Regional and Cellular Mapping of cAMP Response Element-Mediated Transcription during Naltrexone-Precipitated Morphine Withdrawal

Journal of Neuroscience

Volumn 22, Issue 9, 2002, Pages 3663-3672

  Shaw Lutchman, Tamara Z ^a,b   Barrot, Michel ^a   Wallace, Tanya ^b   Gilden, Lauren ^b   Zachariou, Venetia ^a,d   Impey, Soren ^c   Duman, Ronald S ^b   Storm, Daniel ^c   Nestler, Eric J ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF PATRAS   (Greece)

Author keywords

Amygdala; cAMP; CREB; Dorsal raphe; Gene expression; Locus ceruleus; Nucleus accumbens; Ventral tegmental area

Indexed keywords

BETA GALACTOSIDASE; CORTICOTROPIN RELEASING FACTOR; CYCLIC AMP; MORPHINE; MU OPIATE RECEPTOR; NALTREXONE; OPIATE; TYROSINE 3 MONOOXYGENASE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN;

AMYGDALOID NUCLEUS; ANIMAL EXPERIMENT; AROUSAL; ARTICLE; AUTONOMIC NERVOUS SYSTEM; CELL SUBPOPULATION; CONTROLLED STUDY; CYCLIC AMP RESPONSIVE ELEMENT; DORSAL RAPHE NUCLEUS; DRUG WITHDRAWAL; GENE CONTROL; HOMEOSTASIS; MALE; MOOD; MORPHINE ADDICTION; MOUSE; NERVE CELL PLASTICITY; NONHUMAN; NUCLEUS ACCUMBENS; OPIATE ADDICTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; REWARD; TEGMENTUM; TRANSGENIC MOUSE; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; CYTOLOGY; DNA RESPONSIVE ELEMENT; DRUG EFFECT; FEMALE; GENETIC TRANSCRIPTION; GENETICS; LOCUS CERULEUS; METABOLISM; PHYSIOLOGY; RAPHE NUCLEUS; REPORTER GENE; UPREGULATION; VENTRAL TEGMENTUM; WITHDRAWAL SYNDROME;

AMYGDALA; ANIMALS; BETA-GALACTOSIDASE; CORTICOTROPIN-RELEASING HORMONE; CYCLIC AMP; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; FEMALE; GENES, REPORTER; LOCUS COERULEUS; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MORPHINE; NALTREXONE; NUCLEUS ACCUMBENS; RAPHE NUCLEI; RECEPTORS, OPIOID, MU; RESPONSE ELEMENTS; SUBSTANCE WITHDRAWAL SYNDROME; TRANSCRIPTION, GENETIC; TYROSINE 3-MONOOXYGENASE; UP-REGULATION; VENTRAL TEGMENTAL AREA;

EID: 0036581180     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.22-09-03663.2002     Document Type: Article

References (52)

