Nutrigenomic analysis of diet-gene interactions of functional supplements for weight management

Current Genomics

Volumn 9, Issue 4, 2008, Pages 239-251

  Lau, Francis C ^a   Bagchi, Manashi ^a   Sen, Chandan ^b   Roy, Sashwati ^b   Bagchi, Debasis ^a,c  

^a InterHealth Nutraceuticals Inc   (United States)

^b THE OHIO STATE UNIVERSITY WEXNER MEDICAL CENTER   (United States)

^c CREIGHTON UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

( ) Hydroxycitric acid; Cardiovascular disease; Diabetes; Garcinia cambogia; Glucose tolerance factor; Insulin resistance; Microarrays; Nutrigenomics; Nutritional interventions; Obesity; Overweight; Supplemental chromium

Indexed keywords

ACETYL COENZYME A; CALCIUM SALT; CALSEQUESTRIN; CHROMEMATE; CHROMIUM DERIVATIVE; CHROMIUM PICOLINATE; COMPLEMENTARY DNA; ENOLASE; EPOXIDE HYDROLASE; GARCINIA CAMBOGIA EXTRACT; GLUCOSE 6 PHOSPHATE ISOMERASE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HYDROXYCITRIC ACID; INSULIN; INTERSTITIAL COLLAGENASE; LEPTIN; LIPODEX 2; NICOTINIC ACID DERIVATIVE; PERILIPIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PHENTERMINE; PLACEBO; POTASSIUM SALT; RIMONABANT; SEROTONIN RECEPTOR; SIBUTRAMINE; STROMELYSIN 2; SUPER CITRIMAX; TETRAHYDROLIPSTATIN; TISSUE PLASMINOGEN ACTIVATOR; TRACE ELEMENT; TROPOMYOSIN; UNINDEXED DRUG;

ABDOMINAL OBESITY; ADIPOGENESIS; ANTIANGIOGENIC ACTIVITY; BROWN ADIPOSE TISSUE; CHRONIC DISEASE; CLINICAL TRIAL; DIABETIC OBESITY; DIET; DIET SUPPLEMENTATION; DIET THERAPY; DISEASE ASSOCIATION; DNA MICROARRAY; DRUG EFFICACY; DRUG SAFETY; EPIDEMIC; EXERCISE; GARCINIA CAMBOGIA; GENE EXPRESSION PROFILING; GENE INTERACTION; GENETIC ANALYSIS; HUMAN; LIPOLYSIS; LOW DRUG DOSE; MALIGNANT NEOPLASTIC DISEASE; METABOLIC DISORDER; MOLECULAR BIOLOGY; NONHUMAN; NUTRIGENOMICS; NUTRITIONAL SCIENCE; OBESITY; PREVALENCE; PROTEIN SYNTHESIS INHIBITION; RECEPTOR UPREGULATION; REVIEW; SOCIOECONOMICS; WEIGHT REDUCTION; WORLD HEALTH ORGANIZATION;

GARCINIA CAMBOGIA; MUS; RATTUS;

EID: 45749107833     PISSN: 13892029     EISSN: None     Source Type: Journal    
DOI: 10.2174/138920208784533638     Document Type: Review

References (122)

1. Ordovas, J. M. The quest for cardiovascular health in the genomic era: nutrigenetics and plasma lipoproteins. Proc. Nutr. Soc. 2004, 63: 145-152.
2. kaput, J., Noble, J., Hatipoglu, B., Kohrs, K.; Dawson, K., Bartholomew, A. Application of nutrigenomic concepts to Type 2 diabetes mellitus. Nutr. Metab. Cardiovasc. Dis. 2007, 17: 80-103.
3. Afman, L., Muller, M. Nutrigenomics from molecular nutrition to prevention of disease. J. Am. Diet Assoc. 2006, 106: 569-576.
