Ventral medial prefrontal cortex and emotional perseveration: The memory for prior extinction training

Behavioural Brain Research

Volumn 146, Issue 1-2, 2003, Pages 121-130

  Morgan, Maria A ^a,b   Schulkin, Jay ^b,c,d   Ledoux, Joseph E ^a  

^a NEW YORK UNIVERSITY   (United States)

^b AMERICAN COLLEGE OF OBSTETRICIANS AND GYNECOLOGISTS   (United States)

^c GEORGETOWN UNIVERSITY   (United States)

^d NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

Author keywords

Context; Extinction; Fear conditioning; Inhibition; MPFCv; Reacquisition

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DISEASE PREDISPOSITION; EMOTION; EXPERIENCE; FEAR; MALE; MEMORY; NONHUMAN; PERSEVERATION; PREFRONTAL CORTEX; PRIORITY JOURNAL; RAT; RAT STRAIN; STIMULUS RESPONSE; TRAINING;

EID: 0345688218     PISSN: 01664328     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbr.2003.09.021     Document Type: Article

References (56)

1. Barrett D., Shumake J., Jones D., Gonzalez-Lima F. Metabolic mapping of mouse brain activity after extinction of a conditioned emotional response. J. Neurosci. 23:2003;5740-5749.
2. Bechara A., Tranel D., Damasio H., Damasio A.R. Failure to respond autonomically to anticipated future outcomes following damage to prefrontal cortex. Cereb. Cortex. 6:1996;215-225.
3. Blanchard R.J., Blanchard D.C. Crouching as an index of fear. J. Comp. Physiol. Psychol. 67:1969;370-375.
4. Bouton ME. Context and retrieval in extinction and in other examples of interference in simple associative learning. In: Dachowski L, Flaherty CF, editors. Current topics in animal learning: brain, emotion, and cognition. Hillsdale, NJ: Erlbaum; 1991, p. 25-53.
5. Bouton M.E. Context, ambiguity, and classical conditioning. Current Directions in Psychological Science. 3:1994;49-53.
6. Bouton M.E. Conditioning, remembering, and forgetting. J. Exp. Psychol.: Anim. Behav. Process. 20:1994;219-231.
7. Bouton M.E., Bolles R.C. Conditioned fear assessed by freezing and by the suppression of three different baselines. Anim. Learn. Behav. 8:1980;429-434.
8. Bouton M.E., King D.A. Effect of context on performance to conditioned stimuli with mixed histories of reinforcement and nonreinforcement. J. Exp. Psychol.: Anim. Behav. Process. 12:1986;4-15.
9. Bouton M.E., Swartzentruber D. Slow reacquisition following extinction: context, encoding, and retrieval mechanisms. J. Exp. Psychol.: Anim. Behav. Process. 15:1989;43-53.
10. Butter C. Perseveration in extinction and in discrimination reversal tasks following selective frontal ablations in Macaca Mulatta. Physiol. Behav. 4:1969;163-171.
11. Cohen JD, O'Reilly RC. A preliminary theory of the interactions between prefrontal cortex and hippocampus that contribute to planning and prospective memory. In: Brandimonte M, Einstein GO, McDaniel MA, editors. Prospective memory: theory and applications. Hillsdale, NJ: Erlbaum; 1996. p. 267-95.
12. Conde F., Maire-Lepoivre E., Audinat E., Crepel F. Afferent connections of the medial frontal cortex of the rat. II. Cortical and subcortical afferents. J. Comp. Neurol. 352:1995;567-593.
13. Damasio AR, Tranel D, Damasio H. Somatic markers and the guidance of behavior. In: Levin H, Eisenberg H, Benton A, editors. Frontal lobe function and dysfunction. New York: Oxford University Press; 1991. p. 217-28.
14. Davidson R.J. Anxiety and affective style: role of prefrontal cortex and amygdala. Biol. Psychiatry. 51(1):2002;68-80.
15. Diamond A. Developmental time course in human infants and infant monkeys, and the neural bases, of inhibitory control in reaching. Annu. NY Academy Sci. 608:1990;637-676.
16. Dias R., Robbins T.W., Roberts A.C. Dissociation in prefrontal cortex of affective and attentional shifts. Nature. 380:1996;69-72.
17. Falls WA, Davis M. Behavioral and physiological analysis of fear inhibition. In: Friedman MJ, Charney DS, Deutch AY, editors. Neurobiological and clinical consequences of stress: from normal adaptation to PTSD. Philadelphia: Lippincott-Raven; 1995. p. 177-202.
18. Falls W.A., Miserendino M.J.D., Davis M. Extinction of fear-potentiated startle: blockade by infusion of an NMDA antagonist into the amygdala. J. Neurosci. 12:1992;854-863.
19. Fanselow M.S. Conditional and unconditional components of postshock freezing. Pavlov J. Biol. Sci. 15:1980;177-182.
20. Frysztak R.J., Neafsey E.J. The effect of medial frontal cortex lesions on cardiovascular conditioned emotional responses in the rat. Brain Res. 643:1994;181-193.
21. Fuster JM. The prefrontal cortex. Philadelphia: Lippincott; 1997.
22. Gewirtz J.C., Falls W.A., Davis M. Normal conditioned inhibition and extinction of freezing and fear-potentiated startle following electrolytic lesions of medial prefrontal cortex in rats. Behav. Neurosci. 111:1997;712-726.
23. Goldberg E, Bilder Jr, RM. The frontal lobes and hierarchical organization of cognitive control. In: Perecman E, editor. The frontal lobes revisited. New York: IRBN Press; 1987. p. 159-87.
