-
1
-
-
23444460121
-
Novel immunomodulator FTY720 is phosphorylated in rats and humans to form a single stereoisomer. Identification, chemical proof, and biological characterization of the biologically active species and its enantiomer
-
Albert R, Hinterding K, Brinkmann V, Guerini D, Muller-Hartwieg C, Knecht H et al. (2005) Novel immunomodulator FTY720 is phosphorylated in rats and humans to form a single stereoisomer. Identification, chemical proof, and biological characterization of the biologically active species and its enantiomer. J Med Chem 48:5373-7
-
(2005)
J Med Chem
, vol.48
, pp. 5373-5377
-
-
Albert, R.1
Hinterding, K.2
Brinkmann, V.3
Guerini, D.4
Muller-Hartwieg, C.5
Knecht, H.6
-
2
-
-
33845975665
-
Apigenin inhibition of involucrin gene expression is associated with a specific reduction in phosphorylation of protein kinase Cdelta Tyr311
-
Balasubramanian S, Zhu L, Eckert RL (2006) Apigenin inhibition of involucrin gene expression is associated with a specific reduction in phosphorylation of protein kinase Cdelta Tyr311. J Biol Chem 281:36162-72
-
(2006)
J Biol Chem
, vol.281
, pp. 36162-36172
-
-
Balasubramanian, S.1
Zhu, L.2
Eckert, R.L.3
-
3
-
-
33748742901
-
Sphingosine 1-phosphate receptor expression profile and regulation of migration in human thyroid cancer cells
-
Balthasar S, Samulin J, Ahlgren H, Bergelin N, Lundqvist M, Toescu EC et al. (2006) Sphingosine 1-phosphate receptor expression profile and regulation of migration in human thyroid cancer cells. Biochem J 398:547-56
-
(2006)
Biochem J
, vol.398
, pp. 547-556
-
-
Balthasar, S.1
Samulin, J.2
Ahlgren, H.3
Bergelin, N.4
Lundqvist, M.5
Toescu, E.C.6
-
4
-
-
0036765743
-
Akt activation induced by lysophosphatidic acid and sphingosine-1-phosphate requires both mitogen-activated protein kinase kinase and p38 mitogen-activated protein kinase and is cell-line specific
-
Baudhuin LM, Cristina KL, Lu J, Xu Y (2002) Akt activation induced by lysophosphatidic acid and sphingosine-1-phosphate requires both mitogen-activated protein kinase kinase and p38 mitogen-activated protein kinase and is cell-line specific. Mol Pharmacol 62:660-71
-
(2002)
Mol Pharmacol
, vol.62
, pp. 660-671
-
-
Baudhuin, L.M.1
Cristina, K.L.2
Lu, J.3
Xu, Y.4
-
6
-
-
0042197268
-
Are p27 and p21 cytoplasmic oncoproteins?
-
Blagosklonny MV (2002) Are p27 and p21 cytoplasmic oncoproteins? Cell Cycle 1:391-3
-
(2002)
Cell Cycle
, vol.1
, pp. 391-393
-
-
Blagosklonny, M.V.1
-
7
-
-
3042743990
-
FTY720: Sphingosine 1-phosphate receptor-1 in the control of lymphocyte egress and endothelial barrier function
-
Brinkmann V, Cyster JG, Hla T (2004) FTY720: sphingosine 1-phosphate receptor-1 in the control of lymphocyte egress and endothelial barrier function. Am J Transplant 4:1019-25
-
(2004)
Am J Transplant
, vol.4
, pp. 1019-1025
-
-
Brinkmann, V.1
Cyster, J.G.2
Hla, T.3
-
8
-
-
27844517355
-
Sphingosine 1-phosphate and ceramide 1-phosphate: Expanding roles in cell signaling
-
Chalfant CE, Spiegel S (2005) Sphingosine 1-phosphate and ceramide 1-phosphate: expanding roles in cell signaling. J Cell Sci 118:4605-12
-
(2005)
J Cell Sci
, vol.118
, pp. 4605-4612
-
-
Chalfant, C.E.1
Spiegel, S.2
-
9
-
-
0028904053
-
Insulin action and the insulin signaling network
-
Cheatham B, Kahn CR (1995) Insulin action and the insulin signaling network. Endocr Rev 16:117-42
-
(1995)
Endocr Rev
, vol.16
, pp. 117-142
-
-
Cheatham, B.1
Kahn, C.R.2
-
10
-
-
0034602154
-
Antiproliferative properties of sphingosine 1-phosphate in human hepatic myofibroblasts. A cyclooxygenase-2 mediated pathway
-
Davaille J, Gallois C, Habib A, Li L, Mallat A, Tao J et al. (2000) Antiproliferative properties of sphingosine 1-phosphate in human hepatic myofibroblasts. A cyclooxygenase-2 mediated pathway. J Biol Chem 275:34628-33
-
