Structural characterizations of nonpeptidic thiadiazole inhibitors of matrix metalloproteinases reveal the basis for stromelysin selectivity

Protein Science

Volumn 7, Issue 10, 1998, Pages 2118-2126

  Finzel, B C ^a   Baldwin, E T ^a   Bryant Jr , G L ^a   Hess, G F ^a   Wilks, J W ^a   Trepod, C M ^a   Mott, J E ^a   Marshall, V P ^a   Petzold, G L ^a   Poorman, R A ^a   O'Sullivan, T J ^a   Schostarez, H J ^a   Mitchell, M A ^a  

^a PFIZER INC   (United States)

Author keywords

Collagenase; Drug design; Endopeptidase; Gelatinase; Matrix metalloproteinase; MMP

Indexed keywords

1,3,4 THIADIAZOLE DERIVATIVE; COLLAGENASE; GELATINASE; MATRIX METALLOPROTEINASE; PROTEINASE; STROMELYSIN; THIADIAZOLE DERIVATIVE;

ARTICLE; CONFORMATIONAL TRANSITION; CRYSTALLOGRAPHY; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME CONFORMATION; ENZYME SPECIFICITY; ENZYME STRUCTURE; HYDROGEN BOND; HYDROPHOBICITY; PRIORITY JOURNAL;

EID: 0031787287     PISSN: 09618368     EISSN: None     Source Type: Journal    
DOI: 10.1002/pro.5560071008     Document Type: Article

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