24. Herry C., Garcia R. Prefrontal cortex long-term potentiation, but not long-term depression, is associated with the maintenance of extinction of learned fear in mice. J. Neurosci. 22(2):2002;577-583.
25. Herry C., Vouimba R., Garcia R. Plasticity in the mediodorsal thalamo-prefrontal cortical transmission in behaving mice. J. Neurophysiol. 82:1999;2827-2832.
26. Hurley K.M., Herbert H., Moga M.M., Saper C.B. Efferent projections of the infralimbic cortex of the rat. J. Comp. Neurol. 308:1991;249-276.
27. Jay T.M., Witter M.P. Distribution of hippocampal CA1 and subicular efferents in the prefrontal cortex of the rat studied by means of anterograde transport of Phaseolus vulgaris-leucoagglutinin. J. Comp. Neurol. 313:1991;574-586.
28. Jay T.M., Glowinski J., Thierry A.-M. Selectivity of the hippocampal projection to the prelimbic area of the prefrontal cortex in the rat. Brain Res. 505:1989;337-340.
29. Kennard M.A. The cingulate gyrus in relation to consciousness. J. Nerv. Mental Dis. 121:1955;34-39.
30. Kolb B., Nonneman A.J., Singh R.K. Double dissociation of spatial impairments and perseveration following selective prefrontal lesions in rats. J. Comp. Physiol. Psychol. 87:1974;772-780.
31. Kolb B. Functions of the frontal cortex of the rat: A comparative review. Brain Research Reviews. 8:1984;65-98.
32. Kolb B. Prefrontal cortex. In: Kolb B, Tees RC, editors. The cerebral cortex of the rat. Cambridge: MIT Press; 1990. p. 437-58.
33. Konorski J. Conditioned reflexes and neuron organization. Cambridge: Cambridge University Press; 1948.
34. LeDoux J.E. Emotion: clues from the brain. Annu. Rev. Psychol. 46:1995;209-235.
35. LeDoux J.E. Emotional circuits in the brain. Annu. Rev. Neurosci. 23:2000;155-184.
36. LeDoux J.E., Sakaguchi A., Reis D.J. Subcortical efferent projections of the medial geniculate nucleus mediate emotional responses conditioned by acoustic stimuli. J. Neurosci. 4:1984;683-698.
37. Malloy P. Frontal lobe dysfunction in obsessive-compulsive disorder. In: Perecman E, editor. The frontal lobes revisited. New York: IRBN Press; 1987. p. 207-23.
38. Milad M., Quirk G.J. Neurons in medial prefrontal cortex signal memory for fear extinction. Nature. 420:2002;70-74.
39. Morgan M.A., LeDoux J.E. Differential contribution of dorsal and ventral medial prefrontal cortex to the acquisition and extinction of conditioned fear in rats. Behav. Neurosci. 109:1995;681-688.
40. Morgan M.A., Romanski L.M., LeDoux J.E. Extinction of emotional learning: contribution of medial prefrontal cortex. Neurosci. Lett. 163:1993;109-113.
41. Morrow B.A., Elsworth J.D., Rasmusson A.M., Roth R.H. The role of mesoprefrontal dopamine neurons in the acquisition and expression of conditioned fear in the rat. Neuroscience. 92:1999;553-564.
42. Myers K.M., Davis M. Behavioral and neural analysis of extinction. Neuron. 36:2002;567-584.
43. Nauta W.J.H. The problem of the frontal lobe: A reinterpretation. J. Psychiatr. Res. 8:1971;167-187.
44. Neafsey EJ, Terreberry RR, Hurley KM, Ruit KG, Frysztak RJ. Anterior cingulate cortex in rodents: connections, visceral control functions, and implications for emotion. In: Vogt BA, Gabriel M, editors. Neurobiology of cingulate cortex and limbic thalamus. Boston: Birkhauser; 1993. p. 206-23.
45. Pavlov IP. Conditioned reflexes. Oxford: Oxford University Press; 1927.
46. Pavlov IP. Complete works, vol. III. Moscow: Acad. Sci. Publ. House; 1949.
47. Paxinos G, Watson C. The Rat brain in stereotaxic coordinates. 2nd ed. San Diego, CA: Academic Press; 1986.
48. Phillips R.G., LeDoux J.E. Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning. Behav. Neurosci. 106:1992;274-285.
49. Porrino LJ. Cortical mechanisms of reinforcement. In: Vogt BA, Gabriel M, editors. Neurobiology of cingulate cortex and limbic thalamus. Boston: Birkhauser; 1993. p. 445-60.
50. Quirk G.J., Russo G.K., Barron J.L., Lebron K. The role of ventromedial prefrontal cortex in the recovery of extinguished fear. J. Neurosci. 20(16):2000;6225-6231.
51. Rolls ET. A theory of emotion and consciousness, and its application to understanding the neural basis of emotion. In: Gazzaniga MS, editor. The cognitive neurosciences. New York: Wiley-Liss; 1995. p. 1091-106.
52. Saper C.B. Role of the cerebral cortex and striatum in emotional motor response. Progr. Brain Res. 107:1996;537-550.
53. Schulkin J. Preoperative events. Their effects on behavior following brain damage. Hillsdale, NJ: Lawrence Erlbaum Associates; 1989.
54. Terreberry R.R., Neafsey E.J. Rat medial frontal cortex: a visceral motor region with a direct projection to the solitary nucleus. Brain Res. 278:1983;245-249.
55. Terreberry R.R., Neafsey E.J. The rat medial frontal cortex projects directly to autonomic regions of the brainstem. Brain Res. Bull. 19:1987;639-649.
56. Thorpe S.J., Rolls E.T., Maddison S. The orbitofrontal cortex: neuronal activity in the behaving monkey. Exper. Brain Res. 49:1983;93-115.