Initiation and maintenance of Th2 cell identity

Current Opinion in Immunology

Volumn 20, Issue 3, 2008, Pages 265-271

  Nakayama, Toshinori ^a   Yamashita, Masakatsu ^a  

^a CHIBA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 13; INTERLEUKIN 4; INTERLEUKIN 5; POLYCOMB GROUP PROTEIN; STAT6 PROTEIN; TRANSCRIPTION FACTOR GATA 3;

ALLERGY; CD4+ T LYMPHOCYTE; CELL DIFFERENTIATION; CELL FUNCTION; CELL SURVIVAL; CHROMATIN ASSEMBLY AND DISASSEMBLY; GENE LOCUS; HUMORAL IMMUNITY; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVIEW; TH1 CELL; TH2 CELL; TRANSCRIPTION REGULATION;

ANIMALS; CYTOKINES; EPIGENESIS, GENETIC; GATA3 TRANSCRIPTION FACTOR; GENE EXPRESSION REGULATION; HUMANS; IMMUNOLOGIC MEMORY; LYMPHOCYTE ACTIVATION; MICE; MYELOID-LYMPHOID LEUKEMIA PROTEIN; TH2 CELLS;

EID: 45449098427     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.coi.2008.03.011     Document Type: Review

References (44)

1. Ansel K.M., Djuretic I., Tanasa B., and Rao A. Regulation of Th2 differentiation and Il4 locus accessibility. Annu Rev Immunol 24 (2006) 607-656
2. Mowen K.A., and Glimcher L.H. Signaling pathways in Th2 development. Immunol Rev 202 (2004) 203-222
3. Szabo S.J., Sullivan B.M., Peng S.L., and Glimcher L.H. Molecular mechanisms regulating Th1 immune responses. Annu Rev Immunol 21 (2003) 713-758
4. Ivanov I.I., McKenzie B.S., Zhou L., Tadokoro C.E., Lepelley A., Lafaille J.J., Cua D.J., and Littman D.R. The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell 126 (2006) 1121-1133
5. Sakaguchi S., Ono M., Setoguchi R., Yagi H., Hori S., Fehervari Z., Shimizu J., Takahashi T., and Nomura T. Foxp3+ CD25+ CD4+ natural regulatory T cells in dominant self-tolerance and autoimmune disease. Immunol Rev 212 (2006) 8-27
6. Marrack P., and Kappler J. Control of T cell viability. Annu Rev Immunol 22 (2004) 765-787
7. Stockinger B., Kassiotis G., and Bourgeois C. CD4 T-cell memory. Semin Immunol 16 (2004) 295-303
8. Yamashita M., Ukai-Tadenuma M., Kimura M., Omori M., Inami M., Taniguchi M., and Nakayama T. Identification of a conserved GATA3 response element upstream proximal from the interleukin-13 gene locus. J Biol Chem 277 (2002) 42399-42408
9. Avni O., Lee D., Macian F., Szabo S.J., Glimcher L.H., and Rao A. T(H) cell differentiation is accompanied by dynamic changes in histone acetylation of cytokine genes. Nat Immunol 3 (2002) 643-651
10. Fields P.E., Kim S.T., and Flavell R.A. Cutting edge: changes in histone acetylation at the IL-4 and IFN-gamma loci accompany Th1/Th2 differentiation. J Immunol 169 (2002) 647-650
11. Baguet A., and Bix M. Chromatin landscape dynamics of the Il4-Il13 locus during T helper 1 and 2 development. Proc Natl Acad Sci U S A 101 (2004) 11410-11415
12. Yamashita M., Ukai-Tadenuma M., Miyamoto T., Sugaya K., Hosokawa H., Hasegawa A., Kimura M., Taniguchi M., DeGregori J., and Nakayama T. Essential role of GATA3 for the maintenance of type 2 helper T (Th2) cytokine production and chromatin remodeling at the Th2 cytokine gene loci. J Biol Chem 279 (2004) 26983-26990
13. Zhu J., Min B., Hu-Li J., Watson C.J., Grinberg A., Wang Q., Killeen N., Urban Jr. J.F., Guo L., and Paul W.E. Conditional deletion of Gata3 shows its essential function in T(H)1-T(H)2 responses. Nat Immunol 5 (2004) 1157-1165
14. Pai S.Y., Truitt M.L., and Ho I.C. GATA-3 deficiency abrogates the development and maintenance of T helper type 2 cells. Proc Natl Acad Sci U S A 101 (2004) 1993-1998
15. Maurice D., Hooper J., Lang G., and Weston K. c-Myb regulates lineage choice in developing thymocytes via its target gene Gata3. EMBO J 26 (2007) 3629-3640
16. Wei X., and Kee B.L. Growth factor independent 1B (Gfi1b) is an E2A target gene that modulates Gata3 in T-cell lymphomas. Blood 109 (2007) 4406-4414
17. Dontje W., Schotte R., Cupedo T., Nagasawa M., Scheeren F., Gimeno R., Spits H., and Blom B. Delta-like1-induced Notch1 signaling regulates the human plasmacytoid dendritic cell versus T-cell lineage decision through control of GATA-3 and Spi-B. Blood 107 (2006) 2446-2452
