Super CitriMax (HCA-SX) attenuates increases in oxidative stress, inflammation, insulin resistance, and body weight in developing obese Zucker rats

Molecular and Cellular Biochemistry

Volumn 304, Issue 1-2, 2007, Pages 93-99

  Asghar, Mohammad ^a   Monjok, Emmanuel ^a   Kouamou, Ghislaine ^a   Ohia, Sunny E ^a   Bagchi, Debasis ^b,c   Lokhandwala, Mustafa F ^a  

^a UNIVERSITY OF HOUSTON   (United States)

^b CREIGHTON UNIVERSITY MEDICAL CENTER   (United States)

^c InterHealth Nutraceuticals Inc   (United States)

Author keywords

Blood pressure; Garcinia cambogia; HOMA; Hypertension; Metabolic syndrome; Syndrome X

Indexed keywords

C REACTIVE PROTEIN; CALCIUM SALT; CARBONYL DERIVATIVE; DRINKING WATER; GLUCOSE; HYDROXYCITRIC ACID; INSULIN; INTERLEUKIN 6; MALONALDEHYDE; PLANT EXTRACT; POTASSIUM SALT; SUPER CITRIMAX; TRIACYLGLYCEROL; TYROSINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY WEIGHT; CHEMICAL ANALYSIS; CONTROLLED STUDY; DIET SUPPLEMENTATION; DRUG DOSE INCREASE; ENZYME LINKED IMMUNOSORBENT ASSAY; FOOD INTAKE; GARCINIA CAMBOGIA; GLUCOSE BLOOD LEVEL; IMMUNOBLOTTING; INFLAMMATION; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; KIDNEY PARENCHYMA; LIVER; MALE; NITRATION; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; OXIDATIVE STRESS; RAT; RAT STRAIN; SUPPLEMENTATION; TRIACYLGLYCEROL BLOOD LEVEL; WEIGHT GAIN; WEIGHT REDUCTION; ZUCKER RAT;

ANIMALS; BODY WEIGHT; CITRATES; DISEASE PROGRESSION; DRUG EVALUATION, PRECLINICAL; EATING; INFLAMMATION; INSULIN RESISTANCE; MALE; OBESITY; OXIDATIVE STRESS; RATS; RATS, ZUCKER; TRIGLYCERIDES;

ANIMALIA; GARCINIA CAMBOGIA; RATTUS;

EID: 34648835014     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-007-9489-3     Document Type: Article

References (36)