4. Ferguson, L. R. Nutrigenomics: integrating genomic approaches into nutrition research. Mol. Diagn. Ther. 2006, 10: 101-108.
5. http://whqlibdoc.who.int/trs/WHO_TRS_894_(part1).pdf (Accessed 2000).
6. http://www.who.int/nutrition/topics/obesity/en/index.html. (Accessed 2007).
7. Caballero, B. The Global Epidemic of Obesity: An Overview. Epidemiol. Rev. 2007.
8. Chopra, M., Galbraith, S., Damton-Hill, I. A global response to a global problem: the epidemic of overnutrition. Bull. World Health Organ. 2002, 80: 952-958.
9. Ogden, C. L., Flegal, K. M., Carroll, M. D., Johnson, C. L. Prevalence and trends in overweight among US children and adolescents, 1999-2000. JAMA 2002, 288: 1728-1732.
10. Flegal, K. M., Carroll, M. D., Ogden, C. L., Johnson, C. L. Prevalence and trends in obesity among US adults, 1999-2000. JAMA 2002, 288: 1723-1727.
11. Hedley, A. A., Ogden, C. L., Johnson, C. L., Carroll, M. D., Curtin, L. R., Flegal, K. M.: Prevalence of overweight and obesity among. US children, adolescents, and adults, 1999-2002. JAMA 2004, 291: 2847-2850.
12. Bachman, K H. Obesity, weight management, and health care costs: a primer. Dis. Manag. 2007, 10: 129-137.
13. NIH. Clinical Guidelines on the Identification, Evaluation, and Treatment of Overweight and Obesity in Adults: The Evidence Report. Place Published, 2000.
14. http://www.cdc.gov/nchs/fastats/overwt.htm. (Accessed July 2007).
15. Wang, Y., Beydoun, M. A. The Obesity Epidemic in the United States - Gender, Age, Socioeconomic, Racial/Ethnic, and Geographic Characteristics: A Systematic Review and Meta-Regression Analysis. Epidemiol. Rev. 2007, 29: 6-28.
16. Ross, R., Dagnone, D., Jones, P. J., Smith, H., Paddags, A., Hudson, R., Janssen, I. Reduction in obesity and related comorbid conditions after diet-induced weight loss or exercise-induced weight loss in men. A randomized, controlled trial. Ann. Intern. Med. 2000, 133: 92-103.
17. Blackburn, G. L. Treatment approaches: food first for weight management and health. Obes. Res. 2001, 9(Suppl 4): 223S-227S.
18. http://www.mypyramid.gov/. (Accessed 2007).
19. Pittler, M. H., Ernst, E.: Dietary supplements for body-weight reduction: a systematic review. Am. J. Clin. Nutr. 2004, 79: 529-536.
20. Bagchi, M., Preuss, H. G., Zafra-Stone, S.,,Bagchi, D., in: Bagchi, D., Preuss, H. G. (Eds.), Obesity: Epidemiology, Pathophysiology, and Prevention, CRC Press, Boca Raton 2007, pp. 339-347.
21. Zafra-Stone, S., Bagchi, M., Preuss, H. G., Grover, G. J., Bagchi, D., in: Bagchi, D., Preuss, H. G. (Eds.), Obesity: Epidemiology, Pathophysiology, and Prevention, CRC Press, Boca Raton 2007, pp. 349-370.
22. Mariman, E. C. Nutrigenomics and nutrigenetics: the 'omics' revolution in nutritional science. Bioteahnol. Appl. Biochem. 2006, 44: 119-128.
23. Mutch, D. M., Wahli, W., Williamson, G.: Nutrigenomics and nutrigenetics: the emerging faces of nutrition. FASEB J 2005, 49: 1602-1616.
24. Kaput, J., Rodriguez, R. L. Nutritional genomics: the next frontier in the postgenomic era. Physiol. Genomics 2004; 16: 166-177.
