Effects of subtype-selective group I mGluR antagonists on synchronous activity induced by 4-aminopyridine/CGP 55845 in adult guinea pig hippocampal slices

Neuropharmacology

Volumn 55, Issue 1, 2008, Pages 47-54

  Salah, Alejandro ^a   Perkins, Katherine L ^a,b  

^a SUNY DOWNSTATE MEDICAL CENTER   (United States)

^b SUNY Downstate Medical Center   (United States)

Author keywords

Electrophysiology; GABA; Metabotropic glutamate receptor; mGluR1; mGluR5

Indexed keywords

3 [(2 METHYL 4 THIAZOLYL)ETHYNYL]PYRIDINE; 4 AMINOPYRIDINE; 4 CARBOXY 2 METHYLPHENYLGLYCINE; BENZYL[3 [[1 (3,4 DICHLOROPHENYL)ETHYL]AMINO] 2 HYDROXYPROPYL]PHOSPHINIC ACID; GLUTAMIC ACID; IONOTROPIC RECEPTOR ANTAGONIST; METABOTROPIC RECEPTOR 1; METABOTROPIC RECEPTOR 5; METABOTROPIC RECEPTOR ANTAGONIST; RECEPTOR SUBTYPE;

ANIMAL TISSUE; ARTICLE; BRAIN SLICE; CELL INTERACTION; CONTROLLED STUDY; ELECTROPHYSIOLOGY; EPILEPTIC DISCHARGE; GABAERGIC SYSTEM; GUINEA PIG; HIPPOCAMPUS; INTERNEURON; NONHUMAN; POSTSYNAPTIC POTENTIAL; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL;

4-AMINOPYRIDINE; ACTION POTENTIALS; ANIMALS; DRUG COMBINATIONS; DRUG INTERACTIONS; EXCITATORY AMINO ACID ANTAGONISTS; GABA ANTAGONISTS; GUINEA PIGS; HIPPOCAMPUS; PHOSPHINIC ACIDS; POTASSIUM CHANNEL BLOCKERS; PROPANOLAMINES;

EID: 45649084348     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2008.04.010     Document Type: Article

References (55)