(2000)
J Biol Chem
, vol.275
, pp. 34628-34633
-
-
Davaille, J.1
Gallois, C.2
Habib, A.3
Li, L.4
Mallat, A.5
Tao, J.6
-
11
-
-
0036144679
-
Caspase activation and disruption of mitochondrial membrane potential during UV radiation-induced apoptosis of human keratinocytes requires activation of protein kinase C
-
Denning MF, Wang Y, Tibudan S, Alkan S, Nickoloff BJ, Qin JZ (2002) Caspase activation and disruption of mitochondrial membrane potential during UV radiation-induced apoptosis of human keratinocytes requires activation of protein kinase C. Cell Death Differ 9:40-52
-
(2002)
Cell Death Differ
, vol.9
, pp. 40-52
-
-
Denning, M.F.1
Wang, Y.2
Tibudan, S.3
Alkan, S.4
Nickoloff, B.J.5
Qin, J.Z.6
-
12
-
-
0034653704
-
Constitutive expression of insulin-like growth factor-1 in epidermal basal cells of transgenic mice leads to spontaneous tumor promotion
-
DiGiovanni J, Bol DK, Wilker E, Beltran L, Carbajal S, Moats S et al. (2000) Constitutive expression of insulin-like growth factor-1 in epidermal basal cells of transgenic mice leads to spontaneous tumor promotion. Cancer Res 60:1561-70
-
(2000)
Cancer Res
, vol.60
, pp. 1561-1570
-
-
DiGiovanni, J.1
Bol, D.K.2
Wilker, E.3
Beltran, L.4
Carbajal, S.5
Moats, S.6
-
13
-
-
0028609621
-
Alterations in murine keratinocyte differentiation induced by activated rasHa genes are mediated by protein kinase C-alpha
-
Dlugosz AA, Cheng C, Williams EK, Dharia AG, Denning MF, Yuspa SH (1994) Alterations in murine keratinocyte differentiation induced by activated rasHa genes are mediated by protein kinase C-alpha. Cancer Res 54:6413-20
-
(1994)
Cancer Res
, vol.54
, pp. 6413-6420
-
-
Dlugosz, A.A.1
Cheng, C.2
Williams, E.K.3
Dharia, A.G.4
Denning, M.F.5
Yuspa, S.H.6
-
14
-
-
0026627746
-
Transcripts encoding protein kinase C-alpha, -delta, -epsilon, -zeta, and -eta are expressed in basal and differentiating mouse keratinocytes in vitro and exhibit quantitative changes in neoplastic cells
-
Dlugosz AA, Mischak H, Mushinski JF, Yuspa SH (1992) Transcripts encoding protein kinase C-alpha, -delta, -epsilon, -zeta, and -eta are expressed in basal and differentiating mouse keratinocytes in vitro and exhibit quantitative changes in neoplastic cells. Mol Carcinog 5:286-92
-
(1992)
Mol Carcinog
, vol.5
, pp. 286-292
-
-
Dlugosz, A.A.1
Mischak, H.2
Mushinski, J.F.3
Yuspa, S.H.4
-
15
-
-
14644388087
-
Sphingosine 1-phosphate regulates myogenic differentiation: A major role for S1P2 receptor
-
Donati C, Meacci E, Nuti F, Becciolini L, Farnararo M, Bruni P (2005) Sphingosine 1-phosphate regulates myogenic differentiation: a major role for S1P2 receptor. FASEB J 19:449-51
-
(2005)
FASEB J
, vol.19
, pp. 449-451
-
-
Donati, C.1
Meacci, E.2
Nuti, F.3
Becciolini, L.4
Farnararo, M.5
Bruni, P.6
-
16
-
-
0035742583
-
Insulin and insulin-like growth factor I receptors: Similarities and differences in signal transduction
-
Dupont J, LeRoith D (2001) Insulin and insulin-like growth factor I receptors: similarities and differences in signal transduction. Horm Res 55(Suppl 2):22-6
-
(2001)
Horm Res
, vol.55
, Issue.SUPPL. 2
, pp. 22-26
-
-
Dupont, J.1
LeRoith, D.2
-
17
-
-
0346057835
-
Epidermal homeostasis: The role of the growth hormone and insulin-like growth factor systems
-
Edmondson SR, Thumiger SP, Werther GA, Wraight CJ (2003) Epidermal homeostasis: the role of the growth hormone and insulin-like growth factor systems. Endocr Rev 24:737-64
-
(2003)
Endocr Rev
, vol.24
, pp. 737-764
-
-
Edmondson, S.R.1
Thumiger, S.P.2
Werther, G.A.3
Wraight, C.J.4
-
18
-
-
0036245242
-
Getting under the skin of epidermal morphogenesis
-
Fuchs E, Raghavan S (2002) Getting under the skin of epidermal morphogenesis. Nat Rev Genet 3:199-209
-
(2002)
Nat Rev Genet
, vol.3
, pp. 199-209
-
-
Fuchs, E.1
Raghavan, S.2
-
19
-
-
33644990745
