Inhibition of cardiac hERG potassium channels by tetracyclic antidepressant mianserin

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 378, Issue 1, 2008, Pages 73-83

  Scherer, Daniel ^a   Von Löwenstern, Katharina ^a   Zitron, Edgar ^a   Scholz, Eberhard P ^a   Bloehs, Ramona ^a   Kathöfer, Sven ^a   Thomas, Dierk ^a   Bauer, Alexander ^a   Katus, Hugo A ^a   Karle, Christoph A ^a   Kiesecker, Claudia ^a  

^a UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

Author keywords

Acquired Long QT; Antidepressant; Arrhythmia; hERG; Mianserin; Potassium channel

Indexed keywords

AMITRIPTYLINE; FLUOXETINE; MIANSERIN; POTASSIUM CHANNEL HERG;

ANIMAL CELL; ARTICLE; CELL STRAIN HEK293; CONTROLLED STUDY; DRUG EFFECT; HUMAN; HUMAN CELL; IC 50; NONHUMAN; OOCYTE; PATCH CLAMP; QT PROLONGATION; VOLTAGE CLAMP; XENOPUS;

ANIMALS; ANTIDEPRESSIVE AGENTS, SECOND-GENERATION; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHYSIOLOGY; ETHER-A-GO-GO POTASSIUM CHANNELS; FEMALE; HUMANS; INHIBITORY CONCENTRATION 50; KIDNEY; MIANSERIN; OOCYTES; PATCH-CLAMP TECHNIQUES; TOXICITY TESTS; XENOPUS;

EID: 45849127940     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00210-008-0289-4     Document Type: Article

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