Stimulation of protein kinase A activity in the rat amygdala enhances reward-related learning

Biological Psychiatry

Volumn 52, Issue 2, 2002, Pages 111-118

  Jentsch, J David ^a   Olausson, Peter ^a   Nestler, Eric J ^a   Taylor, Jane R ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Addiction; Conditioned stimulus; Learning; Pavlovian reinforcement; Stimulus reward

Indexed keywords

CHOLERA TOXIN; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; ENZYME ACTIVATOR; PROTEIN KINASE A ACTIVATOR; UNCLASSIFIED DRUG;

AMYGDALOID NUCLEUS; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONDITIONED REFLEX; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; LEARNING; MALE; NONHUMAN; PREDICTION; PRIORITY JOURNAL; RAT; REWARD; STIMULUS RESPONSE; WATER AVAILABILITY;

ADJUVANTS, IMMUNOLOGIC; AMYGDALA; ANALYSIS OF VARIANCE; ANIMALS; APPETITIVE BEHAVIOR; CHOLERA TOXIN; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; ENZYME ACTIVATION; ENZYME INHIBITORS; LEARNING; LOCOMOTION; MALE; RATS; RATS, SPRAGUE-DAWLEY; REWARD; SUCROSE; THIONUCLEOTIDES; TIME FACTORS;

EID: 0037100365     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3223(02)01358-6     Document Type: Article

References (41)

1. Genetic demonstration of a role for PKA in the late phase of LTP and in hippocampus-based long-term memory
2. Acquisition, maintenance and reinstatement of intravenous cocaine self-administration under a second-order schedule of reinforcement in rats: Effects of conditioned cues and continuous access to cocaine
3. Addiction, dopamine and the molecular mechanisms of memory
4. Different training procedures recruit either one or two critical periods for contextual memory consolidation, each of which requires protein synthesis and PKA
5. Deficient long-term memory in mice with a targeted mutation of the cAMP-response element-binding protein
6. Differential effects of excitotoxic lesions of the basolateral amygdala, ventral subiculum and medial prefrontal cortex on responding with conditioned reinforcement and locomotor activity potentiated by intraaccumbens infusions of d-amphetamine
7. Limbic activation during cue-induced cocaine craving
8. Effects of cAMP simulate a late stage of LTP in hippocampal CA1 neurons
9. Deficits in memory tasks of mice with CREB mutations depend on gene dosage
10. A role for amygdala PKA and PKC in the acquisition of long-term conditional fear memories in rats
11. Activation of memory circuits during cue-elicited cocaine craving
12. Enhanced appetitive conditioning following repeated pretreatment with d-amphetamine
13. Double dissociation of the behavioural effects of R(+) 7-OH-DPAT infusions in the central and basolateral amygdala nuclei upon Pavlovian and instrumental conditioned appetitive behaviours
14. CAMP contributes to mossy fiber LTP initiating both a covalently mediated early phase and macromolecular synthesis-dependent late phase
15. Postsynaptic induction and PKA-dependent expression of LTP in the lateral amygdala
16. Different hippocampal molecular requirements for short- and long-term retrieval of one-trial avoidance learning
17. Impulsivity resulting from frontostriatal dysfunction in drug abuse: Implications for the control of behavior by reward-related stimuli
18. Enhanced reward-related responding following cholera toxin infusion into the nucleus accumbens
19. Synaptic plasticity and dynamic modulation of the postsynaptic membrane
20. Neurobiology of Pavlovian fear conditioning
21. Genetic approaches to memory storage
22. Reinstatement of drug-seeking behavior produced by heroin-predictive environmental stimuli
23. Time-dependent processes in memory storage
24. Interaction of neuromodulatory systems in modulating memory storage
25. Lesions of the basolateral amygdala abolish the ability of drug associated cues to reinstate responding during withdrawal from self-administered cocaine
26. Molecular basis of long-term plasticity underlying addiction
27. A macromolecular synthesis-dependent late phase of long-term potentiation requiring cAMP in the medial perforant pathway of rat hippocampal slices
28. Conditioning factors in drug abuse: Can they explain compulsion?
29. Cocaine-seeking by rats: Regulation, reinforcement and activation
30. Dissociable roles of the central and basolateral amygdala in appetitive emotional learning
31. Opposite modulation of opiate withdrawal behaviors upon microinfusion of a protein kinase A inhibitor versus activator into the LC or PAG
32. Synaptic plasticity in the basolateral amygdala in transgenic mice expressing dominant-negative cAMP response element-binding protein (CREB) in forebrain
33. Drug addiction: Bad habits add up
34. The neural basis of drug craving: An incentive-sensitization theory of addiction
35. Memory consolidation of auditory Pavlovian fear conditioning requires protein synthesis and protein kinase A in the amygdala
36. Stress-induced relapse to heroin and cocaine seeking in rats: A review
37. A million dollar question: Does LTP = memory?
38. Enhanced responding for conditioned reward produced by intra-accumbens amphetamine is potentiated after cocaine sensitization
39. Repeated intermittent administration of psychomotor stimulant drugs differentially alters the acquisition of Pavlovian appetitive approach behavior in rats
40. A general role for adaptations in G-proteins and the cyclic AMP system in mediating the chronic actions of morphine and cocaine on neuronal function
41. Epileptic focus induced by intrahippocampal cholera toxin in rat: Time course and properties in vivo and vitro