The association between DRD2/ANKK1, 5-HTTLPR gene, and specific personality trait on antisocial alcoholism among Han Chinese in Taiwan

American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics

Volumn 147, Issue 4, 2008, Pages 447-453

  Wu, Chin Yeh ^a   Wu, Yi Syuan ^a   Lee, Jia Fu ^b   Huang, San Yuan ^c   Yu, Lung ^a   Ko, Huei Chen ^a   Lu, Ru Band ^a,c,d  

^a NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^b Armed Forces Pei Tou Hospital   (Taiwan)

^c TRI SERVICE GENERAL HOSPITAL   (Taiwan)

^d NATIONAL CHENG KUNG UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

Alcoholism; Antisocial personality disorder; Dopamine; Gene; Personality traits; Serotonin

Indexed keywords

ALCOHOL DEHYDROGENASE; ANKYRIN; SEROTONIN TRANSPORTER;

5 HTTLPR GENE; ALCOHOLISM; ANKK1 GENE; ARTICLE; AVOIDANCE BEHAVIOR; CHINESE; COMORBIDITY; DRD2 GENE; GENE; GENETIC POLYMORPHISM; GENOTYPE; PRIORITY JOURNAL; PSYCHOPATHY; TAIWAN;

ALCOHOLISM; ANTISOCIAL PERSONALITY DISORDER; ASIAN CONTINENTAL ANCESTRY GROUP; CASE-CONTROL STUDIES; EPIDEMIOLOGY, MOLECULAR; EXPLORATORY BEHAVIOR; GENOTYPE; HUMANS; PERSONALITY; RECEPTORS, DOPAMINE D2; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; TAIWAN;

EID: 45149125202     PISSN: 15524841     EISSN: 1552485X     Source Type: Journal    
DOI: 10.1002/ajmg.b.30626     Document Type: Article

References (67)