25. Corthesy-Theulaz, I., den Dunnen, J. T., Ferre, P., Geurts, J. M., Muller, M., van Belzen, N., van Ommen, B. Nutrigenomics: the impact of biomics technology on nutrition research. Ann. Nutr. Metab. 2005, 49: 355-365.
26. Gillies, P. J. Nutrigenomics: the Rubicon of molecular nutrition. J. Am. Diet. Assoc. 2003, 103: S50-55.
27. Elliott, R. M., Johnson, I. T. Nutrigenomic approaches for obesity research. Obes. Rev. 2007, 8(Suppl 1): 77-81.
28. Ahima, R. S. Obesity: much silence makes a mighty noise. Gastro-enterology 2007, 132: 2085-2086.
29. Gibbs, W. W. Obesity: an overblown epidemic? Sci. Am. 2005, 292: 70-77.
30. http://www.surgeongeneral.gov/topics/obcsity/calltoaction/Callto Action.pdf. (Accessed August, 2007).
31. Haffner, S., Taegtmeyer, H. Epidemic obesity and the metabolic syndrome. Circulation 2003, 108: 1541-1545.
32. Dburandhar, N. V., Kulkarni, P. R., Ajinkya, S. M., Sherikar, A. A., Atkinson, R. L. Association of adenovirus infection with human obesity. Obes. Res. 1997, 5: 464-469.
33. Atkinson, R. L., Dhurandhar, N. V., Allison, D. B., Bowen, R. L., Israel, B. A., Albu, J. B., Augustus, A. S. Human adenovirus-36 is associated with increased body weight and paradoxical reduction of serum lipids. Int. J. Obes. (Lond.) 2005, 29: 281-286.
34. Whigham, L. D., Israel, B. A., Atkinson, R. L. Adipogenic potential of multiple human adenoviruses in vivo and in vitro in animals. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2006, 290: R190-194.
35. Ley, R. E., Turnbaugh, P. J., Klein, S., Gordon, J. I. Microbial ecology: human gut microbes associated with obesity. Nature 2006, 444: 1022-1023.
36. Turnbaugh, P. J., Ley, R. E., Mahowald, M. A., Magrini, V., Mardis, E. R., Gordon, J. I. An obesity-associated gut microbiome with increased capacity for energy harvest. Nature 2006, 444: 1027-1031.
37. Livingston, E. H., Fink, A. S. Quality of life: cost and future of bariatric surgery. Arch. Surg. 2003, 138: 383-388.
38. Peeters, A., Barendregt, J. J., Willekens, F., Mackenbach, J. P., AI Maroon, A., d Bonneux, L. Obesity in adulthood and its consequences for life expectancy: a life-table analysis. Ann. Intern. Med. 2003, 138: 24-32.
39. Haslam, D. Obesity: a medical history. Obes. Rev. 2007, 8(Suppl 1): 31-36.
40. Shaw, D. I., Hall, W. L., Williams, C. M. Metabolic syndrome: what is it and what are the implications? Proc. Nutr. Soc. 2005, 64: 349-357.
41. Haslam, D. W., James, W. P. Obesity. Lancet 2005, 366: 1197-1209.
42. Joyal, S. V. A perspective on the current strategies for the treatment of obesity. Curr. Drug Targets CNS Neurol. Disord. 2004, 3: 341-356.
43. Walker, C. G., Zariwala, M. G., Holness, M. J., Sugden, M. C. Diet, obesity and diabetes: a current update. Clin. Sci. (Lond.) 2007, 112: 93-111.
44. From the NIH: Successful diet and exercise therapy is conducted in Vermont for "diabesity". JAMA 1980, 243: 519-520.
45. Astrup, A., Finer, N. Redefining type 2 diabetes: 'diabesity' or 'obesity dependent diabetes mellitus'? Obes. Rev. 2000, 1: 57-59.
