High-density lipoprotein hydrolysis by endothelial lipase activates PPARα: A candidate mechanism for high-density lipoprotein-mediated repression of leukocyte adhesion

Circulation Research

Volumn 98, Issue 4, 2006, Pages 490-498

  Ahmed, Waleed ^a   Orasanu, Gabriela ^a   Nehra, Vedika ^a   Asatryan, Liana ^c   Rader, Daniel J ^b   Ziouzenkova, Ouliana ^a   Plutzky, Jorge ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Adhesion molecules; Endothelial cells; HDL cholesterol; High density lipoproteins; Lipase; PPARs; Transcriptional regulation

Indexed keywords

ACYL COENZYME A OXIDASE; CELL ADHESION MOLECULE; CELL NUCLEUS RECEPTOR; ENDOTHELIAL LIPASE; HIGH DENSITY LIPOPROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; TETRAHYDROLIPSTATIN; TRIACYLGLYCEROL LIPASE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1; LIPG PROTEIN, HUMAN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; ATHEROSCLEROSIS; CONTROLLED STUDY; COW; EMBRYO; ENDOTHELIUM CELL; ENZYME ACTIVATION; GENE OVEREXPRESSION; GENE TARGETING; HUMAN; HUMAN CELL; HYDROLYSIS; INFLAMMATION; LEUKOCYTE ADHERENCE INHIBITION; LIGAND BINDING; LIPOLYSIS; LIPOPROTEIN METABOLISM; MONOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; WILD TYPE; ANIMAL; CATTLE; CELL ADHESION; CELL CULTURE; DOSE RESPONSE; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; LEUKOCYTE; METABOLISM; PHYSIOLOGY;

ACYL-COA OXIDASE; ANIMALS; CATTLE; CELL ADHESION; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION; HUMANS; HYDROLYSIS; LEUKOCYTES; LIPASE; LIPOLYSIS; LIPOPROTEINS, HDL; MICE; PPAR ALPHA; TUMOR NECROSIS FACTOR-ALPHA; VASCULAR CELL ADHESION MOLECULE-1;

EID: 33645298823     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.0000205846.46812.be     Document Type: Article

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