Physico-chemical properties of a novel (-)-hydroxycitric acid extract and its effect on body weight, selected organ weights, hepatic lipid peroxidation and DNA fragmentation, hematology and clinical chemistry, and histopathological changes over a period of 90 days

Molecular and Cellular Biochemistry

Volumn 260, Issue 1, 2004, Pages 171-186

  Shara, Michael ^a   Ohia, Sunny E ^a   Schmidt, Robert E ^b   Yasmin, Taharat ^a   Zardetto Smith, Andrea ^a   Kincaid, Anthony ^a   Bagchi, Manashi ^a   Chatterjee, Archana ^a   Bagchi, Debasis ^a   Stohs, Sidney J ^a  

^a CREIGHTON UNIVERSITY MEDICAL CENTER   (United States)

^b IDEXX LABORATORIES   (United States)

Author keywords

( ) hydroxycitric acid; 90 day toxicity study; Body and selected organ weights; Garcinia cambogia; Hematology and clinical chemistry; Hepatic lipid peroxidation and DNA damage; Histopathology

Indexed keywords

ACETYL COENZYME A; ACETYLCHOLINE; ADENOSINE TRIPHOSPHATE CITRATE LYASE; CHOLESTEROL; CITRIC ACID; COENZYME A; DNA FRAGMENT; ENZYME INHIBITOR; FATTY ACID; HYDROXYCITRIC ACID; LEPTIN; OXALOACETIC ACID; SEROTONIN; TRIACYLGLYCEROL;

AMES TEST; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD EXAMINATION; BODY WEIGHT; CATALYSIS; CENTRAL NERVOUS SYSTEM; CHOLESTEROL SYNTHESIS; CONTROLLED STUDY; CYTOSOL; DOSE RESPONSE; DRUG EFFICACY; DRUG MECHANISM; DRUG SAFETY; FATTY ACID SYNTHESIS; FEMALE; FOOD INTAKE; GARCINIA CAMBOGIA; HISTOPATHOLOGY; LABORATORY TEST; LIPID PEROXIDATION; MALE; NONHUMAN; ORGAN WEIGHT; PHYSICAL CHEMISTRY; RAT; RAT STRAIN; REVERTANT; SEROTONIN RELEASE; WEIGHT REDUCTION;

ADMINISTRATION, ORAL; ANIMALS; BLOOD PROTEINS; BODY WEIGHT; BRAIN DISEASES; CITRATES; DNA FRAGMENTATION; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GARCINIA CAMBOGIA; HEART DISEASES; HEMATOLOGIC TESTS; KIDNEY DISEASES; LIPID PEROXIDATION; LIPIDS; LIVER; LUNG DISEASES; MALE; ORGAN SIZE; PLANT EXTRACTS; RATS; RATS, SPRAGUE-DAWLEY; TIME FACTORS;

ANIMALIA; BACTERIA (MICROORGANISMS); GARCINIA; GARCINIA CAMBOGIA;

EID: 3042677564     PISSN: 03008177     EISSN: None     Source Type: Journal    
DOI: 10.1023/B:MCBI.0000026069.53960.75     Document Type: Article

References (24)