-
The role of protein kinase C delta activation and STAT3 Ser727 phosphorylation in insulin-induced keratinocyte proliferation
-
Gartsbein M, Alt A, Hashimoto K, Nakajima K, Kuroki T, Tennenbaum T (2006) The role of protein kinase C delta activation and STAT3 Ser727 phosphorylation in insulin-induced keratinocyte proliferation. J Cell Sci 119:470-81
-
(2006)
J Cell Sci
, vol.119
, pp. 470-481
-
-
Gartsbein, M.1
Alt, A.2
Hashimoto, K.3
Nakajima, K.4
Kuroki, T.5
Tennenbaum, T.6
-
20
-
-
0032721707
-
Insulin-like growth factor-I and binding protein-3 and risk of cancer
-
Giovannucci E (1999) Insulin-like growth factor-I and binding protein-3 and risk of cancer. Horm Res 51(Suppl 3):34-41
-
(1999)
Horm Res
, vol.51
, Issue.SUPPL. 3
, pp. 34-41
-
-
Giovannucci, E.1
-
21
-
-
33644651282
-
Severely impaired insulin signaling in chronic wounds of diabetic ob/ob mice: A potential role of tumor necrosis factor-alpha
-
Goren I, Muller E, Pfeilschifter J, Frank S (2006) Severely impaired insulin signaling in chronic wounds of diabetic ob/ob mice: a potential role of tumor necrosis factor-alpha. Am J Pathol 168:765-77
-
(2006)
Am J Pathol
, vol.168
, pp. 765-777
-
-
Goren, I.1
Muller, E.2
Pfeilschifter, J.3
Frank, S.4
-
22
-
-
0030603158
-
Inhibition of protein kinase C mu by various inhibitors. Differentiation from protein kinase c isoenzymes
-
Gschwendt M, Dieterich S, Rennecke J, Kittstein W, Mueller HJ, Johannes FJ (1996) Inhibition of protein kinase C mu by various inhibitors. Differentiation from protein kinase c isoenzymes. FEBS Lett 392:77-80
-
(1996)
FEBS Lett
, vol.392
, pp. 77-80
-
-
Gschwendt, M.1
Dieterich, S.2
Rennecke, J.3
Kittstein, W.4
Mueller, H.J.5
Johannes, F.J.6
-
23
-
-
33845291120
-
Sphingosine kinases, sphingosine 1-phosphate, apoptosis and diseases
-
Hait NC, Oskeritzian CA, Paugh SW, Milstien S, Spiegel S (2006) Sphingosine kinases, sphingosine 1-phosphate, apoptosis and diseases. Biochim Biophys Acta 1758:2016-26
-
(2006)
Biochim Biophys Acta
, vol.1758
, pp. 2016-2026
-
-
Hait, N.C.1
Oskeritzian, C.A.2
Paugh, S.W.3
Milstien, S.4
Spiegel, S.5
-
24
-
-
0037401876
-
Signaling and biological actions of sphingosine 1-phosphate
-
Hla T (2003) Signaling and biological actions of sphingosine 1-phosphate. Pharmacol Res 47:401-7
-
(2003)
Pharmacol Res
, vol.47
, pp. 401-407
-
-
Hla, T.1
-
25
-
-
0029932093
-
The insulin-like growth factor 1 receptor is expressed by epithelial cells with proliferative potential in human epidermis and skin appendages: Correlation of increased expression with epidermal hyperplasia
-
Hodak E, Gottlieb AB, Anzilotti M, Krueger JG (1996) The insulin-like growth factor 1 receptor is expressed by epithelial cells with proliferative potential in human epidermis and skin appendages: correlation of increased expression with epidermal hyperplasia. J Invest Dermatol 106:564-70
-
(1996)
J Invest Dermatol
, vol.106
, pp. 564-570
-
-
Hodak, E.1
Gottlieb, A.B.2
Anzilotti, M.3
Krueger, J.G.4
-
26
-
-
0023132743
-
Decreased protein kinase C activity in psoriatic versus normal epidermis
-
Horn F, Marks F, Fisher GJ, Marcelo CL, Voorhees JJ (1987) Decreased protein kinase C activity in psoriatic versus normal epidermis. J Invest Dermatol 88:220-2
-
(1987)
J Invest Dermatol
, vol.88
, pp. 220-222
-
-
Horn, F.1
Marks, F.2
Fisher, G.J.3
Marcelo, C.L.4
Voorhees, J.J.5
-
27
-
-
0035853775
-
Sphingosine 1-phosphate and activation of endothelial nitric-oxide synthase: Differential regulation of Akt and MAP kinase pathways by EDG and bradykinin receptors in vascular endothelial cells
-
Igarashi J, Bernier SG, Michel T (2001) Sphingosine 1-phosphate and activation of endothelial nitric-oxide synthase: differential regulation of Akt and MAP kinase pathways by EDG and bradykinin receptors in vascular endothelial cells. J Biol Chem 276:12420-6
