No association between alcoholism and multiple polymorphisms at the dopamine D2 receptor gene (DRD2) in three distinct taiwanese populations

Biological Psychiatry

Volumn 39, Issue 6, 1996, Pages 419-429

  Lu, Ru Band ^a   Ko, Huei Chen ^b   Chang, Fong Ming ^b,c   Castiglione, Carmela M ^c   Schoolfield, Gloria ^c   Pakstis, Andrew J ^c   Kidd, Judith R ^c   Kidd, Kenneth K ^c  

^a TRI SERVICE GENERAL HOSPITAL   (Taiwan)

^b NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Alcoholism; Dopamine D2 receptor gene (DRD2); Genotype; Haplotype; Linkage disequilibrium; Molecular genetics; Polymorphism; Population

Indexed keywords

DOPAMINE 2 RECEPTOR;

ALCOHOLISM; ARTICLE; CONTROLLED STUDY; GENETIC POLYMORPHISM; GENETIC VARIABILITY; HAPLOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; MOLECULAR GENETICS; PRIORITY JOURNAL; TAIWAN;

EID: 0030002965     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-3223(95)00182-4     Document Type: Article

References (48)

1. Amadeo S, Abbar M, Fourcade ML, et al (1993): D2 dopamine receptor gene and alcoholism. J Psychiatry Res 27:173-179.
2. American Psychiatric Association (1987): Diagnostic and Statistical Manual of Mental Disorders, 3rd ed rev. Washington DC: American Psychiatric Association.
3. Anderson MA, Gusella JF (1984): Use of cyclosporin A in establishing Epstein-Barr virus-transformed human lymphoblastoid cell lines. In Vitro 20:856-858.
4. Aston CE, Hill SY (1990): Segregation analysis of alcoholism in families ascertained through a pair of male alcoholics. Am J Hum Genet 46:879-887.
5. Babor TF, Hofmann M, Delboca FK, et al (1992): Type of alcoholics: evidence for an empirically derived typology based on indicators of vulnerability and severity. Arch Gen Psychiatry 49:599-608.
6. Barr CL, Kidd KK (1993): Population frequencies of A allele at the dopamine D2 receptor locus. Biol Psychiatry 34:204-209.
7. Blum K, Noble EP, Sheridan PJ, Montgomery A, et al (1990): Allelic association of human dopamine D2 receptor gene in alcoholism. JAMA 263:2055-2060.
8. Blum K, Noble EP, Sheridan PJ, et al (1991): Association of the Al allele of the D2 dopamine receptor gene with severe alcoholism. Alcohol 8:409-416.
9. Blum K, Noble EP, Sheridan PJ, et al (1993): Genetic predisposition in alcoholism: association of the D2 dopamine receptor TaqI B1 RFLP with severe alcoholics. Alcohol 10:59-67.
10. Bolos AM, Dean M, Lucas-Derse S, Ramsburg M, Brown GL, Goldman D (1990): Population and pedigree studies reveal a lack of association between the dopamine D2 receptor gene and alcoholism. JAMA 264:3156-3160.
11. Bowcock AM, Bucci C, Hebert JM, et al (1987): Study of 47 DNA markers in five populations from four continents. Gene Geography 1:47-64.
12. Bowcock AM, Kidd JR, Mountain JL, et al (1991): Drift, admixture, and selection in human evolution: A study with DNA polymorphism. Proc Natl Acad Sci USA 88:839-843.
13. Cadoret RJ, Cain CA, Grove WM (1985): Development of alcoholism in adoptees raised apart from alcoholic biological relatives. Arch Gen Psychiatry 38:861-868.
14. Castiglione CM, Deinard AS, Speed W, et al (1995): Physical mapping, PCR typing, allele frequencies, and haplotyping of three polymorphisms at the DRD2 locus. (Submitted for publication.)
15. Cheng TA (1993): Epidemiology of alcoholism among four aboriginal groups in Taiwan. Proceedings of the Symposium on Drink and Health Problems among Aboriginal Groups in Taiwan. pp 9-19.
16. Cloninger CR, Bohman M, Sigvardsson S (1981): Inheritance of alcohol abuse: cross-fostering analysis of adopted men. Arch Gen Psychiatry 38:861-868.
17. Cloninger CR (1987): Neurogenic adaptive mechanisms in alcoholism. Science 236:410-416.
18. Conneally PM (1991): Association between the D2 Dopamine receptor gene and alcoholism. Arch Gen Psychiatry 48:664-665.
19. Crabb DW (1990): Biological markers for increased risk of alcoholism and for quantitation of alcohol consumption. J Clin Invest 85:311-315.
20. Dempster AP, Laird NM, Rubin DB (1977): Maximum likelihood from incomplete data via the EM algorithm. J R Stat Soc B 39:1-38.
21. Gejman PV, Ram A, Gelernter J, et al (1994): No structure mutation in the dopamine D2 receptor gene in alcoholism or schizophrenia. Analysis using denaturing gradient gel electrophoresis. JAMA 271:204-208.