46. McTigue, K. M., Harris, R., Hemphill, B., Lux, L., Sutton, S., Bunton, A. J., Lohr, K. N. Screening and interventions for obesity in adults: summary of the evidence for the U.S. Preventive Services Task Force. Ann. Intern. Med. 2003, 139: 933-949.
47. Bray, G. A. Medical consequences of obesity. J. Clin. Endocrinol. Metab. 2004, 89: 2583-2589.
48. Anderson, J. W., Konz, E. C. Obesity and disease management: effects of weight loss on comorbid conditions. Obes. Res. 2001, 9 (Suppl 4): 326S-334S.
49. Bray, G. A. The missing link - lose weight, live longer. N. Engl. J. Med. 2007, 357: 818-820.
50. Wadden, T. A., Butryn, M. L., Wilson, C. Lifestyle modification for the management of obesity. Gastroenterology 2007, 132: 2226-2238.
51. Pi-Sunyer, F. X. The obesity epidemic: pathophysiology and consequences of obesity. Obes. Res. 2002, 10(Suppl 2): 97S-104S.
52. Schnee, D. M., Zaiken, K., McCloskey, W. W. An update on the pharmacological treatment of obesity. Curr. Med. Res. Opin. 2006, 22: 1463-1474.
53. 2, C. A., Ryan, D. H. Drug treatment of the overweight patient. Gastroenterology 2007, 132: 2239-2252.
54. Zafra-Stone, S., Bagchi, M., Preuss, H. G., Bagchi, D., in: Vincent, J. B. (Ed.), The nutritional biochemistry of chromium (III), Elsevier, Amsterdam 2007, pp. 183-206.
55. Lefavi, R. G., Anderson, R. A., Keith, R. E., Wilson, G. D., McMillan, J. L., and, Stone, M. H.: Efficacy of chromium supplementation in athletes: emphasis on anabolism. Int. J. Sport Nutr. 1992, 2: 111-122.
56. Meriz, W. Chromium research from a distance: from 1959 to 1980. J. Am. Coll. Nutr. 1998, 17: 544-547.
57. Shapcott, D; Hubert, J., Proceedings of the Symposium on Chromium in Nutrition and Metabolism, held in Sherbrooke, Canada on July 13-15, 1979, Elsevier/North-Holland Biomedical Press, Amsterdam 1979.
58. Mertz, W. Effects and metabolism of glucose tolerance factor. Nutr. Rev. 1975, 33:129-135.
59. Mertz, W. Chromium in human nutrition: a review. J. Nutr. 1993, 123: 626-633.
60. Mertz W., Toepfer, E. W., Roginski, E. E., Polansky, M. M. Present knowledge of the role of chromium. Fed. Proc. 1974, 33: 2275-2280.
61. Grant K. E, Chandler, R. M., Castle, A. L., Ivy, J. L. Chromium and exercise training: effect on obese women. Med. Sci. Sports Exerc. 1997, 29: 992-998.
62. Crawford, V., Scheckenbach, R., Preuss, H. G. Effects of niacinbound chromium supplementation on body composition in over-weight African-American women. Diabetes Obes. Metab. 1999, 1: 331-337.
63. Preuss, H. G., Garis, R. I., Bramble, J. D., Bagchi, D., Bagchi, M., Rao, C. V., Satyaharayana, S. Efficacy of a novel calcium/potassium salt of (-)-hydroxycitric acid in weight control. Int J. Clin. Pharmacol. Res. 2005, 25:133-144.
64. Downs, B. W., Bagchi, M., Subbaraju, G. V., Shara, M. A., Preuss, H. G., Bagchi, D. Bioefficacy of a novel calcium-potassium salt of (-)-hydroxycitric acid. Mutat. Res. 2005, 579: 149-162.
