Inhibition of nuclear factor κB by direct modification in whole cells - Mechanism of action of nordihydroguaiaritic acid, curcumin and thiol modifiers

Biochemical Pharmacology

Volumn 55, Issue 7, 1998, Pages 965-973

  Brennan, Paul ^a   O'Neill, Luke A J ^a  

^a TRINITY COLLEGE DUBLIN   (Ireland)

Author keywords

Curcumin; Interleukin 1; N ethylmaleimide; Nordihydroguaiaritic acid; Nuclear factor B; Tumor necrosis

Indexed keywords

1 CHLORO 2,4 DINITROBENZENE; ANTIOXIDANT; CURCUMIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1ALPHA; N ETHYLMALEIMIDE; NORDIHYDROGUAIARETIC ACID; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; DNA BINDING; DNA PROBE; DOSE RESPONSE; ELECTROPHORETIC MOBILITY; GENE ACTIVATION; GENE EXPRESSION REGULATION; HUMAN; IN VITRO STUDY; LEUKEMIA CELL LINE; LYMPHOMA CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; THYMOMA;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTIOXIDANTS; BLOTTING, WESTERN; CELL NUCLEUS; CELLS, CULTURED; CHOLAGOGUES AND CHOLERETICS; CURCUMIN; DEOXYCHOLIC ACID; DINITROCHLOROBENZENE; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ETHYLMALEIMIDE; HUMANS; INTERLEUKIN-1; MICE; NF-KAPPA B; NORDIHYDROGUAIARETIC ACID; SUBCELLULAR FRACTIONS; SULFHYDRYL REAGENTS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0032055394     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(97)00535-2     Document Type: Article

References (40)

