Human adenosine A1 receptor and P2Y2-purinoceptor-mediated activation of the mitogen-activated protein kinase cascade in transfected CHO cells

British Journal of Pharmacology

Volumn 124, Issue 7, 1998, Pages 1491-1499

  Dickenson, John M ^c   Blank, Jonathan L ^b   Hill, Stephen J ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^b UNIVERSITY OF LEICESTER   (United Kingdom)

^c NOTTINGHAM TRENT UNIVERSITY   (United Kingdom)

Author keywords

Adenosine A1 receptor; CHO cells; MAP kinase; P2Y2 purinoceptors

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 [1 (3 AMIDINOTHIOPROPYL) 1H INDOL 3 YL] 3 (1 METHYL 1H INDOL 3 YL)MALEIMIDE; 2 MORPHOLINO 8 PHENYLCHROMONE; 6 N CYCLOPENTYLADENOSINE; ADENOSINE A1 RECEPTOR; DAIDZEIN; GENISTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PERTUSSIS TOXIN; PURINE P2Y RECEPTOR; WORTMANNIN; ADENOSINE RECEPTOR; LUCIFERASE; PROTEIN KINASE (CALCIUM,CALMODULIN); PURINE P2 RECEPTOR; PURINE P2Y2 RECEPTOR;

ANIMAL CELL; ARTICLE; CHO CELL; GENETIC TRANSFECTION; NONHUMAN; PRIORITY JOURNAL; ANIMAL; ENZYME ACTIVATION; GENETICS; HAMSTER; HUMAN; METABOLISM; PHOSPHORYLATION; REPORTER GENE;

ANIMALS; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CHO CELLS; CRICETINAE; ENZYME ACTIVATION; GENES, REPORTER; HUMANS; LUCIFERASES; PHOSPHORYLATION; RECEPTORS, PURINERGIC P1; RECEPTORS, PURINERGIC P2; TRANSFECTION;

EID: 0031595230     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0701977     Document Type: Article

References (43)

