Using yeast to screen for inhibitors of protein tyrosine phosphatase 1B

Biochemical Pharmacology

Volumn 68, Issue 9, 2004, Pages 1807-1814

  Montalibet, Jacqueline ^a,b   Kennedy, Brian P ^a  

^a MERCK FROSST CENTRE FOR THERAPEUTIC RESEARCH   (Canada)

^b Gina Cody School of Engineering and Computer Science   (Canada)

Author keywords

Biological assay; Enzyme inhibitors; Protein tyrosine phosphatase; PTP1B; Saccharomyces cerevisiae; v Src

Indexed keywords

2,3 BIPHENYL 1 [3 BROMO 4 [PHOSPHONO(DIFLUOROMETHYL)]PHENYL]PROPAN 3 ONE; 3 (4 CHLOROPHENYL) 1 [3 BROMO 4 [PHOSPHONO(DIFLUOROMETHYL)]PHENYL] 2 THIAPROPANE; 7 BROMO 6 PHOSPHONO(DIFLUOROMETHYL) 3 NAPHTHALENONITRILE; N BENZOYLGLUTAMYL [4 PHOSPHONO(DIFLUOROMETHYL)]PHENYLALANYL [4 PHOSPHONO(DIFLUOROMETHYL)]PHENYLALANINAMIDE; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE PHOSPHATASE 1B; PROTEIN TYROSINE PHOSPHATASE 1B INHIBITOR; UNCLASSIFIED DRUG; VANADIC ACID;

ABSORPTION; ARTICLE; CATALYSIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG SCREENING; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME MECHANISM; MITOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SACCHAROMYCES CEREVISIAE;

CELL DIVISION; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; PROTEIN-TYROSINE-PHOSPHATASE; SACCHAROMYCES CEREVISIAE; VANADATES;

EID: 4644349812     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2004.06.024     Document Type: Article

References (32)

