On the origin of interictal activity in human temporal lobe epilepsy in vitro

Science

Volumn 298, Issue 5597, 2002, Pages 1418-1421

  Cohen, Ivan ^a   Navarro, Vincent ^a   Clemenceau, Stéphane ^a   Baulac, Michel ^a   Miles, Richard ^a  

^a PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; NEURAL NETWORKS; ORGANIC ACIDS; PATIENT MONITORING;

NEURONS;

BIOCHEMISTRY;

4 AMINOBUTYRIC ACID RECEPTOR BLOCKING AGENT; GLUTAMATE RECEPTOR ANTAGONIST;

DISEASE;

ARTICLE; CONTROLLED STUDY; DEPOLARIZATION; ELECTROENCEPHALOGRAM; EPILEPTIC DISCHARGE; GABAERGIC SYSTEM; HIPPOCAMPUS; HUMAN; HUMAN TISSUE; IN VITRO STUDY; INTERNEURON; NERVE CELL NETWORK; NERVE POTENTIAL; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; SUBICULUM; SYNAPTIC MEMBRANE; TEMPORAL LOBE EPILEPSY;

ACTION POTENTIALS; ADULT; ELECTROENCEPHALOGRAPHY; EPILEPSY, TEMPORAL LOBE; EXCITATORY AMINO ACID ANTAGONISTS; GAMMA-AMINOBUTYRIC ACID; GLUTAMIC ACID; HIPPOCAMPUS; HUMANS; INTERNEURONS; MEMBRANE POTENTIALS; MICROELECTRODES; MIDDLE AGED; NERVE FIBERS; NEURONS, AFFERENT; PYRAMIDAL CELLS; SIGNAL TRANSDUCTION; SYNAPTIC TRANSMISSION; TEMPORAL LOBE;

EID: 0037111851     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1076510     Document Type: Article

References (28)

1. D. V. Lewis, Curr. Opin. Neurol. 12, 197 (1999).
2. M. Dichter, W. A. Spencer, J. Neurophysiol. 32, 649 (1969).
3. R. K. S. Wong, R. D. Traub, J. Neurophysiol. 49, 442 (1983).
4. R. A. McKinney et al., Nature Med. 3, 990 (1997).
5. P. Salin et al., J. Neurosci. 15, 8234 (1995).
6. R. S. Fisher, Brain Res. Rev. 14, 245 (1989).
7. B. W. Colder et al., J. Neurophysiol. 75, 2496 (1996).
8. R. Kohling et al., Brain 121, 1073 (1998).
9. P. A Schwartzkroin et al., Ann. Neurol. 13, 249 (1983).
10. P. A. Schwartzkroin, M. M. Haglund, Epilepsia 27, 523 (1986).
11. Patients were between 22 and 54 years old and had suffered from pharmacoresistant focal seizures for 25 years on average. Seizure frequency was 11 ± 10 (mean ± SD) per month. Functional imaging, morphological studies, and inspection of slices revealed a hippocampal sclerosis of variable severity. Surface EEG recordings were obtained from all patients, and intracranial recordings were obtained from hippocampal structures in four cases.
12. S. Lehericy et al., Neuroradiology 39, 788 (1997).
13. J. Engel Jr., Curr. Opin. Neurol. 7, 140 (1994).
14. 2. The time between tissue reception and slice preparation was typically 45 min.
15. Intracellular records were made with 2 M KAc-filled glass microelectrodes and extracellular signals were recorded with etched tungsten wires as described in [I. Cohen, R. Miles, J. Physiol. (London) 524, 485 (2000)].
16. F. H. Lopes da Silva, M. P. Witter, P. H Boeijinga, A. H. Lohman, Physiol. Rev. 70, 453 (1990).
17. A receptor-mediated IPSPs were suppressed by picrotoxin (50 μM), bicuculline (10 μM), or gabazine (SR-95531; 5 μM).
18. J. R. Greene, S. Totterdell, J. Comp. Neurol. 380, 395 (1997).
19. M. Stewart, R. K. S. Wong, J. Neurophysiol. 70, 232 (1993).
20. P. Parra, A. I. Gulyas, R. Miles, Neuron 20, 983 (1998).
21. D. A. Prince, B. J. Wilder, Arch. Neurol. 16, 194 (1967).
22. I. Cohen et al., unpublished data (n = 49).
23. Y. Ben-Ari, E. Cherubini, R. Corradetti, J. L. Gaiarsa, J. Physiol. (London) 416, 303 (1989).
24. C. Rivera et al., Nature 397, 251 (1999).
25. C. Vale, D. H. Sanes, J. Neurosci. 20, 1912 (2000).
26. T. Sutula et al., J. Comp. Neurol. 390, 578 (1998).
27. P. R. Patrylo, F. E. Dudek, J. Neurophysiol. 79, 418 (1998).
28. We thank P. Parra, D. Fricker, R. Traub, H. Korn, and F. Gabbiani for help and comments on the manuscript, Supported by INSERM, Fondation Française pour la Recherche sur L'Epilepsie, NIH (MHS4671), CNRS, and Fondation pour la Recherche Médicale.