1. 3H]Methoxymethyl-3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine binding to metabotropic glutamate receptor subtype 5 in rodent brain: in vitro and in vivo characterization. The Journal of Pharmacology and Experimental Therapeutics 303 (2002) 1044-1051
2. Arvanov V.L., Holmes K.H., Keele N.B., and Shinnick-Gallagher P. The functional role of metabotropic glutamate receptors in epileptiform activity induced by 4-aminopyridine in the rat amygdala slice. Brain Research 669 (1995) 140-144
3. Avoli M., Barbarosie M., Lücke A., Nagao T., Lopantsev V., and Köhling R. Synchronous GABA-mediated potentials and epileptiform discharges in the rat limbic system in vitro. Journal of Neuroscience 16 (1996) 3912-3924
4. Babb T.L., Pretorius J.K., Kupfer W.R., and Crandall P.H. Glutamate decarboxylase-immunoreactive neurons are preserved in human epileptic hippocampus. Journal of Neuroscience 9 (1989) 2562-2574
5. Barton M.E., Peters S.C., and Shannon H.E. Comparison of the effect of glutamate receptor modulators in the 6 Hz and maximal electroshock seizure models. Epilepsy Research 56 (2003) 17-26
6. Bear M.F. Therapeutic implications of the mGluR theory of fragile X mental retardation. Genes, Brain, and Behavior 4 (2005) 393-398
7. Buckle P.J., and Haas H.L. Enhancement of synaptic transmission by 4-aminopyridine in hippocampal slices of the rat. Journal of Physiology 326 (1982) 109-122
8. Burke J.P., and Hablitz J.J. Modulation of epileptiform activity by metabotropic glutamate receptors in immature rat neocortex. Journal of Neurophysiology 73 (1995) 205-217
9. Camón L., Vives P., de Vera N., and Martínez E. Seizures and neuronal damage induced in the rat by activation of group I metabotropic glutamate receptors with their selective agonist 3,5-dihydroxyphenylglycine. Journal of Neuroscience Research 51 (1998) 339-348
10. Chapman A.G., Yip P.K., Yap J.S., Quinn L.P., Tang E., Harris J.R., and Meldrum B.S. Anticonvulsant actions of LY 367385 ((+)-2-methyl-4-carboxyphenylglycine) and AIDA ((RS)-1-aminoindan-1,5-dicarboxylic acid). European Journal of Pharmacology 368 (1999) 17-24
11. Chapman A.G., Nanan K., Williams M., and Meldrum B.S. Anticonvulsant activity of two metabotropic glutamate group I antagonists selective for the mGlu5 receptor: 2-methyl-6-(phenylethynyl)-pyridine (MPEP), and (E)-6-methyl-2-styryl-pyridine (SIB 1893). Neuropharmacology 39 (2000) 1567-1574
12. Charpak S., Gahwiler B.H., Do K.Q., and Knopfel T. Potassium conductances in hippocampal neurons blocked by excitatory amino-acid transmitters. Nature 347 (1990) 765-767
13. + channels. The EMBO Journal 22 (2003) 5403-5411
14. Chuang S.C., Bianchi R., and Wong R.K.S. Group I mGluR activation turns on a voltage-gated inward current in hippocampal pyramidal cells. Journal of Neurophysiology 83 (2000) 2844-2853
15. Chuang S.C., Zhao W., Bauchwitz R., Yan Q., Bianchi R., and Wong R.K. Prolonged epileptiform discharges induced by altered group I metabotropic glutamate receptor-mediated synaptic responses in hippocampal slices of a fragile X mouse model. Journal of Neuroscience 25 (2005) 8048-8055
16. Chuang S.C., Zhao W., Young S.R., Conquet F., Bianchi R., and Wong R.K.S. Activation of group I mGluRs elicits different responses in murine CA1 and CA3 pyramidal cells. Journal of Physiology 541 (2002) 113-121
17. Clark B.P., Baker S.R., Goldsworthy J., Harris J.R., and Kingston A.E. (+)-2-Methyl-4-carboxyphenylglycine (LY367385) selectively antagonises metabotropic glutamate mGluR1 receptors. Bioorganic & Medicinal Chemistry Letters 7 (1997) 2777-2780
18. + channels. Annals of the New York Academy Sciences 68 (1999) 233-285
19. Cohen I., Navarro V., Clemenceau S., Baulac M., and Miles R. On the origin of interictal activity in human temporal lobe epilepsy in vitro. Science 298 (2002) 1418-1421
20. Dale L.B., Babwah A.V., and Ferguson S.S.G. Mechanisms of metabotropic glutamate receptor desensitization: role in the patterning of effector enzyme activation. Neurochemistry International 41 (2002) 319-326
21. B receptors in the CA1 region of rat hippocampus. Neuropharmacology 32 (1993) 1071-1073
22. B receptor-mediated effects in human and rat neocortical neurones in vitro. Neuropharmacology 38 (1999) 1755-1766
23. Francesconi W., Cammalleri M., and Sanna P.P. The metabotropic glutamate receptor 5 is necessary for late-phase long-term potentiation in the hippocampal CA1 region. Brain Research 1022 (2004) 12-18
24. Gasparini F., Lingenhöhl K., Stoehr N., Flor P.J., Heinrich M., Vranesic I., Biollaz M., Allgeier H., Heckendorn R., Urwyler S., Varney M.A., Johnson E.C., Hess S.D., Rao S.P., Sacaan A.I., Santori E.M., Veliçelebi G., and Kuhn R. 2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist. Neuropharmacology 38 (1999) 1493-1503
25. Hermans E., and Challiss R.A.J. Structural, signaling and regulatory properties of the group I metabotropic glutamate receptors: prototypic family C G-protein-coupled receptors. The Biochemical Journal 359 (2001) 465-484
26. van Hooft J.A., Giuffrida R., Blatow M., and Monyer H. Differential expression of group I metabotropic glutamate receptors in functionally distinct hippocampal interneurons. Journal of Neuroscience 20 (2000) 3544-3551
27. Joly C., Gomeza J., Brabet I., Curry K., Bockaert J., and Pin J.P. Molecular, functional, and pharmacological characterization of the metabotropic glutamate receptor type 5 splice variants: comparison with mGluR1. Journal of Neuroscience 15 (1995) 3970-3981
