CsA can induce DNA double-strand breaks: Implications for BMT regimens particularly for individuals with defective DNA repair

Bone Marrow Transplantation

Volumn 41, Issue 11, 2008, Pages 983-989

  O'Driscoll, M ^a   Jeggo, P A ^a  

^a UNIVERSITY OF SUSSEX   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BUSULFAN; CYCLOSPORIN; DOUBLE STRANDED DNA; FLUDARABINE; METHOTREXATE; POLYDEOXYRIBONUCLEOTIDE SYNTHASE;

ARTICLE; BONE MARROW TRANSPLANTATION; CELL LINE; CHEMOPROPHYLAXIS; CONTROLLED STUDY; DNA REPAIR; DNA REPLICATION; DNA STRAND BREAKAGE; DRUG RESPONSE; DRUG SENSITIVITY; GRAFT VERSUS HOST REACTION; HUMAN; HUMAN CELL; IMMUNOSUPPRESSIVE TREATMENT; MUTATION; PRE B LYMPHOCYTE; PRIORITY JOURNAL; TREATMENT INDICATION;

BONE MARROW TRANSPLANTATION; CELL LINE; CYCLOSPORINE; DNA BREAKS, DOUBLE-STRANDED; DNA LIGASES; DNA REPAIR-DEFICIENCY DISORDERS; HUMANS; IMMUNOSUPPRESSIVE AGENTS; PRECURSOR CELLS, B-LYMPHOID; SYNDROME; TRANSPLANTATION CONDITIONING;

EID: 45449095238     PISSN: 02683369     EISSN: 14765365     Source Type: Journal    
DOI: 10.1038/bmt.2008.18     Document Type: Article

References (43)