18. Fang T.C., Yashiro-Ohtani Y., Del Bianco C., Knoblock D.M., Blacklow S.C., and Pear W.S. Notch directly regulates Gata3 expression during T helper 2 cell differentiation. Immunity 27 (2007) 100-110. Notch signaling plays multiple roles in Th1/Th2 cell differentiation. This study addressed how Notch mediates Th2 cell differentiation. Notch is shown to regulate GATA3 expression to generate optimal Th2 cell responses.
19. Amsen D., Antov A., Jankovic D., Sher A., Radtke F., Souabni A., Busslinger M., McCright B., Gridley T., and Flavell R.A. Direct regulation of Gata3 expression determines the T helper differentiation potential of Notch. Immunity 27 (2007) 89-99. Notch signaling plays multiple roles in Th1/Th2 cell differentiation. This study also addressed how Notch mediates Th2 cell differentiation. By using T-cell-specific ablation of the Notch effector RBP-J or the Notch1 and 2 receptors, these authors show Notch was required for the parasite-induced Th2 cell responses. The regulation of the expression of the GATA3 gene was also demonstrated.
20. Minter L.M., Turley D.M., Das P., Shin H.M., Joshi I., Lawlor R.G., Cho O.H., Palaga T., Gottipati S., Telfer J.C., et al. Inhibitors of gamma-secretase block in vivo and in vitro T helper type 1 polarization by preventing Notch upregulation of Tbx21. Nat Immunol 6 (2005) 680-688
21. Maekawa Y., Tsukumo S., Chiba S., Hirai H., Hayashi Y., Okada H., Kishihara K., and Yasutomo K. Delta1-Notch3 interactions bias the functional differentiation of activated CD4+ T cells. Immunity 19 (2003) 549-559
22. Amsen D., Blander J.M., Lee G.R., Tanigaki K., Honjo T., and Flavell R.A. Instruction of distinct CD4 T helper cell fates by different notch ligands on antigen-presenting cells. Cell 117 (2004) 515-526
23. Das J., Chen C.H., Yang L., Cohn L., Ray P., and Ray A. A critical role for NF-kappa B in GATA3 expression and TH2 differentiation in allergic airway inflammation. Nat Immunol 2 (2001) 45-50
24. Shin H.M., Minter L.M., Cho O.H., Gottipati S., Fauq A.H., Golde T.E., Sonenshein G.E., and Osborne B.A. Notch1 augments NF-kappaB activity by facilitating its nuclear retention. EMBO J 25 (2006) 129-138
25. Vacca A., Felli M.P., Palermo R., Di Mario G., Calce A., Di Giovine M., Frati L., Gulino A., and Screpanti I. Notch3 and pre-TCR interaction unveils distinct NF-kappaB pathways in T-cell development and leukemia. EMBO J 25 (2006) 1000-1008
26. Kimura M.Y., Hosokawa H., Yamashita M., Hasegawa A., Iwamura C., Watarai H., Taniguchi M., Takagi T., Ishii S., and Nakayama T. Regulation of T helper type 2 cell differentiation by murine Schnurri-2. J Exp Med 201 (2005) 397-408
27. Stevens L., Htut T.M., White D., Li X., Hanidu A., Stearns C., Labadia M.E., Li J., Brown M., and Yang J. Involvement of GATA3 in protein kinase C theta-induced Th2 cytokine expression. Eur J Immunol 36 (2006) 3305-3314
28. Felli M.P., Vacca A., Calce A., Bellavia D., Campese A.F., Grillo R., Di Giovine M., Checquolo S., Talora C., Palermo R., et al. PKC theta mediates pre-TCR signaling and contributes to Notch3-induced T-cell leukemia. Oncogene 24 (2005) 992-1000
29. Yamashita M., Shinnakasu R., Asou H., Kimura M., Hasegawa A., Hashimoto K., Hatano N., Ogata M., and Nakayama T. Ras-ERK MAPK cascade regulates GATA3 stability and Th2 differentiation through ubiquitin-proteasome pathway. J Biol Chem 280 (2005) 29409-29419
30. Fields P.E., Lee G.R., Kim S.T., Bartsevich V.V., and Flavell R.A. Th2-specific chromatin remodeling and enhancer activity in the Th2 cytokine locus control region. Immunity 21 (2004) 865-876
31. Lee D.U., and Rao A. Molecular analysis of a locus control region in the T helper 2 cytokine gene cluster: a target for STAT6 but not GATA3. Proc Natl Acad Sci U S A 101 (2004) 16010-16015
32. Spilianakis C.G., and Flavell R.A. Long-range intrachromosomal interactions in the T helper type 2 cytokine locus. Nat Immunol 5 (2004) 1017-1027