1. American Psychiatric Association. 1994. Diagnostic and Statistical manual of mental disorders 4th edition. Washington: American Psychiatric Association.
2. Berman SM, Noble EP. 1995. Reduced visuospatial performance in children with the D2 dopamine receptor A1 allele. Behav Genet 25:45-58.
3. Blum K, Noble EP, Sheridan PJ, Montgomery A, Ritchie T, Jagadeeswaran P, Nogami H, Briggs AH, Cohn JB. 1990. Allelic association of human dopamine D2 receptor gene in alcoholism. JAMA 263:2055-2060.
4. Chen WJ, Chen HM, Chen CC, Yu WY, Cheng AT. 2002. Cloninger's tridimensional personality questionnaire: Psychometric properties and construct validity in Taiwanese adults. Compr Psychiatry 43:158-166.
5. Chen YC, Lu RB, Peng GS, Wang MF, Wang HK, Ko HC, Chang YC, Lu JJ, Li TK, Yin SJ. 1999. Alcohol metabolism and cardiovascular response in an alcoholic patient homozygous for the ALDH2*2 variant gene allele. Alcohol Clin Exp Res 23:1853-1860.
6. Choi IG, Kee BS, Son HG, Ham BJ, Yang BH, Kim SH, Lee JS, Son BK, Lee BY, Lee SY, Chai YG, Shin HD. 2006. Genetic polymorphisms of alcohol and aldehyde dehydrogenase, dopamine and serotonin transporters in familial and non-familial alcoholism. Eur Neuropsychopharmacol 16:123-128.
7. Cloninger CR, Sigvardsson S, Bohman M. 1988. Childhood personality predicts alcohol abuse in young adults. Alcohol Clin Exp Res 12:494-505.
8. Cloninger CR. 1987a. Neurogenetic adaptive mechanisms in alcoholism. Science 236:410-416.
9. Cloninger CR. 1987b. A systematic method for clinical description and classification of personality variants. A proposal. Arch Gen Psychiatry 44:573-588.
10. Compton PA, Anglin MD, Khalsa-Denison ME, Paredes A. 1996. The D2 dopamine receptor gene, addiction, and personality: Clinical correlates in cocaine abusers. Biol Psychiatry 39:302-304.
11. Edenberg HJ, Foroud T, Koller DL, Goate A, Rice J, Van Eerdewegh P, Reich T, Cloninger CR, Nurnberger JI Jr, Kowalczuk M, Wu B, Li TK, Conneally PM, Tischfield JA, Wu W, Shears S, Crowe R, Hesseibrock V, Schuckit M, Porjesz B, Begleiter H. 1998. A family-based analysis of the association of the dopamine D2 receptor (DRD2) with alcoholism. Alcohol Clin Exp Res 22:505-512.
12. Endicott J, Spitzer RL. 1978. A diagnostic interview: The schedule for affective disorders and schizophrenia. Arch Gen Psychiatry 35:837-844.
13. Endicott J, Spitzer RL. 1979. Use of the research diagnostic criteria and the schedule for affective disorders and schizophrenia to study affective disorders. Am J Psychiatry 136:52-56.
14. Ferguson RA, Goldberg DM. 1997. Genetic markers of alcohol abuse. Clin Chim Acta 257:199-250.
15. Gebhardt C, Leisch F, Schussler P, Fuchs K, Stompe T, Sieghart W, Hornik K, Kasper S, Aschauer HN. 2000. Non-association of dopamine D4 and D2 receptor genes with personality in healthy individuals. Psychiatr Genet 10:131-137.
16. Gelernter J, Kranzler H, Cubells JF. 1997. Serotonin transporter protein (SLC6A4) allele and haplotype frequencies and linkage disequilibria in African- and European-American and Japanese populations and in alcohol-dependent subjects. Hum Genet 101:243-246.
17. Grandy DK, Zhang Y, Civelli O. 1993. PCR detection of the TaqA RFLP at the DRD2 locus. Hum Mol Genet 2:2197.
18. Hallikainen T, Saito T, Lachman HM, Volavka J, Pohjalainen T, Ryynanen OP, Kauhanen J, Syvalahti E, Hietala J, Tiihonen J. 1999. Association between low activity serotonin transporter promoter genotype and early onset alcoholism with habitual impulsive violent behavior. Mol Psychiatry 4:385-3388.
19. Hammoumi S, Payen A, Favre JD, Balmes JL, Benard JY, Husson M, Ferrand JP, Martin JP, Daoust M. 1999. Does the short variant of the serotonin transporter linked polymorphic region constitute a marker of alcohol dependence? Alcohol 17:107-112.
20. Hasin DS, Grant BF. 1987. Psychiatric diagnosis of patients with substance abuse problems: A comparison of two procedures, the DIS and the SADS-L. Alcoholism, drug abuse/dependence, anxiety disorders and antisocial personality disorder. J Psychiatr Res 21:7-22.
21. Heils A, Teufel A, Petri S, Stober G, Riederer P, Bengel D, Lesch KP. 1996. Allelic variation of human serotonin transporter gene expression. J Neurochem 66:2621-2624.
22. Helzer JE, Canino GJ, Yeh EK, Bland RC, Lee CK, Hwu HG, Newman S. 1990. Alcoholism - North America and Asia. A comparison of population surveys with the Diagnostic Interview Schedule. Arch Gen Psychiatry 47:313-319.