22. Gelernter J, O'Malley S, Risch N, et al (1991): No association between an allele of the D2 Dopamine receptor gene (DRD2) and alcoholism. JAMA 266:1801-1807.
23. Gelernter J, Kennedy JL, Van Tol HHM, Civelli O, Kidd KK (1992): The D4 dopamine receptor (DRD4) maps to distal 11p close to HRAS. Genomics 13:208-210.
24. Gelernter J, Goldman D, Risch N (1993): The A1 allele at the D2 dopamine receptor gene and alcoholism. A reappraisal. JAMA 269:1673-1677.
25. Gilligan SB, Reich T, Cloninger CR (1987): Etiological heterogeneity in alcoholism. Genet Epidemiol 4:395-414.
26. Goldman D, Brown GL, Albaugh B, et al (1993): DRD2 Dopamine receptor genotype, linkage disequilibrium, and alcoholism in American Indians and other populations. Alcohol Clin Exp Res 17:199-204.
27. Grandy DK, Zhang Y, Civelli O (1993): PCR detection of the TaqA RFLP at the DRD2 locus. Hum Mol Genet 2:2197.
28. Grandy DK, Litt M, Allen L, et al (1989): The human dopamine D2 receptor gene is located in chromosome 11 at q22-q23 and identifies a TaqI polymorphism. Am J Hum Genet 45:527-530.
29. Hartl DL (1980): Principles of Population Genetics. Sunderland, MA: Sinauer Associates Inc.
30. Hauge XY, Grandy DK, Eubanks JH, Evans GA, Civelli O, Litt M (1991): Detection and characterization of an additional DNA polymorphism in the dopamine D2 receptor gene. Genomics 10:527-530.
31. Hawley ME, Pakstis AJ, Kidd KK (1994): A computer program implementing the EM algorithm for haplotype frequency estimation. Am J Phys Anthropol (suppl) 18:104.
32. Hawley ME, Kidd KK (1995): A computer program for estimation of haplotype allele frequencies. J Heredity (in press.)
33. Horgan J (1992): D2 or not D2. A barroom brawl over an "alcoholism gene". [News] Scientific American April; 29-32.
34. Kidd JR, Black FL, Weiss KM, Balazs I, Kidd KK (1991): Studies of three Amerindian populations using nuclear DNA polymorphisms. Hum Biol 63:775-794.
35. Kidd KK (1993): Association of disease with genetic markers: Deja vu all over again. Am J Med Genet 48:71-73.
36. Merikangas KR (1990): The genetic epidemiology of alcoholism. Psychol Med 20:11-22,
37. Morey LC, Skinner HA (1986): Empirically derived classifications of alcohol-related problem. In Gradanter M (ed), Recent Developments in Alcoholism, vol 5. New York: Plenum Co, pp 145-168.
38. Noble EP, Blum K, Ritchie T, Montgomery A, Sheridan PJ (1991): Allelic association of the D2 dopamine receptor gene with receptor-binding characteristics in alcoholism. Arch Gen Psychiatry 48:648-654.
39. O'Hara BF, Smith SS, Bird G, et al (1993): Dopamine D2 receptor RFLPs, haplotypes and their association with substance use in Black and Caucasian research volunteers. Hum Hered 43:209-218.
40. Parsian A, Todd RD, Devor EJ, et al (1991): Alcoholism and allele of the human D2 Dopamine receptor locus: Studies of association and linkage. Arch Gen Psychiatry 48:655-663.
41. Pato CN, Macciardi F, Pato MT, Verga M, Kennedy JL (1993): Review of the putative association of dopamine D2 receptor and alcoholism: a meta-analysis. Am J Med Genet 48:78-82.
42. Pickens RW, Svikis DS, McGue M, Lykken DT, Heston LL, Clayton PJ (1991): Heterogeneity in the inheritance of alcoholism: a study of male and female twins. Arch Gen Psychiatry 48:19-28.
43. Sambrook J, Fritsch EF, Maniatis T (1989). Molecular Cloning. A laboratory Manual (2nd ed). Cold Spring Harbor, NYk: Cold Spring Harbor Lab Press.
44. Suarez BK, Parsian A, Hampe CL, Todd RD, Reich T, Cloninger CR (1994): Linkage disequilibria at the D2 dopamine receptor locus (DRD2) in alcoholics and controls. Genomics 19:12-20.
45. Thomasson HR, Edenberg HT, Crabb DW, et al (1991): Alcohol and aldehyde dehydrogenase and alcoholism in Chinese men. Am J Hum Genet 48:677-681.
46. Thomasson HR, Crabb DW, Edenberg HT, et al (1994): Low frequency of the ADH 2*2 allele among Atayal natives of Taiwan with alcohol use disorder. Alcohol Clin Exp Res 18:640-643.
47. Turner E, Ewing J, Shilling P, et al (1992): Lack of association between an RFLP near the D2 Dopamine receptor gene in severe alcoholism. Biol Psychiatry 31:285-290.
48. Zucker RA (1987): The four alcoholisms: a developmental account of an etiological process. In Rivers PC (ed), Alcohol and Addictive Behavior. Lincoln, NE: University of Nebraska Press, pp 27-83.