Hoe 140 and pseudo-irreversible antagonism in the rat vas deferens in vitro

European Journal of Pharmacology

Volumn 398, Issue 1, 2000, Pages 131-138

  Asghar, Aziz U R ^a   Wheeldon, Alan ^a,b,c   Coleman, Robert A ^a,b,d   Bountra, Chas ^a,b   McQueen, Daniel S ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b GLAXOSMITHKLINE   (United Kingdom)

^c NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

^d Pharmagene Plc   (United Kingdom)

Author keywords

Bradykinin; Bradykinin receptor; Hoe 140; insurmountable; Rat; Vas deferens Antagonism

Indexed keywords

BRADYKININ B2 RECEPTOR; BRADYKININ B2 RECEPTOR ANTAGONIST; DEXTRO ARGINYLBRADYKININ[3 HYDROXYPROLINE 5,8 [3 (2 THIENYL)ALANINE] 7 DEXTRO PHENYLALANINE]; ICATIBANT;

ANIMAL TISSUE; ARTICLE; DRUG EFFECT; DRUG RECEPTOR BINDING; ELECTROSTIMULATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; VAS DEFERENS;

15-HYDROXY-11 ALPHA,9 ALPHA-(EPOXYMETHANO)PROSTA-5,13-DIENOIC ACID; ANGIOTENSIN II; ANIMALS; BRADYKININ; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRIC STIMULATION; MALE; MUSCLE CONTRACTION; MUSCLE, SMOOTH; NOREPINEPHRINE; RATS; RATS, WISTAR; RECEPTORS, BRADYKININ; VAS DEFERENS;

EID: 0034625649     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(00)00281-8     Document Type: Article

References (49)

