Yin-Yang 1 regulates effector cytokine gene expression and TH2 immune responses

Journal of Allergy and Clinical Immunology

Volumn 122, Issue 1, 2008, Pages

  Guo, Jia ^a   Lin, Xin ^a   Williams, Marc A ^a   Hamid, Qutayba ^b   Georas, Steve N ^a  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^b MCGILL UNIVERSITY   (Canada)

Author keywords

allergic inflammation; asthma; cytokine gene regulation; T lymphocyte; transcription factors

Indexed keywords

CD4 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 2; INTERLEUKIN 4; OVALBUMIN; TRANSCRIPTION FACTOR YY1;

ALLELE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN PRESENTING CELL; ARTICLE; ASTHMA; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; DISEASE MODEL; FEMALE; GENE CONTROL; GENE EXPRESSION PROFILING; HETEROZYGOTE; IMMUNE RESPONSE; INFLAMMATION; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; RESPIRATORY TRACT BIOPSY; RESPIRATORY TRACT INFLAMMATION; SPLEEN CELL; TH2 CELL; TRANSGENIC MOUSE;

EID: 46049100204     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jaci.2008.03.012     Document Type: Article

References (58)

1. Shi Y., Lee J.S., and Galvin K.M. Everything you have ever wanted to know about Yin Yang 1. Biochim Biophys Acta 1332 (1997) F49-F66
2. Thomas M.J., and Seto E. Unlocking the mechanisms of transcription factor YY1: are chromatin modifying enzymes the key?. Gene 236 (1999) 197-208
3. Kim J.D., Hinz A.K., Bergmann A., Huang J.M., Ovcharenko I., Stubbs L., et al. Identification of clustered YY1 binding sites in imprinting control regions. Genome Res 16 (2006) 901-911
4. Cunningham J.T., Rodgers J.T., Arlow D.H., Vazquez F., Mootha V.K., and Puigserver P. mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex. Nature 450 (2007) 736-740
5. Gordon S., Akopyan G., Garban H., and Bonavida B. Transcription factor YY1: structure, function, and therapeutic implications in cancer biology. Oncogene 25 (2006) 1125-1142
6. Wilkinson F.H., Park K., and Atchison M.L. Polycomb recruitment to DNA in vivo by the YY1 REPO domain. Proc Natl Acad Sci U S A 103 (2006) 19296-19301
7. Cai Y., Jin J., Yao T., Gottschalk A.J., Swanson S.K., Wu S., et al. YY1 functions with INO80 to activate transcription. Nat Struct Mol Biol 14 (2007) 872-874
8. Sui G., Affar el B., Shi Y., Brignone C., Wall N.R., Yin P., et al. Yin Yang 1 is a negative regulator of p53. Cell 117 (2004) 859-872
9. He Y., Dupree J., Wang J., Sandoval J., Li J., Liu H., et al. The transcription factor Yin Yang 1 is essential for oligodendrocyte progenitor differentiation. Neuron 55 (2007) 217-230
10. Liu H., Schmidt-Supprian M., Shi Y., Hobeika E., Barteneva N., Jumaa H., et al. Yin Yang 1 is a critical regulator of B-cell development. Genes Dev 21 (2007) 1179-1189
11. Hobbs K., Negri J., Klinnert M., Rosenwasser L.J., and Borish L. Interleukin-10 and transforming growth factor-beta promoter polymorphisms in allergies and asthma. Am J Respir Crit Care Med 158 (1998) 1958-1962
12. Kalayci O., Birben E., Wu L., Oguma T., Storm Van's Gravesande K., Subramaniam V., et al. Monocyte chemoattractant protein-4 core promoter genetic variants: influence on YY-1 affinity and plasma levels. Am J Respir Cell Mol Biol 29 (2003) 750-756
13. Silverman E.S., Palmer L.J., Subramaniam V., Hallock A., Mathew S., Vallone J., et al. Transforming growth factor-beta1 promoter polymorphism C-509T is associated with asthma. Am J Respir Crit Care Med 169 (2004) 214-219
14. Cameron L., Webster R.B., Strempel J.M., Kiesler P., Kabesch M., Ramachandran H., et al. Th2 cell-selective enhancement of human IL13 transcription by IL13-1112C>T, a polymorphism associated with allergic inflammation. J Immunol 177 (2006) 8633-8642
15. Guo J., Casolaro V., Seto E., Yang W.M., Chang C., Seminario M.C., et al. Yin-Yang 1 activates interleukin-4 gene expression in T cells. J Biol Chem 276 (2001) 48871-48878
16. Ye J., Ghosh P., Cippitelli M., Subleski J., Hardy K.J., Ortaldo J.R., et al. Characterization of a silencer regulatory element in the human interferon-gamma promoter. J Biol Chem 269 (1994) 25728-25734