23. Hesselbrock V, Stabenau J, Hesselbrock M, Mirkin P, Meyer R. 1982. A comparison of two interview schedules. The Schedule for Affective Disorders and Schizophrenia-Lifetime and the National Institute for Mental Health Diagnostic Interview Schedule. Arch Gen Psychiatry 39:674-677.
24. Higley JD, Linnoila M. 1997. A nonhuman primate model of excessive alcohol intake. Personality and neurobiological parallels of type I- and type II-like alcoholism. Recent Dev Alcohol 13:191-219.
25. Hill EM, Stoltenberg SF, Bullard KH, Li S, Zucker RA, Burmeister M. 2002. Antisocial alcoholism and serotonin-related polymorphisms: Association tests. Psychiatr Genet 12:143-153.
26. Huang SY, Lin WW, Ko HC, Lee JF, Wang TJ, Chou YH, Yin SJ, Lu RB. 2004. Possible interaction of alcohol dehydrogenase and aldehyde dehydrogenase genes with the dopamine D2 receptor gene in anxiety-depressive alcohol dependence. Alcohol Clin Exp Res 28:374-384.
27. Huang SY, Lin WW, Wan FJ, Chang AJ, Ko HC, Wang TJ, Wu PL, Lu RB. 2007. Monoamine oxidase A (MAOA) polymorphisms might modify the association between dopamine D2 receptor (DRD2) gene and alcohol dependence. J Psychiatry Neurosci 32:185-192.
28. Hwu HG, Yeh EK, Chang LY. 1989. Prevalence of psychiatric disorders in Taiwan defined by the Chinese Diagnostic Interview Schedule. Acta Psychiatr Scand 79:136-147.
29. Hwu HG, Yeh YL, Wang JD, Yeh EK. 1990. Alcoholism among Taiwan aborigines defined by the Chinese Diagnostic Interview Schedule: A comparison with alcoholism among Chinese. Acta Psychiatr Scand 82:374-380.
30. Ishiguro H, Saito T, Akazawa S, Mitushio H, Tada K, Enomoto M, Mifune H, Toru M, Shibuya H, Arinami T. 1999. Association between drinking-related antisocial behavior and a polymorphism in the serotonin transporter gene in a Japanese population. Alcohol Clin Exp Res 23:1281-1284.
31. Johann M, Bobbe G, Putzhammer A, Wodarz N. 2003. Comorbidity of alcohol dependence with attention-deficit hyperactivity disorder: Differences in phenotype with increased severity of the substance disorder, but not in genotype (serotonin transporter and 5-hydroxytryptamine-2c receptor). Alcohol Clin Exp Res 27:1527-1534.
32. Kranzler HR, Hernandez-Avila CA, Gelernter J. 2002. Polymorphism of the 5-HT1B receptor gene (HTR1B): Strong within-locus linkage disequilibrium without association to antisocial substance dependence. Neuropsychopharmacology 26:115-122.
33. Kravitz HM, Fawcett J, McGuire M, Kravitz GS, Whitney M. 1999. Treatment attrition among alcohol-dependent men: Is it related to novelty seeking personality traits? J Clin Psychopharmacol 19:51-56.
34. Kutcher SP, Yanchyshyn G, Cohen C. 1985. Diagnosing affective disorder in adolescents: The use of the Schedule for Affective Disorders and Schizophrenia. Can J Psychiatry 30:605-608.
35. Kweon YS, Lee HK, Lee CT, Pae CU. 2005. Association of the serotonin transporter gene polymorphism with Korean male alcoholics. J Psychiatr Res 39:371-376.
36. Lappalainen J, Dean M, Charbonneau L, Virkkunen M, Linnoila M, Goldman D. 1995. Mapping of the serotonin 5-HT1D beta autoreceptor gene on chromosome 6 and direct analysis for sequence variants. Am J Med Genet 60:157-161.
37. Lee MS, Lee HY, Lee HJ, Ryu SH. 2004. Serotonin transporter promoter gene polymorphism and long-term outcome of antidepressant treatment. Psychiatr Genet 14:111-115.
38. Lesch KP, Bengel D, Heils A, Sabol SZ, Greenberg BD, Petri S, Benjamin J, Muller CR, Hamer DH, Murphy DL, 1996. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 274:1527-1531.
39. Lu RB, Ko HC, Lin WL, Lin YT, Ho SL, 1989. CSF neurochemical study of tardive dyskinesia. Biol Psychiatry. 25(6):717-724.
40. Lu RB, Ko HC, Chang FM, Castiglione CM, Schoolfield G, Pakstis AJ, Kidd JR, Kidd KK. 1996. No association between alcoholism and multiple polymorphisms at the dopamine D2 receptor gene (DRD2) in three distinct Taiwanese populations. Biol Psychiatry 39:419-429.
41. Lu RB, Ko HC, Lee JF, Lin WW, Huang SY, Wang TJ, Wu YS, Lu TE, Chou YH. 2005. No alcoholism-protection effects of ADH1B*2 allele in antisocial alcoholics among Han Chinese in Taiwan. Alcohol Clin Exp Res 29:2101-2107.
42. Lu RB, Lee JF, Ko HC, Lin WW, Chen K, Shih JC. 2002. No association of the MAOA gene with alcoholism among Han Chinese males in Taiwan. Prog Neuropsychopharmacol Biol Psychiatry 26:457-461.
43. Lu RB, Lin WW, Lee JF, Ko HC, Shih JC. 2003. Neither antisocial personality disorder nor antisocial alcoholism is associated with the MAO-A gene in Han Chinese males. Alcohol Clin Exp Res 27:889-893.