1. Asghar A.U.R., Wheeldon A., Birch P.J. Characterisation of bradykinin receptors in the electrically-stimulated rat vas deferens. Br. J. Pharmacol. 108:1993;. 59P.
2. Bathon J.M., Proud D. Bradykinin antagonists. Annu. Rev. Pharmacol. Toxicol. 31:1991;129-162.
3. Bhoola K.D., Figueroa C.D., Worthy K. Bioregulation of kinins: kallikreins, kininogens, and kininases. Pharmacol. Rev. 44:1992;1-80.
4. Bond R.A., Ornstein A.G., Clarke D.E. Unsurmountable antagonism to 5-hydroxytryptamine in rat kidney results from pseudoirreversible inhibition rather than multiple receptors or allosteric receptor modulation. J. Pharmacol. Exp. Ther. 249:1989;401-410.
5. Braas K.M., Manning D.C., Perry D.C., Snyder S.H. Bradykinin analogues: differential agonist and antagonist activities suggesting multiple receptors. Br. J. Pharmacol. 94:1988;3-5.
6. Burch R.M., Kyle D.J. Recent developments in the understanding of bradykinin receptors. Life Sci. 50:1992;829-838.
7. Burch R.M., Farmer S.G., Steranka L.R. Bradykinin receptor antagonists. Med. Res. Rev. 10:1990;237-269.
8. Clark R.B., Knoll B.J., Barber R. Partial agonists and G-protein coupled receptor desensitization. Trends Pharmacol. Sci. 20:1999;279-286.
9. 2 kinin receptors in formalin-induced nociceptive response in the mouse. Br. J. Pharmacol. 110:1993;193-198.
10. Cuthbert A.W., MacVinish L.J., Pickles R.J. Antagonism of kinin effects on epithelial by Hoe 140: apparently competitive and non-competitive interactions. Br. J. Pharmacol. 107:1992;797-802.
11. 2 receptor gene. Biochem. Biophys. Res. Commun. 187:1992;1306-1313.
12. Erdos E. Bradykinin, kallidin and kallikrein. Erdos E. Handbook of Experimental Pharmacology Supplement to Vol. 25. 1979;817 Springer-Verlag, Berlin.
13. Farmer S.G., Burch R.M. Biochemical and molecular pharmacology of kinin receptors. Annu. Rev. Pharmacol. Toxicol. 32:1992;511-536.
14. 2 receptor antagonist, Hoe 140, in isolated blood vessels from different species. Br. J. Pharmacol. 112:1994;683-689.
15. 3 receptors in the guinea-pig trachea, and are blocked by HOE 140. Br. J. Pharmacol. 105:1992;293-296.
16. Griesbacher T., Lembeck F. Analysis of the antagonistic actions of HOE 140 and other novel bradykinin analogues on the guinea-pig ileum. Eur. J. Pharmacol. 211:1992;393-398.
17. Hall J.M. Bradykinin receptors: pharmacological properties and biological roles. Pharmacol. Ther. 56:1992;131-190.
18. 2 bradykinin receptors. Mol. Pharmacol. 45:1994;1-8.
19. Hock F.J., Wirth K., Albus U., Linz W., Gerhards H.J., Wiemer G., Henke S., Breipohl G., Konig W., Knolle J. Hoe 140 a new potent and long acting bradykinin-antagonist: in vitro studies. Br. J. Pharmacol. 102:1991;769-773.
20. Huidobro-Toro J.P., Herreros R., Pinto-Corrado A. Pre- and postsynaptic bradykinin responses in the rat vas deferens: asymmetric distribution of the postsynaptic effect. Eur. J. Pharmacol. 121:1986;305-311.
21. 2-receptors. Naunyn-Schmiedberg’s Arch. Pharmacol. 328:1985;295-300.
22. Kenakin T.P. The classification of drugs and drug receptors in isolated tissues. Pharmacol. Rev. 36:1984;165-222.
23. Khorana H.G. Rhodopsin, photoreceptor of the rod cell. An emerging pattern for structure and function. J. Biol. Chem. 267:1992;1-4.
24. 2-adrenergic receptor-Gs complex: evidence for agonist-specific states. Mol. Pharmacol. 52:1997;144-154.
25. Kyle D.J., Martin J.A., Farmer S.G., Burch R.M. Design and conformational analysis of several highly potent bradykinin receptor antagonists. J. Med. Chem. 34:1991;1230-1233.
26. Leeb-Lundberg L.M., Mathis S.A., Herzig M.C. Antagonists of bradykinin that stabilize a G-protein-uncoupled state of the B2 receptor act as inverse agonists in rat myometrial cells. J. Biol. Chem. 269:1994;25970-25973.
27. Lembeck F., Griesbacher T., Eckhardt M., Henke S., Breipohl G., Knolle J. New, long-acting, potent bradykinin antagonists. Br. J. Pharmacol. 102:1991;297-304.
28. 2 bradykinin receptors in rat myometrial membranes. Eur. J. Pharmacol. 199:1991;363-365.
29. Llona I., Vavrek R., Stewart J., Huidobro-Toro J.P. Identification of pre- and postsynaptic bradykinin receptor sites in the vas deferens: evidence for different structural prerequisites. J. Pharmacol. Exp. Ther. 241:1987;608-614.
30. Marceau F., Levesque L., Drapeau G., Rioux F., Salvino J.M., Wolfe H.R., Seoane P.R., Sawutz D.G. Effects of peptide and nonpeptide antagonists of bradykinin B2 receptors on the venoconstrictor action of bradykinin. J. Pharmacol. Exp. Ther. 269:1994;1136-1143.
31. Marie J., Koch C., Pruneau D., Paquet J.L., Groblewski T., Larguier R., Lombard C., Deslauriers B., Maigret B., Bonnafous J.C. Constitutive activation of the human bradykinin B2 receptor induced by mutations in transmembrane helices III and VI. Mol. Pharmacol. 551:1999;92-101.
32. 2 bradykinin receptor. Proc. Natl. Acad. Sci. U. S. A. 88:1991;7724-7728.
33. 2 pharmacological selectivity. Mol. Pharmacol. 44:1993;346-355.
34. 2-receptors on endothelial cells induces relaxation and contraction in porcine basilar artery in vitro. Br. J. Pharmacol. 128:1999;241-247.
35. Onaran H.O., Gürdal H. Ligand efficacy and affinity in an interacting 7TM receptor model. Trends Pharmacol. Sci. 20:1999;274-278.
36. Prins N.H., Briejer M.R., Schuurkes J.A. Characterization of the contraction to 5-HT in the canine colon longitudinal muscle. Br. J. Pharmacol. 120:1997;714-720.
37. 2 receptor in the guinea-pig. Br. J. Pharmacol. 116:1995;2106-2112.
38. Regoli D., Barabé J. Pharmacology of bradykinin and related kinins. Pharmacol. Rev. 32:1980;1-46.
39. 2 receptor characterization. Trends Pharmacol. Sci. 11:1990;156-161.
40. Regoli D., Jukic D., Gobeil F., Rhaleb N.E. Receptors for bradykinin and related kinins: a critical analysis. Can. J. Physiol. Pharmacol. 8:1993;556-567.
41. Regoli D., Allogho S.N., Rizzi A., Gobeil F.J. Bradykinin receptors and their antagonists. Eu. J. Pharmacol. 348:1998;1-10.
42. 8]bradykinin). Eur. J. Pharmacol. 210:1992;115-120.
43. Rifo J., Pourrat M., Vavrek R.J., Stewart J.M., Huidobro-Toro J.P. Bradykinin receptor antagonists used to characterize the heterogeneity of bradykinin-induced responses in rat vas deferens. Eur. J. Pharmacol. 142:1987;305-312.
44. 1 receptor antagonist. Br. J. Pharmacol. 107:1992;1173-1180.
45. Robertson M.J., Dougall I.G., Harper D., McKechnie K.C., Leff P. Agonist-antagonist interactions at angiotensin receptors: application of a two-state receptor model. Trends Pharmacol. Sci. 15:1994;364-369.
46. Taylor J.E., Defeudis F.V., Moreau J.P. Bradykinin-antagonists: therapeutic perspectives. Drug Dev. Res. 16:1989;1-11.
47. Tousignant C., Dion S., Drapeau G., Regoli D. Characterization of pre- and postjunctional receptors for neurokinins and kinins in the rat vas deferens. Neuropeptides. 9:1987;333-343.
48. Trifilieff A., Amrani Y., Landry Y., Gies J.P. Comparative action of new highly potent bradykinin receptor antagonists in the guinea-pig trachea. Eur. J. Pharmacol. 239:1993;227-229.
49. Tucek S., Proska J. Allosteric modulation of muscarinic acetylcholine receptors. Trends Pharmacol. Sci. 16:1995;205-212.