-
(2001)
J Biol Chem
, vol.276
, pp. 12420-12426
-
-
Igarashi, J.1
Bernier, S.G.2
Michel, T.3
-
28
-
-
0037310755
-
Antiproliferative property of sphingosine 1-phosphate in rat hepatocytes involves activation of Rho via Edg-5
-
Ikeda H, Satoh H, Yanase M, Inoue Y, Tomiya T, Arai M et al. (2003) Antiproliferative property of sphingosine 1-phosphate in rat hepatocytes involves activation of Rho via Edg-5. Gastroenterology 124:459-69
-
(2003)
Gastroenterology
, vol.124
, pp. 459-469
-
-
Ikeda, H.1
Satoh, H.2
Yanase, M.3
Inoue, Y.4
Tomiya, T.5
Arai, M.6
-
30
-
-
0037096804
-
Phosphorylation of Akt/PKB is required for suppression of cancer cell apoptosis and tumor progression in human colorectal carcinoma
-
Itoh N, Semba S, Ito M, Takeda H, Kawata S, Yamakawa M (2002) Phosphorylation of Akt/PKB is required for suppression of cancer cell apoptosis and tumor progression in human colorectal carcinoma. Cancer 94:3127-34
-
(2002)
Cancer
, vol.94
, pp. 3127-3134
-
-
Itoh, N.1
Semba, S.2
Ito, M.3
Takeda, H.4
Kawata, S.5
Yamakawa, M.6
-
31
-
-
0033604585
-
The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB
-
Kandel ES, Hay N (1999) The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB. Exp Cell Res 253:210-29
-
(1999)
Exp Cell Res
, vol.253
, pp. 210-229
-
-
Kandel, E.S.1
Hay, N.2
-
32
-
-
0036910375
-
Signalling mechanisms in sphingosine 1-phosphate-promoted mesangial cell proliferation
-
Katsuma S, Hada Y, Ueda T, Shiojima S, Hirasawa A, Tanoue A et al. (2002) Signalling mechanisms in sphingosine 1-phosphate-promoted mesangial cell proliferation. Genes Cells 7:1217-30
-
(2002)
Genes Cells
, vol.7
, pp. 1217-1230
-
-
Katsuma, S.1
Hada, Y.2
Ueda, T.3
Shiojima, S.4
Hirasawa, A.5
Tanoue, A.6
-
33
-
-
0038447079
-
Sphingosine-1-phosphate promotes mouse melanocyte survival via ERK and Akt activation
-
Kim DS, Hwang ES, Lee JE, Kim SY, Park KC (2003) Sphingosine-1-phosphate promotes mouse melanocyte survival via ERK and Akt activation. Cell Signal 15:919-26
-
(2003)
Cell Signal
, vol.15
, pp. 919-926
-
-
Kim, D.S.1
Hwang, E.S.2
Lee, J.E.3
Kim, S.Y.4
Park, K.C.5
-
34
-
-
0242384063
-
Sphingosine-1-phosphate inhibits human keratinocyte proliferation via Akt/protein kinase B inactivation
-
Kim DS, Kim SY, Kleuser B, Schafer-Korting M, Kim KH, Park KC (2004) Sphingosine-1-phosphate inhibits human keratinocyte proliferation via Akt/protein kinase B inactivation. Cell Signal 16:89-95
-
(2004)
Cell Signal
, vol.16
, pp. 89-95
-
-
Kim, D.S.1
Kim, S.Y.2
Kleuser, B.3
Schafer-Korting, M.4
Kim, K.H.5
Park, K.C.6
-
35
-
-
33745871646
-
Regulation of apoptosis by insulin-like growth factor (IGF)-I
-
Kooijman R (2006) Regulation of apoptosis by insulin-like growth factor (IGF)-I. Cytokine Growth Factor Rev 17:305-23
-
(2006)
Cytokine Growth Factor Rev
, vol.17
, pp. 305-323
-
-
Kooijman, R.1
-
36
-
-
33746109991
-
Epidermalmorphogenesis: The transcriptional program of human keratinocytes during stratification
-
Koria P, Andreadis ST (2006) Epidermalmorphogenesis: the transcriptional program of human keratinocytes during stratification. J Invest Dermatol 126:1834-41
-
(2006)
J Invest Dermatol
, vol.126
, pp. 1834-1841
-
-
Koria, P.1
Andreadis, S.T.2
-
37
-
-
0032939970
-
Activation of the insulin-like growth factor-1 receptor promotes the survival of human keratinocytes following ultraviolet B irradiation
-
Kuhn C, Hurwitz SA, Kumar MG, Cotton J, Spandau DF (1999) Activation of the insulin-like growth factor-1 receptor promotes the survival of human keratinocytes following ultraviolet B irradiation. Int J Cancer 80:431-8
-
(1999)
Int J Cancer
, vol.80
, pp. 431-438
-
-
Kuhn, C.1
Hurwitz, S.A.2
Kumar, M.G.3
Cotton, J.4
Spandau, D.F.5
-
38
-
-
0034845958
-
PKB/Akt: A key mediator of cell proliferation, survival and insulin responses?