1. Baldwin S. Jr. The NFκB and the IκB proteins: New discoveries and insights. Annu Rev Immunol. 14:1996;649-681.
2. Ballard D.W., Bohnlein E., Lowenthal J.W., Wano Y., Franza B.R., Greene W.C. HTLV-I tax induces cellular proteins that activate the κB element in the IL-2 receptor α gene. Science. 241:1988;1652-1655.
3. Cybulsky M.I., Fries J.W., Williams A.J., Sultan P., Eddy R., Byers M., Shows T., Gimbrone M.A. Jr, Collins T. Gene structure, chromosomal location, and basis for alternative mRNA splicing of the human VCAM1 gene. Proc Natl Acad Sci USA. 88:1991;7859-7863.
4. Edbrooke M.R., Burt D.W., Cheshire J.K., Woo P. Identification of cis-acting sequences responsible for phorbol ester induction of human serum amyloid A gene expression via a nuclear factor κB-like transcription factor. Mol Cell Biol. 9:1989;1908-1916.
5. Hoyos B., Ballard D.W., Bohnlein E., Siekevitz M., Greene W.C. Kappa B-specific DNA binding proteins role in the regulation of human interleukin-2 gene expression . Science. 244:1989;457-460.
6. Nabel G., Baltimore D. An inducible transcription factor activates expression of human immunodeficiency virus in T cells. Nature. 326:1987;711-713.
7. Baeuerle P.A., Henkel T. Function and activation of NFκB in the immune system. Annu Rev Immunol. 12:1994;141-179.
8. Beg A.A., Finco T.S., Nantermet P.V., Baldwin A.S. Jr. Tumor necrosis factor and interleukin-1 lead to phosphorylation and loss of IκBα a mechanism for NFκB activation. Mol Cell Biol. 13:1993;3301-3310.
9. Cordle S.R., Donald R., Read M.A., Hawiger J. Lipopolysaccharide induces phosphorylation of MAD3 and activation of c-Rel and related NFκB proteins in human monocytic THP-1 cells. J Biol Chem. 268:1993;11803-11810.
10. Henkel T., Machleidt T., Alkalay I., Kronke M., Ben Neriah Y., Baeuerle P.A. Rapid proteolysis of IκBα is necessary for activation of transcription factor NFκB. Nature. 365:1993;182-185.
11. Chen Z.J., Parent L., Maniatis T. Site-specific phosphorylation of IκBα by a novel ubiquitination-dependent protein kinase activity. Cell. 84:1996;853-862.
12. Lee F.S., Hagler J., Chen Z.J., Maniatis T. Activation of the IκBα kinase complex by MEKK1, a kinase of the JNK pathway. Cell. 88:1997;213-222.
13. Schouten G.J., Vertegaal A.C.O., Whiteside S.T., Israel A., Toebes M., Dorsman J.C., van der Eb A.J., Zantema A. IκBα is a target for the mitogen-activated 90 kDa ribosomal S6 kinase. EMBO J. 16:1997;3133-3144.
14. Schreck R., Rieber P., Baeuerle P.A. Reactive oxygen intermediates as apparently widely used messengers in the activation of the NFκB transcription factor and HIV-1. EMBO J. 10:1991;2247-2258.
15. Schreck R., Meier B., Mannel D.N., Droge W., Baeuerle P.A. Dithiocarbamates as potent inhibitors of nuclear factor κB activation in intact cells. J Exp Med. 175:1992;1181-1194.
16. Suzuki Y.J., Aggarwal B.B., Packer L. Alpha-lipoic acid is a potent inhibitor of NFκB activation in human T cells. Biochem Biophys Res Commun. 189:1992;1709-1715.
17. Schmidt K.N., Amstad P., Cerutti P., Baeuerle P.A. Identification of hydrogen peroxide as the relevant messenger in the activation pathway of transcription factor NFκB. Adv Exp Med Biol. 387:1996;63-68.
18. Mahon T.M., O'Neill L.A. Studies into the effect of the tyrosine kinase inhibitor herbimycin A on NFκB activation in T lymphocytes. Evidence for covalent modification of the p50 subunit. J Biol Chem. 270:1995;28557-28564.
19. Matthews J.R., Kaszubska W., Turcatti G., Wells T.N., Hay R.T. Role of cysteine 62 in DNA recognition by the P50 subunit of NFκB. Nucleic Acids Res. 21:1993;1727-1734.
20. Matthews J.R., Wakasugi N., Virelizier J.L., Yodoi J., Hay R.T. Thioredoxin regulates the DNA binding activity of NFκB by reduction of a disulphide bond involving cysteine 62. Nucleic Acids Res. 20:1992;3821-3830.
21. Galter D., Mihm S., Droge W. Distinct effects of glutathione disulphide on the nuclear transcription factor κB and the activator protein-1. Eur J Biochem. 221:1994;639-648.
22. Brennan P., O'Neill L.A. Effects of oxidants and antioxidants on nuclear factor κB activation in three different cell lines evidence against a universal hypothesis involving oxygen radicals. Biochim Biophys Acta. 1260:1995;167-175.
23. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem. 72:1976;248-254.
24. Stylianou E., O'Neill L.A., Rawlinson L., Edbrooke M.R., Woo P., Saklatvala J. Interleukin 1 induces NFκB through its type I but not its type II receptor in lymphocytes. J Biol Chem. 267:1992;15836-15841.
25. Brennan P., O'Neill L.A. 2-mercaptoethanol restores the ability of nuclear factor κB (NFκB) to bind DNA in nuclear extracts from interleukin 1-treated cells incubated with pyrollidine dithiocarbamate (PDTC). Evidence for oxidation of glutathione in the mechanism of inhibition of NFκB by PDTC. Biochem J. 320:1996;975-981.
26. Toledano M.B., Leonard W.J. Modulation of transcription factor NFκB binding activity by oxidation-reduction in vitro. Proc Natl Acad Sci USA. 88:1991;4328-4332.
27. Droge W., Schulze-Osthoff K., Mihm S., Galter D., Schenk H., Eck H.P., Roth S., Gmunder H. Functions of glutathione and glutathione disulfide in immunology and immunopathology. FASEB J. 8:1994;1131-1138.
28. Finco T.S., Beg A.A., Baldwin A.S. Jr. Inducible phosphorylation of IκBα is not sufficient for its dissociation from NFκB and is inhibited by protease inhibitors. Proc Natl Acad Sci USA. 91:1994;11884-11888.
29. Li C.J., Zhang L.J., Dezube B.J., Crumpacker C.S., Pardee A.B. Three inhibitors of type 1 human immunodeficiency virus long terminal repeat-directed gene expression and virus replication. Proc Natl Acad Sci USA. 90:1993;1839-1842.
30. Israel N., Gougerot-Pocidalo M.A., Aillet F., Virelizier J.L. Redox status of cells influences constitutive or induced NFκB translocation and HIV long terminal repeat activity in human T and monocytic cell lines. J Immunol. 149:1992;3386-3393.
31. Mukhopadhyay A., Basu N., Ghatak N., Gujral P.K. Anti-inflammatory and irritant activities of curcumin analogues in rats. Agents Actions. 12:1982;508-515.
32. Appleby S.B., Ristimaki A., Neilson K., Narko K., Hla T. Structure of the human cyclo-oxygenase-2 gene. Biochem J. 302:1994;723-727.
33. Geller D.A., Nussler A.K., Di Silvio M., Lowenstein C.J., Shapiro R.A., Wang S.C., Simmons R.L., Billiar T.R. Cytokines, endotoxin, and glucocorticoids regulate the expression of inducible nitric oxide synthase in hepatocytes. Proc Natl Acad Sci USA. 90:1993;522-526.
34. Singh S., Aggarwal B.B. Activation of transcription factor NFκB is suppressed by curcumin (diferuloylmethane). J Biol Chem. 270:1995;24995-25000.
35. Robinson T.W., Sevanian A., Forman H.J. Inhibition of arachidonic acid release by NDGA and its antioxidant action in rat alveolar macrophages and Chinese hamster lung fibroblasts. Toxicol Appl Pharmacol. 105:1990;113-122.
36. Sreejayan R.M.A. Curcuminoids as potent inhibitors of lipid peroxidation. J Pharm Pharmacol. 46:1994;1013-1016.
37. Flohe L., Brigelius-Flohe R., Saliou C., Traber M., Packer L. Redox regulation of NFκB activation. Free Radic Biol Med. 22:1997;1115-1126.
38. Bowie A.G., Moynagh P.N., O'Neill L.A.J. Lipid peroxidation is involved in the activation of NFκB by TNF but not IL1 in the human endothelial cell line ECV304. J Biol Chem. 272:1997;25941-25950.
39. Xu S., Robbins D.J., Christerson L.B., English J.M., Vanderbilt C.A., Cobb M.H. Cloning of rat MEK kinase 1 cDNA reveals an endogenous membrane-associated 195-kDa protein with a large regulatory domain. Proc Natl Acad Sci USA. 93:1996;5291-5295.
40. Sulciner D.J., Irani K., Yu Z.X., Ferrans V.J., Goldschmidt-Clermont P., Finkel T. rac1 regulates a cytokine-stimulated, redox-dependent pathway necessary for NFκB activation. Mol Cell Biol. 16:1996;7115-7121.