ T cells. Eur. J. Immunol. 1993. 23: 523-529.
6. Assenmacher, M., Schmitz, J. and Radbruch, A., Flow cytometric determination of cytokines in activated murine T helper lymphocytes: expression of interleukin-10 in interferon-gamma and in interleukin-4-expressing cells. Eur. J. Immunol. 1994. 24: 1097-1101.
7. Svetic, A., Jian, Y. C., Lu, P., Finkelman, F. D. and Gause, W. C., Brucella abortus induces a novel cytokine gene expression pattern characterized by elevated IL-10 and IFN-γ in CD4+ T cells. Int. Immunol. 1993. 5: 877-883.
8. Hsieh, B., Schrenzel, M. D., Mulvania, T., Lepper, H. D., Di Molfetto-Landon, L. and Ferrick, D. A., In vivo cytokine production in murine listeriosis. Evidence for immunoregulation by gamma delta+ T cells. J. Immunol. 1996. 156: 232-237.
9. Sher, A. and Coffman, R. L., Regulation of immunity to parasites by T cells and T cell-derived cytokines. Annu. Rev. Immunol. 1992. 10: 385-409.
10. Florquin, S., Amraoui, Z. and Goldman, M., T cells made deficient in interleukin-2 production by exposure to staphylococcal enterotoxin B in vivo are primed for interferon-gamma and interleukin-10 secretion. Eur. J. Immunol. 1995. 25: 1148-1153.
11. Linsley, P. S. and Ledbetter, J. A., The role of the CD28 receptor during T cell responses to antigen. Annu. Rev. Immunol. 1993. 11: 191-212.
12. Smith, K. A., Interleukin-2: inception, impact, and implications. Science 1988. 240: 1169-1176.
13. Kneitz, B., Herrmann, T., Yonehara, S. and Schimpl, A., Normal clonal expansion but impaired Fas-mediated cell death and anergy induction in interleukin-2-deficient mice. Eur. J. Immunol. 1995. 25: 2572-2577.
14. Schorle, H., Holtschke, T., Hünig, T., Schimpl, A. and Horak, I., Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting. Nature 1991. 352: 621-624.
15. Sadlack, B., Merz, H., Schorle, H., Schimpl, A., Feller, A. C. and Horak, I., Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene. Cell 1993. 75: 253-261.
16. Fiorentino, D. F, Zlotnik, A., Vieira, P., Mosmann, T. R., Howard, M., Moore, K. W. and O'Garra, A., IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells. J. Immunol. 1991. 146: 3444-3451.
17. Fiorentino, D. F., Zlotnik, A., Mosmann, T. R., Howard, M. and O'Garra, A., IL-10 inhibits cytokine production by activated macrophages. J. Immunol. 1991. 147: 3815-3822.
18. Moore, K. W., O'Garra, A., de Waal Malefyt, R., Vieira, P. and Mosmann, T. R., Interleukin-10. Annu. Rev. Immunol. 1993. 11: 165-190.
19. Bamford, R. N., Grant, A. J., Burton, J. D., Peters, C., Kurys, G., Goldman, C. K., Brennan, J., Roessler, E. and Waldmann, T. A., The interleukin (IL) 2 receptor beta chain is shared by IL-2 and a cytokine, provisionally designated IL-T, that stimulates T-cell proliferation and the induction of lymphokine-activated killer cells. Proc. Natl. Acad. Sci. USA 1994. 91: 4940-4944.
20. Cunha, F. Q., Moncada, S. and Liew, F. Y., Interleukin-10 (IL-10) inhibits the induction of nitric oxide synthase by interferon-gamma in murine macrophages. Biochem. Biophys. Res. Commun. 1992. 182: 1155-1159.
21. Gazzinelli, R. T., Oswald, I. P., Hieny, S., James, S. L. and Sher, A., The microbicidal activity of interferon-gamma-treated macrophages against Trypanosoma cruzi involves an L-arginine-dependent, nitrogen oxidemediated mechanism inhibitable by interleukin-10 and transforming growth factor-beta. Eur. J. Immunol. 1992. 22: 2501-2506.
22. Gazzinelli, R. T., Oswald, I. P., James, S. L. and Sher, A., IL-10 inhibits parasite killing and nitrogen oxide production by IFN-gamma-activated macrophages. J. Immunol. 1992. 148: 1792-1796.