-
Lawlor MA, Alessi DR (2001) PKB/Akt: a key mediator of cell proliferation, survival and insulin responses? J Cell Sci 114:2903-10
-
(2001)
J Cell Sci
, vol.114
, pp. 2903-2910
-
-
Lawlor, M.A.1
Alessi, D.R.2
-
39
-
-
0028957113
-
Molecular and cellular aspects of the insulin-like growth factor I receptor
-
LeRoith D, Werner H, Beitner-Johnson D, Roberts CT Jr (1995) Molecular and cellular aspects of the insulin-like growth factor I receptor. Endocr Rev 16:143-63
-
(1995)
Endocr Rev
, vol.16
, pp. 143-163
-
-
LeRoith, D.1
Werner, H.2
Beitner-Johnson, D.3
Roberts Jr, C.T.4
-
40
-
-
0033233483
-
Protein kinase Cdelta targets mitochondria, alters mitochondrial membrane potential, and induces apoptosis in normal and neoplastic keratinocytes when overexpressed by an adenoviral vector
-
Li L, Lorenzo PS, Bogi K, Blumberg PM, Yuspa SH (1999) Protein kinase Cdelta targets mitochondria, alters mitochondrial membrane potential, and induces apoptosis in normal and neoplastic keratinocytes when overexpressed by an adenoviral vector. Mol Cell Biol 19:8547-58
-
(1999)
Mol Cell Biol
, vol.19
, pp. 8547-8558
-
-
Li, L.1
Lorenzo, P.S.2
Bogi, K.3
Blumberg, P.M.4
Yuspa, S.H.5
-
41
-
-
33645644483
-
Protein kinase C negatively regulates Akt activity and modifies UVC-induced apoptosis in mouse keratinocytes
-
Li L, Sampat K, Hu N, Zakari J, Yuspa SH (2006) Protein kinase C negatively regulates Akt activity and modifies UVC-induced apoptosis in mouse keratinocytes. J Biol Chem 281:3237-43
-
(2006)
J Biol Chem
, vol.281
, pp. 3237-3243
-
-
Li, L.1
Sampat, K.2
Hu, N.3
Zakari, J.4
Yuspa, S.H.5
-
42
-
-
18644376449
-
PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest
-
Liang J, Zubovitz J, Petrocelli T, Kotchetkov R, Connor MK, Han K et al. (2002) PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest. Nat Med 8:1153-60
-
(2002)
Nat Med
, vol.8
, pp. 1153-1160
-
-
Liang, J.1
Zubovitz, J.2
Petrocelli, T.3
Kotchetkov, R.4
Connor, M.K.5
Han, K.6
-
43
-
-
0035542735
-
1Alpha,25-dihydroxyvitamin D3 protects human keratinocytes from apoptosis by the formation of sphingosine-1-phosphate
-
Manggau M, Kim DS, Ruwisch L, Vogler R, Korting HC, Schafer-Korting M et al. (2001) 1Alpha,25-dihydroxyvitamin D3 protects human keratinocytes from apoptosis by the formation of sphingosine-1-phosphate. J Invest Dermatol 117:1241-9
-
(2001)
J Invest Dermatol
, vol.117
, pp. 1241-1249
-
-
Manggau, M.1
Kim, D.S.2
Ruwisch, L.3
Vogler, R.4
Korting, H.C.5
Schafer-Korting, M.6
-
44
-
-
0030934532
-
Wound healing - aiming for perfect skin regeneration
-
Martin P (1997) Wound healing - aiming for perfect skin regeneration. Science 276:75-81
-
(1997)
Science
, vol.276
, pp. 75-81
-
-
Martin, P.1
-
45
-
-
44049111287
-
Protein kinase C in normal human epidermal keratinocytes during proliferation and calcium-induced differentiation
-
Matsui MS, Chew SL, DeLeo VA (1992) Protein kinase C in normal human epidermal keratinocytes during proliferation and calcium-induced differentiation. J Invest Dermatol 99:565-71
-
(1992)
J Invest Dermatol
, vol.99
, pp. 565-571
-
-
Matsui, M.S.1
Chew, S.L.2
DeLeo, V.A.3
-
46
-
-
0022470383
-
Characterization of insulin-like growth factor-I/somatomedin-C receptors on human keratinocyte monolayers
-
Misra P, Nickoloff BJ, Morhenn VB, Hintz RL, Rosenfeld RG (1986) Characterization of insulin-like growth factor-I/somatomedin-C receptors on human keratinocyte monolayers. J Invest Dermatol 87:264-7
