Adipose differentiation-related protein and regulators of lipid homeostasis identified by gene expression profiling in the murine db/db diabetic kidney

American Journal of Physiology - Renal Physiology

Volumn 286, Issue 5 55-5, 2004, Pages

  Mishra, Rangnath ^a   Emancipator, Steven N ^a   Miller, Casey ^a   Kern, Timothy ^a   Simonson, Michael S ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Diabetes; Microarray; Peroxisome proliferator activated receptor ; Transcriptome

Indexed keywords

ISOPROTEIN; LIPID; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; RNA; TRIACYLGLYCEROL;

ADIPOCYTE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DENSITY; DIABETES MELLITUS; DNA MICROARRAY; FAT BODY; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENETIC TRANSCRIPTION; GLOMERULUS; HISTOPATHOLOGY; HOMEOSTASIS; HYPERGLYCEMIA; IMMUNOHISTOCHEMISTRY; KIDNEY ARTERY; KIDNEY CORTEX; KIDNEY DISEASE; KIDNEY INJURY; LIPID STORAGE; LIPID TRANSPORT; MALE; MOLECULAR BIOLOGY; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATION; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN LOCALIZATION; REGULATORY MECHANISM; UPREGULATION; WESTERN BLOTTING;

EID: 1942439127     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00323.2003     Document Type: Article

References (51)