65. Shara; M., Ohia, S. E., Schmidt, R. E., Yasmin, T., Zardetto-Smith, A., Kincaid, A., Bagchi, M., Chatterjee, A., Bagchi, D., Stohs, S. J. Physico-chemical properties of a novel (-)-hydroxycitric acid extract and its effect on body weight, selected organ weights, hepatic lipid peroxidation and DNA fragmentation, hematology and clinical chemistry, and histopathological changes over a period of 90 days. Mol. Cell Biochem. 2004, 260: 171-186.
66. Preuss, H. G., Bagchi, D., Bagchi, M., Rao, C. V., Dey, D. K., Satyanarayana, S. Effects of a natural extract of (-)-hydroxycitric acid (HCA-SX) and a combination of HCA-SX plus niacin-bound chromium and Gymnema sylvestre extract on weight loss. Diabetes Obes. Metab. 2004, 6:171-180.
67. Shara, M., Ohia, S. E., Yasmin, T., Zardetto-Smith, A., Kincaid, A., Bagchi, M., Chatterjee, A., Bagchi, D., Stohs, S. J. Dose- and time-dependent effects of a novel (-)-hydroxycitric acid extract on body weight, hepatic and testicular lipid peroxidation, DNA fragmentation and bistopathological data over a period of 90 days. Mol. Cell Biochem. 2003, 254:339-346.
68. Ohia S. E., Opere. C. A., LeDay, A. M., Bagchi, M., Bagchi, D., Stohs, S. J. Safety and mechanism of appetite suppression by a novel hydroxycitric acid extract (HCA-SX). Mol. Cell Biochem. 2002, 238: 89-103.
69. Soni, M. G., Burdock, G. A., Preuss, H. G., Stohs, S. J., Ohia, S. E., Bagchi, D. Safety assessment of (-)-hydroxycitric acid and Super CitriMax, a novel calcium/potassium salt. Food Chem. Toxicol. 2004, 42:1513-1529.
70. Asghar. M.. Monjok, E., Kouamou, G., Ohia, S. E., Bagchi, D., Lokhandwala, M. F. Super CitriMax (HCA-SX) attenuates increases in oxidative stress, inflammation, insulin resistance, and body weight in developing obese Zucker rats. Mol. Cell Biochem. 2007.
71. Conte, A. A. A non-prescription alternative in weight reduction therapy. Am. J. Bariatr. Med. 1993, 17.
72. Thom, E. Hydroxycitrite (HCA) in the treatment of obesity. Int. J. Obes. Relat. Metab. Disord. 1996, 20:75.
73. Mertz, W. Chromium-occurrence and function in biological systems. Physiol. Rev. 1969, 49: 163-239.
74. Haylock, S. J., Buckley, P. D., and Blackwell, L. F.: The relationship of chromium to the glucose tolerance factor. II. J. Inorg. Biochem. 1983, 19:105-117.
75. Mirsky, N., Weiss, A., Dori, Z. Chromium in biological systems, I. Some observations on glucose tolerance factor in yeast. J. Inorg. Biochem. 1980, 13:11-21.
76. Yamamoto, A., Wada, O., Ono, T. A low-molecular-weight, chromium-binding substance in mammals. Toxicol. Appl. Pharmacol. 1981, 59:515-523.
77. Rink, C., Roy, S., Khanna, S., Rink, T., Bagchi, D., Sen, C. K. Transcriptome of the subcutaneous adipose tissue in response to oral supplementation of type 2 Leprdb obese diabetic mice with niacin-bound chromium. Physiol. Genomics 2006, 27: 370-379.
78. Kocaefe, Y. C., Israeli, D., Ozguc, M., Danos, O., Garcia, L. Myogenic program induction in mature fat tissue (with MyoD expression). Exp. Cell Res. 2005, 308: 300-308.
79. Comi, G. P., Fortunato, F., Lucchiari, S., Bordoni, A., Prelle, A., Jann, S., Keller, A., Ciscato, P., Galbiati, S., Chiveri, L., Torrente, Y., Scarlato,. G., Bresolin, N. Beta-enolase deficiency, a new metabolic myopathy of distal glycolysis. Ann. Neurol. 2001, 50: 202-207.
