Blockade of the HERG human cardiac K+ channel by the antidepressant drug amitriptyline

British Journal of Pharmacology

Volumn 129, Issue 7, 2000, Pages 1474-1480

  Jo, Su Hyun ^a   Youm, Jae Boum ^b   Lee, Chin O ^a   Earm, Yung E ^b   Ho, Won Kyung ^b  

^a Pohang University of Science and Technology (POSTECH)   (South Korea)

^b Seoul National University College of Medicine   (South Korea)

Author keywords

Amitriptyline; HERG channel; LQT; Torsades de pointes; Use dependence; Voltage dependence

Indexed keywords

AMITRIPTYLINE; ANTIDEPRESSANT AGENT; POTASSIUM CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DEPOLARIZATION; DOSE RESPONSE; DRUG EFFECT; HEART ATRIUM MUSCLE; HEART MUSCLE CELL; NONHUMAN; OOCYTE; POTASSIUM CURRENT; PRIORITY JOURNAL; RAT; XENOPUS;

EID: 0034026769     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0703222     Document Type: Article

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