1. Barger PM and Kelly DP. PPAR signaling in the control of cardiac energy metabolism. Trends Cardiovasc Med 10: 238-245, 2000.
2. Bower G, Brown DM, Steffes MW, Vernier RL, and Mauer M. Studies of the glomerular mesangium and the juxtaglomerular apparatus in the genetically diabetic mouse. Lab Invest 43: 333-341, 1980.
3. Brasaemle DL, Barber T, Wolins NE, Serrero G, Blanchette-Mackie EJ, and Londos C. Adipose differentiation-related protein is a ubiquitously expressed lipid storage droplet-associated protein. J Lipid Res 38: 2249-2263, 1997.
4. Chen H, Charlat O, Tartaglia LA, Woolf EA, Weng X, Ellis SJ, Lakey ND, Culpepper J, More KJ, Breitbart RE, Duyk GM, Tepper RI, and Morgenstern JP. Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice. Cell 84: 491-495, 1996.
5. Clarkson MR, Murphy M, Gupta S, Lambe T, Mackenzie HS, Godson C, Martin F, and Brady HR. High glucose-altered gene expression in mesangial cells. J Biol Chem 277: 9707-9712, 2002.
6. Cohen MP, Sharma K, Jin Y, Hud E, Wu VY, Tomaszewski J, and Ziyadeh FN. Prevention of diabetic nephropathy in db/db mice with glycated albumin antagonists: a novel treatment strategy. J Clin Invest 95: 2338-2345, 1995.
7. Cooper ME and Gilbert RE. Pathogenesis, treatment, and prevention of diabetic nephropathy. In: Comprehensive Clinical Nephrology, edited by Johnson RJ and Feehally J. Philadelphia, PA: Mosby, 2000, p. 35.1-35.12.
8. Dalla Vestra M, Saller A, Bortoloso E, Mauer M, and Fioretto P. Structural involvement in type I and type II diabetic nephropathy. Diabetes Metab 26: 8-14, 2000.
9. Dennis G, Sherman BT, Hosack DA, Yang J, Gao W, Lane HC, and Lempicki RA. DAVID: database for annotation, visualization, and integrated discovery. Genome Biol 4: R60-60.11, 2003.
10. Eisen MB, Spellman PT, Brown PO, and Botstein D. Cluster analysis and display of genome-wide expression patterns. Proc Natl Acad Sci USA 95: 14863-14868, 1998.
11. Finck BN, Han X, Courtois M, Aimond F, Nerbonne JM, Kovacs A, Gross RW, and Kelly DP. A critical role for PPARa-mediated lipotoxicity in the pathogenesis of diabetic cardiomyopathy: modulation by dietary fat content. Proc Natl Acad Sci USA 100: 1226-1231, 2003.
12. Fried LF, Orchard TJ, and Kasiske BL. Effect of lipid reduction on the progression of renal disease: a meta-analysis. Kidney Int 59: 260-269, 2001.
13. Gao J and Serrero G. Adipose differentiation related protein (ADRP) expressed in transfected COS-7 cells selectively stimulates long chain fatty acid uptake. J Biol Chem 274: 16825-16830, 1999.
14. Gao J, Ye H, and Serrero G. Stimulation of adipose differentiation related protein (ADRP) expression in adipocyte precursors by long-chain fatty acids. J Cell Physiol 182: 297-302, 2000.
15. Gartner K. Glomerular hyperfiltration during the onset of diabetes mellitus in two strains of diabetic mice. Diabetologia 15: 59-63, 1978.
16. Guan YF and Breyer MD. Peroxisome proliferator-activated receptors (PPARs): novel therapeutic targets in renal disease. Kidney Int 60: 14-30, 2001.
17. Heid HW, Moll R, Schwetlick I, Rackwitz HR, and Keenan TW. Adipophilin is a specific marker of lipid accumulation in diverse cell types and diseases. Cell Tissue Res 294: 309-321, 1998.
18. 1, its type II receptor, and activation of the Smad signaling pathway in the db/db mouse. Am J Pathol 158: 1653-1663, 2001.
19. Ibrahim HN and Hostetter TH. Diabetic nephropathy. J Am Soc Nephrol 8: 487-493, 1997.
20. Jiang HP and Serrero G. Isolation and characterization of a full-length cDNA coding for an adipose differentiation-related protein. Proc Natl Acad Sci USA 89: 7856-7860, 1992.
21. Keane WF. The role of lipids in renal disease: future challenges. Kidney Int 57: S27-S31, 2000.
22. Lee CH, Olson P, and Evans RM. Lipid metabolism, metabolic diseases, and peroxisome proliferator-activated receptors. Endocrinology 144: 2201-2207, 2003.
23. Lee GH, Proenca R, Montez JM, Carroll KM, Darvishzadeh JG, Lee JI, and Friedman JM. Abnormal splicing of the leptin receptor in diabetic mice. Nature 379: 632-635, 1996.
24. Like AA, Lavine RL, Poffenbarger PL, and Chick WL. Studies in the diabetic mouse. VI. Evolution of glomerular lesions and associate proteinuria. Am J Pathol 66: 193-224, 1972.
25. Livak KJ and Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2-ΔΔCT method. Methods 25: 402-408, 2001.
26. Londos C, Brasaemle DL, Schultz CJ, Segrest JP, and Kimmel AR. Perilipins, ADRP, and other proteins that associate with intracellular neutral lipid droplets in animal cells. Semin Cell Dev Biol 10: 51-58, 1999.
27. Mason RM and Abdel Wahab N. Extracellular matrix metabolism in diabetic nephropathy. J Am Soc Nephrol 14: 1358-1373, 2003.