-
(1986)
J Invest Dermatol
, vol.87
, pp. 264-267
-
-
Misra, P.1
Nickoloff, B.J.2
Morhenn, V.B.3
Hintz, R.L.4
Rosenfeld, R.G.5
-
47
-
-
34447625046
-
Akt activation induces epidermal hyperplasia and proliferation of epidermal progenitors
-
Murayama K, Kimura T, Tarutani M, Tomooka M, Hayashi R, Okabe M et al. (2007) Akt activation induces epidermal hyperplasia and proliferation of epidermal progenitors. Oncogene 26:4882-8
-
(2007)
Oncogene
, vol.26
, pp. 4882-4888
-
-
Murayama, K.1
Kimura, T.2
Tarutani, M.3
Tomooka, M.4
Hayashi, R.5
Okabe, M.6
-
48
-
-
0037337159
-
Regulation of the ABC kinases by phosphorylation: Protein kinase C as a paradigm
-
Newton AC (2003) Regulation of the ABC kinases by phosphorylation: protein kinase C as a paradigm. Biochem J 370:361-71
-
(2003)
Biochem J
, vol.370
, pp. 361-371
-
-
Newton, A.C.1
-
49
-
-
34447261457
-
PI-3K/Akt signal pathway plays a crucial role in arsenite-induced cell proliferation of human keratinocytes through induction of cyclin D1
-
Ouyang W, Li J, Zhang D, Jiang BH, Huang DC (2007) PI-3K/Akt signal pathway plays a crucial role in arsenite-induced cell proliferation of human keratinocytes through induction of cyclin D1. J Cell Biochem 101:969-78
-
(2007)
J Cell Biochem
, vol.101
, pp. 969-978
-
-
Ouyang, W.1
Li, J.2
Zhang, D.3
Jiang, B.H.4
Huang, D.C.5
-
50
-
-
33750472978
-
Regulation of epidermal homeostasis and repair by phosphoinositide 3-kinase
-
Pankow S, Bamberger C, Klippel A, Werner S (2006) Regulation of epidermal homeostasis and repair by phosphoinositide 3-kinase. J Cell Sci 119:4033-46
-
(2006)
J Cell Sci
, vol.119
, pp. 4033-4046
-
-
Pankow, S.1
Bamberger, C.2
Klippel, A.3
Werner, S.4
-
51
-
-
2442482586
-
Opposite roles of protein kinase C isoforms in proliferation, differentiation, apoptosis, and tumorigenicity of human HaCaT keratinocytes
-
Papp H, Czifra G, Bodo E, Lazar J, Kovacs I, Aleksza M et al. (2004) Opposite roles of protein kinase C isoforms in proliferation, differentiation, apoptosis, and tumorigenicity of human HaCaT keratinocytes. Cell Mol Life Sci 61:1095-105
-
(2004)
Cell Mol Life Sci
, vol.61
, pp. 1095-1105
-
-
Papp, H.1
Czifra, G.2
Bodo, E.3
Lazar, J.4
Kovacs, I.5
Aleksza, M.6
-
52
-
-
13944280988
-
G protein mediated signaling pathways in lysophospholipid induced cell proliferation and survival
-
Radeff-Huang J, Seasholtz TM, Matteo RG, Brown JH (2004) G protein mediated signaling pathways in lysophospholipid induced cell proliferation and survival. J Cell Biochem 92:949-66
-
(2004)
J Cell Biochem
, vol.92
, pp. 949-966
-
-
Radeff-Huang, J.1
Seasholtz, T.M.2
Matteo, R.G.3
Brown, J.H.4
-
53
-
-
0027250173
-
Effect of insulin-like growth factor-I/somatomedin C on thymidine incorporation in cultured psoriatic keratinocytes after growth arrest in growth factor-free medium
-
Ristow HJ (1993) Effect of insulin-like growth factor-I/somatomedin C on thymidine incorporation in cultured psoriatic keratinocytes after growth arrest in growth factor-free medium. Growth Regul 3:129-37
-
(1993)
Growth Regul
, vol.3
, pp. 129-137
-
-
Ristow, H.J.1
-
54
-
-
34848865946
-
Upregulation of hypoxia-inducible factors in normal and psoriatic skin
-
Rosenberger C, Solovan C, Rosenberger AD, Jinping L, Treudler R, Frei U et al. (2007) Upregulation of hypoxia-inducible factors in normal and psoriatic skin. J Invest Dermatol 127:2445-52