23. Oswald, I. P., Gazzinelli, R. T., Sher, A. and James, S. L., IL-10 synergizes with IL-4 and transforming growth factor-beta to inhibit macrophage cytotoxic activity. J. Immunol. 1992. 148: 3578-3582.
24. Manz, R., Assenmacher, M., Pfluger, E., Miltenyi, S. and Radbruch, A., Analysis and sorting of live cells according to secreted molecules, relocated to a cell-surface affinity matrix. Proc. Natl. Acad. Sci. USA 1995. 9264: 1921-1925.
25. Assenmacher, M., Scheffold, A., Schmitz, J., Segura Checa, J. A., Miltenyi, S. and Radbruch, A., Specific expression of surface interferon-gamma on interferon-gamma producing T cells from mouse and man. Eur. J. Immunol. 1996. 26: 263-267.
26. Assenmacher, M., Schmitz, J. and Radbruch, A., Immunodetection of cytokine-producing cells using flow cytometry. INSERM, Le Vesinet 1994. 63: 80-88.
27. Scheffold, A., Miltenyi, S. and Radbruch, A., Magnetofluorescent liposomes for increased sensitivity of immunofluorescence. Immunotechnology 1995. 1: 127-137.
28. Sander, B., Andersson, J. and Andersson, U., Assessment of cytokines by immunofluorescence and the paraformaldehyde-saponin procedure, Immunol. Rev. 1991. 119: 65-93.
29. Jung, T., Schauer, U., Heusser, C., Neumann, C. and Rieger, C., Detection of intracellular cytokines by flow cytometry. J. Immunol. Methods 1993. 159: 197-207.
30. Schmitz, J., Assenmacher, M. and Radbruch, A., Regulation of T helper cell cytokine expression: functional dichotomy of antigen-presenting cells. Eur. J. Immunol. 1993. 23: 191-199.
31. Jung, T., Schauer, U., Rieger, C., Wagner, K., Einsle, K., Neumann, C. and Heusser, C., Interleukin-4 and interleukin-5 are rarely co-expressed by human T cells. Eur. J. Immunol. 1995. 25: 2413-2416.
32. Openshaw, P., Murphy, E. E., Hosken, N. A., Maino, V., Davis, K., Murphy, K. and O'Garra, A., Heterogeneity of intracellular cytokine synthesis at the single-cell level in polarized T helper 1 and T helper 2 populations. J. Exp. Med. 1995. 182: 1357-1367.
33. Schmitz, J. and Radbruch, A., Distinct antigen presenting cell-derived signals induce Th cell proliferation and expression of effector cytokines. Int. Immunol. 1992. 4: 43-51.
34. Hoiden, I. and Moller, G., Interferon-gamma and growth factor production by murine T cells derived from three different lymphoid tissues. Eur. J. Immunol. 1991. 21: 2703-2709.
35. Minasi, L. E., Kamogawa, Y., Carding, S., Bottomly, K. and Flavell, R. A., The selective ablation of interleukin 2-producing cells isolated from transgenic mice. J. Exp. Med. 1993. 177: 1451-1459.
36. Hsieh, C. S., Macatonia, S. E., O'Garra, A. and Murphy, K. M., Pathogen-induced Th 1 phenotype development in CD4+ alpha beta-TCR transgenic T cells is macrophage dependent. Int. Immunol. 1993. 5: 371-382.
37. Seder, R. A., Gazzinelli, R., Sher, A. and Paul, W. E., Interleukin 12 acts directly on CD4+ T cells to enhance priming for Interferon gamma production and diminishes interleukin 4 inhibition of such priming. Proc. Natl. Acad. Sci. USA 1993. 90: 10188-10192.
38. Desai, B. B., Quinn, P. M., Wolitzky, A. G., Mongini, P. K., Chizzonite, R. and Gately, M. K., IL-12 receptor. II. Distribution and regulation of receptor expression. J. Immunol. 1992. 148: 3125-3132.
39. Chizzonite, R., Truitt, T., Desai, B. B., Nunes, P., Podlaski, F. J., Stern, A. S. and Gately, M. K., IL-12 receptor. I. Characterization of the receptor on phytohemagglutinin-activated human lymphoblasts. J. Immunol. 1992. 148: 3117-3124.
40. Kuhn, R., Lohler, J., Rennick, D., Rajewsky, K. and Müller, W., Interleukin-10-deficient mice develop chronic enterocolitis. Cell 1993. 75: 263-274.
