In vivo triggering through 4-1BB enables TH-independent priming of CTL in the presence of an intact CD28 costimulatory pathway

Journal of Immunology

Volumn 168, Issue 8, 2002, Pages 3755-3762

  Diehl, Linda ^a   Van Mierlo, Geertje J D ^a   Den Boer, Annemieke T ^a   Van der Voort, Ellen ^a   Fransen, Marieke ^a   Van Bostelen, Liesbeth ^a   Krimpenfort, Paul ^a   Melief, Cornelis J M ^a   Mittler, Robert ^a   Toes, Rene E M ^a   Offringa, Rienk ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CANCER VACCINE; CD28 ANTIGEN; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 4 1BB; PEPTIDE DERIVATIVE; T LYMPHOCYTE RECEPTOR; TUMOR NECROSIS FACTOR RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; DRUG POTENCY; IMMUNE RESPONSE; IMMUNITY; IMMUNOSTIMULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION;

EID: 0037090182     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.168.8.3755     Document Type: Article

References (25)

1. T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions
2. + T-helper and a T-killer cell
3. Help for cytotoxic-T-cell responses is mediated by CD40 signalling
4. Immunobiology of dendritic cells
5. Costimulatory regulation of T cell function
6. CD28/B7 system of T cell costimulation
7. Signals through 4-1BB are costimulatory to previously activated splenic T cells and inhibit activation-induced cell death
8. Cutting edge: 4-1BB is a bona fide CD8 T cell survival signal
9. Molecular and biological characterization of human 4-1BB and its ligand
10. Costimulation of CD28-T lymphocytes by 4-1BB ligand
11. + T cell proliferation and lead to the amplification in vivo of cytotoxic T cell responses
12. Role of 4-1BB ligand in costimulation of T lymphocyte growth and its upregulation on M12 B lymphomas by cAMP
13. Potential role of 4-1BB in T cell activation: Comparison with the costimulatory molecule CD28
14. Analysis of 4-1BB ligand (4-1BBL)-deficient mice and of mice lacking both 4-1BBL and CD28 reveals a role for 4-1BBL in skin allograft rejection and in the cytotoxic T cell response to influenza virus
15. 4-1BB ligand, a member of the TNF family, is important for the generation of antiviral CD8 T cell responses
16. 4-1BB costimulation is required for protective anti-viral immunity after peptide vaccination
17. Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors
18. Anti-4-1BB monoclonal antibodies abrogate T cell-dependent humoral immune responses in vivo through the induction of helper T cell anergy
19. Analysis of the B7 costimulatory pathway in allograft rejection
20. Analysis of 4-1BBL and laminin binding to murine 4-1BB, a member of the tumor necrosis factor receptor superfamily, and comparison with human 4-1BB
21. Cross-priming of CTL responses in vivo does/1 not require antigenic peptides in the endoplasmic reticulum of immunizing cells
22. Peptide vaccination can lead to enhanced tumor growth through specific T-cell tolerance induction
23. CD40 activation in vivo overcomes peptide-induced peripheral cytotoxic T-lymphocyte tolerance and augments anti-tumor vaccine efficacy
24. - T cells
25. CD28-independent, TRAF2-dependent costimulation of resting T cells by 4-1BB ligand