44. Marques FZ, Hutz MH, Bau CH. 2006. Influence of the serotonin transporter gene on comorbid disorders among alcohol-dependent individuals. Psychiatr Genet 16:125-131.
45. Masse LC, Tremblay RE. 1997. Behavior of boys in kindergarten and the onset of substance use during adolescence. Arch Gen Psychiatry 54:62-68.
46. Matsushita S, Yoshino A, Murayama M, Kimura M, Muramatsu T, Higuchi S. 2001. Association study of serotonin transporter gene regulatory region polymorphism and alcoholism. Am J Med Genet 105:446-450.
47. Merikangas KR, Stevens DE, Fenton B, Stolar M, O'Malley S, Woods SW, Risch N. 1998. Co-morbidity and familial aggregation of alcoholism and anxiety disorders. Psychol Med 28:773-788.
48. Merikangas KR. 1990. The genetic epidemiology of alcoholism. Psychol Med 20:11-22.
49. Meyer-Lindenberg A, Buckholtz JW, Kolachana BR, Hariri A, Pezawas L, Blasi G, Wabnitz A, Honea R, Verchinski B, Callicott JH, Egan M, Mattay VD, Weinberger R, 2006. Neural mechanisms of genetic risk for impulsivity and violence in humans. Proc Natl Acad Sci U S A 103:6269-6274.
50. Murakami F, Shimomura T, Kotani K, Ikawa S, Nanba E, Adachi K. 1999. Anxiety traits associated with a polymorphism in the serotonin transporter gene regulatory region in the Japanese. J Hum Genet 44:15-17.
51. Neville MJ, Johnstone EC, Walton RT. 2004. Identification and characterization of ANK K1: A novel kinase gene closely linked to DRD2 on chromosome band 11q23.1. Hum Mutat 23:540-545.
52. Noble EP. 1998. The D2 dopamine receptor gene: A review of association studies in alcoholism and phenotypes. Alcohol 16:33-45.
53. Noble EP. 2003. D2 dopamine receptor gene in psychiatric and neurologic disorders and its phenotypes. J Med Genet 116B:103-125.
54. Reich T, Hinrichs A, Culverhouse R, Bierut L. 1999. Genetic studies of alcoholism and substance dependence. Am J Hum Genet 65:599-605.
55. Rice JP, Saccone NL, Rasmussen E. 2001. Definition of the phenotype. Adv Genet 42:69-76.
56. Rogers R, Cunnien AJ. 1986. Multiple schedule of affective disorders and schizophrenia (SADS) in the assessment of criminal defendants. J Forensic Sci 31:222-230.
57. Sander T, Harms H, Lesch KP, Dufeu P, Kuhn S, Hoehe M, Rommelspacher H, Schmidt LG. 1997. Association analysis of a regulatory variation of the serotonin transporter gene with severe alcohol dependence. Alcohol Clin Exp Res 21:1356-1359.
58. Soyka M, Preuss UW, Koller G, Zill P, Bondy B. 2004. Association of 5-HT1B receptor gene and antisocial behavior in alcoholism. J Neural Transm 111:101-109.
59. Stoltenberg SF, Twitchell GR, Hanna GL, Cook EH, Fitzgerald HE, Zucker RA, Little KY. 2002. Serotonin transporter promoter polymorphism, peripheral indexes of serotonin function and personality measures in families with alcoholism. Am J Med Genet 114:230-234.
60. Svrakic DM, Przybeck TR, Cloninger CR. 1991. Further contribution to the conceptual validity of the unified biosocial model of personality: US and Yugoslav data. Compr Psychiatry 32:195-209.
61. Thompson J, Thomas N, Singleton A, Piggott M, Lloyd S, Perry EK, Morris CM, Perry RH, Ferrier IN, Court JA. 1997. D2 dopamine receptor gene (DRD2) Taq1 A polymorphism: Reduced dopamine D2 receptor binding in the human striatum associated with the A1 allele. Pharmacogenetics 7:479-484.
62. Thompson MD, Gonzalez N, Nguyen T, Comings DE, George SR, O'Dowd BF. 2000. Serotonin transporter gene polymorphisms in alcohol dependence. Alcohol 22:61-67.
63. Turker T, Sodmann R, Goebel U, Jatzke S, Knapp M, Lesch KP, Schuster R, Schutz H, Weiler G, Stober G. 1998. High ethanol tolerance in young adults is associated with the low-activity variant of the promoter of the human serotonin transporter gene. Neurosci Let 248:147-150.
64. van den Bree MB, Svikis DS, Pickens RW. 1998. Genetic influences in antisocial personality and drug use disorders. Drug Alcohol Depend 49:177-187.
65. Wang TJ, Huang SY, Lin WW, Lo HY, Wu PL, Wang YS, Wu YS, Ko HC, Shih JC, Lu RB. 2007. Possible interaction between MAOA and DRD2 genes associated with antisocial alcoholism among Han Chinese men in Taiwan. Prog Neuropsychopharmacol Biol Psychiatry 31:108-114.
66. Zhang AY, Snowden LR. 1999. Ethnic characteristics of mental disorders in five U.S. communities. Cultur Divers Ethnic Minor Psychol 5:134-146.
67. Zucker RA. 1986. The four alcoholisms: A developmental account of the etiologic process. Nebr Symp Motiv 34:27-83.