33. Lee G.R., Spilianakis C.G., and Flavell R.A. Hypersensitive site 7 of the TH2 locus control region is essential for expressing TH2 cytokine genes and for long-range intrachromosomal interactions. Nat Immunol 6 (2005) 42-48
34. Cai S., Lee C.C., and Kohwi-Shigematsu T. SATB1 packages densely looped, transcriptionally active chromatin for coordinated expression of cytokine genes. Nat Genet 38 (2006) 1278-1288. SATB1 (special AT-rich sequence binding protein 1) is known to organize the cell-type-specific nuclear architecture by anchoring specialized DNA sequences, and recruit chromatin remodeling factors to control the transcription of the various genes. Chromatin loop analyses in Th2 cells revealed that SATB1 is important for the formation of high-order chromatin structure around the Th2 cytokine gene loci.
35. Ansel K.M., Greenwald R.J., Agarwal S., Bassing C.H., Monticelli S., Interlandi J., Djuretic I.M., Lee D.U., Sharpe A.H., Alt F.W., et al. Deletion of a conserved Il4 silencer impairs T helper type 1-mediated immunity. Nat Immunol 5 (2004) 1251-1259
36. Djuretic I.M., Levanon D., Negreanu V., Groner Y., Rao A., and Ansel K.M. Transcription factors T-bet and Runx3 cooperate to activate Ifng and silence Il4 in T helper type 1 cells. Nat Immunol 8 (2007) 145-153. Runx3 is shown to be a potential regulator of HSIV (IL-4 silencer)-mediated IL-4 gene silencing in Th1 cells. Th1 cells that lack the HSVI are less sensitive to the repression of IL-4 production by T-bet or Runx3.
37. Naoe Y., Setoguchi R., Akiyama K., Muroi S., Kuroda M., Hatam F., Littman D.R., and Taniuchi I. Repression of interleukin-4 in T helper type 1 cells by Runx/Cbf beta binding to the Il4 silencer. J Exp Med 204 (2007) 1749-1755. Runx3 is shown to be a potential regulator of HSIV (IL-4 silencer)-mediated IL-4 gene silencing in Th1 cells. The enforced expression of GATA3 in Th1 cells induced the dissociation of the Runx complex from the IL-4 silencer.
38. Li B., Carey M., and Workman J.L. The role of chromatin during transcription. Cell 128 (2007) 707-719
39. Yamashita M., Hirahara K., Shinnakasu R., Hosokawa H., Norikane S., Kimura M.Y., Hasegawa A., and Nakayama T. Crucial role of MLL for the maintenance of memory T helper type 2 cell responses. Immunity 24 (2006) 611-622. The authors report that MLL, a Trithorax gene product is required for the maintenance of memory Th2 cell function. MLL possesses an intrinsic histone methyltransferase (H3-K4) activity. This is the first example of the identification of a molecule that controls the function of memory Th cells.
40. Bernstein B.E., Kamal M., Lindblad-Toh K., Bekiranov S., Bailey D.K., Huebert D.J., McMahon S., Karlsson E.K., Kulbokas III E.J., Gingeras T.R., et al. Genomic maps and comparative analysis of histone modifications in human and mouse. Cell 120 (2005) 169-181
41. Yokoyama A., Wang Z., Wysocka J., Sanyal M., Aufiero D.J., Kitabayashi I., Herr W., and Cleary M.L. Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression. Mol Cell Biol 24 (2004) 5639-5649
42. Kimura M.Y., Iwamura C., Suzuki A., Miki T., Hasegawa A., Sugaya K., Yamashita M., Ishii S., and Nakayama T. Schnurri-2 controls memory Th1 and Th2 cell numbers in vivo. J Immunol 178 (2007) 4926-4936. The generation of memory Th1 and Th2 cells is regulated by Schnurri-2, a C2H2 type zinc finger transcription factor. Deactivation of NF-κB at the contraction phase is demonstrated to be required for generating a sufficient number of memory Th1 and Th2 cells. A crucial transcription factor that regulates the number of memory Th1/Th2 cells is identified.
43. Luckey C.J., Bhattacharya D., Goldrath A.W., Weissman I.L., Benoist C., and Mathis D. Memory T and memory B cells share a transcriptional program of self-renewal with long-term hematopoietic stem cells. Proc Natl Acad Sci U S A 103 (2006) 3304-3309
44. Yamashita M., Kuwahara M., Suzuki A., Hirahara K., Shinnakasu R., Hosokawa H., Hasegawa A., Motohashi S., Iwama A., and Nakayama T. Bmi1 regulates memory CD4 T cell survival via repression of the Noxa gene. J Exp Med 205 (2008) 1087-1097