1. Barrot M, Olivier JDA, Zachariou V, Neve RL, Nestler EJ (2000) Influence of CREB in the nucleus accumbens shell on the sensitivity to aversive and nociceptive stimuli. Soc Neurosci Abstr 26:485.
2. Berke JD, Hyman SE (2000) Addiction, dopamine, and the molecular mechanisms of memory. Neuron 25:515-532.
3. Bonci A, Williams JT (1997) Increased probability of GABA release during withdrawal from morphine. J Neurosci 17:796-803.
4. Boundy VA, Gold SJ, Messer CJ, Chen J, Son JH, Joh TH, Nestler EJ (1998) Regulation of tyrosine hydroxylase promoter activity by chronic morphine in TH9.0-LacZ transgenic mice. J Neurosci 18:9989-9995.
5. Caille S, Espejo E, Reneric JP, Cador M, Koob F, Stinus L (1999) Total neurochemical lesion of noradrenergic neurons of the locus ceruleus does not alter either naloxone-precipitated or spontaneous opiate withdrawal nor does it influence the ability of clonidine to reverse opiate withdrawal. J Pharmacol Exp Ther 290:881-892.
6. Carlezon Jr WA, Thome J, Olson VG, Lane-Ladd SB, Brodkin ES, Hiroi N, Duman RS, Neve RL, Nestler EJ (1998) Regulation of cocaine reward by CREB. Science 18:2272-2275.
7. Christie MJ, Williams JT, Osborne P, Bellchambers C (1997) Where is the locus in opioid withdrawal? Trends Pharmacol Sci 18:134-140.
8. Cole R, Konradi C, Douglass J, Hyman S (1995) Neuronal adaptations to amphetamine and dopamine: Molecular mechanisms of prodynorphin gene regulation in rat striatum. Neuron 14:813-823.
9. Davis M (1998) Are different parts of the extended amygdala involved in fear versus anxiety? Biol Psychiatry 44:1239-1247.
10. Diana M, Pistis M, Muntoni A, Gessa G (1995) Profound decrease of mesolimbic dopaminergic neuronal activity in morphine withdrawn rats. J Pharmacol Exp Ther 272:781-785.
11. Diana M, Muntoni AL, Pistis M, Melis M, Gessa G (1999) Lasting reduction in mesolimbic dopamine neuronal activity after morphine withdrawal. Eur J Neurosci 11:1037-1041.
12. Duman RS, Tallman JF, Nestler EJ (1988) Acute and chronic opiate regulation of adenylate cyclase in brain: specific effects in locus coeruleus. J Pharmacol Exp Ther 246:1033-1039.
13. Georges F, Stinus L, Bloch B, Le Moine C (1999) Chronic morphine exposure and spontaneous withdrawal are associated with modifications of dopamine receptor and neuropeptide gene expression in the rat striatum. Eur J Neurosci 11:481-490.
14. Guitart X, Thompson MA, Mirante CK, Greenberg ME, Nestler EJ (1992) Regulation of cyclic AMP response element-binding protein (CREB) phosphorylation by acute and chronic morphine in the rat locus coeruleus. J Neurochem 199258:1168-1170.
15. Hayward MD, Duman RS, Nestler EJ (1990) Induction of the c-fos proto-oncogene during opiate withdrawal in the locus coeruleus and other regions of rat brain. Brain Res 525:256-266.
16. Heimer L, Alheid G (1991) Piecing together the puzzle of basal forebrain anatomy. In: The basal forebrain: anatomy to function (Napier TC, Kalivas PW and Hanin I, eds)pp 1-42. New York: Plenum.
17. Heimer L, Harlan R, Alheid G, Garcia M, Olmos J (1997) Substantia innominata: a notion which impedes clinical-anatomical correlations in neuropsychiatric disorders. Neuroscience 76:957-1006.
18. Heinrichs S, Menzaghi F, Schulteis G, Koob G, Stinus L (1995) Suppression of corticotropin-releasing factor in the amygdala attenuates aversive consequences of morphine withdrawal. Behav Pharmacol 6:74-80.
19. Impey S, Smith DM, Obrietan K, Donahue R, Wade C, Storm DR (1998) Stimulation of cAMP response element (CRE)-mediated transcription during contextual learning. Nat Neurosci 1:595-601.
20. Jolas T, Nestler E, Aghajaman GK (2000) Chronic morphine increases GABA tone on serotonergic neurons of the dorsal raphe nucleus: association of an upregulation of the cyclic AMP pathway. Neuroscience 95:433-443.
21. Kasckow JW, Regmi A, Gill PS, Parkes DG, Geracioti TD (1997) Regulation of corticotropin-releasing factor (CRF) messenger ribonucleic acid and CRF peptide in the amygdala: studies in primary amygdalar culture. Endocrinology 138:4774-4782.
22. Konradi C, Cole R, Green D, Senatus P, Leveque JC, Pollack A, Grossbard S, Hyman SE (1995) Analysis of the proenkephalin second messenger-inducible enhancer in rat striatal cultures. J Neurochem 65:1007-1015.
23. Koob GF (1999) Stress, corticotropin-releasing factor, and drug addiction. Ann NY Acad Sci 897:27-45.
24. Koob GF, Le Moal M (2001) Drug addiction, dysregulation of reward, and allostasis. Neuropsychopharmacology 24:97-129.