41. Davidson, N. J., Leach, M. W., Fort, M. M., Thompson-Snipes, L., Kuhn, R., Müller, W., Berg, D. J. and Rennick, D. M., T helper cell 1-type CD4+ T cells, but not B cells, mediate colitis in interleukin 10-deficient mice. J. Exp. Med. 1996. 184: 241-251.
42. Gazzinelli, R. T., Wysocka, M., Hieny, S., Scharton-Kersten, T., Cheever, A., Kuhn, R., Muller, W., Trinchieri, G. and Sher, A., In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD4+ T cells and accompanied by overproduction of IL-12, IFN-gamma, and TNF-alpha. J. Immunol. 1996. 157: 798-805.
43. de Waal Malefyt, R., Abrams, J., Bennett, B., Figdor, C. G. and de Vries, J. E., Interleukin 10 (IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes. J. Exp. Med. 1991. 174: 1209-1220.
44. Mingari, M. C., Maggi, E., Cambiaggi, A., Annunziato, F., Schiavetti, F., Manetti, R., Moretta, L. and Romagnani, S., Development in vivo of human CD4+ thymocytes into functionally mature Th2 cells. Exogenous interleukin-12 is required for priming thymocytes to produce both Th1 cytokines and interleukin-10. Bur. J. Immunol. 1996. 26: 1083-1087.
45. Meyaard, L., Hovenkamp, E., Otto, S. A. and Miedema, F., IL-12-induced IL-10 production by human T cells as a negative feedback for IL-12-induced immune responses. J. Immunol. 1996. 156: 2776-2782.
46. Jeannin, P., Deneste, Y., Seveso, M., Life, P. and Bonnefoy, J. Y., IL-12 synergizes with IL-2 and other stimuli in inducing IL-10 production by human T cells. J. Immunol. 1996. 156: 3159-3165.
47. Daftarian, P. M., Kumar, A., Kryworuchko, M. and Diaz-Mitoma, F., IL-10 production is enhanced in human T cells by IL-12 and IL-6 and in monocytes by tumor necrosis factor-alpha. J. Immunol. 1996. 157: 12-20.
48. Gerosa, F., Paganin, C., Peritt, D., Paiola, F., Scupoli, M. T., Aste-Amezaga, M., Frank, I. and Trinchieri, G., Interleukin-12 primes human CD4 and CD8 T cell clones for high production of both interferon-gamma and interleukin-10. J. Exp. Med. 1996. 183: 2559-2569.
49. Miltenyi, S., Müller, W, Weichel, W. and Radbruch, A., High gradient magnetic cell separation with MACS. Cytometry 1990. 11: 231-238.
50. Mosmann, T. R., Cherwinski, H., Bond, M. W., Giedlin, M. A. and Coffman, R. L., Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J. Immunol. 1986. 136: 2348-2357.
51. Abrams, J. S., Roncarolo, M. G., Yssel, H., Andersson, U., Gleich, G. J. and Silver, J. E., Strategies of anti-cytokine monoclonal antibody development: immunoassay of IL-10 and IL-5 in clinical samples, Immunol. Rev. 1992. 127: 5-24.
52. Sander, B., Hoiden, I., Andersson, U., Moller, E. and Abrams, J. S., Similar frequencies and kinetics of cytokine producing cells in murine peripheral blood and spleen. Cytokine detection by immunoassay and intracellular immunostaining. J. Immunol. Methods 1993. 166: 201-214.
53. Prat, M., Gribaudo, G., Comoglio, P. M., Cavallo, G. and Landolfo, S., Monoclonal antibodies against murine gamma interferon. Proc. Natl. Acad. Sci. USA 1984. 81: 4515-4519.
54. Spitalny, G. L. and Havell, E. A., Monoclonal antibody to murine gamma interferon inhibits lymphokine-induced antiviral and macrophage tumoricidal activities. J. Exp. Med. 1984. 159: 1560-1565.
55. Mosmann, T. R., Schumacher, J. H., Fiorentino, D. F., Leverah, J., Moore, K. W. and Bond, M. W., Isolation of monoclonal antibodies specific for IL-4, IL-5, IL-6, and a new Th2-specific cytokine (IL-10), cytokine synthesis inhibitory factor, by using a solid phase radioimmunoadsorbent assay. J. Immunol. 1990. 145: 2938-2945.