Association analysis of a regulatory variation of the serotonin transporter gene with severe alcohol dependence

Alcoholism: Clinical and Experimental Research

Volumn 21, Issue 8, 1997, Pages 1356-1359

  Sander, Thomas ^c   Harms, Helmut ^d   Lesch, Klaus Peter ^b   Dufeu, Peter ^d   Kuhn, Silke ^d   Hoehe, Margret ^a   Rommelspacher, Hans ^d   Schmidt, Lutz G ^d  

^a MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^b UNIVERSITY OF WÜRZBURG   (Germany)

^c CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^d NONE

Author keywords

Alcohol dependence; Association; Genetics; Serotonin transporter; Withdrawal syndrome

Indexed keywords

ALCOHOLISM; ARTICLE; CONTROLLED STUDY; DELIRIUM; DISEASE ASSOCIATION; DISEASE SEVERITY; DNA POLYMORPHISM; FEMALE; GENE EXPRESSION; GENETIC ANALYSIS; GENETIC VARIABILITY; GENOTYPE; HUMAN; HYPOTHESIS; MAJOR CLINICAL STUDY; MALE; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; SEIZURE;

EID: 0030725422     PISSN: 01456008     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1530-0277.1997.tb04462.x     Document Type: Article

References (30)

1. Merikangas KR: The genetic epidemiology of alcoholism. Psychol Med 20:11-22, 1990
2. Pickens RW, Svikis DS, McGue M, Lykken DT, Heston LL, Clayton PJ: Heterogeneity in the inheritance of alcoholism: A study of male and female twins. Arch Gen Psychiatry 48:19-28, 1991
3. Lander ES, Schork NJ: Genetic dissection of complex traits. Science 265:2037-2048, 1994
4. Crabbe JC, Belknap JK, Buck KJ: Genetic animal models of alcohol and drug abuse. Science 264:1715-1723, 1994
5. Owen MJ, Nemeroff CB: The role of serotonin in the pathology of depression: Focus on the serotonin transporter. Clin Chem 40:288-295,1994
6. LeMarquand D, Pihl RO, Benkelfat C: Serotonin and alcohol intake, abuse, and dependence: Clinical evidence. Biol Psychiatry 36:326-337, 1994
7. LeMarquand D, Pihl RO, Benkelfat C: Serotonin and alcohol intake, abuse, and dependence: Findings of animal studies. Biol Psychiatry 36:395-421, 1994
8. Heils A, Teufel A, Petri S, Stöber G, Riederer P, Bengel D, Lesch KP: Allelic variation of human serotonin transporter gene expression. J Neurochem 66:2621-2624, 1996
9. Lesch KP, Heils A, Riederer P: The role of neurotransporters in excitotoxicity, neural cell death, and other neurodegenerative processes. J Mol Med 74:365-378, 1996
10. Lesch KP, Bengel D, Heils A, Sabol SZ, Greenberg BD, Petri S, Benjamin J, Müller CR, Hamer DH, Murphy DL: Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 274:1527-1531, 1996
11. Meltzer H, Arora R: Genetic control of serotonin uptake in blood platelets: A twin study. Psychiatry Res 24:263-269, 1988
12. Fils-Aime M-L, Eckhardt MJ, George DT, Brown GL, Mefford I, Linnoila M: Early-onset alcoholics have lower cerebrospinal fluid 5-hydroxyindoleacetic acid levels than late-onset alcoholics. Arch Gen Psychiatry 53:211-216, 1996
13. Coccaro EF, Kavoussi RJ, Sheline YI, Lish JD, Csermansky JG: Impulsive aggression in personality disorder with tritiated paroxetine binding in the platelet. Arch Gen Psychiatry 53:531-536, 1996
14. Melo JA, Shendure J, Pociask K, Silver LM: Identification of sex-specific quantitative trait loci controlling alcohol preference in C57BL/6 mice. Nature Genet 13:147-152, 1996
15. World Health Organization: International Classification of Diseases: Clinical Descriptions and Diagnostic Guidelines, 10th rev. Geneva, World Health Organization, 1992
16. Robins LE, Wing J, Wittchen HU, Helzer JE, Babor TF, Burke J, Farmer A, Jablenski A, Pickens R, Riegier DA: The Composite International Diagnostic Interview: An epidemiologic instrument suitable for use in conjunction with different diagnostic systems and in different cultures. Arch Gen Psychiatry 45:1069-1077, 1988
17. Buchholz KK, Heath AC, Reich T, Hesselbrock VM, Kramer JR, Nurnberger JI Jr, Schuckit MA: Can we subtype alcoholism? A latent class analysis of data from relatives of alcoholics in a multicenter family study of alcoholism. Alcohol Clin Exp Res 20:1462-1471, 1996
18. Miller SA, Dykes D, Plesky HF: A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res 16:1215, 1988
19. SAS Institute, Inc.: SAS/STAT User's Guide, Release 6.03 Edition. Cary, NC, SAS Institute, 1988
20. SSPS, Inc.: Statistical Package for Social Sciences, Version 4.01. Munich, SSPS, Inc., 1991
21. Lesch KP, Gross J, Franzek E, Wolozin BL, Riederer P, Murphy DL: Primary structure of the serotonin transporter in unipolar depression and bipolar disorder. Biol Psychiatry 37:215-223, 1995
22. Altemus M, Murphy DL, Greenberg B, Lesch KP: Intact coding region of the serotonin transporter in obsessive-compulsive disorder. Am J Med Genet 67:409-411, 1996
23. Di Bella D, Catalano M, Balling U, Smeraldi E, Lesch KP: Systematic screening for mutations in the coding region of the human serotonin transporter (5-HTT) gene using PCR and DGGE. Am J Med Genet 67:541-545, 1996
24. Giros B, Jaber M, Jones SR, Wightman RM, Caron MG: Hyper-locomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter. Nature 379:606-612, 1996
25. De Deurwaerdere P, Bonhomme N, Lucas G, Le Moal M, Spampinato U: Serotonin enhances striatal dopamine outflow in vivo through dopamine uptake sites. J Neurochem 66:210-215, 1996
26. Mirovsky Y, Yu YL, Wagner GC, Sekowski A, Goldberg M, Fisher H: Novel synergistic treatment of ethanol withdrawal seizures in rat with dopamine and serotonin agonists. Alcohol Clin Exp Res 19:160-163, 1995
27. 2C serotonin receptor. Nature 374:542-546, 1996
28. Statnick MA, Dailey JW, Jobe PC, Browning RA: Abnormalities in brain concentration, high-affinity uptake, and tryptophan hydroxylase activity in severe-seizure genetically epilepsy-prone rats. Epilepsia 37:311-321, 1996
29. Falk CT, Rubinstein P: Haplotype relative risks: An easy reliable way to construct a proper control sample. Ann Hum Genet 51:227-233, 1987
30. 3 receptor genes in alcohol dependence. Psychiatr Genet 5:177-181, 1996