1. Jequier E: Pathways to obesity. Int J Obes Relat Metab Disord 260: S12-S17, 2002
2. Flegal KM, Carroll MD, Kuczmarski RJ, Johnson CL: Overweight and obesity in the United States: Prevalence and trends, 1960-1994. Int J Obes Relat Metab Disord 22: 39-47, 1998
3. Colditz GA: Economic costs of obesity. Am J Clin Nutr 55: 503S-507S, 1992
4. Wolf AM, Colditz GA: Current estimates of the economic cost of obesity in the United States. Obes Res 6: 97-106, 1998
5. Haller CA, Benowitz NL: Adverse cardiovascular and central nervous system events associated with dietary supplements containing ephedra alkaloids. N Engl J Med 343: 1833-1838, 2000
6. Jena BS, Jayaprakasha GK, Singh RP, Sakariah KK: Chemistry and biochemistry of (-)-hydroxycitric acid from Garcinia. J Agric Food Chem 50: 10-22, 2002
7. Sergio W: A natural food, the Malabar Tamarind, may be effective in the treatment of obesity. Med Hypotheses 29: 39-40, 1988
8. Ramos RR, Saenz JLS, Agular RJA: Extract of Garcinia Cambogia in controlling obesity. Invest Med Int 22: 97-100, 1995
9. Lowenstein JM: Effect of (-)-hydroxycitrate on fatty acid synthesis by rat liver in vivo. J Biol Chem 246: 629-632, 1971
10. Sullivan AC, Triscari J, Hamilton JG, Miller ON, Wheatley VR: Effect of (-)-hydroxycitrate upon the accumulation of lipid in the rat. I. lipogenesis. Lipids 9: 121-128, 1974
11. Sullivan AC, Triscari J, Hamilton JG, Miller ON: Effect of (-)-hydroxycitrate upon the accumulation of lipid in the rat. II. Appetite. Lipids 9: 129-134, 1973
12. Triscari J, Sullivan AC: Anti-obesity activity of a novel lipid synthesis inhibitor. Int J Obes 8: 227-239, 1984
13. Ohia SE, Awe O, LeDay AM, Opere CA, Bagchi D: Effect of hydroxycitric acid on serotonin release from isolated rat brain cortex. Res Comm Mol Pathol Pharmacol 109: 210-216, 2001
14. Ohia SE, Opere CA, LeDay AM, Bagchi M, Bagchi D, Stohs SJ: Safety and mechanism of appetite suppression by a novel hydroxycitric acid extract (HCA-SX). Mol Cell Biochem 238: 89-103, 2002
15. Loe YC, Bergeron N, Rodriguez N, Schwarz J-M: Gas chromatography/mass spectrometry method to quantify blood hydroxycitrate concentration. Analytical Biochem 292: 148-154, 2001
16. Conte, AA: A non-prescription alternative in weight reduction therapy. Am J Bariat Med (Summer): 17-19, 1993
17. Mattes DR, Bormann L: Effects of (-)-hydroxycitric acid on appetitive variables. Physiol Behav 71: 87-94, 2000
18. Westerterp-Plantenga MS, Kovacs EMR: The effect of (-)-hydroxycitrate on energy intake and satiety in overweight humans. Int J Obes 26: 870-872, 2002
19. Kovacs EM, Westerterp-Plantenga MS, de Vries M, Brouns F, Saris WH: Effects of 2-week ingestion of (-)-hydroxycitrate and (-)-hydroxycitrate combined with medium-chain triglycerides on satiety and food intake. Physiol Behav 74: 543-549, 2001
20. Preuss HG, Bagchi D, Rao CVS, Echard BW, Satyanarayana S, Bagchi M: Effect of (-)-hydroxycitric acid on weight loss, body mass index and plasma leptin levels in human subjects. FASEB 16 (abstr 742.16): A1020, 2002
21. Buege J, Aust S: Microsomal lipid peroxidation. Meth Enzymol 52: 302-310, 1978
22. Bagchi D, Carryl OR, Tran MX, Krohn RL, Bagchi DJ, Garg A, Bagchi M, Mitra S, Stohs SJ: Stress, diet and alcohol-induced oxidative gastrointestinal mucosal injury in rats and protection by bismuth subsalicylate. J Appl Toxicol 18: 3-13, 1998
23. Largilliere C, Melancon SB: Free malondialdehyde determination in human plasma by high-performance liquid chromatography. Anal Biochem 170: 123-126, 1988
24. Bagchi M, Balmoori J, Bagchi D, Ray SD, Kuszynski C, Stolis SJ: Smokeless tobacco, oxidative stress, apoptosis, and antioxidants in human oral keratinocytes. Free Rad Biol Med 26: 992-1000, 1999