-
(2007)
J Invest Dermatol
, vol.127
, pp. 2445-2452
-
-
Rosenberger, C.1
Solovan, C.2
Rosenberger, A.D.3
Jinping, L.4
Treudler, R.5
Frei, U.6
-
55
-
-
33645224054
-
Insulin-like growth factor 1 receptor signaling regulates skin development and inhibits skin keratinocyte differentiation
-
Sadagurski M, Yakar S, Weingarten G, Holzenberger M, Rhodes CJ, Breitkreutz D et al. (2006) Insulin-like growth factor 1 receptor signaling regulates skin development and inhibits skin keratinocyte differentiation. Mol Cell Biol 26:2675-87
-
(2006)
Mol Cell Biol
, vol.26
, pp. 2675-2687
-
-
Sadagurski, M.1
Yakar, S.2
Weingarten, G.3
Holzenberger, M.4
Rhodes, C.J.5
Breitkreutz, D.6
-
56
-
-
4644268278
-
Involvement of Smad signaling in sphingosine 1-phosphate-mediated biological responses of keratinocytes
-
Sauer B, Vogler R, von Wenckstern H, Fujii M, Anzano MB, Glick AB et al. (2004) Involvement of Smad signaling in sphingosine 1-phosphate-mediated biological responses of keratinocytes. J Biol Chem 279:38471-9
-
(2004)
J Biol Chem
, vol.279
, pp. 38471-38479
-
-
Sauer, B.1
Vogler, R.2
von Wenckstern, H.3
Fujii, M.4
Anzano, M.B.5
Glick, A.B.6
-
57
-
-
0037862006
-
Unravelling the activation mechanisms of protein kinase B/Akt
-
Scheid MP, Woodgett JR (2003) Unravelling the activation mechanisms of protein kinase B/Akt. FEBS Lett 546:108-12
-
(2003)
FEBS Lett
, vol.546
, pp. 108-112
-
-
Scheid, M.P.1
Woodgett, J.R.2
-
58
-
-
33644554236
-
Molecular determinants of Akt-induced keratinocyte transformation
-
Segrelles C, Moral M, Lara MF, Ruiz S, Santos M, Leis H et al. (2006) Molecular determinants of Akt-induced keratinocyte transformation. Oncogene 25:1174-85
-
(2006)
Oncogene
, vol.25
, pp. 1174-1185
-
-
Segrelles, C.1
Moral, M.2
Lara, M.F.3
Ruiz, S.4
Santos, M.5
Leis, H.6
-
59
-
-
34347384206
-
The sphingosine 1-phosphate receptor S1P2 triggers hepatic wound healing
-
Serriere-Lanneau V, Teixeira-Clerc F, Li L, Schippers M, de Wries W, Julien B et al. (2007) The sphingosine 1-phosphate receptor S1P2 triggers hepatic wound healing. FASEB J 21:2005-13
-
(2007)
FASEB J
, vol.21
, pp. 2005-2013
-
-
Serriere-Lanneau, V.1
Teixeira-Clerc, F.2
Li, L.3
Schippers, M.4
de Wries, W.5
Julien, B.6
-
60
-
-
0034746437
-
PKCdelta activation: A divergence point in the signaling of insulin and IGF-1-induced proliferation of skin keratinocytes
-
Shen S, Alt A, Wertheimer E, Gartsbein M, Kuroki T, Ohba M et al. (2001) PKCdelta activation: a divergence point in the signaling of insulin and IGF-1-induced proliferation of skin keratinocytes. Diabetes 50:255-64
-
(2001)
Diabetes
, vol.50
, pp. 255-264
-
-
Shen, S.1
Alt, A.2
Wertheimer, E.3
Gartsbein, M.4
Kuroki, T.5
Ohba, M.6
-
61
-
-
0036799377
-
PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization
-
Shin I, Yakes FM, Rojo F, Shin NY, Bakin AV, Baselga J et al. (2002) PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization. Nat Med 8:1145-52
-
(2002)
Nat Med
, vol.8
, pp. 1145-1152
-
-
Shin, I.1
Yakes, F.M.2
Rojo, F.3
Shin, N.Y.4
Bakin, A.V.5
Baselga, J.6
-
62
-
-
17144395975
-
The activation of Akt/PKB signaling pathway and cell survival
-
Song G, Ouyang G, Bao S (2005) The activation of Akt/PKB signaling pathway and cell survival. J Cell Mol Med 9:59-71
-
(2005)
J Cell Mol Med
, vol.9
, pp. 59-71
-
-
Song, G.1
Ouyang, G.2
Bao, S.3
-
63
-
-