1. Aschan J. Allogeneic haematopoietic stem cell transplantation: Current status and future outlook. Br Med Bull 2006; 77-78: 23-36.
2. Gennery A, Slatter M, Bhattacharya A, Jeggo P, Abinun M, Flood T et al. Bone marrow transplantation for Nijmegan breakage syndrome. J Pediatr Hematol Oncol 2005; 27: 239.
3. Resnick IB, Shapira MY, Slavin S. Nonmyeloablative stem cell transplantation and cell therapy for malignant and non-malignant diseases. Transpl Immunol 2005; 14: 207-219.
4. O'Driscoll M, Gennery AR, Seidel J, Concannon P, Jeggo PA. An overview of three disorders associated with genetic instability: LIG4 syndrome, RS-SCID and ATR-Seckel syndrome. DNA Repair 2004; 3: 1227-1235.
5. Buck D, Malivert L, de Chasseval R, Barraud A, Fondaneche M-C, Sanal O et al. Cernunnos, a novel nonhomologous end-joining factot, is mutated in human immunodeficiency with microcephaly. Cell 2006; 124: 287-299.
6. O'Driscoll M, Cerosaletti KM, Girard P-M, Dai Y, Stumm M, Kysela B et al. DNA ligase IV mutations identified in patients exhibiting development delay and immunodeficiency. Mol Cell 2001; 8: 1175-1185.
7. Moshous D, Callebaut I, de Chasseval R, Corneo B, Cavazzana-Calvo M, Le Deist F, et al. Artemis, a novel DNA double-strand break repair/ V(D)J recombination protein, is mutated in human severe combined immune deficiency. Cell 2001; 105: 177-186.
8. Ahnesorg P, Smith P, Jackson SP. XLF interacts with the XRCC4-DNA ligase IV complex to promote DNA non-homologous end-joining. Cell 2006; 124: 301-313.
9. O'Marcaigh A, DeSantes K, Hu D, Pabst H, Horn B, Li L et al. Bone marrow transplantation for T-B- severe combined immunodeficiency disease in Athabascan-speaking native Americans. Bone Marrow Transplant 2001; 27: 703-709.
10. Enders A, Fisch P, Schwarz K, Duffner U, Pannicke U, Nikolopoulos E et al. A severe form of human combined immunodeficiency due to mutations in DNA ligase IV. J Immunol 2006; 176: 5060-5068.
11. van der Burg M, van Veelen LR, Verkaik NS, Wiegant WW, Hartwig NG, Barendregt BH et al. A new type of radiosensitive T-B-NK + severe combined immunodeficiency caused by a LIG4 mutation. J Clin Invest 2006; 116: 137-145.
12. Gruhn B, Seidel J, Zintl F, Varon R, Tonnies H, Neitzel H et al. Successful bone marrow transplantation in a patient with DNA ligase IV deficiency and bone marrow failure. Orphanet J Rare Dis 2007; 2 5.
13. Kobayashi N, Agematsu K, Sugita K, Sako M, Nonoyama S, Yachie A et al Novel Artemis gene mutations of radiosensitive severe combined immunodeficiency in Japanese families. Hum Genet 2003; 112: 348-352.
14. Buckley RH. Molecular defects in human severe combined immunodeficiency and approaches to immune reconstitution. Ann Rev Immunol 2004; 22: 625-655.
15. Deeg HJ, Leisenring W, Storb R, Nims J, Flowers MED, Witherspoon RP et al. Long-term outcome after marrow transplantation for severe aplastic anemia. Blood 1998; 91: 3637-3645.
16. Duncan N, Craddock C. Optimizing the use of cyclosporin in allogeneic stem cell transplantation. Bone Marrow Transplant 2006; 38: 169-174.
17. Reynolds NJ, Al-Daraji WI. Calcineurin inhibitors and sirolimus: mechanisms of action and applications in dermatology. Clin Exp Dermatol 2002; 27: 555-561.
18. Grawunder U, Zimmer D, Fugmann S, Schwarz K, Lieber MR. DNA ligase IV is essential for V(D)J recombination and DNA double-strand break repair in human precursor lymphocytes. Mol Cell 1998; 2: 477-484.
19. Riballo E, Kuhne M, Rief N, Doherty AJ, Smith GC, Recio MJ et al. A pathway of double strand break rejoining dependent upon ATM, Artemis and proteins locating to g-H2AX foci. Mol Cell 2004; 16: 715-724.
20. Rogakou EP, Pilch DR, Orr AH, Ivanova VS, Bonner WM. DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139. J Biol Chem 1998; 273: 5858-5868.
21. Rogakou EP, Boon C, Redon C, Bonner WM. Megabase chromatin domains involved in DNA double-strand breaks in vivo. J Cell Biol 1999; 146: 905-916.
22. Fernandez-Capetillo O, Lee A, Nussenzweig M, Nussenzweig A. H2AX: The histone guardian of the genome. DNA Repair 2004; 3: 959-967.
23. Fernandez-Capetillo O, Chen HT, Celeste A, Ward I, Romanienko PJ, Morales JC et al. DNA damage-induced G2-M checkpoint activation by historic H2AX and 53BP1. Nat Cell Biol 2002; 4: 993-997.
24. Lindahl T. Instability and decay of the primary structure of DNA. Nature 1993; 362: 709-714.
25. Caldecott KW. XRCCI and DNA strand break repair. DNA Repair 2003; 2: 955-969.
26. Caldecott KW. Mammalian single-strand break repair: Mechanisms and links with chromatin. DNA Repair 2007; 6: 443-453.
27. Caldecott KW. Mammalian DNA single-strand break repair: An X-ra(y)ted affair. Bioessays 2001; 23: 447-455.
28. Ahlers C, Kreideweiss S, Nordheim A, Ruhlmann A. Cyclosporin A inhibits Ca2+ -mediated upregulation of the DNA repair enzyme DNA polymerase beta in human peripheral blood mononuclear cells. Eur J Biochem 1999; 264: 952-959.
29. Lobrich M, Jeggo PA. Harmonising the response to DSBs: A new string in the ATM bow. DNA Repair 2005; 4: 749-759.
30. Takata M, Sasaki MS, Sonoda E, Morrison C, Hashimoto M, Utsumi H et al. Homologous recombination and non-homologous end-joining pathways of DNA double-strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells. EMBO J 1998: 17: 5497-5508.
31. Ruutu T, Niederwieser D, Gratwohl A, Apperley J. A survey of the prophylaxis and treatment of acute GVHD in Europe: A report of the European Group for Blood and Marrow Transplantation (EBMT). Bone Marrow Transplant 1997: 19: 759-764.
32. Deeg HJ, Socie G. Malignancies after hematopoietic stem cell transplantation: Many questions, some answers. Blood 1998: 91 1833-1844.
33. Buell JF, Gross TG, Woodle ES. Malignancy after transplantation. Transplantation 2005; 80 (2(S)): 254-264.
34. Tremblay F, Fernandes M, Habbab F, de Edwardes M, Loertscher R, Meterissian S, Malignancy after renal transplantation: Incidence and role of type of immunosuppression. Ann Surg Oncol 2002; 9: 785-788.
35. Herman M, Weinstein T, Korzets A, Chagnac A, Ori Y, Zevin D et al. Effect of cyclosporin A on DNA repair and cancer incidence in kidney transplant recipients. J Lab Clin Med 2001; 137: 14-20.
36. Herman M, Ori Y, Chagnac A, Weinstein T, Korzets A. Zevin D et al. DNA repair in mononuclear cells: Role of serine threonine phosphatases. J Lab Clin Med 2002; 140: 255-262.
37. Yarosh DB, Pena AV, Nay SL, Canning MT, Brown DA. Calcineurin inhibitors decrease DNA repair and apoptosis in human keratinocytes following ultraviolet B irradiation. J Investig Dermatol 2005; 125: 1020-1025.
38. O'Donovan P, Perrett CM, Zhang X, Montaner B, Xu Y-Z, Harwood CA et al. Azathioprine and UVA light generate mutagenic oxidative DNA damage. Science 2005; 309: 1871-1874.
39. Karran P, Thiopurines, DNA damage, DNA repair and therapy-related cancer. Br Med Bull 2006; 79-80: 153-170.
40. Franco S, Gostissa M, Zha S, Lombard DB, Murphy MM, Zarrin AA et al H2AX prevents DNA breaks from progressing to chromosome breaks and translocations. Mol Cell 2006; 21: 201-214.
41. Franco S, Alt FW, Manis JP. Pathways that suppress programmed DNA breaks from progressing to chromosomal breaks and translocations. DNA Repair 2006; 5: 1030-1041.
42. Couedel C, Mills KD, Barchi M, Shen L, Olshen A, Johnson RD et al. Collaboraion of homologous recombination and nonhomologous end-joining factors for the survival and integrity of mice and cells. Genes Dev 2004; 18: 1293-1304.
43. Kolb HJ, Socie G, Duell T, Van Lint MT, Tichelli A, Apperley JF et al Malignant neoplasms in long-term survivors of bone marrow transplantation. Ann Intern Med 1999; 131: 738-744.