17. Ye J., Cippitelli M., Dorman L., Ortaldo J., and Young H. The nuclear factor YY1 suppresses the human gamma interferon promoter through two mechanisms: inhibition of AP1 binding and activation of a silencer element. Mol Cell Biol 16 (1996) 4744-4753
18. Mordvinov V.A., Schwenger G.T., Fournier R., De Boer M.L., Peroni S.E., Singh A.D., et al. Binding of YY1 and Oct1 to a novel element that downregulates expression of IL-5 in human T cells. J Allergy Clin Immunol 103 (1999) 1125-1135
19. Schwenger G.T., Fournier R., Hall L.M., Sanderson C.J., and Mordvinov V.A. Nuclear factor of activated T cells and YY1 combine to repress IL-5 expression in a human T-cell line. J Allergy Clin Immunol 104 (1999) 820-827
20. Soutto M., Zhang F., Enerson B., Tong Y., Boothby M., and Aune T.M. A minimal IFN-gamma promoter confers Th1 selective expression. J Immunol 169 (2002) 4205-4212
21. Sweetser M.T., Hoey T., Sun Y.L., Weaver W.M., Price G.A., and Wilson C.B. The roles of nuclear factor of activated T cells and yin-yang 1 in activation-induced expression of the interferon-gamma promoter in T cells. J Biol Chem 273 (1998) 34775-34783
22. Donohoe M.E., Zhang X., McGinnis L., Biggers J., Li E., and Shi Y. Targeted disruption of mouse Yin Yang 1 transcription factor results in peri-implantation lethality. Mol Cell Biol 19 (1999) 7237-7244
23. Lorente M., Perez C., Sanchez C., Donohoe M., Shi Y., and Vidal M. Homeotic transformations of the axial skeleton of YY1 mutant mice and genetic interaction with the Polycomb group gene Ring1/Ring1A. Mech Dev 123 (2006) 312-320
24. Affar el B., Gay F., Shi Y., Liu H., Huarte M., Wu S., et al. Essential dosage-dependent functions of the transcription factor yin yang 1 in late embryonic development and cell cycle progression. Mol Cell Biol 26 (2006) 3565-3581
25. Barnden M.J., Allison J., Heath W.R., and Carbone F.R. Defective TCR expression in transgenic mice constructed using cDNA-based alpha- and beta-chain genes under the control of heterologous regulatory elements. Immunol Cell Biol 76 (1998) 34-40
26. National Asthma Education and Prevention Program. Expert Panel Report: guidelines for the diagnosis and management of asthma (1997), National Institutes of Health, Bethesda (MD)
27. American Thoracic Society. Guidelines for fiberoptic bronchoscopy in adults. Medical Section of the American Lung Association. Am Rev Respir Dis 136 (1987) 1066
28. Bergeron C., Boulet L.P., Page N., Laviolette M., Zimmermann N., Rothenberg M.E., et al. Influence of cigarette smoke on the arginine pathway in asthmatic airways: increased expression of arginase I. J Allergy Clin Immunol 119 (2007) 391-397
29. Djukanovic R., Roche W., Wilson J., Beasley C., Twentyman O., Howarth P., et al. Mucosal inflammation in asthma. Am Rev Respir Dis 142 (1990) 434-457
30. Li B., Tournier C., Davis R.J., and Flavell R.A. Regulation of IL-4 expression by the transcription factor JunB during T helper cell differentiation. EMBO J 18 (1999) 420-432
31. Ho I.C., and Glimcher L.H. Transcription: tantalizing times for T cells. Cell 109 suppl (2002) S109-S120
32. Bruhn K., Nelms K., Boulay J., Paul W., and Lenardo M. Molecular dissection of the murine interleukin-4 promoter. Proc Natl Acad Sci U S A 90 (1993) 9707-9711
33. Szabo S.J., Jacobson N.G., Dighe A.S., Gubler U., and Murphy K.M. Developmental commitment to the Th2 lineage by extinction of IL-12 signaling. Immunity 2 (1995) 665-675
34. Rooney J., Hodge M., McCaffrey P., Rao A., and Glimcher L. A common factor regulates both Th1- and Th2-specific cytokine gene expression. EMBO J 13 (1994) 625-633
35. Ho A.M., Jain J., Rao A., and Hogan P.G. Expression of the transcription factor NFATp in a neuronal cell line and in the murine nervous system. J Biol Chem 269 (1994) 28181-28186
36. Davydov I., Krammer P., and Li-Weber M. Nuclear factor-IL-6 activates the human IL-4 promoter in T cells. J Immunol 155 (1995) 5273-5279
37. Georas S.N. Inhaled glucocorticoids, lymphocytes, and dendritic cells in asthma and obstructive lung diseases. Proc Am Thorac Soc 1 (2004) 215-221