28. Meyer T. Immunosuppresion for diabetic glomerular disease. Kidney Int 63: 377-378, 2003.
29. Mishra R, Leahy P, and Simonson M. Gene expression profiling reveals role for EGF-family ligands in mesangial cell proliferation. Am J Physiol Renal Physiol 283: F1151-F1159, 2002.
30. Ong AC and Moorhead JF. Tubular lipidosis: epiphenomenon or pathogenetic lesion in human renal disease? Kidney Int 45: 753-762, 1994.
31. Ouali F, Djouadi F, Merlet-Benichou C, and Bastin J. Dietary lipids regulate β-oxidation enzyme gene expression in the developing rat kidney. Am J Physiol Renal Physiol 275: F777-F784, 1998.
32. Phillips AO and Steadman R. Diabetic nephropathy: the central role of renal proximal tubular cells in tubulointerstitial injury. Histol Histopathol 17: 247-252, 2002.
33. Ruan XZ, Varghese Z, and Moorhead JF. Inflammation modifies lipid-mediated renal injury. Nephrol Dial Transplant 18: 27-32, 2003.
34. Sahadevan M and Kasiske BL. Hyperlipidemia in kidney disease: causes and consequences. Curr Opin Nephrol Hypertens 11: 323-329, 2002.
35. Sharma K, McCue P, and Dunn SR. Diabetic kidney disease in the db/db mouse. Am J Physiol Renal Physiol 284: F1138-F1144, 2003.
36. Sharma K and Ziyadeh FN. Hyperglycemia and diabetic kidney disease. The case for transforming growth factor-β as a key mediator. Diabetes 44: 1139-1146, 1995.
37. Simonson M, Robinson A, Schulak J, and Hricik D. Inhibition of endothelin-1 improves survival and vasculopathy in rat cardiac transplants treated with cyclosporine. Transplantation 73: 1054-1059, 2002.
38. Simonson MS, Emancipator SN, Knauss T, and Hricik DE. Elevated neointimal endothelin-1 in transplantation-associated arteriosclerosis of renal allograft recipients. Kidney Int 54: 960-971, 1998.
39. Smulders YM, van Eeden AE, Stehouwer CD, Weigers RN, Slaats EH, and Silberbusch J. Can reduction in hypertriglyceridaemia slow progression of microalbuminuria in patients with non-insulin-dependent diabetes mellitus? Eur J Clin Invest 27: 997-1002, 1997.
40. Storey JD. A direct approach to false discovery rates. J Royal Stat Soc, Ser B 64: 479-498, 2002.
41. Storey JD and Tibshirani R. SAM thresholding and false discovery rates for detecting differential expression in DNA microarrays. In: The Analysis of Gene Expression Data: Methods and Software, edited by Parmigiani G, Garrett ES, Irizarry RA, and Zeger SL. New York: Springer, 2003, p. 320-349.
42. Sun L, Halaihel N, Zhang W, Rogers T, and Levi M. Role of sterol regulatory element-binding protein 1 in regulation of renal lipid metabolism and glomerulosclerosis in diabetes mellitus. J Biol Chem 277: 18919-18927, 2002.
43. Tansey JT, Sztalryd C, Gruia-Gray J, Roush DL, Zee JV, Gavrilova O, Reitman ML, Deng CX, Li C, Kimmel AR, and Londos C. Perilipin ablation results in a lean mouse with aberrant adipocyte lipolysis, enhanced leptin production, and resistance to diet-induced obesity. Proc Natl Acad Sci USA 98: 6494-6499, 2001.
44. Thomsen JL and Hansen TP. Lipids in the proximal tubules of the kidney in diabetic coma. Am J Forensic Med Pathol 21: 416-418, 2000.
45. Tusher VG, Tibshirani R, and Chu G. Significance analysis of microarrays applied to the ionizing radiation response. Proc Natl Acad Sci USA 98: 5116-5121, 2001.
46. Unger RH. Lipotoxic diseases. Annu Rev Med 53: 319-336, 2002.
47. Wada J, Makino H, and Kanwar YS. Gene expression and identification of gene therapy targets in diabetic nephropathy. Kidney Int 61: 73-78, 2002.
48. Wada J, Zhang H, Tsuchiyama Y, Hiragushi K, Hida K, Shikata K, Kanwar YS, and Makino H. Gene expression profile in streptoxotocin-induced diabetic mice kidneys undergoing glomerulosclerosis. Kidney Int 59: 1363-1373, 2001.
49. Yagyu H, Chen G, Yakoyama M, Hirata K, Augustus A, Kako Y, Seo T, Hu Y, Lutz EP, Merkel M, Bensadoun A, Homma S, and Goldberg IJ. Lipoprotein lipase (LpL) on the surface of cardiomyocytes increases lipid uptake and produces cardiomyopathy. J Clin Invest 111: 419-426, 2003.
50. Zhou YT, Grayburn P, Karim A, Shimabukuro M, Higa M, Baetens D, Orci L, and Unger RH. Lipotoxic heart disease in obese rats: implications for human obestity. Proc Natl Acad Sci USA 97: 1784-1789, 2000.
51. Ziyadeh FN, Hoffman BB, Han DC, Iglesias MC, Hong SW, Isono M, Chen S, McGowen TA, and Sharma K. Long-term prevention of renal insufficiency, excess matrix gene expression, and glomerular mesangial matrix expansion by treatment with monoclonal anti-transforming growth factor beta antibody in db/db diabetic mice. Proc Natl Acad Sci USA 97: 7667-7669, 2000.