28. B receptors are blocked. Journal of Neurophysiology 93 (2005) 2656-2667
29. Kawabata S., Tsutsumi R., Kohara A., Yamaguchi T., Nakanishi S., and Okada M. Control of calcium oscillations by phosphorylation of metabotropic glutamate receptors. Nature 383 (1996) 89-92
30. Kohling R., Lucke A., Straub H., Speckmann E.J., Tuxhorn I., Wolf P., Pannek H., and Oppel F. Spontaneous sharp waves in human neocortical slices excised from epileptic patients. Brain 121 (1998) 1073-1087
31. Lee A.C., Wong R.K.S., Chuang S.-C., Shin H.-S., and Bianchi R. Role of synaptic metabotropic glutamate receptors in epileptiform discharges in hippocampal slices. Journal of Neurophysiology 88 (2002) 1625-1633
32. Löscher W., Dekundy A., Nagel J., Danysz W., Parsons C.G., and Potschka H. mGlu1 and mGlu5 receptor antagonists lack anticonvulsant efficacy in rodent models of difficult-to-treat partial epilepsy. Neuropharmacology 50 (2006) 1006-1015
33. Luján R., Nusser Z., Roberts J.D., Shigemoto R., and Somogyi P. Perisynaptic location of metabotropic glutamate receptors mGluR1 and mGluR5 on dendrites and dendritic spines in the rat hippocampus. European Journal of Neuroscience 8 (1996) 1488-1500
34. Mannaioni G., Marino M.J., Valenti O., Traynelis S.F., and Conn P.J. Metabotropic glutamate receptors 1 and 5 differentially regulate CA1 pyramidal cell function. Journal of Neuroscience 21 (2001) 5925-5934
35. + current in hippocampal CA1 pyramidal neurons: implications in epileptogenesis. Journal of Neurophysiology 86 (2001) 2878-2886
36. Merlin L.R., and Wong R.K.S. Role of group I metabotropic glutamate receptors in the patterning of epileptiform activities in vitro. Journal of Neurophysiology 78 (1997) 539-544
37. Merlin L.R. Differential roles for mGluR1 and mGluR5 in the persistent prolongation of epileptiform bursts. Journal of Neurophysiology 87 (2002) 621-625
38. A receptors in the hippocampus. Science 253 (1991) 1420-1423
39. Moldrich R.X., Chapman A.G., De Sarro G., and Meldrum B.S. Glutamate metabotropic receptors as targets for drug therapy in epilepsy. European Journal of Pharmacology 476 (2003) 3-16
40. O'Leary D.M., Movsesyan V., Vicini S., and Faden A.I. Selective mGluR5 antagonists MPEP and SIB-1893 decrease NMDA or glutamate-mediated neuronal toxicity through actions that reflect NMDA receptor antagonism. British Journal of Pharmacology 131 (2000) 1429-1437
41. Perkins K.L. GABA application to hippocampal CA3 or CA1 stratum lacunosum-moleculare excites an interneuron network. Journal of Neurophysiology 87 (2002) 1404-1414
42. Perreault P., and Avoli M. 4-Aminopyridine-induced epileptiform activity and a GABA-mediated long-lasting depolarization in the rat hippocampus. Journal of Neuroscience 12 (1992) 104-115
43. Romano C., Sesma M.A., McDonald C.T., O'Malley K., Van den Pol A.N., and Olney J.W. Distribution of metabotropic glutamate receptor mGluR5 immunoreactivity in rat brain. The Journal of Comparative Neurology 355 (1995) 455-469
44. Rutecki P.A., Lebeda F.L., and Johnston D. 4-Aminopyridine produces epileptiform activity in hippocampus and enhances synaptic excitation and inhibition. Journal of Neurophysiology 57 (1987) 1911-1924
45. Shannon H.E., Peters S.C., and Kingston A.E. Anticonvulsant effects of LY456236, a selective mGlu1 receptor antagonist. Neuropharmacology 49 (2005) 188-195
46. Smolders I., Lindekens H., Clinckers R., Meurs A., O'Neill M.J., Lodge D., and Ebinger G. In vivo modulation of extracellular hippocampal glutamate and GABA levels and limbic seizures by group I and II metabotropic glutamate receptor ligands. Journal of Neurochemistry 88 (2004) 1068-1077
47. + current in hippocampal neurons. Nature 336 (1988) 379-381
48. Tateyama M., and Kubo Y. Coupling profile of the metabotropic glutamate receptor 1α is regulated by the C-terminal domain. Molecular and Cellular Neurosciences 34 (2007) 445-452
49. Taylor G.W., Merlin L.R., and Wong R.K.S. Synchronized oscillations in hippocampal CA3 neurons induced by metabotropic glutamate receptor activation. Journal of Neuroscience 15 (1995) 8039-8052
50. Thomsen C., and Dalby N.O. Roles of metabotropic glutamate receptor subtypes in modulation of pentylenetetrazole-induced seizure activity in mice. Neuropharmacology 37 (1998) 1465-1473
51. Tizzano J.P., Griffey K.I., and Schoepp D.D. Induction or protection of limbic seizures in mice by mGluR subtype selective agonists. Neuropharmacology 34 (1995) 1063-1067
52. Valenti O., Conn P.J., and Marino M.J. Distinct physiological roles of the Gq-coupled metabotropic glutamate receptors co-expressed in the same neuronal populations. Journal of Cellular Physiology 191 (2002) 125-137
53. Wong R.K., Bianchi R., Chuang S.C., and Merlin L.R. Group I mGluR-induced epileptogenesis: distinct and overlapping roles of mGluR1 and mGluR5 and implications for antiepileptic drug design. Epilepsy Currents 5 (2005) 63-68
54. Wong R.K., Chuang S.C., and Bianchi R. Plasticity mechanisms underlying mGluR-induced epileptogenesis. Advances in Experimental Medicine and Biology 548 (2004) 69-75
55. Yan Q.J., Rammal M., Tranfaglia M., and Bauchwitz R.P. Suppression of two major fragile X syndrome mouse model phenotypes by the mGluR5 antagonist MPEP. Neuropharmacology 49 (2005) 1053-1066