Autocrine IL-4 gene regulation at late phases of TCR activation in differentiated TH2 cells

Journal of Immunology

Volumn 169, Issue 6, 2002, Pages 3030-3037

  Dorado, Beatriz ^a   Jerez, María J ^a   Flores, Natalia ^a   Martín Saavedra, Francisco M ^a   Durán, Cristina ^a   Ballester, Sara ^a  

^a INSTITUTO DE SALUD CARLOS III   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CD3 ANTIGEN; INTERLEUKIN 4; IONOMYCIN; MESSENGER RNA; NUCLEAR PROTEIN; STAT6 PROTEIN; T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR NFAT;

ANIMAL CELL; ARTICLE; AUTOCRINE EFFECT; CELL MATURATION; COMPLEX FORMATION; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOKINE PRODUCTION; GENE ACTIVATION; GENE CONTROL; GENE EXPRESSION; GENETIC TRANSCRIPTION; IMMUNOMODULATION; LYMPHOCYTE CLONE; LYMPHOCYTE DIFFERENTIATION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN INDUCTION; REPORTER GENE; SIGNAL TRANSDUCTION; TH2 CELL;

EID: 0037105387     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.169.6.3030     Document Type: Article

References (46)

1. + T cell clones
2. + T-cells
3. Interleukin 4 (IL-4) inhibits secretion of IL-1β, tumor necrosis factor α and IL-6 by human monocytes
4. Identification of a T cell-derived B cell growth factor distinct from interleukin 2
5. Regulatory role of IL4 and other cytokines in the function and development of human T-cell clones
6. Coordinate and cooperative roles for NF-AT and AP-1 in the regulation of the murine IL-4 gene
7. Genes that regulate interleulin-4 expression in T cells
8. T cell priming enhances IL-4 gene expression by increasing nuclear factor of activated T cells
9. Regulation of IL-4 expression by the transcription factor JunB during T helper cell differentiation
10. NFAT5, a constitutively nuclear NFAT protein that does not cooperate with Fos and Jun
11. T-cell receptor stimulation elicits an early phase of activation and a later phase of deactivation of the transcription factor NFAT1
12. Concerted dephosphorylation of the transcription factor NFAT1 induces a conformational switch that regulates transcriptional activity
13. NF-ATp, a T lymphocyte DNA-binding protein that is a target for calcineurin and immunosuppressive drugs
14. Requirement for integration of phorbol 12-myristate 13-acetate and calcium pathways is preserved in the transactivation domain of NFAT1
15. Identification of cis-acting regulatory elements controlling IL4 gene expression in T-cells: Roles for NF-Y and NF-ATc
16. Stat6 inhibits human interleukin-4 promoter activity in T cells
17. Characterization of P5, a novel NFAT/AP-1 site in the human IL-4 promoter
18. The protooncogene c-maf is responsible for tissue-specific expression of interleukin-4
19. NFAT driven interleukin-4 transcription potentiated by NIP45
20. Gene expression elicited by NFAT in the presence or absence of cooperative recruitment of Fos and Jun
21. Multiple closely-linked NFAT/octamer and HMG I (Y) binding sites are part of the interleukin-4 promoter
22. HMG I(Y) interferes with the DNA binding of NFAT factors and the induction of the interleukin 4 promoter in T cells
23. Inhibition of NF-AT-dependent transcription by NF-κB: Implications for differential gene expression in T helper cell subsets
24. Involvement of Jun and Rel proteins in up-regulation of interleukin-4 gene activity by the T cell accessory molecule CD28
25. Stat6 is required for mediating responses to IL-4 and for development of Th2 cells
26. Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene
27. Essential role of Stat6 in IL-4 signalling
28. IL-4 and IL-13 production in differentiated Th type 2 cells is not IL-4 dependent
29. Identification of a Stat-6-responsive element in the promoter of the human interleukin-4 gene
30. Cytokine transcriptional events during helper T cell subset differentiation
31. Both a monoclonal antibody and antisera specific for determinants unique to individual cloned helper T cell lines can substitute for antigen and antigen-presenting cells in the activation of T cells
32. Monoclonal antibodies to murine CD3ε define distinct epitopes, one of which may interact with CD4 during T cell activation
33. Establishment of mouse cell lines which constitutively secrete large quantities of interleukin 2, 3, 4 or 5, using modified cDNA expression vectors
34. Production of a monoclonal antibody to and molecular characterization of B-cell stimulatory factor-1
35. Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
36. NFκB in Th2 cells: Delayed and long-lasting induction through the TCR complex
37. Cloning of murine Stat6 and human Stat6, Stat proteins that are tyrosine phosphorylated in response to IL-4 and IL-3 but are not required for mitogenesis
38. Interaction of calcineurin with a domain of the transcription factor NFATI that controls nuclear import
39. Region-specific initiation of mouse mammary tumor virus RNA synthesis by endogenous RNA polymerase II in preparations of cell nuclei
40. Cloning and characterization of the abundant cytoplasmic 7S RNA from mouse cells
41. NFATx, a novel member of the nuclear factor of activated T cells family that is expressed predominantly in the thymus
42. Successive expression and activation of NFAT family members during thymocyte differentiation
43. An interleukin-4-induced transcription factor: IL4 Stat
44. Expression of NFAT-family proteins in normal human T cells
45. + T helper 2 (Th2) cells but not in Th1 cells
46. NFATc3, a lymphoid-specific NFATc family member that is calcium-regulated and exhibits distinct DNA binding specificity