25. Lane-Ladd S, Pineda J, Boundy V, Pfeuffer T, Krupinski J, Aghajanian GK, Nestler EJ (1997) CREB in the LC: biochemical, physiological and behavioural evidence for a role in opiate dependence. J Neurosci 17:7890-7901.
26. LeDoux JE (2000) Emotion circuits in the brain. Annu Rev Neurosci 23:155-184.
27. Maldonado R, Stinus L, Gold LH, Koob GF (1992) Role of different brain structures in the expression of the physical morphine withdrawal syndrome. J Pharmacol Exp Ther 261:669-677.
28. Maldonado R, Blendy JA, Tzavara E, Gass P, Roques BP, Hanoune J, Schutz G (1996) Reduction of morphine abstinence in mice with a mutation in the gene encoding. Science 273:657-659.
29. Mansour A, Fox C, Akil H, Watson S (1995) Opioid-receptor mRNA expression in the rat CNS: anatomical and functional implications. Trends Neurosci 18:22-29.
30. Martin KC, Kandel ER (1996) Cell adhesion molecules, CREB, and the formation of new synaptic connections. Neuron 17:567-570.
31. Montminy M (1997) Transcriptional regulation by cAMP. Annu Rev Biochem 66:807-822.
32. Morgan JI, Curran T (1995) Immediate-early genes: ten years on. Trends Neurosci 18:66-67.
33. Nestler EJ (2001) Molecular basis of neural plasticity underlying addiction. Nat Rev Neurosci 2:119-128.
34. Nestler EJ, Aghajanian GK (1997) Molecular and cellular basis of addiction. Science 278:58-63.
35. Nestler EJ, Tallman JF (1988) Chronic morphine treatment increases cyclic AMP-dependent protein kinase activity in the rat locus coeruleus. Mol Pharmacol 33:127-132.
36. Nestler EJ, Hope BT, Widnell KL (1993) Drug addiction: a model for the molecular basis of neural plasticity. Neuron 11:995-1006.
37. Pham TA, Impey S, Storm DR, Stryker MP (1999) CRE-mediated gene transcription in neocortical neuronal plasticity during the developmental critical period. Neuron 22:63-72.
38. Pliakas AM, Carlson RR, Neve RL, Konradi C, Nestler EJ, Carlezon Jr WA (2001) Altered responsiveness to cocaine and increased immobility in the forced swim test associated with elevated CREB expression in the nucleus accumbens. J Neurosci 21:7397-7403.
39. Rasmussen K, Beitner DB, Krystal JH, Aghajanian GK, Nestler EJ (1990) Opiate withdrawal and the rat locus coeruleus: behavioral, electrophysiological, and biochemical correlates. J Neurosci 10:2308-2317.
40. Robbins TW, Everitt BJ (1996) Neurobehavioural mechanisms of reward and motivation. Curr Opin Neurobiol 6:228-236.
41. Rosetti ZL, Hmaidan Y, Gessa G (1992) Marked inhibition of mesolimbic dopamine release: a common feature of ethanol, morphine, cocaine and amphetamine abstinence in rats. Eur J Pharmacol 221:227-234.
42. Shaywitz A, Greenberg ME (1999) CREB: A stimulus-induced transcription factor activated by a diverse array of extracellular signals. Annu Rev Biochem 68:821-861.
43. Silva AJ, Murphy GG (1999) cAMP and memory: a seminal lesson from Drosophila and Aplysia. Brain Res Bull 50:441-442.
44. Sklair-Tavron L, Shi WX, Lane SB, Harris HW, Bunney BS, Nestler EJ (1996) Chronic morphine induces visible changes in the morphology of mesolimbic dopamine neurons. Proc Natl Acad Sci USA 93:11202-11207.
45. Spengler D, Rupprecht R, Van LP, Holsboer F (1992) Identification and characterization of a 3′,5′-cyclic adenosine monophosphate-responsive element in the human corticotropin-releasing hormone gene promoter. Mol Endocrinol 6:1931-1941.
46. Terwilliger RZ, Beitner-Johnson D, Sevarino KA, Crain SM, Nestler EJ (1991) A general roll for adaptations in G-proteins and the cyclic AMP system in mediating the chronic actions of morphine and cocaine on neuronal function. Brain Res 548:100-110.
47. Thome J, Sakai N, Shin K, Steffen C, Zhang YJ, Impey S, Storm D, Duman RS (2000) cAMP response element-mediated gene transcription is upregulated by chronic antidepressant treatment. J Neurosci 20:4030-4036.
48. Turgeon SM, Pollack AE, Fink JS (1997) Enhanced CREB phosphorylation and changes in c-Fos and FRA expression in striatum accompany amphetamine sensitization. Brain Res 749:120-126.
49. Unterwald EM, Cox BM, Kreek MJ, Cote TE, Izenwasser S (1993) Chronic repeated cocaine administration alters basal and opioid-regulated adenylyl cyclase activity. Synapse 15:33-38.
50. Widnell K, Russel D, Nestler E (1994) Regulation of expression of cAMP response element-binding protein in the LC in vivo and in a LC-like cell line in vitro. Proc Natl Acad Sci USA 91:10947-10951.
51. Williams JT, Christie MJ, Manzoni O (2001) Cellular and synaptic adaptations mediating opioid dependence. Physiol Rev 81:299-343.
52. Yin JC, Tully T (1996) CREB and the formation of long-term memory. Curr Opin Neurobiol 6:264-268.