Nonvirally modified autologous primary hepatocytes correct diabetes and prevent target organ injury in a large preclinical model

PLoS ONE

Volumn 3, Issue 3, 2008, Pages

  Chen, Nelson K F ^a   Wong, Jen San ^a,b   Kee, Irene H C ^b   Lai, Siang Hui ^c   Thng, Choon Hua ^a   Ng, Wai Har ^a   Ng, Robert T H ^b   Tan, Soo Yong ^b   Lee, Shu Yen ^d   Tan, Mark E H ^a   Sivalingam, Jaichandran ^a   Chow, Pierce K H ^b   Kon, Oi Lian ^a  

^a DIVISION OF MEDICAL ONCOLOGY   (Singapore)

^b SINGAPORE GENERAL HOSPITAL   (Singapore)

^c HEALTH SCIENCES AUTHORITY   (Singapore)

^d SINGAPORE NATIONAL EYE CENTRE   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

C PEPTIDE; COMPLEMENTARY DNA; GLUCOSE; INSULIN; MESSENGER RNA; TRANSCRIPTOME; STREPTOZOCIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA; ARTICLE; CELL ISOLATION; CELL TRANSPLANTATION; CONTROLLED STUDY; DIABETES MELLITUS; DYSLIPIDEMIA; ELECTROPORATION; EX VIVO STUDY; EXPRESSION VECTOR; EYE; FEMALE; GENE TRANSFER; GLUCOSE BLOOD LEVEL; GLUCOSE INTOLERANCE; HYPERGLYCEMIA; KIDNEY; LIVER; LIVER CELL; LIVER FUNCTION; MALE; METABOLIC DISORDER; NONHUMAN; ORGAN INJURY; PLASMID; STREPTOZOCIN DIABETES; SWINE; ANIMAL; DNA MICROARRAY; EXPERIMENTAL DIABETES MELLITUS; GENE EXPRESSION PROFILING; GENE THERAPY; GENETICS; GLUCOSE TOLERANCE TEST; HUMAN; INJURY; METABOLISM; PANCREAS ISLET BETA CELL; PATHOLOGY; RADIOIMMUNOASSAY; RETINA; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SECRETION; TRANSPLANTATION;

SUIDAE;

ANIMALS; AORTA; BLOOD GLUCOSE; C-PEPTIDE; DIABETES MELLITUS, EXPERIMENTAL; ELECTROPORATION; GENE EXPRESSION PROFILING; GENE THERAPY; GENE TRANSFER TECHNIQUES; GLUCOSE TOLERANCE TEST; HEPATOCYTES; HUMANS; INSULIN; INSULIN-SECRETING CELLS; KIDNEY; LIVER; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RADIOIMMUNOASSAY; RETINA; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; STREPTOZOCIN; SWINE;

EID: 45849128015     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0001734     Document Type: Article

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