38. Dorado B., Jerez M.J., Flores N., Martin-Saavedra F.M., Duran C., and Ballester S. Autocrine IL-4 gene regulation at late phases of TCR activation in differentiated Th2 cells. J Immunol 169 (2002) 3030-3037
39. Pfeuffer I., Klein-Hebling S., Heinfling A., Chuvpilo S., Escher C., Brabletz T., et al. Octamer factors exert a dual effect on the IL-2 and IL-4 promoters. J Immunol 153 (1994) 5572-5585
40. Li-Weber M., Davydov I., Krafft H., and Krammer P. The role of NF-Y and IRF-2 in the regulation of human IL-4 gene expression. J Immunol 153 (1994) 4122-4133
41. Georas S., Cumberland J., Burke T., Chen R., Park E., Ono S., et al. Characterization of a novel repressor element in the interleukin 4 promoter. Leukemia 14 (2000) 629-635
42. Agarwal S., Viola J.P., and Rao A. Chromatin-based regulatory mechanisms governing cytokine gene transcription. J Allergy Clin Immunol 103 (1999) 990-999
43. Valapour M., Guo J., Schroeder J.T., Keen J., Cianferoni A., Casolaro V., et al. Histone deacetylation inhibits IL4 gene expression in T cells. J Allergy Clin Immunol 109 (2002) 238-245
44. Fields P.E., Lee G.R., Kim S.T., Bartsevich V.V., and Flavell R.A. Th2-specific chromatin remodeling and enhancer activity in the Th2 cytokine locus control region. Immunity 21 (2004) 865-876
45. Spilianakis C.G., Lalioti M.D., Town T., Lee G.R., and Flavell R.A. Interchromosomal associations between alternatively expressed loci. Nature 435 (2005) 637-645
46. Lee G.R., Kim S.T., Spilianakis C.G., Fields P.E., and Flavell R.A. T helper cell differentiation: regulation by cis elements and epigenetics. Immunity 24 (2006) 369-379
47. Garban H.J., and Bonavida B. Nitric oxide inhibits the transcription repressor Yin-Yang 1 binding activity at the silencer region of the Fas promoter: a pivotal role for nitric oxide in the up-regulation of Fas gene expression in human tumor cells. J Immunol 167 (2001) 75-81
48. Santiago F.S., Lowe H.C., Bobryshev Y.V., and Khachigian L.M. Induction of the transcriptional repressor Yin Yang-1 by vascular cell injury. Autocrine/paracrine role of endogenous fibroblast growth factor-2. J Biol Chem 276 (2001) 41143-41149
49. Yao Y.L., Yang W.M., and Seto E. Regulation of transcription factor YY1 by acetylation and deacetylation. Mol Cell Biol 21 (2001) 5979-5991
50. Hiromura M., Choi C.H., Sabourin N.A., Jones H., Bachvarov D., and Usheva A. YY1 is regulated by O-linked N-acetylglucosaminylation (O-glcNAcylation). J Biol Chem 278 (2003) 14046-14052
51. Bird J., Brown D., Mullen A., Moskowitz N., Mahowald M., Sider J., et al. Helper T cell differentiation is controlled by the cell cycle. Immunity 9 (1998) 229-237
52. Richter A., Lohning M., and Radbruch A. Instruction for cytokine expression in T helper lymphocytes in relation to proliferation and cell cycle progression. J Exp Med 190 (1999) 1439-1450
53. Laouar Y., and Crispe I.N. Functional flexibility in T cells: independent regulation of CD4+ T cell proliferation and effector function in vivo. Immunity 13 (2000) 291-301
54. Ben-Sasson S.Z., Gerstel R., Hu-Li J., and Paul W.E. Cell division is not a "clock" measuring acquisition of competence to produce IFN-gamma or IL-4. J Immunol 166 (2001) 112-120
55. Cohn L., Elias J.A., and Chupp G.L. Asthma: mechanisms of disease persistence and progression. Annu Rev Immunol 22 (2004) 789-815
56. Kuperman D., Schofield B., Wills-Karp M., and Grusby M.J. Signal transducer and activator of transcription factor 6 (Stat6)-deficient mice are protected from antigen-induced airway hyperresponsiveness and mucus production. J Exp Med 187 (1998) 939-948
57. Zhang D.H., Yang L., Cohn L., Parkyn L., Homer R., Ray P., et al. Inhibition of allergic inflammation in a murine model of asthma by expression of a dominant-negative mutant of GATA-3. Immunity 11 (1999) 473-482
58. Finotto S., De Sanctis G.T., Lehr H.A., Herz U., Buerke M., Schipp M., et al. Treatment of allergic airway inflammation and hyperresponsiveness by antisense-induced local blockade of GATA-3 expression. J Exp Med 193 (2001) 1247-1260