0038218405
-
Sphingosine-1-phosphate: An enigmatic signalling lipid
-
Spiegel S, Milstien S (2003) Sphingosine-1-phosphate: an enigmatic signalling lipid. Nat Rev Mol Cell Biol 4:397-407
-
(2003)
Nat Rev Mol Cell Biol
, vol.4
, pp. 397-407
-
-
Spiegel, S.1
Milstien, S.2
-
64
-
-
0035949699
-
AKT plays a central role in tumorigenesis
-
Testa JR, Bellacosa A (2001) AKT plays a central role in tumorigenesis. Proc Natl Acad Sci USA 98:10983-5
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 10983-10985
-
-
Testa, J.R.1
Bellacosa, A.2
-
65
-
-
0038511959
-
Inhibition of Akt phosphorylation by thrombin, histamine and lysophosphatidylcholine in endothelial cells. Differential role of protein kinase C
-
Thors B, Halldorsson H, Clarke GD, Thorgeirsson G (2003) Inhibition of Akt phosphorylation by thrombin, histamine and lysophosphatidylcholine in endothelial cells. Differential role of protein kinase C. Atherosclerosis 168:245-53
-
(2003)
Atherosclerosis
, vol.168
, pp. 245-253
-
-
Thors, B.1
Halldorsson, H.2
Clarke, G.D.3
Thorgeirsson, G.4
-
66
-
-
0021817855
-
Insulin binding properties of normal and transformed human epidermal cultured keratinocytes
-
Verrando P, Ortonne JP (1985) Insulin binding properties of normal and transformed human epidermal cultured keratinocytes. J Invest Dermatol 85:328-32
-
(1985)
J Invest Dermatol
, vol.85
, pp. 328-332
-
-
Verrando, P.1
Ortonne, J.P.2
-
67
-
-
0037378439
-
Sphingosine-1-phosphate and its potentially paradoxical effects on critical parameters of cutaneous wound healing
-
Vogler R, Sauer B, Kim DS, Schafer-Korting M, Kleuser B (2003) Sphingosine-1-phosphate and its potentially paradoxical effects on critical parameters of cutaneous wound healing. J Invest Dermatol 120:693-700
-
(2003)
J Invest Dermatol
, vol.120
, pp. 693-700
-
-
Vogler, R.1
Sauer, B.2
Kim, D.S.3
Schafer-Korting, M.4
Kleuser, B.5
-
68
-
-
0033925870
-
Differential roles of insulin receptor and insulin-like growth factor-1 receptor in differentiation of murine skin keratinocytes
-
Wertheimer E, Trebicz M, Eldar T, Gartsbein M, Nofeh-Moses S, Tennenbaum T (2000) Differential roles of insulin receptor and insulin-like growth factor-1 receptor in differentiation of murine skin keratinocytes. J Invest Dermatol 115:24-9
-
(2000)
J Invest Dermatol
, vol.115
, pp. 24-29
-
-
Wertheimer, E.1
Trebicz, M.2
Eldar, T.3
Gartsbein, M.4
Nofeh-Moses, S.5
Tennenbaum, T.6
-
69
-
-
25844473435
-
Role of PI3K/ Akt signaling in insulin-like growth factor-1 (IGF-1) skin tumor promotion
-
Wilker E, Lu J, Rho O, Carbajal S, Beltran L, DiGiovanni J (2005) Role of PI3K/ Akt signaling in insulin-like growth factor-1 (IGF-1) skin tumor promotion. Mol Carcinog 44:137-45
-
(2005)
Mol Carcinog
, vol.44
, pp. 137-145
-
-
Wilker, E.1
Lu, J.2
Rho, O.3
Carbajal, S.4
Beltran, L.5
DiGiovanni, J.6
-
70
-
-
0034123916
-
Reversal of epidermal hyperproliferation in psoriasis by insulin-like growth factor I receptor antisense oligonucleotides
-
Wraight CJ, White PJ, McKean SC, Fogarty RD, Venables DJ, Liepe IJ et al. (2000) Reversal of epidermal hyperproliferation in psoriasis by insulin-like growth factor I receptor antisense oligonucleotides. Nat Biotechnol 18:521-6
-
(2000)
Nat Biotechnol
, vol.18
, pp. 521-526
-
-
Wraight, C.J.1
White, P.J.2
McKean, S.C.3
Fogarty, R.D.4
Venables, D.J.5
Liepe, I.J.6
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