80. Baranova, A., Collantes, R., Gowder, S. J., Elariny, H., Schlauch, K., Younoszai, A., King, S., Randhawa, M., Pusulury, S., Alsheddi, T., Ong, J. P., Martin, L. M., Chandhoke, V., Younossi, Z. M. Obesity-related differential gene expression in the visceral adipose tissue. Obes. Surg. 2005, 15: 758-765.
81. Moore, J. W., Maher, M. A., Banz, W. J., Zeinel, M. B. Chromium picolinate modulates rat vascular smooth muscle cell intracellular calcium metabolism. J. Nutr. 1998, 128: 180-184.
82. McCarty, M. F. PKC-mediated modulation of L-type calcium channels may contribute to fat-induced insulin resistance. Med. Hypotheses 2006, 66: 824-831.
83. Eyre, H., Akkari, P. A., Wilton, S. D., Callen, D. C., Baker, E., Laing, N. G. Assignment of the human skeletal muscle alpha-tropomyosin gene (TPMI) to band l5q22 by fluorescense in situ hybridization. Cytogenet. Cell Genet. 1995, 69: 15-17.
84. Ruiz-Opazo, N., Weinberger, J., Nadal-Ginard, B. Comparison of alpha-tropomyosin sequences from smooth and striated muscle. Nature 1985, 315: 67-70.
85. Gordon, A. M., Homsher, E., Regnier, M. Regulation of contraction in striated muscle. Physiol. Rev. 2000, 80: 853-924.
86. Stocker, A. Molecular mechanisms of vitamin E transport. Ann. N. Y. Acad. Sci. 2004, 1031: 44-59.
87. Bjornson, L. K., Gniewkowski, C., Kayden, H. J. Comparison of exchange of alpha-tocopherol and free cholesterol between rat plasma lipoproteins and erythrocytes. J. Lipid Res. 1975, 16: 39-53.
88. Traber, M. G., Burton, G. W., Hamilton, R. L.: Vitamin E trafficking. Ann. N. Y. Acad Sci. 2004, 1031: 1-12.
89. Cinti, S. Adipocyte differentiation and transdifferentiation: plasticity of the adipose organ. J. Endocrinol. Invest. 2002, 25: 823-835.
90. Zhou, Z., Yon Toh, S., Chen, Z., Guo, K., Ng, C. P., Ponniah, S., Lin, S. C., Hong, W., Li, P. Cidea-deficient mice have lean phenotype and are resistant to obesity. Nat Genet. 2003, 35: 49-56.
91. Roy, S., Rink, C., Khanna, S., Phillips, C., Bagchi, D., Bagchi, M., Sen, C. K. Body weight and abdominal fat gene expression profile in response to a novel hydroxycitric acid-based dietary supplement. Gene Expr. 2004, 11: 251-262.
92. Li, C., Wong, W. H. Model-based analysis of oligonucleotide arrays: expression index computation and outlier detection. Proc. Natl. Acad. Sci. USA 2001, 98: 31-36.
93. Ohia, S. E., Awe, S. O., LeDay, A. M., Opere, C. A., Bagchi, D. Effect of hydroxycitric acid on serotonin release from isolated rat brain cortex. Res. Commun. Mol. Pathol. Pharmacol. 2001, 109: 210-216.
94. Langin, D., Dicker, A., Tavernier, G., Hoffstedt, J., Mairal, A., Ryden, M., Amer, E., Sicard, A., Jenkins, C. M., Viguerie, N., van Harmelen, V., Gross, R. W., Holm, C., Amer, P. Adipocyte lipases and defect of lipolysis in human obesity. Diabetes 2005, 54: 3190-3197.
95. Roy, S., Shah, H., Rink, C., Khanna, S., Bagchi, D., Bagchi, M., Sen, C. K. Transcriptome of primary adipocytes from obese women in response to a novel hydroxycitric acid-based dietary supplement. DNA Cell Biol. 2007, 26:627-639.