1. Jebb SA (1999) The Nutrition Society Medical Lecture. Obesity from molecules to man. Proc Nutr Soc 58:1-14
2. Nakamura T, Tokunaga K, Shimomura I, Nishida M, Yoshida S, Kotani K, Islam AH, Keno Y, Kobatake T, Nagai Y, Fujioka S, Tarui S, Matuzawa Y (1994) Contribution of visceral fat accumulation to the development of coronary artery disease in non-obese men. Atherosclerosis 107:239-246
3. Behn A, Ur E (2006) The obesity epidemic and its cardiovascular consequences. Curr Opin Cardiol 21:353-360
4. Chander PN, Gealekman O, Brodsky SV, Elitok S, Tojo A, Crabtree M, Gross SS, Goligorsky MS (2004) Nephropathy in Zucker diabetic fat rat is associated with oxidative and nitrosative stress: Prevention by chronic therapy with a peroxynitrite scavenger ebselen. J Am Soc Nephrol 15:2391-2403
5. Xu ZG, Lanting L, Vaziri ND, Li Z, Sepassi L, Rodriguez-Iturbe B, Natarajan R (2005) Upregulation of angiotensin II type 1 receptor, inflammatory mediators, and enzymes of arachidonate metabolism in obese Zucker rat kidney: Reversal by angiotensin II type 1 receptor blockade. Circulation 111:1962-1969
6. Dahlman I, Forsgren M, Sjogren A, Nordstrom EA, Kaaman M, Naslund E, Attersand A, Arner P (2006) Downregulation of electron transport chain genes in visceral adipose tissue in type 2 diabetes independent of obesity and possibly involving tumor necrosis factor-{alpha}. Diabetes 55:1792-1799
7. Uysal KT, Wiesbrock SM, Marino MW, Hotamisligil GS (1997) Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function. Nature 389:610-614
8. Sarafidis PA, Ruilope LM (2006). Insulin resistance, hyperinsulinemia, and renal injury: Mechanisms and implications. Am J Nephrol 26:232-244
9. Talpur N, Echard BW, Yasmin T, Bagchi D, Preuss HG (2003) Effects of niacin-bound chromium, Maitake mushroom fraction SX and (-)-hydroxycitric acid on the metabolic syndrome in aged diabetic Zucker fatty rats. Mol Cell Biochem 252:369-377
10. Saengsirisuwan V, Perez FR, Sloniger JA, Maier T, Henriksen EJ (2004) Interactions of exercise training and alpha-lipoic acid on insulin signaling in skeletal muscle of obese Zucker rats. Am J Physiol Endocrinol Metab 287:E529-E536
11. Banday AA, Marwaha A, Tallam LS, Lokhandwala MF (2005) Tempol reduces oxidative stress, improves insulin sensitivity, decreases renal dopamine D1 receptor hyperphosphorylation, and restores D1 receptor-G-protein coupling and function in obese Zucker rats. Diabetes 54:2219-2226
12. Soni MG, Burdock GA, Preuss HG, Stohs SJ, Ohia SE, Bagchi D (2004) Safety assessment of (-)-hydroxycitric acid and Super CitriMax, a novel calcium/potassium salt. Food Chem Toxicol 42:1513-1529
13. Jena BS, Jayaprakasha GK, Singh RP, Sakariah KK (2002) Chemistry and biochemistry of (-)-hydroxycitric acid from Garcinia. J Agric Food Chem 50:10-22
14. Ramos RR, Saenz JL, Aguilar CF (1995) Extract of Garcinia cambogia in the control of obesity. Invest Med Int 22:97-100
15. Shimomura I, Tokunaga K, Jiao S, Funahashi T, Keno Y, Kobatake T, Kotani K, Suzuki H, Yamamoto T, Tarui S, Matuzawa Y (1992) Marked enhancement of acyl-CoA synthetase activity and mRNA, paralleled to lipoprotein lipase mRNA, in adipose tissues of Zucker obese rats (fa/fa). Biochim Biophys Acta 1124:112-118
16. Pikavance LC, Tadayyon M, Widdowson PS, Buckingham RE, Wilding JPH (1999) Therapeutic index for rosiglitazone in dietary obese rats: separation of efficacy and haemodilution. Brit J Pharmacol 128:1570-1576
17. Buege JA, Aust SD (1978) Microsomal lipid peroxidation. Methods Enzymol 52:302-310
18. Schacter E, Williams JA, Lim M, Levine RL (1994) Differential susceptibility of plasma proteins to oxidative modification. Examination by Western blot immunoassay. Free Radic Biol Med 17:429-437
19. Koo JR, Vaziri ND (2003) Effects of diabetes, insulin and antioxidants on NO synthase abundance and NO interaction with reactive oxygen species. Kidney Int 63:195-201
20. Schaap LA, Pluijm SM, Deeg DJ, Visser M (2006) Inflammatory markers and loss of muscle mass (sarcopenia) and strength. Am J Med 119:526.e9-526.e17
21. Asghar M, Zeyssig R, Monjok E, Kouamou G, Ohia SE, Lokhandwala MF, Bagchi D (2006) Hydroxycitric acid (HCA-SX) decreases oxidative stress and insulin resistance and increases brain serotonin levels in obese Zucker rats. Exp Biol Meeting 20:A655.4
22. Mauri MC, Rudelli R, Somaschini E, Roncoroni L, Papa R, Mantero M, Longhini M, Penati G (1996) Neurobiological and psychopharmacological basis in the therapy of bulimia and anorexia. Prog Neuropsychopharmacol Biol Psychiatry 20:207-240
23. Widdowson PS, Upton R, Henderson L, Buckingham R, Wilson S, Williams G (1997) Reciprocal regional changes in brain NPY receptor density during dietary restriction and dietary-induced obesity in the rat. Brain Res 774:1-10
24. Curzon G, Gibson EL, Oluyomi AO (1997) Appetite suppression by commonly used drugs depends on 5-HT receptors but not on 5-HT availability. Trends Pharmacol Sci 18:21-25
25. Williams G, Bing C, Cai XJ, Harrold JA, King PJ, Liu XH (2001) The hypothalamus and the control of energy homeostasis: Different circuits, different purposes. Physiol Behav 74:683-701
26. Gertow K, Rosell M, Sjogren P, Eriksson P, Vessby B, de Faire U, Hamsten A, Hellenius ML, Fisher RM (2006) Fatty acid handling protein expression in adipose tissue, fatty acid composition of adipose tissue and serum, and markers of insulin resistance. Eur J Clin Nutr 60:1406-1413
27. Asghar M, Lokhandwala MF (2006) Antioxidant tempol lowers age-related increase in insulin resistance in Fischer 344 rats. Clin Exp Hypertens 28:533-541
28. Petersen AM, Pedersen BK (2005) The anti-inflammatory effect of exercise. J Appl Physiol 98:1154-1162
29. Halse R, Pearson SL, McCormack JG, Yeaman SJ, Taylor R (2001) Effects of tumor necrosis factor-alpha on insulin action in cultured human muscle cells. Diabetes 50:1102-1109
30. Youd JM, Rattigan S, Clark MG (2000) Acute impairment of insulin-mediated capillary recruitment and glucose uptake in rat skeletal muscle in vivo by TNF-alpha. Diabetes 49:1904-1909
31. Saghizadeh M, Ong JM, Garvey WT, Henry RR, Kern PA (1996) The expression of TNF alpha by human muscle. Relationship to insulin resistance. J Clin Invest 97:1111-1116
32. Mishima Y, Kuyama A, Tada A, Takahashi K, Ishioka T, Kibata M (2001) Relationship between serum tumor necrosis factor-alpha and insulin resistance in obese men with Type 2 diabetes mellitus. Diabetes Res Clin Pract 52:119-123
33. Hotamisligil GS (1999) Mechanisms of TNF-alpha-induced insulin resistance. Exp Clin Endocrinol Diabetes 107:119-125
34. Giugliano D, Ceriello A, Paolisso G (1996) Oxidative stress and diabetic vascular complications. Diabetes Care 19:257-267
35. Nitenberg A, Cosson E, Pham I (2006) Postprandial endothelial dysfunction: Role of glucose, lipids and insulin. Diabetes Metab 32:S28-S33
36. Ugochukwu NH, Figgers CL (2007) Dietary caloric restriction improves the redox status at the onset of diabetes in hepatocytes of streptozotocin-induced diabetic rats. Chem Biol Interact 165:45-53