1. AKIYAMA, T., ISHIDA, J., NAKAGAWA, S., OGAWARA, H., WATA-NABE, S., ITOH, N., SHIBAYA, M. & FUKAMI, Y. (1987). Genistein, a specific inhibitor of tyrosine specific protein kinases. J. Biol. Chem., 262, 5592-5595.
2. BLENIS, J. (1993). Signal trunsduction via the MAP kinases: Proceed at your own RISK. Proc. Natl. Acad. Sci. U.S.A., 90, 5889-5892.
3. DAVIS, P.D., HILL, C.H., KEECH, E., LAWTON, G., NIXON, J.S., SEDGWICK, A.D., WADSWORTH, J., WESTMACOTT, D. & WILKINSON, S.E. (1989). Potent selective inhibitors of protein kinase C. FEBS Lett., 259, 61-63.
4. DENHARDT, D.T. (1996). Signal-tranducing protein phosphorylalion cascades mediated by Ras/Rho proteins in the mammalian cell: the potential for multiplex signalling. Biochem J., 318, 729-747.
5. 1 receptors and endogenous cholecystokinin receptors in CHO cells. Eur. J. Pharmacol., 302, 141-151.
6. 2 activity in CHO cells. Eur. J. Pharmacol., 321, 77-86.
7. 1 receptor activates the MAP kinase signalling pathway in transfected CHO-K1 cells. Br. J. Pharmacol., 123, 140.
8. DUDLEY, D.T., PANG, L., DECKER, S.J., BRIDGES, A.J. & SALTIEL, A.R. (1995). A synthetic inhibitor of the mitogen-activatcd protein kinase cascade. Proc. Natl. Acad. Sci. U.S.A., 92, 7686-7689.
9. EDWARDS, D.R. (1994). Cell signalling and the control of gene transcription. Trends Pharmacol. Sci., 15, 239-244.
10. EGUCHI, S., MATSUMOTO, T., MOTLEY, E.D., UTSUNOMIYA, H. & INAGAMI, T. (1996). Identification of an essential signalling cascade for mitogen-activated protein kinase activation by angiotensin II in cultured rat vascular smooth muscle cells. J. Biol. Chem., 271, 14169-14175.
11. FAURE, M., VOYNO-YASENETSKAYA, T.A. & BOURNE, H.R. (1994). cAMP and βγ subunits of heterotrimeric G proteins stimulate the mitogen-activated protein kinase pathway in COS-7 cells. J. Biol. Chem., 269, 7851-7854.
12. 1A receptor via a G protein βγ subunit initiated pathway. Biochemistry, 35, 13716-13722.
13. GRAHAM, A., MCLEES, A., KENNEDY, C., GOULD, G.W. & PLEVIN, R. (1996). Stimulation by the nucleotides, ATP and UTP of mitogen-activated protein kinase in Eahy 926 endothelial cells. Br. J. Pharmacol., 117, 1341-1347.
14. GUAN. K-L. (1994). The mitogen activated protein kinase signal transduction pathway: From the cell to the nucleus. Cell. Signaling, 6, 581-589.
15. q-mediated mitogen activated protein kinase activation. J. Biol. Chem., 270, 17148-17153.
16. HAWES, B.E., LUTTRELL, L.M., VAN BIESEN, T. & LEFKOWITZ, R.J. (1996). Phosphatidylinositol 3-kinase is an early intermediate in the Gβγ-mediated mitogen-activated protein kinase signaling pathway. J. Biol. Chem., 271, 12133-12136.
17. HUANG, N.N., WANG, D. & HEPPEL, L.A. (1989). Extracellular ATP is a mitogen for 3T3 cells, 3T6 cells and A431 cells and acts synergistically with other growth factors. Proc. Natl. Acad. Sci. U.S.A., 86, 7904-7908.
18. HUWILER, A. & PFEILSCHIFTER, J. (1994). Stimulation by extracellular ATP and UTP of the mitogen-activated protein kinase cascade and proliferation of rat renal mesangial cells. Br. J Pharmacol., 113, 1455-1463.
19. 2-purinoceptor in cultured CHO-K1 cells. Br. J. Pharmacol., 110, 1305-1310.
20. 1 receptor in CHO-K1 cells to calcium mobilisation via a pertussis toxin-sensitive mechanism. Br. J. Pharmacol., 111, 1252-1256.
21. KARIN, M. (1995). The regulation of AP-1 activity by mitogen-activated protein kinases. J. Biol. Chem., 270, 16483-16486.
22. ras. Proc. Natl. Acad. Sci. U.S.A., 91, 12706-12710.
23. KUSUHARA, M., YAMAGUCHI, K., KURANAMI, M., SUZAKI, A., ISHIKAWA, S., MOON, H., ADACHI, I., HORI, S. & HANDA, S. (1992). Stimulation of anchorage independent cell growth by endothelin in NRK 49F cells. Cancer Res., 52, 3011-3014.
24. LOWRY, O.H., ROSEBROUGH, N.J., FARR, A.C. & RANDALL, R.J. (1951). Protein measurements with the folin phenol reagent. J. Biol. Chem., 193, 265-275.
25. LUTTRELL, L.M., HAWES, B.E., VAN BIESEN, T., LUTTRELL, D.K., LANSING, T.J. & LEFKOWITZ, R.J. (1996). Role of c-Src tyrosine kinase in G-protein coupled receptor and Gβγ subunit mediated activation of mitogen-activated protein kinases. J Biol. Chem., 271, 19443-19450.
26. MALARKEY, K., BELHAM, C.M., PAUL. A., GRAHAM, A., MCLEES, A., SCOTT, P.H. & PLEVIN, R. (1995). The regulation of tyrosine kinase signalling pathways by growth factor and G-protein-coupled receptors. Biochem. J., 309, 361-375.
27. 2-purinoceptors in CHO-K1 cells. Br. J. Pharmacol., 115, 1415-1424.
28. MITCHELL, F.M., RUSSELL, M. & JOHNSON, G.L. (1995). Differential calcium dependence in the activity of c-Jun kinase and mitogen-activated protein kinase by muscarinic acetylcholine receptors in rat 1a cells. Biochem. J., 309, 381-384.
29. NEARY, J.T., WHITTEMORE, S.R., ZHU, Q & NORENBERG, M.D. (1994). Synergistic activation of DNA synthesis in astrocytes by tibroblast growth factors and extracellular ATP. J. Neurochem., 63, 490-494.
30. NEARY, J.T. (1996). Trophic actions of extracellular ATP on astrocytes, synergistic interactions with fibroblast growth factors and underlying signal transduction mechanisms. Ciba Found. Symp., 198, 130-141.
31. 2 by p42 microtubule-associated protein 2 kinase and protein kinase C. J. Biol. Chem., 268, 1960-1964.
32. OLAH, M.E. & STILES, G.L. (1995). Adenosine receptor subtypes: characterisation and therapeutic regulation. Ann. Rev. Pharmacol. Toxicol., 35, 581-606.
33. PATEL, V., GOODWIN, A., WILKIE, N. & BOARDER, M.R. (1996). Phosphorylation and activation of p42 and p44 mitogen-activated protein kinase are required for the P2 purinoceptor stimulation of endothelial prostacyclin production. Biochem. J., 320, 221-226.
34. SEGER, R. & KREB, E.G. (1995). The MAPK signaling cascade. FASEB J., 9, 726-735.
35. i/o-coupled receptors. Biochem. J., 328, 153-158.
36. A: The role of a wortmannin-sensitive pathway. Mol. Pharmacol., 49, 447-457.
37. TAKISHIMA, K., GRISWOLD-PRENNER., I., INGEBRITSEN, T. & ROSNER, M.R. (1991). Epidermal growth factor (EGF) receptor T669 peptide kinase from 3T3-L1 cells is an EGF-stimulated 'MAP' kinase. Proc. Natl. Acad. Sci. U.S.A., 88, 2520-2524.
38. TOUHARA, K., HAWES, B.E., VAN BIESEN, T. & LEFKOWITZ, R.J. (1995). G protein βγ subunits stimulate phosphorylation of She adapter protein. Proc. Natl. Acad. Sci. U.S.A., 92, 9284-9287.
39. UI, M., OKADA, T., HAZEKI, K. & HAZEKI, O. (1995). Wortmannin as a unique probe for an intracellular signalling protein, phosphoinositide 3-kinase. Trends Biochem. Sci., 20, 303-307.
40. o-protein α-subunits activate mitogen-activated protein kinase via a novel protein kinase C-dependent pathway. J. Biol. Chem., 271, 1266-1269.
41. VLAHOS, C.J., MATTER, W.F., HUI, K.Y. & BROWN, R.F. (1994). A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY 294002). J. Biol. Chem., 269, 5241-5248.
42. WAN, Y., KUROSAKI, T. & HUANG, X-Y. (1996). Tyrosine kinases in activation of the MAP kinase cascade by G-prolein coupled receptors. Nature (London), 380, 541-544.
43. XING, J., GINTY, D.D. & GREENBERG, M.E. (1996). Coupling of the Ras-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase, Science, 273, 959-963.