96. Garcia, A., Sekowski, A., Subramanian, V., Brasaemle, D. L. The central domain is required to target and anchor perilipin A to lipid droplets. J. Biol. Chem. 2003, 278: 625-635.
97. Lin, J., Handschin, C., Spiegelman, B. M. Metabolic control through the PGC-1 family of transcription coactivators. Cell Metab. 2005, 1: 361-370.
98. Kim, B. W., Choo, H. J., Lee, J. W., Kim, J. H., Ko, Y. G. Extracellular ATP is generated by ATP synthase complex in adipocyte lipid rafts. Exp. Mol. Med. 2004, 36: 476-485.
99. Gloerich, J., Ruiter, J. P., van den Brink, D. M., Ofman, R., Ferdinandusse, S., Wanders, R. J. Peroxisomal trans-2-enoyl-CoA reductase is involved in phytol degradation. FEBS Lett. 2006, 580: 2092-2096.
100. Schluter, A, Yubero, P., Iglesias, R., Giralt, M., Villarroya, F. The chlorophyll-derived metabolite phytanic acid induces white adipocyte differentiation. Int. J. Obes. Relat. Metab. Disord. 2002, 26: 1277-1280.
101. Jaye, M., Lynch, K. J., Krawiec, J., Marchadier, D., Maugeais, C., Doan, K., South, V., Amin, D., Perrone, M., Rader, D. J. A novel endothelial-derived lipase that modulates HDL metabolism. Nat. Genet. 1999, 21: 424-428.
102. Ahmed, W., Orasanu, G., Nehra, V., Asatryan, L., Rader, D. J., Ziouzenkova, O., Plutzky, J, High-density lipoprotein hydrolysis by endothelial lipase activates PPARalpha: a candidate mechanism for high-density lipoprotein-mediated repression of leukocyte adhesion. Circ. Res. 2006, 98: 490-498.
103. Westerberg, R., Tvrdik, P., Unden, A. B., Mansson, J. E., Norlen, L., Jakobsson, A., Holleran, W. H., Elias, P. M., Asadi, A., Flodhy, P., Toftgard, R., Capecchi, M. R., Jacobsson, A. Role for ELOVL3 and fatty acid chain length in development of hair and skin function. J. Biol. Chem. 2004, 279: 5621-5629.
104. Westerberg, R., Mansson, J. E., Golozoubova, V., Shabalina, I. G., Backlund, E. C., Tvrdik, P., Retterstol, K., Capecchi, M. R., Jacobsson, A.: ELOVL3 is an important component for early onset of lipid recruitment in brown adipose tissue. J. Biol. Chem. 2006, 281: 4958-4968.
105. Przybyla-Zawislak, B. D., Srivastava, P. K., Vazquez-Matias, J., Mohrenweiser, H. W., Maxwell, J. E., Hammock, B. D., Bradbury, J. A., Enayetallah, A. E., Zeldin, D. C., Grant, D. F. Polymorphisms in human soluble epoxide hydrolase. Mol. Pharmacol. 2003, 64:482-490.
106. Lee, C. R., North, K. E., Bray, M. S., Fornage, M., Seubert, J. M., Newman, J. W., Hammock, B. D., Couper, D. J., Heiss, G., Zeldin, D. C. Genetic variation in soluble epoxide hydrolase (EPHX2) and risk of coronary heart disease: The Atherosclerosis Risk in Communities (ARIC) study. Hum. Mol. Genet. 2006, 15: 1640-1649.
107. Wei, Q., Doris, P. A., Pollizotto, M. V., Boerwinkle, E., Jacobs, D. R., Jr., Siscovick, D. S., Fornage, M. Sequence variation in the soluble epoxide hydrolase gene and subclinical coronary atherosclerosis: interaction with cigarette smoking. Atherosclerosis 2007, 190: 26-34.
