RAC1 activity and intracellular ROS modulate the migratory potential of MCF-7 cells through a NADPH oxidase and NFκB-dependent mechanism

Cancer Letters

Volumn 267, Issue 1, 2008, Pages 125-132

  Tobar, Nicolás ^a   Cáceres, Mónica ^a   Santibáñez, Juan F ^a   Smith, Patricio C ^a   Martínez, Jorge ^a  

^a UNIVERSITY OF CHILE   (Chile)

Author keywords

Invasiveness; NF B; Rac1; ROS

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; RAC1 PROTEIN; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; UROKINASE;

ARTICLE; BREAST CANCER; CANCER CELL; CARCINOGENESIS; CELL MIGRATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

CELL LINE; CELL MOVEMENT; HUMANS; NADPH OXIDASE; NF-KAPPA B; RAC1 GTP-BINDING PROTEIN; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION;

EID: 45849152081     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.canlet.2008.03.011     Document Type: Article

References (26)

1. Coussens L.M., and Werb Z. Inflammation and cancer. Nature 420 (2002) 860-867
2. Benhar M., Engeberg D.E., and Levitzki A. ROS, stress-activated kinases and stress signaling in cancer. EMBO Rep. 3 (2002) 420-425
3. Dröge W. Free radicals in the physiological control of cell function. Physiol. Rev. 82 (2002) 47-96
4. Toyokuni S. Novel aspects of oxidative stress-associated carcinogenesis. Antioxid. Redox Signal. 8 (2006) 1373-1377
5. Babior B.M. NADPH oxidase: an update. Blood 93 (1999) 1464-1476
6. Bokoch G.M., and Diebold B.A. Current molecular models for NADPH oxidase regulation by Rac GTPase. Blood 100 (2002) 2692-2696
7. Radisky D.C., Levy D.D., Littlepage L.E., Liu H., Nelson C.M., Fata J.E., Leake D., Godden E.L., Albertson D.G., Nieto M.A., Werb Z., and Bissell M.J. Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability. Nature 436 (2005) 123-127
8. Patel V., Rosenfeldt H.M., Lyons R., Servitja J.-M., Bustelo X.R., Siroff M., and Gutkind J.S. Persistent activation of Rac1 in squamous carcinomas of the head and neck: evidence for an EGFR/Vav2 signaling axis involved in cell invasion. Carcinogenesis 28 (2007) 1145-1152
9. Nimnual A.S., Taylor L.J., and Bar-Sagi D. Redox-dependent downregulation of Rho by Rac. Nat. Cell Biol. 5 (2003) 236-241
10. Mori K., Shibanuma M., and Nose K. Invasive potential induced under long-term oxidative stress in mammary epithelial cells. Cancer Res. 64 (2004) 7464-7472
11. Li N., and Karin M. Is NFκB the sensor of oxidative stress?. FASEB J. 13 (1999) 1137-1143
12. Karin M. Nuclear factor-κB in cancer development and progression. Nature 441 (2006) 431-436
13. Suzuki Y., Shimada J., Shudo K., Matsumura M., Crippa M.P., and Kojima S. Physical interaction between retinoic acid receptor and Sp1: mechanism for induction of urokinase by retinoic acid. Blood 93 (1999) 4264-4276
14. Santibañez J.F. JNK mediates TGF-β1-induced epithelial mesenchymal transdifferentiation of mouse transformed keratinocytes. FEBS Lett. 580 (2006) 5385-5391
15. Cáceres M., Guerrero J., and Martínez J. Overexpression of RhoA-GTP induces activation of the epidermal growth factor receptor, dephosphorylation of focal adhesion kinase and increased motility in breast cancer cells. Exp. Cell Res. 309 (2005) 229-238
16. Benhar M., Dalyot I., Engelberg D., and Levitzki A. Enhanced ROS production in oncogenically transformed cells potentiates c-Jun N-terminal kinase and p38 mitogen-activated protein kinase activation and sensitization to genotoxic stress. Mol. Cell. Biol. 20 (2001) 6913-6926
17. Fritz G., Just I., and Kaina B. Rho GTPases are over-expressed in human tumors. Int. J. Cancer 81 (1999) 682-687
18. Ferraro D., Corso S., Fasano E., Panieri E., Santangelo R., Borrelo S., Giordano S., Pani G., and Galeotti T. Pro-metastatic signaling by c-Met through RAC-1 and reactive oxygen species (ROS). Oncogene 25 (2006) 3689-3698
19. Thiery J.P. Epithelial-mesenchymal transitions: twist in development and pathologies. Curr. Opin. Cell Biol. 15 (2003) 740-746
20. Friedl P., and Wolf K. Tumor-cell invasion and migration: diversity and scape mechanisms. Nat. Rev. Cancer 3 (2003) 362-374
21. Wu W.S., Tsai R.K., Chang C.H., Wang S., Wu J.R., and Chang Y.X. Reactive oxygen species mediated sustained activation of protein kinase C alpha and extracellular signal-regulated kinase for migration of human hepatoma cell Hepg2. Mol. Cancer Res. 4 10 (2006) 747-758
22. Hall A. GTPases and the actin cytoskeleton. Science 279 (1998) 509-514
23. Ridley A.J., Schwartz M.A., Burridge K., Firtel R.A., Ginsberg M.H., Borisy G., Parsons J.T., and Horwitz A.R. Cell migration: integrating signals from front to back. Science 302 (2003) 1704-1709
24. Gloire G., Legrand-Poels S., and Piette J. NF-kappaB activation by reactive oxygen species: fifteen years later. Biochem. Pharmacol. 72 (2006) 1493-1505
25. 2-dependent recruitment of TRAF6 to endosomal Interleukin-1 receptor complexes. Mol. Cell. Biol. 26 (2006) 140-154
26. Sliva D., Rizzo M.T., and Denis English D. Phosphatidylinositol 3-kinase and NFκB regulate motility of invasive MDA-MB-231 human breast cancer cells by the secretion of urokinase-type plasminogen activator. J. Biol. Chem. 277 (2002) 3150-3157