Mepyramine, a histamine H1 receptor inverse agonist, binds preferentially to a G protein-coupled form of the receptor and sequesters G protein

Journal of Biological Chemistry

Volumn 279, Issue 33, 2004, Pages 34431-34439

  Fitzsimons, Carlos P ^b   Monczor, Federico ^a,b,c   Fernández, Natalia ^a,b,c   Shayo, Carina ^a,b,c   Davio, Carlos ^a,c  

^a UNIVERSIDAD DE BUENOS AIRES   (Argentina)

^b INST DE BIOL Y MED EXPERIMENTAL   (Argentina)

^c Facultad de Ciencias Naturales e Instituto M Lillo   (Argentina)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINETRIPHOSPHATE; BIOCHEMISTRY; CALCIUM; CELLS; PROTEINS;

MEPYRAMINE; MOLECULAR MECHANISMS; PHARMACOLOGY; SIGNALING PATHWAYS;

DRUG PRODUCTS;

CALCIUM; G PROTEIN COUPLED RECEPTOR; HISTAMINE H1 RECEPTOR; MEPYRAMINE; PURINE RECEPTOR; ADENOSINE TRIPHOSPHATE; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); HISTAMINE H1 RECEPTOR ANTAGONIST; INOSITOL PHOSPHATE; LIGAND; TRIPROLIDINE;

ANIMAL CELL; ARTICLE; CALCIUM BLOOD LEVEL; CHINESE HAMSTER; CHO CELL; CONTROLLED STUDY; DRUG MECHANISM; GUINEA PIG; MOLECULAR MODEL; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR AFFINITY; SIGNAL TRANSDUCTION; ANIMAL; CELL MEMBRANE; CHEMICAL MODEL; CHEMISTRY; DOSE RESPONSE; HAMSTER; METABOLISM; MOLECULAR CLONING; PROTEIN BINDING; WESTERN BLOTTING;

ANIMALIA; CAVIA PORCELLUS; CRICETINAE; CRICETULUS GRISEUS; SUS SCROFA;

ADENOSINE TRIPHOSPHATE; ANIMALS; BLOTTING, WESTERN; CALCIUM; CELL MEMBRANE; CHO CELLS; CLONING, MOLECULAR; CRICETINAE; DOSE-RESPONSE RELATIONSHIP, DRUG; GTP-BINDING PROTEIN ALPHA SUBUNITS, GQ-G11; GTP-BINDING PROTEINS; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); GUINEA PIGS; HISTAMINE H1 ANTAGONISTS; INOSITOL PHOSPHATES; LIGANDS; MODELS, CHEMICAL; PROTEIN BINDING; PYRILAMINE; RECEPTORS, HISTAMINE H1; TRIPROLIDINE;

EID: 4544300274     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M400738200     Document Type: Article

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