108. Dannewitz, B., Edrich, C., Tomakidi, P., Kohl, A., Gabbert, O., Eickholz, P., Steinberg, T. Elevated gene expression of MMP-1, MMP-10, and TIMP-1 reveal changes of molecules involved in turn-over of extracellular matrix in cyclosporine-induced gingival overgrowth. Cell Tissue Res. 2006, 325: 513-522.
109. Figueroa, J., Vijayagopal, P., Debata, C., Prasad, A., Prasad, C. Azaftig, a urinary proteoglycan from a cachectic cancer patient, causes profound weight loss in mice. Life Sci. 1999, 64: 1339-1347.
110. Obunike, J. C., Sivaram, P., Paka, L., Low, M. G., Goldberg, I. J. Lipoprotein lipase degradation by adipocytes: receptor-associated protein (RAP)-sensitive and proteoglycan-mediated pathways. J. Lipid Res. 1996, 37: 2439-2449.
111. Maquoi, E., Demeulemeester, D., Voros, G., Collen, D., Lijnen, H. R. Enhanced nutritionally induced adipose tissue development in mice with stromelysin-1 gene inactivation. Thromb. Haemost. 2003, 89: 696-704.
112. Sasaki, K., Takagi, M., Konttinen, Y. T., Sasaki, A., Tamaki, Y., Ogino, T., Santavirta, S., Salo, J. Upregulation of matrix metalloproteinase (MMP)-1 and its activator MMP-3 of human osteoblast by uniaxial cyclic stimulation. J. Biomed. Mater. Res. B Appl. Biomater. 2007, 80:491-498.
113. Lijnen, H. R., Van, H. B., Frederix, L., Rio, M. C., Collen, D. Adipocyte hypertrophy in stromelysin-3 deficient mice with nutritionally induced obesity. Thromb. Haemost. 2002, 87:530-535.
114. Chang, S., Young, B. D., Li, S., Qi, X., Richardson, J. A., Olson, E. N. Histone deacetylase 7 maintains vascular integrity by repressing matrix metalloproteinase 10. Cell 2006, 126: 321-334.
115. Cao, Y. Angiogenesis modulates adipogenesis and obesity. J. Clin. Invest. 2007, 117: 2362-2368.
116. Van Guilder, G. P., Hoetzer, G. L., Smith, D. T., Irmiger, H. M., Greiner, J. J., Stauffer, B. L., DeSouza, C. A. Endothelial t-PA release is impaired in overweight and obese adults but can be improved with regular aerobic exercise. Am. J. Physiol. Endocrinol. Metab. 2005, 289: E807-813.
117. Friedman, J. M., Halaas, J. L. Leptin and the regulation of body weight in mammals. Nature 1998, 395: 763-770.
118. Friedman, J. M. Leptin, leptin receptors, and the control of body weight. Nutr. Rev. 1998, 56: s38-46; discussion s54-75.
119. Cohen, P., Zhao, C., Cai, X., Montez, J. M., Rohani, S. C., Feinstein, P., Mombaerts, P., Friedman, J. M. Selective deletion of leptin receptor in neurons leads to obesity. J. Clin. Invest. 2001, 108: 1113-1121.
120. Wittert, G. A., Turnbull, H., Hope, P., Morley, J. E., Horowitz, M. Leptin prevents obesity induced by a high-fat diet after diet-induced weight loss in the marsupial S. crassicaudata. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2004, 286: R734-739.
121. Nijhuis, J., Van Dielen, F. M., Buurman, W. A., Greve, J. W. Leptin in morbidly obese patients: no role for treatment of morbid obesity but important in the postoperative immune response. Obes. Surg. 2004, 14:476-483.
122. Liu-Stratton, Y., Roy, S., Sen, C. K. DNA microarray technology in nutraceutical and food safety. Toxicol. Lett. 2004, 150: 29-42.