1. S.D. Taylor, and B. Hill Recent advances in protein tyrosine phosphatase 1B inhibitors Expert Opin. Investig. Drugs. 13 2004 199 214
2. Z.Y. Zhang, and S.Y. Lee PTP1B inhibitors as potential therapeutics in the treatment of Type 2 diabetes and obesity Expert Opin Investig. Drugs. 12 2003 223 233
3. E. Asante-Appiah, and B.P. Kennedy Protein tyrosine phosphatases: the quest for negative regulators of insulin action Am J Physiol Endocrinol. Metab. 284 2003 E663 E670
4. M. Elchebly, P. Payette, E. Michaliszyn, W. Cromlish, S. Collins, and A.L. Loy Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene Science. 283 1999 1544 1548
5. L.D. Klaman, O. Boss, O.D. Peroni, J.K. Kim, J.L. Martino, and J.M. Zabolotny Increased energy expenditure, decreased adiposity, and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient mice Mol. Cell. Biol. 20 2000 5479 5489
6. B.A. Zinker, C.M. Rondinone, J.M. Trevillyan, R.J. Gum, J.E. Clampit, and J.F. Waring PTP1B antisense oligonucleotide lowers PTP1B protein, normalizes blood glucose, and improves insulin sensitivity in diabetic mice Proc. Natl. Acad. Sci. U.S.A. 99 2002 11357 11362
7. C.M. Rondinone, J.M. Trevillyan, J. Clampit, R.J. Gum, C. Berg, and P. Kroeger Protein tyrosine phosphatase 1B reduction regulates adiposity and expression of genes involved in lipogenesis Diabetes. 51 2002 2405 2411
8. R.J. Gum, L.L. Gaede, S.L. Koterski, M. Heindel, J.E. Clampit, and B.A. Zinker Reduction of protein tyrosine phosphatase 1B increases insulin-dependent signaling in ob/ob mice Diabetes. 52 2003 21 28
9. J.E. Clampit, J.L. Meuth, H.T. Smith, R.M. Reilly, M.R. Jirousek, and J.M. Trevillyan Reduction of protein-tyrosine phosphatase-1B increases insulin signaling in FAO hepatoma cells Biochem. Biophys. Res. Commun. 300 2003 261 267
10. L. Xie, S.Y. Lee, J.N. Andersen, S. Waters, K. Shen, and X.L. Guo Cellular effects of small molecule PTP1B inhibitors on insulin signaling Biochemistry. 42 2003 12792 12804
11. T. Melese, and P. Hieter From genetics and genomics to drug discovery: yeast rises to the challenge Trends Pharmacol. Sci. 23 2002 544 547
12. J.S. Brugge, G. Jarosik, J. Andersen, A. Queral-Lustig, M. Fedor-Chaiken, and J.R. Broach Expression of Rous sarcoma virus transforming protein pp60v-src in Saccharomyces cerevisiae cells Mol. Cell. Biol. 7 1987 2180 2187
13. S. Kornbluth, R. Jove, and H. Hanafusa Characterization of avian and viral p60src proteins expressed in yeast Proc. Natl. Acad. Sci. U.S.A. 84 1987 4455 4459
14. F. Boschelli Expression of p60v-src in Saccharomyces cerevisiae results in elevation of p34CDC28 kinase activity and release of the dependence of DNA replication on mitosis Mol. Cell. Biol. 13 1993 5112 5121
15. F. Boschelli Expression of p60v-src in Saccharomyces cerevisiae results in elevation of p34CDC28 kinase activity and release of the dependence of DNA replication on mitosis Mol Cell Biol. 14 1994 6409
16. M. Florio, L.K. Wilson, J.B. Trager, J. Thorner, and G.S. Martin Aberrant protein phosphorylation at tyrosine is responsible for the growth-inhibitory action of pp60v-src expressed in the yeast Saccharomyces cerevisiae Mol. Biol. Cell. 5 1994 283 296
17. J.B. Trager, and G.S. Martin The role of the Src homology-2 domain in the lethal effect of Src expression in the yeast Saccharomyces cerevisiae Int. J. Biochem. Cell Biol. 29 1997 635 648
18. G. Huyer, S. Liu, J. Kelly, J. Moffat, P. Payette, and B. Kennedy Mechanism of inhibition of protein-tyrosine phosphatases by vanadate and pervanadate J. Biol. Chem. 272 1997 843 851
19. D. Mumberg, R. Muller, and M. Funk Regulatable promoters of Saccharomyces cerevisiae: comparison of transcriptional activity and their use for heterologous expression Nucleic Acids Res. 22 1994 5767 5768
20. Agatep R, Kirkpatrick RD, Parchaliuk DL, Woods RA, Gietz RD. Transformation of Saccharomyces cerevisiae by the lithium acetate/single- stranded carrier DNA/polyethylene glycol (LiAc/ss-DNA/PEG) protocol. Technical Tips Online; 1998.
21. T.R. Hammonds, A. Maxwell, and J.R. Jenkins Use of a rapid throughput in vivo screen to investigate inhibitors of eukaryotic topoisomerase II enzymes Antimicrob. Agents Chemother. 42 1998 889 894
22. S. Desmarais, R.W. Friesen, R. Zamboni, and C. Ramachandran [Difluro(phosphono)methyl]phenylalanine-containing peptide inhibitors of protein tyrosine phosphatases Biochem. J. 337 Pt 2 1999 219 223
23. C. Dufresne, P. Roy, Z. Wang, E. Asante-Appiah, W. Cromlish, and Y. Boie The development of potent non-peptidic PTP-1B inhibitors Bioorg. Med. Chem. Lett. 14 2004 1039 1042
24. E. Asante-Appiah, K. Ball, K. Bateman, K. Skorey, R. Friesen, and C. Desponts The YRD motif is a major determinant of substrate and inhibitor specificity in T-cell protein-tyrosine phosphatase J. Biol. Chem. 276 2001 26036 26043
25. K.L. Guan, and J.E. Dixon Protein tyrosine phosphatase activity of an essential virulence determinant in Yersinia Science. 249 1990 553 556
26. A.J. Flint, T. Tiganis, D. Barford, and N.K. Tonks Development of "substrate-trapping" mutants to identify physiological substrates of protein tyrosine phosphatases Proc. Natl. Acad. Sci. U.S.A. 94 1997 1680 1685
27. G. Swarup, S. Cohen, and D.L. Garbers Inhibition of membrane phosphotyrosyl-protein phosphatase activity by vanadate Biochem. Biophys. Res. Commun. 107 1982 1104 1109
28. K.I. Skorey, B.P. Kennedy, R.W. Friesen, and C. Ramachandran Development of a robust scintillation proximity assay for protein tyrosine phosphatase 1B using the catalytically inactive (C215S) mutant Anal. Biochem. 291 2001 269 278
29. Y.L. Zhang, Y.F. Keng, Y. Zhao, L. Wu, and Z.Y. Zhang Suramin is an active site-directed, reversible, and tight-binding inhibitor of protein-tyrosine phosphatases J. Biol. Chem. 273 1998 12281 12287
30. P. Garcia-Morales, Y. Minami, E. Luong, R.D. Klausner, and L.E. Samelson Tyrosine phosphorylation in T cells is regulated by phosphatase activity: studies with phenylarsine oxide Proc. Natl. Acad. Sci U.S.A. 87 1990 9255 9259
31. C.H. Sibley, V.H. Brophy, S. Cheesman, K.L. Hamilton, E.G. Hankins, and J.M. Wooden Yeast as a model system to study drugs effective against apicomplexan proteins Methods. 1997 13190 13207
32. W.A. Cromlish, P. Payette, and B.P. Kennedy Development and validation of an intact cell assay for protein tyrosine phosphatases using recombinant baculoviruses Biochem. Pharmacol. 58 1999 1539 1546