Studies on the novel antiallergic agent HSR-609: Its penetration into the central nervous system in mice and guinea pigs and its selectivity for the histamine H1-receptor

Japanese Journal of Pharmacology

Volumn 73, Issue 4, 1997, Pages 291-298

  Kakiuchi, Masato ^a   Ohashi, Tetsuo ^a   Musoh, Keiichi ^a   Kawamura, Kimio ^a   Morikawa, Kouji ^a   Kato, Hideo ^a  

^a Abbott Japan Co Ltd   (Japan)

Author keywords

Amphoteric compound; Antiallergic agent; Central nervous system penetration; Histamine H1 receptor; HSR 609

Indexed keywords

3 [4 (8 FLUORO 5,11 DIHYDROBENZ[B]OXEPINO[4,3 B]PYRIDIN 11 YLIDENE)PIPERIDINO]PROPIONIC ACID; 8 FLUORO 5,11 DIHYDRO 11 (1 METHYL 4 PIPERIDYLIDENE)BENZ[B]OXEPINO[4,3 B]PYRIDINE; ANTIALLERGIC AGENT; BRAIN RECEPTOR; CETIRIZINE; CYPROHEPTADINE; ENDOGENOUS COMPOUND; HISTAMINE; HISTAMINE H1 RECEPTOR; KETOTIFEN; MEPYRAMINE; MUSCARINIC RECEPTOR; SEROTONIN 2 RECEPTOR; TERFENADINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BLOOD VESSEL PERMEABILITY; BRAIN CORTEX; CONTROLLED STUDY; DRUG BRAIN LEVEL; DRUG PENETRATION; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; GUINEA PIG; LUNG RECEPTOR; MALE; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; RAT; RECEPTOR AFFINITY;

EID: 0030975853     PISSN: 00215198     EISSN: None     Source Type: Journal    
DOI: 10.1254/jjp.73.291     Document Type: Article

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